rhizoxin A
CHEBI:72590 EXACT SEEDED antimicrobial unspecified
An macrolide antibiotic isolated from the pathogenic plant fungus Rhizopus microsporus. It also exhibits antitumour and antimitotic activity.
Structure
| Standard InChIKey | OWPCHSCAPHNHAV-QIPOKPRISA-N |
|---|---|
| SMILES | C[C@@H]1/C=C/[C@@H]2[C@](O2)([C@H](C[C@H](OC(=O)[C@H]3[C@@H](O3)C[C@@H]4C[C@H]1OC(=O)C4)[C@H](C)[C@H](/C(=C/C=C/C(=C/C5=COC(=N5)C)/C)/C)OC)O)C |
| Stereochemistry | fully defined |
| Cross-references | pubchem:6437358 |
Filing pathway
Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Paraburkholderia rhizoxinica NCBITaxon:412963 |
BGC_CHARACTERIZED | mibig:BGC0001112 | PMID:17154220 |
Occurrences 7
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Rhizopus NCBITaxon:4842 |
LOTUS | DOI:10.7164/ANTIBIOTICS.39.762 |
| Rhizopus microsporus NCBITaxon:58291 |
LOTUS | DOI:10.1039/C39860001702 |
| Rhizopus microsporus NCBITaxon:58291 |
LOTUS | DOI:10.1248/CPB.34.1387 |
| Rhizopus microsporus NCBITaxon:58291 |
LOTUS | DOI:10.7164/ANTIBIOTICS.37.354 |
| Rhizopus microsporus NCBITaxon:58291 |
LOTUS | DOI:10.7164/ANTIBIOTICS.39.424 |
| Burkholderia rhizoxinica NCBITaxon:412963 |
LOTUS | DOI:10.1002/CBIC.200600393 |
| Burkholderia rhizoxinica NCBITaxon:412963 |
LOTUS | DOI:10.7164/ANTIBIOTICS.37.354 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001112 | Paraburkholderia rhizoxinica NCBITaxon:412963 |
CLUSTER_DEMONSTRATED | genbank:AM411073.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Elsewhere in the fleet
- AntibioticMech — CHEBI:72590 (same structure, same inchikey)
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001112 | MIBIG | 5 |
| CHEBI:72590 | CHEBI | 3-star |
This page is generated from data/natural_products/unclassified/rhizoxin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.