aflatoxin G1
naturalproductmech:mibig-06204b676b MINTED SEEDED toxin
Structure
| Standard InChIKey | XWIYFDMXXLINPU-RBHXEPJQSA-N |
|---|---|
| SMILES | COC1=C2C3=C(C(=O)OCC3)C(=O)OC2=C4[C@H]5C=CO[C@H]5OC4=C1 |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA014300, pubchem:14421 |
Filing pathway
Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 3
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Aspergillus oryzae NCBITaxon:5062 |
SOURCE_ASSERTION | mibig:BGC0000004 | DOI:10.1021/ja01082a031 |
| Aspergillus flavus NCBITaxon:5059 |
SOURCE_ASSERTION | mibig:BGC0000007 | DOI:10.1007/s00253-002-1094-5 |
| Aspergillus nomius NCBITaxon:41061 |
SOURCE_ASSERTION | mibig:BGC0000009 | DOI:10.1007/bf00393843 |
Occurrences 2
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Aspergillus flavus NCBITaxon:5059 |
LOTUS | DOI:10.1021/JA01082A031 |
| Aspergillus flavus NCBITaxon:5059 |
LOTUS | DOI:10.1128/AEM.72.1.484-490.2006 |
Biosynthetic gene clusters 3
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000004 | Aspergillus oryzae NCBITaxon:5062 |
CLUSTER_UNSTATED | genbank:AB196490.1 |
| mibig:BGC0000007 | Aspergillus flavus NCBITaxon:5059 |
CLUSTER_UNSTATED | genbank:AY510452.1 |
| mibig:BGC0000009 | Aspergillus nomius NCBITaxon:41061 |
CLUSTER_UNSTATED | genbank:AY510454.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 5
| Assay | Result | Reference |
|---|---|---|
| DSSTox (CPDBAS) Carcinogenic Potency Database Summary Mouse Bioassay Results | ACTIVE | pubchem.aid:1199 |
| DSSTox (CPDBAS) Carcinogenic Potency Database Summary MultiCellCall Results | ACTIVE | pubchem.aid:1205 |
| DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results | ACTIVE | pubchem.aid:1208 |
| DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results | ACTIVE | pubchem.aid:1189 |
| GENE-TOX mutagenicity studies | ACTIVE | pubchem.aid:1259408 |
Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0000004, BGC0000007, BGC0000009. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000004 | MIBIG | 3 |
| BGC0000007 | MIBIG | 3 |
| BGC0000009 | MIBIG | 3 |
This page is generated from data/natural_products/unclassified/aflatoxin-g1.yaml, which is generated from the committed inventories. Neither is edited by hand.