pseurotin

naturalproductmech:mibig-e630fe39e9 MINTED SEEDED enzyme inhibitor

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	SLYDIPAXCVVRNY-BBJHAQHQSA-N
SMILES	CC\C=C/[C@H](O)[C@H](O)C1=C(C)C(=O)[C@@]2(O1)C(O)[C@](NC2=O)(OC)C(=O)C1=CC=CC=C1
Stereochemistry	undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-references	npatlas:NPA03544, pubchem:9845622

Filing pathway

Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Aspergillus fumigatus Af293 NCBITaxon:330879	BGC_CHARACTERIZED	mibig:BGC0001037	PMID:25494235

Occurrences 1

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Pseudeurotium ovale NCBITaxon:205927	LOTUS	DOI:10.1002/HLCA.19760590114

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0001037	Aspergillus fumigatus Af293 NCBITaxon:330879	CLUSTER_DEMONSTRATED	genbank:CM000176.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 3

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
Primary fluorescence-based thiol-reactive (MSTI) qHTS assay for identification of artifact compounds.	OTHER 11.6129 uM; NOT_DETERMINED	Not recorded	pubchem.aid:1845221 assay Primary fluorescence-based thiol-reactive (MSTI) qHTS assay for identification of artifact compounds. evidence reference pubchem.aid:1845221 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1845221, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 11.6129 units uM
Primary qHTS to identify anti-liver cancer compounds using libraries of approved drugs and bioactive compounds	OTHER 12.5893 uM; NOT_DETERMINED	Not recorded	pubchem.aid:2202548 assay Primary qHTS to identify anti-liver cancer compounds using libraries of approved drugs and bioactive compounds evidence reference pubchem.aid:2202548 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 2202548, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 12.5893 units uM
qHTS for Inhibitors of the Aldehyde Dehydrogenase Family (ALDH3A1) Primary screen	ACTIVE	Not recorded	pubchem.aid:2202377 assay qHTS for Inhibitors of the Aldehyde Dehydrogenase Family (ALDH3A1) Primary screen evidence reference pubchem.aid:2202377 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 2202377, deposited by NCGC; assay type Confirmatory. call ACTIVE activity class ENZYME_INHIBITOR

Explore across X-Mech

AntibioticMech (pseurotin) ↗ MediaIngredientMech (naturalproductmech:mibig-e630fe39e9) ↗ TaxonMech: Aspergillus fumigatus Af293 (NCBITaxon:330879) ↗ PathwayMech (mibig:BGC0001037) ↗

Provenance

Source concept	Source	Version
BGC0001037	MIBIG	5

This page is generated from data/natural_products/unclassified/pseurotin.yaml, which is generated from the committed inventories. Neither is edited by hand.