beauveriolide I
CHEBI:180490 EXACT SEEDED
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
A cyclodepsipeptide with formula C27H41N3O5. It was originally isolated from the fungus Beauveria sp. FO-6979 during a screening program for inhibitors of lipid droplet accumulation in murine macrophages. It is an inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT) and effective at reducing atherogenic lesions of the artery and heart in mouse models.
Structure
| Standard InChIKey | ZKSLFHXTWGEITF-JIORRVSTSA-N |
|---|---|
| SMILES | CCCC[C@H](C)[C@@H]1CC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)O1)CC(C)C)C)CC2=CC=CC=C2 |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA006686 |
Filing pathway
Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, nrps, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Cordyceps militaris CM01 NCBITaxon:983644 |
SOURCE_ASSERTION | mibig:BGC0002259 | PMID:31926180 |
Occurrences 4
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Beauveria sp. NCBITaxon:1891652 |
CHEBI | PMID:10092189 |
| Beauveria NCBITaxon:5581 |
LOTUS | DOI:10.1246/BCSJ.66.3041 |
| Cordyceps militaris NCBITaxon:73501 |
LOTUS | DOI:10.1016/J.JBIOTEC.2020.01.002 |
| Cordyceps militaris NCBITaxon:73501 |
CHEBI | PMID:31926180 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0002259 | Cordyceps militaris CM01 NCBITaxon:983644 |
CLUSTER_DEMONSTRATED | genbank:JH126399.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
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Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0002259 | MIBIG | 2 |
| CHEBI:180490 | CHEBI | 3-star |
This page is generated from data/natural_products/unclassified/beauveriolide-i.yaml, which is generated from the committed inventories. Neither is edited by hand.