antimycin A1B
naturalproductmech:mibig-a1391b5f90 MINTED SEEDED
Structure
| Standard InChIKey | UIFFUZWRFRDZJC-UHFFFAOYSA-N |
|---|---|
| SMILES | CCCCCCC1C(C(OC(=O)C(C(OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)O)C)OC(=O)CC(C)C |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | pubchem:12550 |
Filing pathway
Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces argillaceus NCBITaxon:41951 |
BGC_CORRELATED | mibig:BGC0001455 | PMID:29795673 |
Occurrences 0
None cited.
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001455 | Streptomyces argillaceus NCBITaxon:41951 |
CLUSTER_CORRELATED | genbank:LT989885.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Causal graph — bioactivity 3 nodes, 2 edges
Antimycin A1B inhibits Candida albicans and human mitochondrial cytochrome b.
| Subject | Predicate | Object | Evidence |
|---|---|---|---|
| antimycin A1B | inhibits | Candida albicans SC5314 cytochrome b | DOI:10.1016/j.chembiol.2016.06.016 |
| antimycin A1B | inhibits | Homo sapiens cytochrome b | DOI:10.1016/j.chembiol.2016.06.016 |
Every edge carries its own citation; an uncited edge is refused by the corpus tests.
Molecular targets 2
| Target | Assay organism | Measurement | Reference |
|---|---|---|---|
| Cytochrome b | Candida albicans NCBITaxon:5476 |
IC50 5 nM | PMID:27524297 |
| Cytochrome b UniProtKB:P00156 |
Homo sapiens NCBITaxon:9606 |
IC50 7 nM | PMID:27524297 |
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001455 | MIBIG | 6 |
This page is generated from data/natural_products/unclassified/antimycin-a1b.yaml, which is generated from the committed inventories. Neither is edited by hand.