equisetin

naturalproductmech:mibig-4b83bfc007 MINTED SEEDED cytotoxic

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	QNQBPPQLRODXET-AIMHRHHOSA-N
SMILES	[H][C@@]12C[C@H](C)CC[C@@]1([H])[C@@](C)([C@H](\C=C\C)C=C2)C(\O)=C1\C(=O)[C@H](CO)N(C)C1=O
Stereochemistry	fully defined
Cross-references	npatlas:NPA013853, pubchem:54684703

Filing pathway

Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Fusarium heterosporum NCBITaxon:42747	SOURCE_ASSERTION	mibig:BGC0001255	DOI:10.3390/md20110656

Occurrences 8

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Saccharopolyspora erythraea NCBITaxon:1836	LOTUS	DOI:10.1021/NP400761G
Fusarium pallidoroseum NCBITaxon:298378	LOTUS	DOI:10.1021/NP400761G
Ferula equisetacea NCBITaxon:371341	LOTUS	DOI:10.1007/BF00567157
Fusarium equiseti NCBITaxon:61235	LOTUS	DOI:10.1021/JA00203A025
Fusarium heterosporum NCBITaxon:42747	LOTUS	DOI:10.1016/0040-4039(96)01844-8
Fusarium heterosporum NCBITaxon:42747	LOTUS	DOI:10.1016/S0040-4039(98)00269-X
Fusarium heterosporum NCBITaxon:42747	LOTUS	DOI:10.1021/CB400159F
Fusarium heterosporum NCBITaxon:42747	LOTUS	DOI:10.1177/095632029901000202

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0001255	Fusarium heterosporum NCBITaxon:42747	CLUSTER_UNSTATED	genbank:KC439347.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 1

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
NCI human tumor cell line growth inhibition assay. Data for the NCI/ADR-RES Ovarian cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794790 assay NCI human tumor cell line growth inhibition assay. Data for the NCI/ADR-RES Ovarian cell line, single concentration evidence reference pubchem.aid:1794790 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794790, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC

Explore across X-Mech

AntibioticMech (equisetin) ↗ MediaIngredientMech (naturalproductmech:mibig-4b83bfc007) ↗ TaxonMech: Fusarium heterosporum (NCBITaxon:42747) ↗ PathwayMech (mibig:BGC0001255) ↗

Provenance

Source concept	Source	Version
BGC0001255	MIBIG	4

This page is generated from data/natural_products/unclassified/equisetin.yaml, which is generated from the committed inventories. Neither is edited by hand.