notoamide A
naturalproductmech:mibig-edbab72597 MINTED SEEDED
Structure
| Standard InChIKey | KGCIBVDLLPYXFL-OFVWMMNVSA-N |
|---|---|
| SMILES | CC1(C)[C@@H]2C[C@]34CCCN3C(=O)[C@@]2(C[C@@]11C(=O)N(O)C2=C1C=CC1=C2C=CC(C)(C)O1)NC4=O |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA04681, npatlas:NPA004681 |
Filing pathway
Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, terpene, other, pks, from MIBiG.
Producer organisms 3
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Aspergillus sp. MF297-2 NCBITaxon:877550 |
BGC_CORRELATED | mibig:BGC0001084 | PMID:20722388 |
| Aspergillus versicolor NCBITaxon:46472 |
SOURCE_ASSERTION | mibig:BGC0000818 | PMID:23213353 |
| Aspergillus sp. FM242 NCBITaxon:2741095 |
SOURCE_ASSERTION | mibig:BGC0002254 | PMID:32433885 |
Occurrences 4
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Aspergillus NCBITaxon:5052 |
LOTUS | DOI:10.1002/ANIE.200604381 |
| Aspergillus NCBITaxon:5052 |
LOTUS | DOI:10.1021/JA1049302 |
| Aspergillus NCBITaxon:5052 |
LOTUS | DOI:10.1021/NP0102758 |
| Aspergillus NCBITaxon:5052 |
LOTUS | DOI:10.1021/NP800471Y |
Biosynthetic gene clusters 3
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001084 | Aspergillus sp. MF297-2 NCBITaxon:877550 |
CLUSTER_CORRELATED | genbank:HM622670.1 |
| mibig:BGC0000818 | Aspergillus versicolor NCBITaxon:46472 |
CLUSTER_UNSTATED | genbank:JQ708194.1 |
| mibig:BGC0002254 | Aspergillus sp. FM242 NCBITaxon:2741095 |
CLUSTER_UNSTATED | genbank:MT457561.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0000818, BGC0001084, BGC0002254. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001084 | MIBIG | 5 |
| BGC0000818 | MIBIG | 5 |
| BGC0002254 | MIBIG | 3 |
This page is generated from data/natural_products/unclassified/notoamide-a.yaml, which is generated from the committed inventories. Neither is edited by hand.