NaturalProductMech

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jamaicamide C

naturalproductmech:mibig-acd7751f53 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.
What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKeyPRVBXXHHHXSICY-GDKFLGFMSA-N
SMILESCO\C(CCNC(=O)CC\C=C\C(C)CC\C(CCCC=C)=C\Cl)=C\C(=O)N1C(C)C=CC1=O
Stereochemistry undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-referencescyanometdb:CyanoMetDB_1352, npatlas:NPA01111, pubchem:49787033

Filing pathway

Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Lyngbya majuscula
NCBITaxon:158786		 SOURCE_ASSERTION mibig:BGC0001001 DOI:10.1016/j.chembiol.2004.03.030

Occurrences 1

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

TaxonSourceReference
Lyngbya majuscula
NCBITaxon:158786		 LOTUS DOI:10.1016/J.CHEMBIOL.2004.03.030

Biosynthetic gene clusters 1

AccessionHostLocus evidenceGenome
mibig:BGC0001001 Lyngbya majuscula
NCBITaxon:158786 		CLUSTER_UNSTATED genbank:AY522504.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Biosynthesis curated

Written by a curator with claim-level evidence on each step; not derived from a source. This is what the rest of the record exists to support.

#EnzymeReactionSubstrate → productEvidence
1 JamA starter-acid activating/loading ligase (UniProt annotation)
UniProtKB:Q6E7K9		 ungrounded → ungrounded https://www.uniprot.org/uniprotkb/Q6E7K9/entry

Entry 1: Database-described activation of 5-hexenoic acid and loading onto the distinct JamC carrier to form 5-hexenoyl-JamC. JamC is not an enzyme step. This partial starter-unit mechanism is a UniProt database assertion; its contribution to the exact jamaicamide C owner is a curator inference, not an independently inspected compound-specific experiment. Unlike jamaicamide A and B, jamaicamide C retains the terminal alkene compatible with elongation from 5-hexenoyl-JamC without JamB acetylenation. Carrier-bound intermediates remain ungrounded and distinct from free acids and the final owner.

Mechanism & Biosynthesis Overview

PRODUCERS & OCCURRENCE 1 producer (0 causal) 1 cited occurrence BIOSYNTHETIC LOCUS 1 gene cluster 1 curated pathway step NATURAL PRODUCT jamaicamide C naturalproductmech:mibig-acd7751f53 Unclassified TARGETS & BIOACTIVITY 0 molecular targets 0 bioactivities · 1 graph

Causal graph — biosynthesis 6 nodes, 5 edges

Partial JHB JamA/JamC starter-unit graph for jamaicamide C. UniProt describes JamA activation of 5-hexenoic acid and loading onto JamC to form 5-hexenoyl-JamC; the connection to the terminal-alkene congener jamaicamide C is explicitly inferred from the combined source, cluster, and chemical context.

