sporidesmin A
CHEBI:9243 EXACT SEEDED
An organic heteropentacyclic compound that has formula C18H20ClN3O6S2, produced by the saprophyte fungus Pithomyces chartarum. It is a mycotoxin responsible for the hepatogenous photosensitisation disease facial eczema in ruminants.
Structure
| Standard InChIKey | QTONANGUNATZOU-ICTVWZTPSA-N |
|---|---|
| SMILES | COC1=C(Cl)C=C2C(=C1OC)N(C)[C@@H]1N3C(=O)[C@@]4(C)SS[C@@]3(C(=O)N4C)[C@H](O)[C@]21O |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA032651 |
Filing pathway
Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Pithomyces chartarum NCBITaxon:1892770 |
SOURCE_ASSERTION | mibig:BGC0002438 | DOI:10.1101/2021.04.29.441555 |
Occurrences 5
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Delitschia sp. NCBITaxon:2012369 |
CHEBI | PMID:30016827 |
| Pithomyces chartarum NCBITaxon:1892770 |
LOTUS | DOI:10.1021/JF00024A023 |
| Pithomyces chartarum NCBITaxon:1892770 |
LOTUS | DOI:10.1099/00221287-29-1-127 |
| Pithomyces chartarum NCBITaxon:1892770 |
LOTUS | DOI:10.1101/2021.04.29.441555 |
| Pithomyces chartarum NCBITaxon:1892770 |
CHEBI | PMID:16031836 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0002438 | Pithomyces chartarum NCBITaxon:1892770 |
CLUSTER_UNSTATED | genbank:MT353658.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0002438 | MIBIG | 2 |
| CHEBI:9243 | CHEBI | 3-star |
This page is generated from data/natural_products/unclassified/sporidesmin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.