terretonin
naturalproductmech:mibig-b9b0b11d0a MINTED SEEDED antiviralenzyme inhibitor
Structure
| Standard InChIKey | CYHGEJACRPDZDP-IKNWHQMFSA-N |
|---|---|
| SMILES | C[C@]12CCC(=O)C(C1=C(C(=O)[C@@]3([C@@]2(CC(=C)[C@]4([C@H]3C(=O)O[C@@](C4=O)(C)C(=O)OC)C)O)C)O)(C)C |
| Stereochemistry | fully defined |
| Cross-references | pubchem:16196970 |
Filing pathway
Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is terpene, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Aspergillus terreus NIH2624 NCBITaxon:341663 |
SOURCE_ASSERTION | mibig:BGC0000682 | PMID:23116177 |
Occurrences 6
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Mallotus nudiflorus NCBITaxon:300977 |
LOTUS | DOI:10.1080/14786410701852826 |
| Aspergillus terreus NCBITaxon:33178 |
LOTUS | DOI:10.1016/S0040-4020(01)83433-5 |
| Aspergillus terreus NCBITaxon:33178 |
LOTUS | DOI:10.1021/JO00394A023 |
| Aspergillus terreus NCBITaxon:33178 |
LOTUS | DOI:10.1021/NP0501738 |
| Penicillium citreoviride NCBITaxon:64494 |
LOTUS | DOI:10.1016/S0040-4039(00)74810-6 |
| Penicillium citreonigrum NCBITaxon:69768 |
LOTUS | DOI:10.1016/S0040-4039(00)74810-6 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000682 | Aspergillus terreus NIH2624 NCBITaxon:341663 |
CLUSTER_UNSTATED | genbank:CH476609.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 25
| Assay | Result | Reference |
|---|---|---|
| GF-AFC viability counterscreen for inhibitors of alpha-synuclein gene (SNCA) expression | 1.1613 uM | pubchem.aid:1671193 |
| High Throughput Screening for Foot and Mouth Disease Virus Antivirals | 12.5893 uM | pubchem.aid:1159524 |
| Nrf2 qHTS screen for inhibitors | 20.5962 uM | pubchem.aid:504444 |
| Primary fluorescence-based thiol-reactive (MSTI) qHTS assay for identification of artifact compounds. | 9.2245 uM | pubchem.aid:1845221 |
| Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2 | 8.9125 uM | pubchem.aid:1671190 |
| Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2 | 8.9125 uM | pubchem.aid:1671190 |
| Primary redox qHTS assay for identification of artifact compounds. | 18.4052 uM | pubchem.aid:1845223 |
| qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) | 0.0891 uM | pubchem.aid:651820 |
| qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation | 89.1251 uM | pubchem.aid:540263 |
| qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation | 89.1251 uM | pubchem.aid:540263 |
| qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) | 19.9526 uM | pubchem.aid:2517 |
| qHTS Assay for Rab9 Promoter Activators | 5.6234 uM | pubchem.aid:485297 |
| qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins | 79.4328 uM | pubchem.aid:485364 |
| qHTS for Inhibitors of Polymerase Eta | 39.8107 uM | pubchem.aid:588591 |
| qHTS for Inhibitors of Polymerase Iota | 79.4328 uM | pubchem.aid:588590 |
| qHTS for Inhibitors of the Aldehyde Dehydrogenase Family (ALDH1A2) Primary screen | 0.7943 uM | pubchem.aid:2202376 |
| qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) | 11.2202 uM | pubchem.aid:624417 |
| qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) | 21.3313 uM | pubchem.aid:588342 |
| qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 | 23.0999 uM | pubchem.aid:504467 |
| A qHTS for Small Molecule Inhibitors of Shiga Toxin | ACTIVE | pubchem.aid:2315 |
| A qHTS for Small Molecule Inhibitors of Shiga Toxin | ACTIVE | pubchem.aid:2315 |
| Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin | ACTIVE | pubchem.aid:2314 |
| Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin | ACTIVE | pubchem.aid:2314 |
| HTS to identify compounds that promote myeloid differentiation with MLPCN compound set | ACTIVE | pubchem.aid:624256 |
| Luminescence-based primary cell-based high throughput screening assay to identify inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1) | ACTIVE | pubchem.aid:504766 |
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000682 | MIBIG | 3 |
This page is generated from data/natural_products/unclassified/terretonin.yaml, which is generated from the committed inventories. Neither is edited by hand.