SubjectPredicateObjectNotesEvidence
5-Hexenoic acid (free acid; source name) is_database_asserted_substrate_of Starter-acid activation and loading onto JamC Free 5-hexenoic acid enters JamA activation/loading, not the JamB step. The free acid is not equated with a carrier-bound intermediate.
https://www.uniprot.org/uniprotkb/Q6E7K9/entry
https://www.ncbi.nlm.nih.gov/nuccore/AY522504.1
https://www.uniprot.org/uniprotkb/Q6E7K7/entry
https://www.ncbi.nlm.nih.gov/nuccore/AY522504.1
https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=1454205
  • reference
    https://www.uniprot.org/uniprotkb/Q6E7K9/entry
    evidence type
    DATABASE_ASSERTION
    retrieved on
    2026-10-08
    snippet
    the loading of the activated 5-hexenoic acid onto the acyl carrier protein JamC
    notes
    Reviewed UniProtKB Q6E7K9, entry 64/sequence 1, annotation 2026-09-02. UniProt assigns JamA activation of the free 5-hexenoic-acid starter followed by loading onto JamC. This is a ligase assignment, not a claim that JamA alone synthesizes the final natural product. The cited primary papers DOI:10.1016/j.chembiol.2004.03.030 and DOI:10.1038/nchembio.1718 were not inspected; database experimental evidence codes are not promoted to newly verified primary experiments.
  • reference
    https://www.ncbi.nlm.nih.gov/nuccore/AY522504.1
    evidence type
    CURATOR_INFERENCE
    retrieved on
    2026-10-08
    notes
    Native-reference audit for jamA: AY522504.1 is the 69,900-nt JHB cluster reference named by BGC0001001. Complete plus-strand CDS 6630..8408 (1-based inclusive), codon_start 1/table 11, translates exactly to the 592-aa GenBank CDS annotation AAS98774.1 and UniProtKB:Q6E7K9. UniProt explicitly cross-references AY522504/AAS98774.1 and the JHB nucleotide report. This is not an independently downloaded GenPept comparison or proof of historical assay-stock/construct identity, function, chemical incorporation or native production.
  • reference
    https://www.uniprot.org/uniprotkb/Q6E7K7/entry
    evidence type
    DATABASE_ASSERTION
    retrieved on
    2026-10-08
    snippet
    Accepts as substrate the activated form of 5-hexenoic acid from JamA
    notes
    Reviewed UniProtKB Q6E7K7, entry 75/sequence 1, annotation 2026-09-02. UniProt assigns JamC acyl-carrier function and acceptance of activated 5-hexenoic acid from JamA. JamC is a carrier protein, not a separate enzyme or an independently inferred catalytic step. The entry's protein-existence field is Evidence at transcript level. The cited primary papers DOI:10.1016/j.chembiol.2004.03.030 and DOI:10.1038/nchembio.1718 were not inspected; database experimental evidence codes are not promoted to newly verified primary experiments.
  • reference
    https://www.ncbi.nlm.nih.gov/nuccore/AY522504.1
    evidence type
    CURATOR_INFERENCE
    retrieved on
    2026-10-08
    notes
    Native-reference audit for jamC: AY522504.1 is the 69,900-nt JHB cluster reference named by BGC0001001. Complete plus-strand CDS 9718..10020 (1-based inclusive), codon_start 1/table 11, translates exactly to the 100-aa GenBank CDS annotation AAS98798.1 and UniProtKB:Q6E7K7. UniProt explicitly cross-references AY522504/AAS98798.1 and the JHB nucleotide report. This is not an independently downloaded GenPept comparison or proof of historical assay-stock/construct identity, function, chemical incorporation or native production.
  • reference
    https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=1454205
    evidence type
    DATABASE_ASSERTION
    retrieved on
    2026-10-08
    snippet
    Lyngbya majuscula JHB
    notes
    NCBI's strain page lists this heterotypic synonym for Moorena producens JHB, NCBITaxon:1454205, the strain identity used by the reviewed JamABC UniProt entries. The older nucleotide source and seeded record use Lyngbya majuscula, NCBITaxon:158786. The strain-specific naming bridge and exact accession/sequence matches do not equate those taxon IDs or replace the owner's source-owned taxonomy assertions.
Moorena producens JHB JamA ligase is_database_assigned_catalyst_of Starter-acid activation and loading onto JamC UniProt's starter-acid activation/loading assignment. This is not final jamaicamide synthesis by JamA or an independently read primary assay.
https://www.uniprot.org/uniprotkb/Q6E7K9/entry
https://www.ncbi.nlm.nih.gov/nuccore/AY522504.1
https://www.uniprot.org/uniprotkb/Q6E7K7/entry
https://www.ncbi.nlm.nih.gov/nuccore/AY522504.1
