ikarugamycin
CHEBI:75276 EXACT SEEDED antiparasitic
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
A polyketide macrolactam containing a tetramic acid (pyrrolidine-2,4-dione) ring system. It is isolated from Streptomyces as an antibiotic with antiprotozoal and cytotoxic activities.
Structure
| Standard InChIKey | WSUGGLXIPUHOSG-QOMLVTEJSA-N |
|---|---|
| SMILES | [H][C@]12C[C@@H](C)[C@@H](CC)[C@]1([H])C=C[C@]1([H])[C@H]3C\C=C/C(=O)NCCC[C@@H]4NC(=O)C(=C4O)C(=O)\C=C\[C@@H]3C[C@]21[H] |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA03249, pubchem:101647494 |
Filing pathway
Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces sp. ZJ306 NCBITaxon:1469403 |
SOURCE_ASSERTION | mibig:BGC0001435 | PMID:24519911 |
Occurrences 2
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces phaeochromogenes NCBITaxon:1923 |
CHEBI | PMID:4625358 |
| Streptomyces sp. MDG-04-17-069 NCBITaxon:698778 |
CHEBI | PMID:19968258 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001435 | Streptomyces sp. ZJ306 NCBITaxon:1469403 |
CLUSTER_DEMONSTRATED | genbank:KF954512.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
Elsewhere in the fleet
- AntibioticMech — CHEBI:75276 (same structure, same inchikey)
Explore across X-Mech
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001435 | MIBIG | 4 |
| CHEBI:75276 | CHEBI | 3-star |
This page is generated from data/natural_products/unclassified/ikarugamycin.yaml, which is generated from the committed inventories. Neither is edited by hand.