antimycin A1B

naturalproductmech:mibig-a1391b5f90 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	UIFFUZWRFRDZJC-UHFFFAOYSA-N
SMILES	CCCCCCC1C(C(OC(=O)C(C(OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)O)C)OC(=O)CC(C)C
Stereochemistry	undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-references	pubchem:12550

Filing pathway

Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces argillaceus NCBITaxon:41951	BGC_CORRELATED	mibig:BGC0001455	PMID:29795673

Occurrences 0

None cited.

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0001455	Streptomyces argillaceus NCBITaxon:41951	CLUSTER_CORRELATED	genbank:LT989885.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Causal graph — bioactivity 3 nodes, 2 edges

Antimycin A1B inhibits Candida albicans and human mitochondrial cytochrome b.

Subject	Predicate	Object	Notes	Evidence
antimycin A1B	inhibits	Candida albicans SC5314 cytochrome b	BindingDB maps this exact Standard InChIKey to a 5 nM IC50 measurement against Candida albicans cytochrome b; P0C8L0 resolves in UniProtKB to the SC5314 COB/CYTB gene product.	DOI:10.1016/j.chembiol.2016.06.016 reference DOI:10.1016/j.chembiol.2016.06.016 evidence type DATABASE_ASSERTION snippet Antimycin A (200nM) was included on every plate as a control for 100% inhibition. notes BindingDB own-curated row 93 cites PMID 27524297 and reports an equal-qualified 5 nM IC50 at pH 7.4000 and 25.00 C.
antimycin A1B	inhibits	Homo sapiens cytochrome b	BindingDB maps this exact Standard InChIKey to a 7 nM IC50 measurement against Homo sapiens cytochrome b; P00156 resolves in UniProtKB to the human MT-CYB/COB gene product.	DOI:10.1016/j.chembiol.2016.06.016 reference DOI:10.1016/j.chembiol.2016.06.016 evidence type DATABASE_ASSERTION snippet Antimycin A (200nM) was included on every plate as a control for 100% inhibition. notes BindingDB own-curated row 94 cites PMID 27524297 and reports an equal-qualified 7 nM IC50 at pH 7.4000 and 25.00 C.

Every edge carries its own citation; an uncited edge is refused by the corpus tests.

Molecular targets 2

Target	Target organism	Measurement	Evidence
Cytochrome b PROTEIN BINDS	Candida albicans NCBITaxon:5476	IC50 5 nM	PMID:27524297 reference PMID:27524297 evidence type DATABASE_ASSERTION notes BindingDB own-curated affinity; measured at pH 7.4000, 25.00 C C; qualifier EQUAL.
Cytochrome b PROTEIN BINDS UniProtKB:P00156	Homo sapiens NCBITaxon:9606	IC50 7 nM	PMID:27524297 reference PMID:27524297 evidence type DATABASE_ASSERTION notes BindingDB own-curated affinity; measured at pH 7.4000, 25.00 C C; qualifier EQUAL.

Explore across X-Mech

AntibioticMech (antimycin A1B) ↗ MediaIngredientMech (naturalproductmech:mibig-a1391b5f90) ↗ TaxonMech: Streptomyces argillaceus (NCBITaxon:41951) ↗ PathwayMech (mibig:BGC0001455) ↗

Provenance

Source concept	Source	Version
BGC0001455	MIBIG	6

This page is generated from data/natural_products/unclassified/antimycin-a1b.yaml, which is generated from the committed inventories. Neither is edited by hand.