https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=1454205
  • reference
    https://www.uniprot.org/uniprotkb/Q6E7K9/entry
    evidence type
    DATABASE_ASSERTION
    retrieved on
    2026-10-08
    snippet
    the loading of the activated 5-hexenoic acid onto the acyl carrier protein JamC
    notes
    Reviewed UniProtKB Q6E7K9, entry 64/sequence 1, annotation 2026-09-02. UniProt assigns JamA activation of the free 5-hexenoic-acid starter followed by loading onto JamC. This is a ligase assignment, not a claim that JamA alone synthesizes the final natural product. The cited primary papers DOI:10.1016/j.chembiol.2004.03.030 and DOI:10.1038/nchembio.1718 were not inspected; database experimental evidence codes are not promoted to newly verified primary experiments.
  • reference
    https://www.ncbi.nlm.nih.gov/nuccore/AY522504.1
    evidence type
    CURATOR_INFERENCE
    retrieved on
    2026-10-08
    notes
    Native-reference audit for jamA: AY522504.1 is the 69,900-nt JHB cluster reference named by BGC0001001. Complete plus-strand CDS 6630..8408 (1-based inclusive), codon_start 1/table 11, translates exactly to the 592-aa GenBank CDS annotation AAS98774.1 and UniProtKB:Q6E7K9. UniProt explicitly cross-references AY522504/AAS98774.1 and the JHB nucleotide report. This is not an independently downloaded GenPept comparison or proof of historical assay-stock/construct identity, function, chemical incorporation or native production.
  • reference
    https://www.uniprot.org/uniprotkb/Q6E7K7/entry
    evidence type
    DATABASE_ASSERTION
    retrieved on
    2026-10-08
    snippet
    Accepts as substrate the activated form of 5-hexenoic acid from JamA
    notes
    Reviewed UniProtKB Q6E7K7, entry 75/sequence 1, annotation 2026-09-02. UniProt assigns JamC acyl-carrier function and acceptance of activated 5-hexenoic acid from JamA. JamC is a carrier protein, not a separate enzyme or an independently inferred catalytic step. The entry's protein-existence field is Evidence at transcript level. The cited primary papers DOI:10.1016/j.chembiol.2004.03.030 and DOI:10.1038/nchembio.1718 were not inspected; database experimental evidence codes are not promoted to newly verified primary experiments.
  • reference
    https://www.ncbi.nlm.nih.gov/nuccore/AY522504.1
    evidence type
    CURATOR_INFERENCE
    retrieved on
    2026-10-08
    notes
    Native-reference audit for jamC: AY522504.1 is the 69,900-nt JHB cluster reference named by BGC0001001. Complete plus-strand CDS 9718..10020 (1-based inclusive), codon_start 1/table 11, translates exactly to the 100-aa GenBank CDS annotation AAS98798.1 and UniProtKB:Q6E7K7. UniProt explicitly cross-references AY522504/AAS98798.1 and the JHB nucleotide report. This is not an independently downloaded GenPept comparison or proof of historical assay-stock/construct identity, function, chemical incorporation or native production.
  • reference
    https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=1454205
    evidence type
    DATABASE_ASSERTION
    retrieved on
    2026-10-08
    snippet
    Lyngbya majuscula JHB
    notes
    NCBI's strain page lists this heterotypic synonym for Moorena producens JHB, NCBITaxon:1454205, the strain identity used by the reviewed JamABC UniProt entries. The older nucleotide source and seeded record use Lyngbya majuscula, NCBITaxon:158786. The strain-specific naming bridge and exact accession/sequence matches do not equate those taxon IDs or replace the owner's source-owned taxonomy assertions.
Moorena producens JHB JamC acyl carrier is_database_asserted_acyl_carrier_acceptor_for Starter-acid activation and loading onto JamC JamC supplies the carrier, not a separate catalytic reaction. No binding constant, direct protein-interaction assay or uninspected experimental phosphopantetheinylation result is inferred.
https://www.uniprot.org/uniprotkb/Q6E7K9/entry
https://www.ncbi.nlm.nih.gov/nuccore/AY522504.1
https://www.uniprot.org/uniprotkb/Q6E7K7/entry
https://www.ncbi.nlm.nih.gov/nuccore/AY522504.1
https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=1454205
  • reference
    https://www.uniprot.org/uniprotkb/Q6E7K9/entry
    evidence type
    DATABASE_ASSERTION
    retrieved on
    2026-10-08
    snippet
    the loading of the activated 5-hexenoic acid onto the acyl carrier protein JamC
    notes
