cremeomycin

CHEBI:184373 EXACT SEEDED antibacterial

A diazo compound that is cyclohexa-1,3-diene substituted by carboxy, methoxy, diazo and oxo groups at positions 1, 4, 5, and 6, respectively. It is an natural product isolated from Streptomyces cremeus.

Structure

Standard InChIKey	HTCPEWKHGGGJBI-UHFFFAOYSA-N
SMILES	COC1=CC=C(C(O)=O)C(=O)C1=[N+]=[N-]
Stereochemistry	fully defined
Cross-references	npatlas:NPA06413, pubchem:54704722

Filing pathway

Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces cremeus NCBITaxon:66881	SOURCE_ASSERTION	mibig:BGC0001295	PMID:26278892

Occurrences 2

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Streptomyces cremeus NCBITaxon:66881	LOTUS	DOI:10.7164/ANTIBIOTICS.48.516
Streptomyces cremeus NCBITaxon:66881	CHEBI	PMID:7622439

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0001295	Streptomyces cremeus NCBITaxon:66881	CLUSTER_UNSTATED	genbank:KT381192.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Elsewhere in the fleet

AntibioticMech — CHEBI:184373 (same structure, same inchikey)

Provenance

Source concept	Source	Version
BGC0001295	MIBIG	5
CHEBI:184373	CHEBI	3-star

This page is generated from data/natural_products/unclassified/cremeomycin.yaml, which is generated from the committed inventories. Neither is edited by hand.