telomestatin
naturalproductmech:mibig-10668139e4 MINTED SEEDED
Structure
| Standard InChIKey | YVSQVYZBDXIXCC-UHFFFAOYSA-N |
|---|---|
| SMILES | CC1=C2N=C(O1)C1CSC(=N1)C1=COC(=N1)C1=COC(=N1)C1=COC(=N1)C1=COC(=N1)C1=COC(=N1)C1=C(C)OC2=N1 |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | npatlas:NPA06938 |
Filing pathway
Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is ribosomal, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces anulatus NCBITaxon:1892 |
SOURCE_ASSERTION | mibig:BGC0001797 | DOI:10.1038/sj.onc.1209217 |
Occurrences 1
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces anulatus NCBITaxon:1892 |
LOTUS | DOI:10.1021/JA005780Q |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001797 | Streptomyces anulatus NCBITaxon:1892 |
CLUSTER_UNSTATED | genbank:LC318724.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Causal graph — bioactivity 3 nodes, 2 edges
Telomestatin inhibits E. coli DinG and human FANCJ helicases.
| Subject | Predicate | Object | Evidence |
|---|---|---|---|
| telomestatin | inhibits | E. coli ATP-dependent DNA helicase DinG | DOI:10.1074/jbc.M113.496463 |
| telomestatin | inhibits | human Fanconi anemia group J protein | DOI:10.1074/jbc.M113.496463 |
Every edge carries its own citation; an uncited edge is refused by the corpus tests.
Molecular targets 5
| Target | Assay organism | Measurement | Reference |
|---|---|---|---|
| ATP-dependent DNA helicase DinG UniProtKB:P27296 |
Escherichia coli (strain K12) NCBITaxon:83333 |
IC50 1.5 nM | PMID:23935105 |
| ATP-dependent DNA helicase DinG UniProtKB:P27296 |
Escherichia coli (strain K12) NCBITaxon:83333 |
IC50 1 nM | PMID:23935105 |
| Fanconi anemia group J protein UniProtKB:Q9BX63 |
Human | IC50 2.2 nM | PMID:23935105 |
| Fanconi anemia group J protein UniProtKB:Q9BX63 |
Human | IC50 1.9 nM | PMID:23935105 |
| Fanconi anemia group J protein UniProtKB:Q9BX63 |
Human | IC50 2 nM | PMID:23935105 |
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001797 | MIBIG | 3 |
This page is generated from data/natural_products/unclassified/telomestatin.yaml, which is generated from the committed inventories. Neither is edited by hand.