    Reviewed UniProtKB Q6E7K9, entry 64/sequence 1, annotation 2026-09-02. UniProt assigns JamA activation of the free 5-hexenoic-acid starter followed by loading onto JamC. This is a ligase assignment, not a claim that JamA alone synthesizes the final natural product. The cited primary papers DOI:10.1016/j.chembiol.2004.03.030 and DOI:10.1038/nchembio.1718 were not inspected; database experimental evidence codes are not promoted to newly verified primary experiments.
  • reference
    https://www.ncbi.nlm.nih.gov/nuccore/AY522504.1
    evidence type
    CURATOR_INFERENCE
    retrieved on
    2026-10-08
    notes
    Native-reference audit for jamA: AY522504.1 is the 69,900-nt JHB cluster reference named by BGC0001001. Complete plus-strand CDS 6630..8408 (1-based inclusive), codon_start 1/table 11, translates exactly to the 592-aa GenBank CDS annotation AAS98774.1 and UniProtKB:Q6E7K9. UniProt explicitly cross-references AY522504/AAS98774.1 and the JHB nucleotide report. This is not an independently downloaded GenPept comparison or proof of historical assay-stock/construct identity, function, chemical incorporation or native production.
  • reference
    https://www.uniprot.org/uniprotkb/Q6E7K7/entry
    evidence type
    DATABASE_ASSERTION
    retrieved on
    2026-10-08
    snippet
    Accepts as substrate the activated form of 5-hexenoic acid from JamA
    notes
    Reviewed UniProtKB Q6E7K7, entry 75/sequence 1, annotation 2026-09-02. UniProt assigns JamC acyl-carrier function and acceptance of activated 5-hexenoic acid from JamA. JamC is a carrier protein, not a separate enzyme or an independently inferred catalytic step. The entry's protein-existence field is Evidence at transcript level. The cited primary papers DOI:10.1016/j.chembiol.2004.03.030 and DOI:10.1038/nchembio.1718 were not inspected; database experimental evidence codes are not promoted to newly verified primary experiments.
  • reference
    https://www.ncbi.nlm.nih.gov/nuccore/AY522504.1
    evidence type
    CURATOR_INFERENCE
    retrieved on
    2026-10-08
    notes
    Native-reference audit for jamC: AY522504.1 is the 69,900-nt JHB cluster reference named by BGC0001001. Complete plus-strand CDS 9718..10020 (1-based inclusive), codon_start 1/table 11, translates exactly to the 100-aa GenBank CDS annotation AAS98798.1 and UniProtKB:Q6E7K7. UniProt explicitly cross-references AY522504/AAS98798.1 and the JHB nucleotide report. This is not an independently downloaded GenPept comparison or proof of historical assay-stock/construct identity, function, chemical incorporation or native production.
  • reference
    https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=1454205
    evidence type
    DATABASE_ASSERTION
    retrieved on
    2026-10-08
    snippet
    Lyngbya majuscula JHB
    notes
    NCBI's strain page lists this heterotypic synonym for Moorena producens JHB, NCBITaxon:1454205, the strain identity used by the reviewed JamABC UniProt entries. The older nucleotide source and seeded record use Lyngbya majuscula, NCBITaxon:158786. The strain-specific naming bridge and exact accession/sequence matches do not equate those taxon IDs or replace the owner's source-owned taxonomy assertions.
Starter-acid activation and loading onto JamC has_database_asserted_product 5-Hexenoyl-JamC (covalently carrier-bound) Loaded 5-hexenoyl-JamC as named by UniProt. No free-acid, generic ACP or final-owner identifier is substituted for this covalently loaded state.
https://www.uniprot.org/uniprotkb/Q6E7K9/entry
https://www.ncbi.nlm.nih.gov/nuccore/AY522504.1
https://www.uniprot.org/uniprotkb/Q6E7K7/entry
https://www.ncbi.nlm.nih.gov/nuccore/AY522504.1
https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=1454205
  • reference
    https://www.uniprot.org/uniprotkb/Q6E7K9/entry
    evidence type
    DATABASE_ASSERTION
    retrieved on
    2026-10-08
    snippet
    the loading of the activated 5-hexenoic acid onto the acyl carrier protein JamC
    notes
    Reviewed UniProtKB Q6E7K9, entry 64/sequence 1, annotation 2026-09-02. UniProt assigns JamA activation of the free 5-hexenoic-acid starter followed by loading onto JamC. This is a ligase assignment, not a claim that JamA alone synthesizes the final natural product. The cited primary papers DOI:10.1016/j.chembiol.2004.03.030 and DOI:10.1038/nchembio.1718 were not inspected; database experimental evidence codes are not promoted to newly verified primary experiments.
  • reference
    https://www.ncbi.nlm.nih.gov/nuccore/AY522504.1
    evidence type
    CURATOR_INFERENCE
    retrieved on
    2026-10-08
    notes
