sordarin
CHEBI:52549 EXACT SEEDED antifungal
An antifungal metabolite of Sordaria araneosa that inhibits protein synthesis. It has a tetracyclic diterpene glycoside structure.
Structure
| Standard InChIKey | OGGVRVMISBQNMQ-YPBSLCSMSA-N |
|---|---|
| SMILES | C[C@@H]1CC[C@@H]2[C@@H]1C[C@@]3([C@@H]4C[C@]2([C@]3(C(=C4)C(C)C)C(=O)O)C=O)CO[C@H]5[C@H]([C@@H]([C@@H]([C@H](O5)C)OC)O)O |
| Stereochemistry | fully defined |
| Cross-references | pubchem:485851 |
Filing pathway
Terpenoids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Sordaria araneosa NCBITaxon:573841 |
SOURCE_ASSERTION | mibig:BGC0001373 | DOI:10.1111/bph.15724 |
Occurrences 3
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Parascedosporium putredinis NCBITaxon:1442378 |
LOTUS | DOI:10.7164/ANTIBIOTICS.51.1012 |
| Hypoxylon croceum NCBITaxon:2594545 |
LOTUS | DOI:10.1515/ZNC-1999-7-803 |
| Podospora araneosa NCBITaxon:573841 |
LOTUS | DOI:10.1038/JA.2016.40 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001373 | Sordaria araneosa NCBITaxon:573841 |
CLUSTER_UNSTATED | genbank:LC079035.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Elsewhere in the fleet
- AntibioticMech — CHEBI:52549 (same structure, same inchikey)
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001373 | MIBIG | 3 |
| CHEBI:52549 | CHEBI | 3-star |
This page is generated from data/natural_products/terpenoids/sordarin.yaml, which is generated from the committed inventories. Neither is edited by hand.