sceliphrolactam
CHEBI:193157 EXACT SEEDED antifungal
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
A polyene macrocyclic lactam with formula C28H35NO6. It was isolated from an actinomycete, Streptomyces sp. and displays antifungal activity against amphotericin B-resistant Candida albicans.
Structure
| Standard InChIKey | HRAPIHJIKATMEB-GWVUBWKVSA-N |
|---|---|
| SMILES | CC1CNC(=O)\C=C(/O)\C=C\C(\C)=C\C=C\C(O)C(O)C(O)C(=O)\C=C/C=C/C(/C)=C/C=C/C=C/1 |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | npatlas:NPA01145 |
Filing pathway
Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces sp. SD85 NCBITaxon:1849710 |
SOURCE_ASSERTION | mibig:BGC0001770 | PMID:29371699 |
Occurrences 4
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.1038/S41598-018-20018-8 |
| Streptomyces sp. NCBITaxon:1931 |
CHEBI | PMID:21247188 |
| Nocardiopsis NCBITaxon:2013 |
LOTUS | DOI:10.1021/ACS.JNATPROD.8B00708 |
| Streptomyces sp. SD85 NCBITaxon:1849710 |
CHEBI | PMID:29371699 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001770 | Streptomyces sp. SD85 NCBITaxon:1849710 |
CLUSTER_UNSTATED | genbank:KX230849.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
Elsewhere in the fleet
- AntibioticMech — CHEBI:193157 (same structure, same inchikey)
Explore across X-Mech
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001770 | MIBIG | 4 |
| CHEBI:193157 | CHEBI | 3-star |
This page is generated from data/natural_products/unclassified/sceliphrolactam.yaml, which is generated from the committed inventories. Neither is edited by hand.