lysocin E

naturalproductmech:mibig-d34d870776 MINTED SEEDED antibacterial

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	QJPVBLGWZKAQRW-BQBICWQZSA-N
SMILES	CC[C@H](C)[C@@H]1NC(=O)[C@@H](CC2=C[NH]C3=CC=CC=C23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC2=CC=CC=C2)N(C)C(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)C[C@H](O)CC(C)C)[C@@H](C)OC(=O)[C@H]([C@@H](C)O)NC1=O
Stereochemistry	fully defined
Cross-references	npatlas:NPA032822

Filing pathway

Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.

Producer organisms 2

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Lysobacter sp. NCBITaxon:72226	BGC_CHARACTERIZED	mibig:BGC0002384	PMID:32610008
Lysobacter sp. RH2180-5 NCBITaxon:1809648	SOURCE_ASSERTION	mibig:BGC0001657	PMID:27553855

Occurrences 2

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Lysobacter NCBITaxon:68	LOTUS	DOI:10.1021/ACSSYNBIO.0C00067
Lysobacter NCBITaxon:68	LOTUS	DOI:10.1038/JA.2016.102

Biosynthetic gene clusters 2

Accession	Host	Locus evidence	Genome
mibig:BGC0002384	Lysobacter sp. NCBITaxon:72226	CLUSTER_DEMONSTRATED	genbank:MT410681.1
mibig:BGC0001657	Lysobacter sp. RH2180-5 NCBITaxon:1809648	CLUSTER_UNSTATED	genbank:LC128664.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Elsewhere in the fleet

AntibioticMech — antibioticmech:aro-b6c9cc2b59 (same structure, same inchikey)

Explore across X-Mech

AntibioticMech (lysocin E) ↗ MediaIngredientMech (naturalproductmech:mibig-d34d870776) ↗ TaxonMech: Lysobacter sp. (NCBITaxon:72226) ↗ TaxonMech: Lysobacter sp. RH2180-5 (NCBITaxon:1809648) ↗ PathwayMech (mibig:BGC0002384) ↗ PathwayMech (mibig:BGC0001657) ↗

Open questions 1

shared-structure — This structure is reported by more than one MIBiG entry: BGC0001657, BGC0002384. Confirm they describe the same compound rather than an upstream cross-reference error.

Provenance

Source concept	Source	Version
BGC0002384	MIBIG	3
BGC0001657	MIBIG	4

This page is generated from data/natural_products/unclassified/lysocin-e.yaml, which is generated from the committed inventories. Neither is edited by hand.