destruxin A
naturalproductmech:mibig-a824a5c16b MINTED SEEDED
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
Structure
| Standard InChIKey | XIYSEKITPHTMJT-OCCJOITDSA-N |
|---|---|
| SMILES | [H][C@@]12CCCN1C(=O)[C@@H](CC=C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](NC2=O)[C@@H](C)CC |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA09673 |
Filing pathway
Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Metarhizium robertsii ARSEF 23 NCBITaxon:655844 |
BGC_CHARACTERIZED | mibig:BGC0000337 | DOI:10.1016/j.bcp.2013.05.022 |
Occurrences 11
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Metarhizium indigoticum NCBITaxon:1076431 |
LOTUS | DOI:10.1016/J.TETLET.2011.10.013 |
| Trichothecium roseum NCBITaxon:47278 |
LOTUS | DOI:10.7164/ANTIBIOTICS.50.1007 |
| Metarhizium anisopliae NCBITaxon:5530 |
LOTUS | DOI:10.1006/BBRC.1996.1758 |
| Metarhizium anisopliae NCBITaxon:5530 |
LOTUS | DOI:10.1016/0021-9673(96)00090-8 |
| Metarhizium anisopliae NCBITaxon:5530 |
LOTUS | DOI:10.1016/0031-9422(92)83608-2 |
| Metarhizium anisopliae NCBITaxon:5530 |
LOTUS | DOI:10.1016/0031-9422(93)85099-D |
| Metarhizium anisopliae NCBITaxon:5530 |
LOTUS | DOI:10.1021/NP50094A034 |
| Metarhizium anisopliae NCBITaxon:5530 |
LOTUS | DOI:10.1021/NP50118A007 |
| Metarhizium anisopliae NCBITaxon:5530 |
LOTUS | DOI:10.1039/P19890002347 |
| Metarhizium anisopliae NCBITaxon:5530 |
LOTUS | DOI:10.1080/00021369.1966.10858636 |
| Metarhizium anisopliae NCBITaxon:5530 |
LOTUS | DOI:10.1093/CHROMSCI/26.1.15 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000337 | Metarhizium robertsii ARSEF 23 NCBITaxon:655844 |
CLUSTER_DEMONSTRATED | genbank:GL698760.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
Explore across X-Mech
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000337 | MIBIG | 4 |
This page is generated from data/natural_products/unclassified/destruxin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.