    Native-reference audit for jamA: AY522504.1 is the 69,900-nt JHB cluster reference named by BGC0001001. Complete plus-strand CDS 6630..8408 (1-based inclusive), codon_start 1/table 11, translates exactly to the 592-aa GenBank CDS annotation AAS98774.1 and UniProtKB:Q6E7K9. UniProt explicitly cross-references AY522504/AAS98774.1 and the JHB nucleotide report. This is not an independently downloaded GenPept comparison or proof of historical assay-stock/construct identity, function, chemical incorporation or native production.
  • reference
    https://www.uniprot.org/uniprotkb/Q6E7K7/entry
    evidence type
    DATABASE_ASSERTION
    retrieved on
    2026-10-08
    snippet
    Accepts as substrate the activated form of 5-hexenoic acid from JamA
    notes
    Reviewed UniProtKB Q6E7K7, entry 75/sequence 1, annotation 2026-09-02. UniProt assigns JamC acyl-carrier function and acceptance of activated 5-hexenoic acid from JamA. JamC is a carrier protein, not a separate enzyme or an independently inferred catalytic step. The entry's protein-existence field is Evidence at transcript level. The cited primary papers DOI:10.1016/j.chembiol.2004.03.030 and DOI:10.1038/nchembio.1718 were not inspected; database experimental evidence codes are not promoted to newly verified primary experiments.
  • reference
    https://www.ncbi.nlm.nih.gov/nuccore/AY522504.1
    evidence type
    CURATOR_INFERENCE
    retrieved on
    2026-10-08
    notes
    Native-reference audit for jamC: AY522504.1 is the 69,900-nt JHB cluster reference named by BGC0001001. Complete plus-strand CDS 9718..10020 (1-based inclusive), codon_start 1/table 11, translates exactly to the 100-aa GenBank CDS annotation AAS98798.1 and UniProtKB:Q6E7K7. UniProt explicitly cross-references AY522504/AAS98798.1 and the JHB nucleotide report. This is not an independently downloaded GenPept comparison or proof of historical assay-stock/construct identity, function, chemical incorporation or native production.
  • reference
    https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=1454205
    evidence type
    DATABASE_ASSERTION
    retrieved on
    2026-10-08
    snippet
    Lyngbya majuscula JHB
    notes
    NCBI's strain page lists this heterotypic synonym for Moorena producens JHB, NCBITaxon:1454205, the strain identity used by the reviewed JamABC UniProt entries. The older nucleotide source and seeded record use Lyngbya majuscula, NCBITaxon:158786. The strain-specific naming bridge and exact accession/sequence matches do not equate those taxon IDs or replace the owner's source-owned taxonomy assertions.
5-Hexenoyl-JamC (covalently carrier-bound) is_inferred_upstream_precursor_for Jamaicamide C (exact owner; incomplete stereochemistry) This partial starter-unit mechanism is a UniProt database assertion; its contribution to the exact jamaicamide C owner is a curator inference combining explicit JamA/JamC starter-unit loading of 5-hexenoic acid, exact native cluster sequence identity on AY522504.1, the pinned MIBiG BGC0001001 association, and the terminal alkene retained in jamaicamide C (without JamB acetylenation). Carrier-bound intermediates remain ungrounded and distinct from free acids and the final owner.
https://www.uniprot.org/uniprotkb/Q6E7K9/entry
https://www.ncbi.nlm.nih.gov/nuccore/AY522504.1
https://www.uniprot.org/uniprotkb/Q6E7K7/entry
https://www.ncbi.nlm.nih.gov/nuccore/AY522504.1
https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=1454205
https://github.com/CultureBotAI/NaturalProductMech/blob/ec47f1839841f4be14e4d798510bfc30eb2906fe/data/raw/mibig_compounds.tsv
https://github.com/CultureBotAI/NaturalProductMech/blob/ec47f1839841f4be14e4d798510bfc30eb2906fe/data/raw/mibig_compounds.tsv
  • reference
    https://www.uniprot.org/uniprotkb/Q6E7K9/entry
    evidence type
    DATABASE_ASSERTION
    retrieved on
    2026-10-08
    snippet
    the loading of the activated 5-hexenoic acid onto the acyl carrier protein JamC
    notes
    Reviewed UniProtKB Q6E7K9, entry 64/sequence 1, annotation 2026-09-02. UniProt assigns JamA activation of the free 5-hexenoic-acid starter followed by loading onto JamC. This is a ligase assignment, not a claim that JamA alone synthesizes the final natural product. The cited primary papers DOI:10.1016/j.chembiol.2004.03.030 and DOI:10.1038/nchembio.1718 were not inspected; database experimental evidence codes are not promoted to newly verified primary experiments.
  • reference
