NaturalProductMech

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terretonin

naturalproductmech:mibig-b9b0b11d0a MINTED SEEDED enzyme inhibitor

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.
What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKeyCYHGEJACRPDZDP-IKNWHQMFSA-N
SMILESC[C@]12CCC(=O)C(C1=C(C(=O)[C@@]3([C@@]2(CC(=C)[C@]4([C@H]3C(=O)O[C@@](C4=O)(C)C(=O)OC)C)O)C)O)(C)C
Stereochemistryfully defined
Cross-referencespubchem:16196970

Filing pathway

Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is terpene, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Aspergillus terreus NIH2624
NCBITaxon:341663		 SOURCE_ASSERTION mibig:BGC0000682 PMID:23116177

Occurrences 6

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

TaxonSourceReference
Mallotus nudiflorus
NCBITaxon:300977		 LOTUS DOI:10.1080/14786410701852826
Aspergillus terreus
NCBITaxon:33178		 LOTUS DOI:10.1016/S0040-4020(01)83433-5
Aspergillus terreus
NCBITaxon:33178		 LOTUS DOI:10.1021/JO00394A023
Aspergillus terreus
NCBITaxon:33178		 LOTUS DOI:10.1021/NP0501738
Penicillium citreoviride
NCBITaxon:64494		 LOTUS DOI:10.1016/S0040-4039(00)74810-6
Penicillium citreonigrum
NCBITaxon:69768		 LOTUS DOI:10.1016/S0040-4039(00)74810-6

Biosynthetic gene clusters 1

AccessionHostLocus evidenceGenome
mibig:BGC0000682 Aspergillus terreus NIH2624
NCBITaxon:341663 		CLUSTER_UNSTATED genbank:CH476609.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

PRODUCERS & OCCURRENCE 1 producer (0 causal) 6 cited occurrences BIOSYNTHETIC LOCUS 1 gene cluster 0 curated pathway steps NATURAL PRODUCT terretonin naturalproductmech:mibig-b9b0b11d0a Unclassified TARGETS & BIOACTIVITY 0 molecular targets 25 bioactivities · 0 graphs

