teixobactin

naturalproductmech:mibig-04593f87e6 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	LMBFAGIMSUYTBN-IIRRRCHSSA-N
SMILES	CC[C@H](C)[C@H](NC(=O)[C@@H](CC1=CC=CC=C1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H]1[C@H](C)OC(=O)[C@@H](NC(=O)[C@H](C[C@H]2CN=C(N)N2)NC(=O)[C@H](C)NC1=O)[C@@H](C)CC
Stereochemistry	fully defined
Cross-references	pubchem:86341926, npatlas:NPA013751

Filing pathway

Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Eleftheria terrae NCBITaxon:1597781	SOURCE_ASSERTION	mibig:BGC0001207	DOI:10.1038/nature14098

Occurrences 0

None cited.

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0001207	Eleftheria terrae NCBITaxon:1597781	CLUSTER_UNSTATED	genbank:KP006601.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 1

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
Inhibition Assay from US Patent US9402878: "Depsipeptide and uses thereof"	IC50 100 uM; INACTIVE	UniProtKB:Q12809	pubchem.aid:1803122 assay Inhibition Assay from US Patent US9402878: "Depsipeptide and uses thereof" evidence reference pubchem.aid:1803122 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1803122, deposited by BindingDB; assay type Confirmatory. call INACTIVE measurement type IC50 value 100.0 units uM target enzyme UniProtKB:Q12809

Explore across X-Mech

AntibioticMech (teixobactin) ↗ MediaIngredientMech (naturalproductmech:mibig-04593f87e6) ↗ TaxonMech: Eleftheria terrae (NCBITaxon:1597781) ↗ PathwayMech (mibig:BGC0001207) ↗

Provenance

Source concept	Source	Version
BGC0001207	MIBIG	5

This page is generated from data/natural_products/unclassified/teixobactin.yaml, which is generated from the committed inventories. Neither is edited by hand.