aflatoxin G1

naturalproductmech:mibig-06204b676b MINTED SEEDED toxin

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	XWIYFDMXXLINPU-RBHXEPJQSA-N
SMILES	COC1=C2C3=C(C(=O)OCC3)C(=O)OC2=C4[C@H]5C=CO[C@H]5OC4=C1
Stereochemistry	fully defined
Cross-references	npatlas:NPA014300, pubchem:14421

Filing pathway

Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 3

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Aspergillus oryzae NCBITaxon:5062	SOURCE_ASSERTION	mibig:BGC0000004	DOI:10.1021/ja01082a031
Aspergillus flavus NCBITaxon:5059	SOURCE_ASSERTION	mibig:BGC0000007	DOI:10.1007/s00253-002-1094-5
Aspergillus nomius NCBITaxon:41061	SOURCE_ASSERTION	mibig:BGC0000009	DOI:10.1007/bf00393843

Occurrences 2

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Aspergillus flavus NCBITaxon:5059	LOTUS	DOI:10.1021/JA01082A031
Aspergillus flavus NCBITaxon:5059	LOTUS	DOI:10.1128/AEM.72.1.484-490.2006

Biosynthetic gene clusters 3

Accession	Host	Locus evidence	Genome
mibig:BGC0000004	Aspergillus oryzae NCBITaxon:5062	CLUSTER_UNSTATED	genbank:AB196490.1
mibig:BGC0000007	Aspergillus flavus NCBITaxon:5059	CLUSTER_UNSTATED	genbank:AY510452.1
mibig:BGC0000009	Aspergillus nomius NCBITaxon:41061	CLUSTER_UNSTATED	genbank:AY510454.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 5

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Mouse Bioassay Results	ACTIVE	Not recorded	pubchem.aid:1199 assay DSSTox (CPDBAS) Carcinogenic Potency Database Summary Mouse Bioassay Results evidence reference pubchem.aid:1199 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1199, deposited by EPA DSSTox; assay type Other. call ACTIVE activity class TOXIN
DSSTox (CPDBAS) Carcinogenic Potency Database Summary MultiCellCall Results	ACTIVE	Not recorded	pubchem.aid:1205 assay DSSTox (CPDBAS) Carcinogenic Potency Database Summary MultiCellCall Results evidence reference pubchem.aid:1205 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1205, deposited by EPA DSSTox; assay type Other. call ACTIVE activity class TOXIN
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results	ACTIVE	Not recorded	pubchem.aid:1208 assay DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results evidence reference pubchem.aid:1208 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1208, deposited by EPA DSSTox; assay type Other. call ACTIVE activity class TOXIN
DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results	ACTIVE	Not recorded	pubchem.aid:1189 assay DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results evidence reference pubchem.aid:1189 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1189, deposited by EPA DSSTox; assay type Other. call ACTIVE activity class TOXIN
GENE-TOX mutagenicity studies	ACTIVE	Not recorded	pubchem.aid:1259408 assay GENE-TOX mutagenicity studies evidence reference pubchem.aid:1259408 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1259408, deposited by 22071; assay type Other. call ACTIVE activity class TOXIN

Explore across X-Mech

AntibioticMech (aflatoxin G1) ↗ MediaIngredientMech (naturalproductmech:mibig-06204b676b) ↗ TaxonMech: Aspergillus oryzae (NCBITaxon:5062) ↗ TaxonMech: Aspergillus flavus (NCBITaxon:5059) ↗ TaxonMech: Aspergillus nomius (NCBITaxon:41061) ↗ PathwayMech (mibig:BGC0000004) ↗ PathwayMech (mibig:BGC0000007) ↗ PathwayMech (mibig:BGC0000009) ↗

Open questions 1

shared-structure — This structure is reported by more than one MIBiG entry: BGC0000004, BGC0000007, BGC0000009. Confirm they describe the same compound rather than an upstream cross-reference error.

Provenance

Source concept	Source	Version
BGC0000004	MIBIG	3
BGC0000007	MIBIG	3
BGC0000009	MIBIG	3

This page is generated from data/natural_products/unclassified/aflatoxin-g1.yaml, which is generated from the committed inventories. Neither is edited by hand.