Bioactivities 25

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

AssayResultTarget enzymeSource detail
GF-AFC viability counterscreen for inhibitors of alpha-synuclein gene (SNCA) expressionOTHER 1.1613 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1671193
assay
GF-AFC viability counterscreen for inhibitors of alpha-synuclein gene (SNCA) expression
evidence
  • reference
    pubchem.aid:1671193
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1671193, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
1.1613
units
uM
High Throughput Screening for Foot and Mouth Disease Virus AntiviralsOTHER 12.5893 uM; INACTIVENot recorded
pubchem.aid:1159524
assay
High Throughput Screening for Foot and Mouth Disease Virus Antivirals
evidence
  • reference
    pubchem.aid:1159524
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1159524, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
INACTIVE
measurement type
OTHER
value
12.5893
units
uM
Nrf2 qHTS screen for inhibitorsOTHER 20.5962 uM; NOT_DETERMINEDNot recorded
pubchem.aid:504444
assay
Nrf2 qHTS screen for inhibitors
evidence
  • reference
    pubchem.aid:504444
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 504444, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_001138884 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
20.5962
units
uM
Primary fluorescence-based thiol-reactive (MSTI) qHTS assay for identification of artifact compounds.OTHER 9.2245 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1845221
assay
Primary fluorescence-based thiol-reactive (MSTI) qHTS assay for identification of artifact compounds.
evidence
  • reference
    pubchem.aid:1845221
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1845221, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
9.2245
units
uM
Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2OTHER 8.9125 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1671190
assay
Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2
evidence
  • reference
    pubchem.aid:1671190
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1671190, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
8.9125
units
uM
Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2OTHER 8.9125 uM; NOT_DETERMINEDUniProtKB:P18054
pubchem.aid:1671190
assay
Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2
evidence
  • reference
    pubchem.aid:1671190
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1671190, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
8.9125
units
uM
target enzyme
UniProtKB:P18054
Primary redox qHTS assay for identification of artifact compounds.OTHER 18.4052 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1845223
assay
Primary redox qHTS assay for identification of artifact compounds.
evidence
  • reference
    pubchem.aid:1845223
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1845223, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
18.4052
units
uM
qHTS Assay for Inhibitors of Hepatitis C Virus (HCV)OTHER 0.0891 uM; NOT_DETERMINEDNot recorded
pubchem.aid:651820
assay
qHTS Assay for Inhibitors of Hepatitis C Virus (HCV)
evidence
  • reference
    pubchem.aid:651820
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 651820, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
0.0891
units
uM
qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formationOTHER 89.1251 uM; NOT_DETERMINEDNot recorded
pubchem.aid:540263
assay
qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation
evidence
  • reference
    pubchem.aid:540263
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 540263, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_002256 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
89.1251
units
uM
qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formationOTHER 89.1251 uM; NOT_DETERMINEDNot recorded
pubchem.aid:540263
assay
qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation
evidence
  • reference
    pubchem.aid:540263
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 540263, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_005692 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
89.1251
units
uM
qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)OTHER 19.9526 uM; NOT_DETERMINEDNot recorded
pubchem.aid:2517
assay
qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)
evidence
  • reference
    pubchem.aid:2517
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2517, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession 1DE9_A was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
19.9526
units
uM
qHTS Assay for Rab9 Promoter ActivatorsOTHER 5.6234 uM; NOT_DETERMINEDNot recorded
pubchem.aid:485297
assay
qHTS Assay for Rab9 Promoter Activators
evidence
  • reference
    pubchem.aid:485297
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 485297, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_004242 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
5.6234
units
uM
qHTS Assay for the Inhibitors of Schistosoma Mansoni PeroxiredoxinsOTHER 79.4328 uM; NOT_DETERMINEDNot recorded
pubchem.aid:485364
assay
qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins
evidence
  • reference
    pubchem.aid:485364
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 485364, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AAK85233 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
79.4328
units
uM
qHTS for Inhibitors of Polymerase EtaOTHER 39.8107 uM; NOT_DETERMINEDNot recorded
pubchem.aid:588591
assay
qHTS for Inhibitors of Polymerase Eta
evidence
  • reference
    pubchem.aid:588591
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 588591, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_006493 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
39.8107
units
uM
qHTS for Inhibitors of Polymerase IotaOTHER 79.4328 uM; NOT_DETERMINEDNot recorded
pubchem.aid:588590
assay
qHTS for Inhibitors of Polymerase Iota
evidence
  • reference
    pubchem.aid:588590
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 588590, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_009126 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
79.4328
units
uM
qHTS for Inhibitors of the Aldehyde Dehydrogenase Family (ALDH1A2) Primary screenOTHER 0.7943 uM; NOT_DETERMINEDNot recorded
pubchem.aid:2202376
assay
qHTS for Inhibitors of the Aldehyde Dehydrogenase Family (ALDH1A2) Primary screen
evidence
  • reference
    pubchem.aid:2202376
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2202376, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
0.7943
units
uM
qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode)OTHER 11.2202 uM; INACTIVENot recorded
pubchem.aid:624417
assay
qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode)
evidence
  • reference
    pubchem.aid:624417
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 624417, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession AAB64013 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
INACTIVE
measurement type
OTHER
value
11.2202
units
uM
qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project)OTHER 21.3313 uM; NOT_DETERMINEDNot recorded
pubchem.aid:588342
assay
qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project)
evidence
  • reference
    pubchem.aid:588342
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 588342, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AAA29795 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
21.3313
units
uM
qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1OTHER 23.0999 uM; NOT_DETERMINEDNot recorded
pubchem.aid:504467
assay
qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1
evidence
  • reference
    pubchem.aid:504467
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 504467, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AAH15051 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
23.0999
units
uM
A qHTS for Small Molecule Inhibitors of Shiga ToxinACTIVENot recorded
pubchem.aid:2315
assay
A qHTS for Small Molecule Inhibitors of Shiga Toxin
evidence
  • reference
    pubchem.aid:2315
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2315, deposited by NCGC; assay type Screening. Target accession BAC78637 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
activity class
ENZYME_INHIBITOR
A qHTS for Small Molecule Inhibitors of Shiga ToxinACTIVENot recorded
pubchem.aid:2315
assay
A qHTS for Small Molecule Inhibitors of Shiga Toxin
evidence
  • reference
    pubchem.aid:2315
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2315, deposited by NCGC; assay type Screening. Target accession BAC78638 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
activity class
ENZYME_INHIBITOR
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga ToxinACTIVENot recorded
pubchem.aid:2314
assay
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin
evidence
  • reference
    pubchem.aid:2314
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2314, deposited by NCGC; assay type Screening. Target accession BAC78637 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
activity class
ENZYME_INHIBITOR
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga ToxinACTIVENot recorded
pubchem.aid:2314
assay
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin
evidence
  • reference
    pubchem.aid:2314
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2314, deposited by NCGC; assay type Screening. Target accession BAC78638 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
activity class
ENZYME_INHIBITOR
HTS to identify compounds that promote myeloid differentiation with MLPCN compound setACTIVENot recorded
pubchem.aid:624256
assay
HTS to identify compounds that promote myeloid differentiation with MLPCN compound set
evidence
  • reference
    pubchem.aid:624256
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 624256, deposited by NMMLSC; assay type Screening.
call
ACTIVE
Luminescence-based primary cell-based high throughput screening assay to identify inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1)ACTIVENot recorded
pubchem.aid:504766
assay
Luminescence-based primary cell-based high throughput screening assay to identify inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1)
evidence
  • reference
    pubchem.aid:504766
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 504766, deposited by The Scripps Research Institute Molecular Screening Center; assay type Screening. Target accession NP_000466 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
activity class
ENZYME_INHIBITOR

Explore across X-Mech

AntibioticMech (terretonin) ↗ MediaIngredientMech (naturalproductmech:mibig-b9b0b11d0a) ↗ TaxonMech: Aspergillus terreus NIH2624 (NCBITaxon:341663) ↗ PathwayMech (mibig:BGC0000682) ↗

Provenance

Source conceptSourceVersion
BGC0000682MIBIG3

This page is generated from data/natural_products/unclassified/terretonin.yaml, which is generated from the committed inventories. Neither is edited by hand.