    https://www.ncbi.nlm.nih.gov/nuccore/AY522504.1
    evidence type
    CURATOR_INFERENCE
    retrieved on
    2026-10-08
    notes
    Native-reference audit for jamA: AY522504.1 is the 69,900-nt JHB cluster reference named by BGC0001001. Complete plus-strand CDS 6630..8408 (1-based inclusive), codon_start 1/table 11, translates exactly to the 592-aa GenBank CDS annotation AAS98774.1 and UniProtKB:Q6E7K9. UniProt explicitly cross-references AY522504/AAS98774.1 and the JHB nucleotide report. This is not an independently downloaded GenPept comparison or proof of historical assay-stock/construct identity, function, chemical incorporation or native production.
  • reference
    https://www.uniprot.org/uniprotkb/Q6E7K7/entry
    evidence type
    DATABASE_ASSERTION
    retrieved on
    2026-10-08
    snippet
    Accepts as substrate the activated form of 5-hexenoic acid from JamA
    notes
    Reviewed UniProtKB Q6E7K7, entry 75/sequence 1, annotation 2026-09-02. UniProt assigns JamC acyl-carrier function and acceptance of activated 5-hexenoic acid from JamA. JamC is a carrier protein, not a separate enzyme or an independently inferred catalytic step. The entry's protein-existence field is Evidence at transcript level. The cited primary papers DOI:10.1016/j.chembiol.2004.03.030 and DOI:10.1038/nchembio.1718 were not inspected; database experimental evidence codes are not promoted to newly verified primary experiments.
  • reference
    https://www.ncbi.nlm.nih.gov/nuccore/AY522504.1
    evidence type
    CURATOR_INFERENCE
    retrieved on
    2026-10-08
    notes
    Native-reference audit for jamC: AY522504.1 is the 69,900-nt JHB cluster reference named by BGC0001001. Complete plus-strand CDS 9718..10020 (1-based inclusive), codon_start 1/table 11, translates exactly to the 100-aa GenBank CDS annotation AAS98798.1 and UniProtKB:Q6E7K7. UniProt explicitly cross-references AY522504/AAS98798.1 and the JHB nucleotide report. This is not an independently downloaded GenPept comparison or proof of historical assay-stock/construct identity, function, chemical incorporation or native production.
  • reference
    https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=1454205
    evidence type
    DATABASE_ASSERTION
    retrieved on
    2026-10-08
    snippet
    Lyngbya majuscula JHB
    notes
    NCBI's strain page lists this heterotypic synonym for Moorena producens JHB, NCBITaxon:1454205, the strain identity used by the reviewed JamABC UniProt entries. The older nucleotide source and seeded record use Lyngbya majuscula, NCBITaxon:158786. The strain-specific naming bridge and exact accession/sequence matches do not equate those taxon IDs or replace the owner's source-owned taxonomy assertions.
  • reference
    https://github.com/CultureBotAI/NaturalProductMech/blob/ec47f1839841f4be14e4d798510bfc30eb2906fe/data/raw/mibig_compounds.tsv
    evidence type
    DATABASE_ASSERTION
    retrieved on
    2026-10-08
    notes
    Already-held pinned MIBiG inventory, BGC0001001 entry version 5: jamaicamide C, PRVBXXHHHXSICY-GDKFLGFMSA-N, native reference AY522504.1, active/questionable/complete. Its source citation is DOI:10.1016/j.chembiol.2004.03.030; no locus experiment is stated, so CLUSTER_UNSTATED and SOURCE_ASSERTION grades remain.
  • reference
    https://github.com/CultureBotAI/NaturalProductMech/blob/ec47f1839841f4be14e4d798510bfc30eb2906fe/data/raw/mibig_compounds.tsv
    evidence type
    CURATOR_INFERENCE
    retrieved on
    2026-10-08
    notes
    This partial starter-unit mechanism is a UniProt database assertion; its contribution to the exact jamaicamide C owner is a curator inference combining explicit jamaicamide starter-unit function, exact native cluster sequence identity, the pinned MIBiG association of jamaicamide C with AY522504.1, and the owner's compatible terminal alkene (PRVBXXHHHXSICY-GDKFLGFMSA-N). Carrier-bound intermediates remain ungrounded and distinct from free acids and the final owner.

Every edge carries its own citation; an uncited edge is refused by the corpus tests.

Explore across X-Mech

AntibioticMech (jamaicamide C) ↗ MediaIngredientMech (naturalproductmech:mibig-acd7751f53) ↗ TaxonMech: Lyngbya majuscula (NCBITaxon:158786) ↗ PathwayMech (mibig:BGC0001001) ↗

Provenance

Source conceptSourceVersion
BGC0001001MIBIG5

This page is generated from data/natural_products/unclassified/jamaicamide-c.yaml, which is generated from the committed inventories. Neither is edited by hand.