pirazofurin
CHEBI:90284 EXACT SEEDED antimicrobial unspecified
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
A C-glycosyl compound that is 4-hydroxy-1H-pyrazole-5-carboxamide in which the hydrogen at position 3 has been replaced by a β-D-ribofuranosyl group.
Structure
| Standard InChIKey | XESARGFCSKSFID-FLLFQEBCSA-N |
|---|---|
| SMILES | NC(=O)C1=C(O)C([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)=N[NH]1 |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA033439, pubchem:135413551, chembl:CHEMBL2105330 |
Filing pathway
Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces candidus NCBITaxon:67283 |
SOURCE_ASSERTION | mibig:BGC0001985 | DOI:10.1002/anie.201910356 |
Occurrences 2
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces sparsogenes NCBITaxon:67365 |
LOTUS | DOI:10.1016/S0021-9673(01)83861-9 |
| Streptomyces candidus NCBITaxon:67283 |
LOTUS | DOI:10.1128/AAC.5.1.90 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001985 | Streptomyces candidus NCBITaxon:67283 |
CLUSTER_DEMONSTRATED | genbank:MN305320.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
Elsewhere in the fleet
- AntibioticMech — CHEBI:90284 (same structure, same inchikey)
Explore across X-Mech
Open questions 1
name-disagreement — ChEBI calls this structure 'pirazofurin' and MIBiG calls it 'Pyrazofurin'. They share a Standard InChIKey, so if the names denote different compounds then one upstream record has the wrong structure. Check which.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001985 | MIBIG | 4 |
| CHEBI:90284 | CHEBI | 3-star |
This page is generated from data/natural_products/unclassified/pirazofurin.yaml, which is generated from the committed inventories. Neither is edited by hand.