NaturalProductMech

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telomestatin

naturalproductmech:mibig-10668139e4 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.
What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKeyYVSQVYZBDXIXCC-UHFFFAOYSA-N
SMILESCC1=C2N=C(O1)C1CSC(=N1)C1=COC(=N1)C1=COC(=N1)C1=COC(=N1)C1=COC(=N1)C1=COC(=N1)C1=C(C)OC2=N1
Stereochemistry undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-referencesnpatlas:NPA06938

Filing pathway

Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is ribosomal, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Streptomyces anulatus
NCBITaxon:1892		 SOURCE_ASSERTION mibig:BGC0001797 DOI:10.1038/sj.onc.1209217

Occurrences 1

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

TaxonSourceReference
Streptomyces anulatus
NCBITaxon:1892		 LOTUS DOI:10.1021/JA005780Q

Biosynthetic gene clusters 1

AccessionHostLocus evidenceGenome
mibig:BGC0001797 Streptomyces anulatus
NCBITaxon:1892 		CLUSTER_UNSTATED genbank:LC318724.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

PRODUCERS & OCCURRENCE 1 producer (0 causal) 1 cited occurrence BIOSYNTHETIC LOCUS 1 gene cluster 0 curated pathway steps NATURAL PRODUCT telomestatin naturalproductmech:mibig-10668139e4 Unclassified TARGETS & BIOACTIVITY 5 molecular targets 0 bioactivities · 1 graph

Causal graph — bioactivity 3 nodes, 2 edges

Telomestatin inhibits E. coli DinG and human FANCJ helicases.

SubjectPredicateObjectNotesEvidence
telomestatin inhibits E. coli ATP-dependent DNA helicase DinG BindingDB maps this exact Standard InChIKey to 1.0 and 1.5 nM IC50 measurements against E. coli K-12 DinG, and P27296 resolves in UniProtKB to the E. coli K-12 dinG gene product.
DOI:10.1074/jbc.M113.496463
  • reference
    DOI:10.1074/jbc.M113.496463
    evidence type
    PRIMARY_EXPERIMENT
    notes
    BindingDB own-curated rows for PMID 23935105 report telomestatin inhibition of E. coli DinG at pH 8.
telomestatin inhibits human Fanconi anemia group J protein BindingDB maps this exact Standard InChIKey to 1.9, 2.0, and 2.2 nM IC50 measurements against human FANCJ, and Q9BX63 resolves in UniProtKB to the human BRIP1/FANCJ gene product.
DOI:10.1074/jbc.M113.496463
  • reference
    DOI:10.1074/jbc.M113.496463
    evidence type
    PRIMARY_EXPERIMENT
    notes
    BindingDB own-curated rows for PMID 23935105 report telomestatin inhibition of human FANCJ at pH 8.

Every edge carries its own citation; an uncited edge is refused by the corpus tests.

Molecular targets 5

TargetTarget organismMeasurementEvidence
ATP-dependent DNA helicase DinG
PROTEIN BINDS
UniProtKB:P27296		 Escherichia coli (strain K12)
NCBITaxon:83333		 IC50 1.5 nM
PMID:23935105
  • reference
    PMID:23935105
    evidence type
    DATABASE_ASSERTION
    notes
    BindingDB own-curated affinity; measured at pH 8; qualifier EQUAL.
ATP-dependent DNA helicase DinG
PROTEIN BINDS
UniProtKB:P27296		 Escherichia coli (strain K12)
NCBITaxon:83333		 IC50 1 nM
PMID:23935105
  • reference
    PMID:23935105
    evidence type
    DATABASE_ASSERTION
    notes
    BindingDB own-curated affinity; measured at pH 8; qualifier EQUAL.
Fanconi anemia group J protein
PROTEIN BINDS
UniProtKB:Q9BX63		 Human IC50 2.2 nM
PMID:23935105
  • reference
    PMID:23935105
    evidence type
    DATABASE_ASSERTION
    notes
    BindingDB own-curated affinity; measured at pH 8; qualifier EQUAL.
Fanconi anemia group J protein
PROTEIN BINDS
UniProtKB:Q9BX63		 Human IC50 1.9 nM
PMID:23935105
  • reference
    PMID:23935105
    evidence type
    DATABASE_ASSERTION
    notes
    BindingDB own-curated affinity; measured at pH 8; qualifier EQUAL.
Fanconi anemia group J protein
PROTEIN BINDS
UniProtKB:Q9BX63		 Human IC50 2 nM
PMID:23935105
  • reference
    PMID:23935105
    evidence type
    DATABASE_ASSERTION
    notes
    BindingDB own-curated affinity; measured at pH 8; qualifier EQUAL.

Explore across X-Mech

AntibioticMech (telomestatin) ↗ MediaIngredientMech (naturalproductmech:mibig-10668139e4) ↗ TaxonMech: Streptomyces anulatus (NCBITaxon:1892) ↗ PathwayMech (mibig:BGC0001797) ↗

Provenance

Source conceptSourceVersion
BGC0001797MIBIG3

This page is generated from data/natural_products/unclassified/telomestatin.yaml, which is generated from the committed inventories. Neither is edited by hand.