thaxtomin A
naturalproductmech:mibig-c25e1c1376 MINTED SEEDED
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
Structure
| Standard InChIKey | QRDNJYNIEGRRKV-PGRDOPGGSA-N |
|---|---|
| SMILES | CN1[C@H](C(=O)N([C@](C1=O)(CC2=CC(=CC=C2)O)O)C)CC3=CNC4=C3C(=CC=C4)[N+](=O)[O-] |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA009094, npatlas:NPA09094 |
Filing pathway
Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces scabiei 87.22 NCBITaxon:680198 |
BGC_CHARACTERIZED | mibig:BGC0002089 | PMID:31282068 |
| Streptomyces turgidiscabies Car8 NCBITaxon:698760 |
SOURCE_ASSERTION | mibig:BGC0000444 | PMID:22941045 |
Occurrences 13
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces ipomoeae NCBITaxon:103232 |
LOTUS | DOI:10.1021/JF00044A042 |
| Streptomyces scabiei NCBITaxon:1930 |
LOTUS | DOI:10.1021/JF950243O |
| Streptomyces scabiei NCBITaxon:1930 |
LOTUS | DOI:10.1039/C39890000849 |
| Streptomyces scabiei NCBITaxon:1930 |
LOTUS | DOI:10.1094/PHYTO.1998.88.5.442 |
| Streptomyces scabiei NCBITaxon:1930 |
LOTUS | DOI:10.1099/00221287-139-7-1579 |
| Streptomyces scabiei NCBITaxon:1930 |
LOTUS | DOI:10.1111/J.1364-3703.2009.00561.X |
| Streptomyces scabiei NCBITaxon:1930 |
LOTUS | DOI:10.1111/J.1365-2958.2007.05942.X |
| Streptomyces scabiei NCBITaxon:1930 |
LOTUS | DOI:10.1111/MPP.12631 |
| Streptomyces scabiei NCBITaxon:1930 |
LOTUS | DOI:10.1128/AEM.01169-17 |
| Streptomyces scabiei NCBITaxon:1930 |
LOTUS | DOI:10.1128/AEM.64.11.4313-4316.1998 |
| Streptomyces scabiei NCBITaxon:1930 |
LOTUS | DOI:10.1139/W04-043 |
| Streptomyces acidiscabies NCBITaxon:42234 |
LOTUS | DOI:10.1021/JF950766W |
| Streptomyces acidiscabies NCBITaxon:42234 |
LOTUS | DOI:10.1128/JB.184.7.2019-2029.2002 |
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0002089 | Streptomyces scabiei 87.22 NCBITaxon:680198 |
CLUSTER_DEMONSTRATED | genbank:FN554889.1 |
| mibig:BGC0000444 | Streptomyces turgidiscabies Car8 NCBITaxon:698760 |
CLUSTER_UNSTATED | genbank:AY707081.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
Explore across X-Mech
Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0000444, BGC0002089. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0002089 | MIBIG | 2 |
| BGC0000444 | MIBIG | 5 |
This page is generated from data/natural_products/unclassified/thaxtomin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.