lactonamycin
CHEBI:66553 EXACT SEEDED antibacterial
An organic heterohexacyclic compound isolated from the culture broth of Streptomyces rishiriensis. It is an antibiotic with antibacterial activity.
Structure
| Standard InChIKey | XFQJOLWXLJXJSV-VUAGTGNDSA-N |
|---|---|
| SMILES | CO[C@]12CC(=O)O[C@]11C(=O)C3=C(O)C4=C5CN(C)C(=O)C5=C(O)C=C4C=C3C(=O)[C@@]1(CO2)O[C@H]1CC[C@H](O)[C@H](C)O1 |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA011917, pubchem:3075475 |
Filing pathway
Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces rishiriensis NCBITaxon:68264 |
SOURCE_ASSERTION | mibig:BGC0000238 | PMID:18070976 |
Occurrences 4
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces rishiriensis NCBITaxon:68264 |
LOTUS | DOI:10.7164/ANTIBIOTICS.49.953 |
| Streptomyces rishiriensis NCBITaxon:68264 |
LOTUS | DOI:10.7164/ANTIBIOTICS.52.269 |
| Streptomyces rishiriensis NCBITaxon:68264 |
LOTUS | DOI:10.7164/ANTIBIOTICS.52.276 |
| Streptomyces rishiriensis NCBITaxon:68264 |
CHEBI | PMID:8931735 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000238 | Streptomyces rishiriensis NCBITaxon:68264 |
CLUSTER_UNSTATED | genbank:EU147298.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Elsewhere in the fleet
- AntibioticMech — CHEBI:66553 (same structure, same inchikey)
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000238 | MIBIG | 5 |
| CHEBI:66553 | CHEBI | 3-star |
This page is generated from data/natural_products/unclassified/lactonamycin.yaml, which is generated from the committed inventories. Neither is edited by hand.