pyripyropene A
CHEBI:64695 EXACT SEEDED
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
A sesquiterpenoid that consists of (3S,4R,4aR,6S,6aS,12R,12aS,12bS)-4-(acetoxymethyl)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromene-3,6-diol in which the hydrogens of the 3- and 6-hydroxy functions are substituted by acetyl groups.
Structure
| Standard InChIKey | PMMQOFWSZRQWEV-RVTXXDJVSA-N |
|---|---|
| SMILES | [H][C@@]12C[C@H](OC(C)=O)[C@@]3(C)OC4=C([C@H](O)[C@]3([H])[C@@]1(C)CC[C@H](OC(C)=O)[C@@]2(C)COC(C)=O)C(=O)OC(=C4)C1=CN=CC=C1 |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA07480 |
Filing pathway
Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Aspergillus fumigatus Af293 NCBITaxon:330879 |
SOURCE_ASSERTION | mibig:BGC0000129 | PMID:20861902 |
Occurrences 6
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Aspergillus fischeri NCBITaxon:36630 |
LOTUS | DOI:10.7164/ANTIBIOTICS.46.1168 |
| Neosartorya pseudofischeri NCBITaxon:41047 |
LOTUS | DOI:10.7164/ANTIBIOTICS.46.1168 |
| Aspergillus fumigatus NCBITaxon:746128 |
LOTUS | DOI:10.1021/JO951424S |
| Aspergillus fumigatus NCBITaxon:746128 |
LOTUS | DOI:10.7164/ANTIBIOTICS.46.1168 |
| Aspergillus fumigatus NCBITaxon:746128 |
LOTUS | DOI:10.7164/ANTIBIOTICS.47.148 |
| Aspergillus sydowii NCBITaxon:75750 |
LOTUS | DOI:10.1021/NP700737G |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000129 | Aspergillus fumigatus Af293 NCBITaxon:330879 |
CLUSTER_UNSTATED | genbank:CM000174.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
Explore across X-Mech
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000129 | MIBIG | 3 |
| CHEBI:64695 | CHEBI | 3-star |
This page is generated from data/natural_products/unclassified/pyripyropene-a.yaml, which is generated from the committed inventories. Neither is edited by hand.