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myxothiazol

naturalproductmech:mibig-2ae39e1a11 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.
What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKeyXKTFQMCPGMTBMD-ARYLOLAOSA-N
SMILESCOC(\C=C\C1=CSC(=N1)C1=CSC(=N1)C(C)\C=C\C=C\C(C)C)C(C)C(\OC)=C/C(N)=O
Stereochemistry undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-referencesnpatlas:NPA01854

Filing pathway

Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Stigmatella aurantiaca DW4/3-1
NCBITaxon:378806
BGC_CHARACTERIZED mibig:BGC0001024 PMID:10601310

Occurrences 2

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

TaxonSourceReference
Myxococcus fulvus
NCBITaxon:33
LOTUS DOI:10.7164/ANTIBIOTICS.33.1480
Stigmatella aurantiaca
NCBITaxon:41
LOTUS DOI:10.1074/JBC.274.52.37391

Biosynthetic gene clusters 1

AccessionHostLocus evidenceGenome
mibig:BGC0001024 Stigmatella aurantiaca DW4/3-1
NCBITaxon:378806
CLUSTER_DEMONSTRATED genbank:AF188287.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

PRODUCERS & OCCURRENCE 1 producer (1 causal) 2 cited occurrences BIOSYNTHETIC LOCUS 1 gene cluster 0 curated pathway steps NATURAL PRODUCT myxothiazol naturalproductmech:mibig-2ae39e1a11 Unclassified TARGETS & BIOACTIVITY 0 molecular targets 0 bioactivities · 0 graphs

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Provenance

Source conceptSourceVersion
BGC0001024MIBIG5

This page is generated from data/natural_products/unclassified/myxothiazol.yaml, which is generated from the committed inventories. Neither is edited by hand.