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cystothiazole A

CHEBI:65716 EXACT SEEDED antifungalcytotoxic

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

An organonitrogen heterocyclic antibiotic that is 2,4'-bi-1,3-thiazole substituted by an isopropyl group at position 2' and a 3,5,7-trimethoxy-4-methyl-7-oxohepta-1,5-dien-1-yl group at position 4 (the 2E,4R,5S,6E stereoisomer). It is isolated from the culture broth of myxobacterium, Cystobacter fuscus, and exhibits antifungal and cytotoxic activity.

Structure

Standard InChIKeyLRTJMINIVSPVMX-ZVJWTWILSA-N
SMILESCO[C@@H](\C=C\C1=CSC(=N1)C1=CSC(=N1)C(C)C)[C@@H](C)C(\OC)=C/C(=O)OC
Stereochemistryfully defined
Cross-referencesnpatlas:NPA07000, pubchem:5470965

Filing pathway

Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Cystobacter fuscus
NCBITaxon:43		 SOURCE_ASSERTION mibig:BGC0000982 PMID:16041144

Occurrences 5

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

TaxonSourceReference
Cystobacter fuscus
NCBITaxon:43		 LOTUS DOI:10.1016/S0040-4020(98)00694-2
Cystobacter fuscus
NCBITaxon:43		 LOTUS DOI:10.1271/BBB.68.390
Cystobacter fuscus
NCBITaxon:43		 LOTUS DOI:10.1271/BBB.69.1372
Cystobacter fuscus
NCBITaxon:43		 LOTUS DOI:10.7164/ANTIBIOTICS.51.275
Cystobacter fuscus
NCBITaxon:43		 CHEBI PMID:9589062

Biosynthetic gene clusters 1

AccessionHostLocus evidenceGenome
mibig:BGC0000982 Cystobacter fuscus
NCBITaxon:43 		CLUSTER_UNSTATED genbank:AY834753.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

PRODUCERS & OCCURRENCE 1 producer (0 causal) 5 cited occurrences BIOSYNTHETIC LOCUS 1 gene cluster 0 curated pathway steps NATURAL PRODUCT cystothiazole A CHEBI:65716 Unclassified TARGETS & BIOACTIVITY 0 molecular targets 19 bioactivities · 0 graphs

Bioactivities 19

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

AssayResultTarget enzymeSource detail
NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell lineACTIVENot recorded
pubchem.aid:19
assay
NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line
evidence
  • reference
    pubchem.aid:19
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 19, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell lineACTIVENot recorded
pubchem.aid:139
assay
NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line
evidence
  • reference
    pubchem.aid:139
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 139, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Colon cell lineACTIVENot recorded
pubchem.aid:79
assay
NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Colon cell line
evidence
  • reference
    pubchem.aid:79
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 79, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HCT-15 Colon cell lineACTIVENot recorded
pubchem.aid:71
assay
NCI human tumor cell line growth inhibition assay. Data for the HCT-15 Colon cell line
evidence
  • reference
    pubchem.aid:71
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 71, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HT29 Colon cell lineACTIVENot recorded
pubchem.aid:65
assay
NCI human tumor cell line growth inhibition assay. Data for the HT29 Colon cell line
evidence
  • reference
    pubchem.aid:65
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 65, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Ovarian cell lineACTIVENot recorded
pubchem.aid:101
assay
NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Ovarian cell line
evidence
  • reference
    pubchem.aid:101
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 101, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the LOX IMVI Melanoma cell lineACTIVENot recorded
pubchem.aid:23
assay
NCI human tumor cell line growth inhibition assay. Data for the LOX IMVI Melanoma cell line
evidence
  • reference
    pubchem.aid:23
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 23, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the MCF7 Breast cell lineACTIVENot recorded
pubchem.aid:83
assay
NCI human tumor cell line growth inhibition assay. Data for the MCF7 Breast cell line
evidence
  • reference
    pubchem.aid:83
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 83, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the MOLT-4 Leukemia cell lineACTIVENot recorded
pubchem.aid:123
assay
NCI human tumor cell line growth inhibition assay. Data for the MOLT-4 Leukemia cell line
evidence
  • reference
    pubchem.aid:123
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 123, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the NCI-H460 Non-Small Cell Lung cell lineACTIVENot recorded
pubchem.aid:7
assay
NCI human tumor cell line growth inhibition assay. Data for the NCI-H460 Non-Small Cell Lung cell line
evidence
  • reference
    pubchem.aid:7
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 7, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the OVCAR-3 Ovarian cell lineACTIVENot recorded
pubchem.aid:99
assay
NCI human tumor cell line growth inhibition assay. Data for the OVCAR-3 Ovarian cell line
evidence
  • reference
    pubchem.aid:99
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 99, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the OVCAR-4 Ovarian cell lineACTIVENot recorded
pubchem.aid:105
assay
NCI human tumor cell line growth inhibition assay. Data for the OVCAR-4 Ovarian cell line
evidence
  • reference
    pubchem.aid:105
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 105, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the PC-3 Prostate cell lineACTIVENot recorded
pubchem.aid:41
assay
NCI human tumor cell line growth inhibition assay. Data for the PC-3 Prostate cell line
evidence
  • reference
    pubchem.aid:41
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 41, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the RPMI-8226 Leukemia cell lineACTIVENot recorded
pubchem.aid:113
assay
NCI human tumor cell line growth inhibition assay. Data for the RPMI-8226 Leukemia cell line
evidence
  • reference
    pubchem.aid:113
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 113, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the SF-295 Central Nervous System cell lineACTIVENot recorded
pubchem.aid:47
assay
NCI human tumor cell line growth inhibition assay. Data for the SF-295 Central Nervous System cell line
evidence
  • reference
    pubchem.aid:47
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 47, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell lineACTIVENot recorded
pubchem.aid:37
assay
NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line
evidence
  • reference
    pubchem.aid:37
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 37, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the SR Leukemia cell lineACTIVENot recorded
pubchem.aid:115
assay
NCI human tumor cell line growth inhibition assay. Data for the SR Leukemia cell line
evidence
  • reference
    pubchem.aid:115
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 115, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the U251 Central Nervous System cell lineACTIVENot recorded
pubchem.aid:59
assay
NCI human tumor cell line growth inhibition assay. Data for the U251 Central Nervous System cell line
evidence
  • reference
    pubchem.aid:59
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 59, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the UACC-62 Melanoma cell lineACTIVENot recorded
pubchem.aid:31
assay
NCI human tumor cell line growth inhibition assay. Data for the UACC-62 Melanoma cell line
evidence
  • reference
    pubchem.aid:31
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 31, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC

Elsewhere in the fleet

Explore across X-Mech

AntibioticMech (cystothiazole A) ↗ MediaIngredientMech (CHEBI:65716) ↗ TaxonMech: Cystobacter fuscus (NCBITaxon:43) ↗ PathwayMech (mibig:BGC0000982) ↗

Provenance

Source conceptSourceVersion
BGC0000982MIBIG5
CHEBI:65716CHEBI3-star

This page is generated from data/natural_products/unclassified/cystothiazole-a.yaml, which is generated from the committed inventories. Neither is edited by hand.