frontalamide A
naturalproductmech:mibig-09c929043b MINTED SEEDED
Structure
| Standard InChIKey | FZFGBLTUJOOTPO-QRHYNJGYSA-N |
|---|---|
| SMILES | C[C@H]1[C@H](C[C@H]2[C@@]1([C@H]3[C@H](C2)[C@H]4C/C=C\C(=O)NCCC(C5C(=O)C(=C(/C=C/[C@@H]4CC3=O)O)C(=O)N5)O)O)C=C |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | npatlas:NPA024804, pubchem:101515037 |
Filing pathway
Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces sp. SPB78 NCBITaxon:591157 |
BGC_CHARACTERIZED | mibig:BGC0000996 | PMID:20547882 |
| Streptomyces sp. NCBITaxon:1931 |
SOURCE_ASSERTION | mibig:BGC0002509 | DOI:10.6023/cjoc201912017 |
Occurrences 1
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.1073/PNAS.1001513107 |
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000996 | Streptomyces sp. SPB78 NCBITaxon:591157 |
CLUSTER_DEMONSTRATED | genbank:GG657742.1 |
| mibig:BGC0002509 | Streptomyces sp. NCBITaxon:1931 |
CLUSTER_UNSTATED | genbank:MN817126.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0000996, BGC0002509. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000996 | MIBIG | 5 |
| BGC0002509 | MIBIG | 3 |
This page is generated from data/natural_products/unclassified/frontalamide-a.yaml, which is generated from the committed inventories. Neither is edited by hand.