penitrem F

naturalproductmech:mibig-b2dece145a MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	YWORPEZTBDVGCS-JCMMWUKFSA-N
SMILES	[H][C@]12C[C@@]3([H])[C@@]1([H])C1=C(CC2=C)C(Cl)=CC2=C1C1=C(N2)[C@@]2(C)[C@@]([H])(CC[C@@]4(O)[C@@]56O[C@@H]5[C@@H](O)[C@H](O[C@@]6([H])CC[C@]24C)C(C)=C)[C@]1([H])OC3(C)C
Stereochemistry	fully defined
Cross-references	npatlas:NPA05947, pubchem:3086086

Filing pathway

Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is terpene, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Penicillium simplicissimum NCBITaxon:69488	SOURCE_ASSERTION	mibig:BGC0001375	DOI:10.1021/jf020983e

Occurrences 7

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Mucor irregularis NCBITaxon:1290454	LOTUS	DOI:10.1021/ACS.JNATPROD.6B00403
Penicillium crustosum NCBITaxon:36656	LOTUS	DOI:10.1021/JF020983E
Penicillium crustosum NCBITaxon:36656	LOTUS	DOI:10.1039/P19830001847
Penicillium crustosum NCBITaxon:36656	LOTUS	DOI:10.1039/P19830001863
Penicillium solitum NCBITaxon:60172	LOTUS	DOI:10.1021/JF020983E
Penicillium solitum NCBITaxon:60172	LOTUS	DOI:10.1039/P19830001847
Penicillium solitum NCBITaxon:60172	LOTUS	DOI:10.1039/P19830001863

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0001375	Penicillium simplicissimum NCBITaxon:69488	CLUSTER_UNSTATED	genbank:LC027937.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Explore across X-Mech

AntibioticMech (penitrem F) ↗ MediaIngredientMech (naturalproductmech:mibig-b2dece145a) ↗ TaxonMech: Penicillium simplicissimum (NCBITaxon:69488) ↗ PathwayMech (mibig:BGC0001375) ↗

Provenance

Source concept	Source	Version
BGC0001375	MIBIG	4

This page is generated from data/natural_products/unclassified/penitrem-f.yaml, which is generated from the committed inventories. Neither is edited by hand.