Myxarylin

naturalproductmech:mibig-489bd6e2d9 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	YNCKCZXUTZJZTQ-ULQDDVLXSA-N
SMILES	CN[C@H]1CC2=CC=C(O)C(=C2)N2C=NC=C2C[C@@H](C(=O)O)NC(=O)[C@H](CC(C)C)NC1=O
Stereochemistry	fully defined
Cross-references	npatlas:NPA033347

Filing pathway

Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is ribosomal, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Pyxidicoccus fallax NCBITaxon:394095	SOURCE_ASSERTION	mibig:BGC0002631	DOI:10.3390/molecules26247483

Occurrences 1

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Pyxidicoccus fallax NCBITaxon:394095	LOTUS	DOI:10.3390/MOLECULES26247483

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0002631	Pyxidicoccus fallax NCBITaxon:394095	CLUSTER_UNSTATED	genbank:OL539738.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Causal graph — biosynthesis 4 nodes, 3 edges

Proposed BytZ N-terminal methylation context for myxarylin, based on MITE's explicit putative/proposed assignment. Native Pyxidicoccus fallax An d48 (deposit note MCy8396) reference identity is verified independently, not its catalytic activity. No UniProt homolog is substituted for the exact GenPept protein. No primary assay, leader-cleavage mechanism, complete pathway order or source-grade upgrade is adopted; not full-record sign-off.

Subject	Predicate	Object	Notes	Evidence
BytZ native An d48 reference	is_database_proposed_catalyst_of	Proposed BytZ N-terminal methylation	Catalysis is proposed, not established by the sequence match. On2026-10-07, bounded official UniProtKB searches for UID85537 and exact bytZ/taxon394095, plus UniParc UID85537, returned zero candidates. This is not universal UniProt absence; the exact NCBIProtein accession is used. No activity magnitude, knockout phenotype, native cofactor state, binding site or physical complex is asserted.	https://github.com/mite-standard/mite_data/blob/6eacd913b2036376031072f69cbb33908f132998/mite_data/data/MITE0000420.json https://www.ncbi.nlm.nih.gov/protein/UID85537.1 https://www.ncbi.nlm.nih.gov/nuccore/OL539738.1 reference https://github.com/mite-standard/mite_data/blob/6eacd913b2036376031072f69cbb33908f132998/mite_data/data/MITE0000420.json evidence type DATABASE_ASSERTION retrieved on 2026-10-07 notes MITE0000420 version 1, active, identifies BytZ/UID85537.1 and BGC0002631. Its top-level comment explicitly calls the methyltransferase putative and the N-terminal methylation proposed. That qualification governs this graph despite the reaction description's unqualified verb. Heterologous expression and genomic/chemical inference codes remain database assertions; both cited papers were inaccessible. snippet proposed to catalyze N-terminal methylation reference https://www.ncbi.nlm.nih.gov/protein/UID85537.1 evidence type DATABASE_ASSERTION retrieved on 2026-10-07 notes Full independent GenPept reference and coded_by inspected: bytZ, class I SAM-dependent methyltransferase,264 residues, P.fallax strain An d48, note MCy8396/taxon394095. The submission name is not evidence of a direct activity assay. reference https://www.ncbi.nlm.nih.gov/nuccore/OL539738.1 evidence type CURATOR_INFERENCE retrieved on 2026-10-07 notes Complete795-nt plus-strand single CDS1797..2591, codon1/table11. Full CDS translation equals the annotation and independent UID85537.1/all264aa; GTG is an initiating methionine under table11. Independent coded_by DNA/coordinates and source strain/taxon match. This authenticates the genomic reference, not historical assay stocks or constructs.
Unmethylated cyclized peptide, database example	is_database_example_substrate_of	Proposed BytZ N-terminal methylation	MITE encodes an unmethylated cyclized-peptide example. Its identifier remains ungrounded. No leader-cleavage enzyme, cleavage event, reaction order relative to cyclization or additional BytA/BytO catalytic function is inferred from this proposed methylation context.	https://github.com/mite-standard/mite_data/blob/6eacd913b2036376031072f69cbb33908f132998/mite_data/data/MITE0000420.json reference https://github.com/mite-standard/mite_data/blob/6eacd913b2036376031072f69cbb33908f132998/mite_data/data/MITE0000420.json evidence type DATABASE_ASSERTION retrieved on 2026-10-07 notes MITE0000420 version 1, active, identifies BytZ/UID85537.1 and BGC0002631. Its top-level comment explicitly calls the methyltransferase putative and the N-terminal methylation proposed. That qualification governs this graph despite the reaction description's unqualified verb. Heterologous expression and genomic/chemical inference codes remain database assertions; both cited papers were inaccessible.
Proposed BytZ N-terminal methylation	has_database_example_product	Myxarylin	Pinned MITE neutral product matches the owner's full InChIKey YNCKCZXUTZJZTQ-ULQDDVLXSA-N and complete stereo in the retained repository-helper/RDKit2026.03.5 screen. No physiological pathway finality or experimental confirmation is inferred. SOURCE_ASSERTION producer and CLUSTER_UNSTATED locus grades, separate LOTUS occurrence, source data and SEEDED status remain unchanged.	https://github.com/mite-standard/mite_data/blob/6eacd913b2036376031072f69cbb33908f132998/mite_data/data/MITE0000420.json reference https://github.com/mite-standard/mite_data/blob/6eacd913b2036376031072f69cbb33908f132998/mite_data/data/MITE0000420.json evidence type DATABASE_ASSERTION retrieved on 2026-10-07 notes MITE0000420 version 1, active, identifies BytZ/UID85537.1 and BGC0002631. Its top-level comment explicitly calls the methyltransferase putative and the N-terminal methylation proposed. That qualification governs this graph despite the reaction description's unqualified verb. Heterologous expression and genomic/chemical inference codes remain database assertions; both cited papers were inaccessible.

Every edge carries its own citation; an uncited edge is refused by the corpus tests.

Explore across X-Mech

AntibioticMech (Myxarylin) ↗ MediaIngredientMech (naturalproductmech:mibig-489bd6e2d9) ↗ TaxonMech: Pyxidicoccus fallax (NCBITaxon:394095) ↗ PathwayMech (mibig:BGC0002631) ↗

Provenance

Source concept	Source	Version
BGC0002631	MIBIG	2

This page is generated from data/natural_products/unclassified/myxarylin.yaml, which is generated from the committed inventories. Neither is edited by hand.