T-2 toxin
CHEBI:9381 EXACT SEEDED toxin
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
A trichothecene mycotoxin produced by fungi of the genus Fusarium . It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals.
Structure
| Standard InChIKey | BXFOFFBJRFZBQZ-QYWOHJEZSA-N |
|---|---|
| SMILES | CC(=O)OC[C@]12C[C@H](OC(=O)CC(C)C)C(C)=C[C@H]1O[C@@H]1[C@H](O)[C@@H](OC(C)=O)[C@@]2(C)[C@]12CO2 |
| Stereochemistry | fully defined |
| Cross-references | chembl:CHEMBL152423, pubchem:5284461 |
Filing pathway
Terpenoids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is terpene, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Fusarium sporotrichioides NCBITaxon:5514 |
SOURCE_ASSERTION | mibig:BGC0001278 | DOI:10.1128/aem.61.5.1923-1930.1995 |
Occurrences 15
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Fusarium incarnatum NCBITaxon:1894967 |
LOTUS | DOI:10.1021/JF60217A013 |
| Mangifera indica NCBITaxon:29780 |
LOTUS | DOI:10.1016/S0031-9422(00)94210-9 |
| Fusarium heterosporum NCBITaxon:42747 |
LOTUS | DOI:10.1021/NP50015A015 |
| Fusarium oxysporum NCBITaxon:5507 |
LOTUS | DOI:10.1128/AEM.55.1.254-255.1989 |
| Fusarium graminearum NCBITaxon:5518 |
CHEBI | PMID:16604118 |
| Fusarium chlamydosporum NCBITaxon:86545 |
LOTUS | DOI:10.1016/S0953-7562(09)80656-4 |
| Fusarium sporotrichioides NCBITaxon:5514 |
LOTUS | DOI:10.1016/S0953-7562(09)80656-4 |
| Fusarium sporotrichioides NCBITaxon:5514 |
LOTUS | DOI:10.1021/JF00079A054 |
| Fusarium sporotrichioides NCBITaxon:5514 |
LOTUS | DOI:10.1021/JF00100A021 |
| Fusarium sporotrichioides NCBITaxon:5514 |
LOTUS | DOI:10.1021/JO00291A025 |
| Fusarium sporotrichioides NCBITaxon:5514 |
LOTUS | DOI:10.1021/NP50053A021 |
| Fusarium sporotrichioides NCBITaxon:5514 |
LOTUS | DOI:10.1021/NP50077A011 |
| Fusarium sporotrichioides NCBITaxon:5514 |
LOTUS | DOI:10.1128/AEM.55.1.254-255.1989 |
| Fusarium sporotrichioides NCBITaxon:5514 |
LOTUS | DOI:10.1128/AEM.55.9.2195-2199.1989 |
| Fusarium sporotrichioides NCBITaxon:5514 |
CHEBI | PMID:16604118 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001278 | Fusarium sporotrichioides NCBITaxon:5514 |
CLUSTER_UNSTATED | genbank:AF359360.3 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
Bioactivities 1
Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.
| Assay | Result | Target enzyme | Source detail |
|---|---|---|---|
| CCRIS mutagenicity studies | ACTIVE | Not recorded | pubchem.aid:1259407
|
Explore across X-Mech
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001278 | MIBIG | 4 |
| CHEBI:9381 | CHEBI | 3-star |
This page is generated from data/natural_products/terpenoids/t-2-toxin.yaml, which is generated from the committed inventories. Neither is edited by hand.