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capsular polysaccharide

naturalproductmech:mibig-241ecc69e8 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.
What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKeyFJTWZGAJWZJDEU-SRTYELMFSA-N
SMILESCCCO[C@@H]1C([C@]([C@H]([C@H](O1)CO)O[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O)O)O)(O)OP(=O)(O)O)(O)O
Stereochemistryfully defined
Cross-referencespubchem:195740

Filing pathway

Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is saccharide, from MIBiG.

Producer organisms 3

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Actinobacillus pleuropneumoniae
Strain: 8329
NCBITaxon:715
SOURCE_ASSERTION mibig:BGC0000751
PMID:18215476, https://www.ncbi.nlm.nih.gov/nuccore/AY496881.1
  • reference
    PMID:18215476
    evidence type
    DATABASE_ASSERTION
    notes
    MIBiG BGC0000751 entry version 3; citation taken from the entry level
  • reference
    https://www.ncbi.nlm.nih.gov/nuccore/AY496881.1
    evidence type
    CURATOR_INFERENCE
    notes
    Strain context: 8329. GenBank AY496881.1 source feature identifies strain 8329 and serotype 12. This qualifies the deposited locus, not exact capsule-product identity, which remains open in issue #937. No taxon, structure or evidence-grade change. See issue #938. Taxon identity and evidence grade are unchanged; this is not a species-wide experiment. MIBiG source row BGC0000751:1; SHA256 10f7678a33ca41e17dd1ed8c4287624fb18944a4af0cfab96ac88febcc15115c. Curator: codex; date: 2026-10-13.
Actinobacillus pleuropneumoniae serovar 6 str. Femo
Strain: Femo
NCBITaxon:754256
SOURCE_ASSERTION mibig:BGC0000752
PMID:18215476, https://www.ncbi.nlm.nih.gov/nuccore/AY534316.1
  • reference
    PMID:18215476
    evidence type
    DATABASE_ASSERTION
    notes
    MIBiG BGC0000752 entry version 3; citation taken from the entry level
  • reference
    https://www.ncbi.nlm.nih.gov/nuccore/AY534316.1
    evidence type
    CURATOR_INFERENCE
    notes
    Strain context: Femo. GenBank AY534316.1 source feature identifies strain Femo and serotype 6. This qualifies the deposited locus, not exact capsule-product identity, which remains open in issue #937. No taxon, structure or evidence-grade change. See issue #938. Taxon identity and evidence grade are unchanged; this is not a species-wide experiment. MIBiG source row BGC0000752:1; SHA256 2226e3ae1eefad031a9ad65ad4186d8a63bad60f87b215955bc5fcf452350770. Curator: codex; date: 2026-10-13.
Actinobacillus pleuropneumoniae
Strain: isolate 72-14676
NCBITaxon:715
SOURCE_ASSERTION mibig:BGC0000753
PMID:18215476, https://www.ncbi.nlm.nih.gov/nuccore/AY534317.1
  • reference
    PMID:18215476
    evidence type
    DATABASE_ASSERTION
    notes
    MIBiG BGC0000753 entry version 3; citation taken from the entry level
  • reference
    https://www.ncbi.nlm.nih.gov/nuccore/AY534317.1
    evidence type
    CURATOR_INFERENCE
    notes
    Strain context: isolate 72-14676. GenBank AY534317.1 source feature identifies isolate 72-14676 and serotype 7. This qualifies the deposited locus, not exact capsule-product identity, which remains open in issue #937. No taxon, structure or evidence-grade change. See issue #938. Taxon identity and evidence grade are unchanged; this is not a species-wide experiment. MIBiG source row BGC0000753:1; SHA256 6a147ce201f8aebd556b101422715217e53491d71196e7b819b51b837fdc5d87. Curator: codex; date: 2026-10-13.

Occurrences 2

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

TaxonSourceReference
Actinobacillus lignieresii
NCBITaxon:720
LOTUS DOI:10.1016/J.VETMIC.2007.12.003
Actinobacillus pleuropneumoniae
NCBITaxon:715
LOTUS DOI:10.1016/J.VETMIC.2007.12.003

Biosynthetic gene clusters 3

AccessionHostLocus evidenceGenome
mibig:BGC0000751 Actinobacillus pleuropneumoniae
NCBITaxon:715
CLUSTER_UNSTATED genbank:AY496881.1
mibig:BGC0000752 Actinobacillus pleuropneumoniae serovar 6 str. Femo
NCBITaxon:754256
CLUSTER_UNSTATED genbank:AY534316.1
mibig:BGC0000753 Actinobacillus pleuropneumoniae
NCBITaxon:715
CLUSTER_UNSTATED genbank:AY534317.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

PRODUCERS & OCCURRENCE 3 producers (0 causal) 2 cited occurrences BIOSYNTHETIC LOCUS 3 gene clusters 0 curated pathway steps NATURAL PRODUCT capsular polysaccharide naturalproductmech:mibig-241ecc69e8 Unclassified TARGETS & BIOACTIVITY 0 molecular targets 0 bioactivities · 0 graphs

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Open questions 2

shared-structure — This structure is reported by more than one MIBiG entry: BGC0000751, BGC0000752, BGC0000753. Confirm they describe the same compound rather than an upstream cross-reference error.

curator-capsule-exact-product-assignment — Which exact chemical product does each deposited capsule locus support?

Provenance

Source conceptSourceVersion
BGC0000751MIBIG3
BGC0000752MIBIG3
BGC0000753MIBIG3

This page is generated from data/natural_products/unclassified/capsular-polysaccharide.yaml, which is generated from the committed inventories. Neither is edited by hand.