triostin A

naturalproductmech:mibig-f297f48daf MINTED SEEDED cytotoxic

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	GULVULFEAVZHHC-UHFFFAOYSA-N
SMILES	CC(C)C1N(C)C(=O)C2CSSCC(N(C)C(=O)C(C)NC(=O)C(COC1=O)NC(=O)C1=CN=C3C=CC=CC3=N1)C(=O)N(C)C(C(C)C)C(=O)OCC(NC(=O)C1=CN=C3C=CC=CC3=N1)C(=O)NC(C)C(=O)N2C
Stereochemistry	undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-references	npatlas:NPA013641, pubchem:316447

Filing pathway

Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces triostinicus NCBITaxon:45399	SOURCE_ASSERTION	mibig:BGC0000450	PMID:19194935

Occurrences 2

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Streptomyces triostinicus NCBITaxon:45399	LOTUS	DOI:10.1002/BTPR.34
Streptomyces triostinicus NCBITaxon:45399	LOTUS	DOI:10.1021/BI00466A015

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0000450	Streptomyces triostinicus NCBITaxon:45399	CLUSTER_UNSTATED	genbank:AB366635.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 25

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Explore across X-Mech

AntibioticMech (triostin A) ↗ MediaIngredientMech (naturalproductmech:mibig-f297f48daf) ↗ TaxonMech: Streptomyces triostinicus (NCBITaxon:45399) ↗ PathwayMech (mibig:BGC0000450) ↗

Provenance

Source concept	Source	Version
BGC0000450	MIBIG	5

This page is generated from data/natural_products/unclassified/triostin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.

Assay	Result	Target enzyme	Source detail
NCI In Vivo Anticancer Drug Screen. Data for tumor model B16 Melanoma (intraperitoneal) in B6D2F1 (BDF1) mice	ACTIVE	Not recorded	pubchem.aid:192 assay NCI In Vivo Anticancer Drug Screen. Data for tumor model B16 Melanoma (intraperitoneal) in B6D2F1 (BDF1) mice evidence reference pubchem.aid:192 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 192, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice	ACTIVE	Not recorded	pubchem.aid:328 assay NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice evidence reference pubchem.aid:328 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 328, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in CD2F1 (CDF1) mice	ACTIVE	Not recorded	pubchem.aid:330 assay NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in CD2F1 (CDF1) mice evidence reference pubchem.aid:330 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 330, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the bub3 strain	ACTIVE	Not recorded	pubchem.aid:167 assay NCI Yeast Anticancer Drug Screen. Data for the bub3 strain evidence reference pubchem.aid:167 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 167, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the cln2 rad14 strain	ACTIVE	Not recorded	pubchem.aid:165 assay NCI Yeast Anticancer Drug Screen. Data for the cln2 rad14 strain evidence reference pubchem.aid:165 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 165, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the mec2-1 strain	ACTIVE	Not recorded	pubchem.aid:157 assay NCI Yeast Anticancer Drug Screen. Data for the mec2-1 strain evidence reference pubchem.aid:157 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 157, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strain	ACTIVE	Not recorded	pubchem.aid:175 assay NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strain evidence reference pubchem.aid:175 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 175, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the rad50 strain	ACTIVE	Not recorded	pubchem.aid:155 assay NCI Yeast Anticancer Drug Screen. Data for the rad50 strain evidence reference pubchem.aid:155 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 155, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strain	ACTIVE	Not recorded	pubchem.aid:161 assay NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strain evidence reference pubchem.aid:161 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 161, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell line	ACTIVE	Not recorded	pubchem.aid:137 assay NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell line evidence reference pubchem.aid:137 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 137, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the A498 Renal cell line	ACTIVE	Not recorded	pubchem.aid:129 assay NCI human tumor cell line growth inhibition assay. Data for the A498 Renal cell line evidence reference pubchem.aid:129 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 129, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line	ACTIVE	Not recorded	pubchem.aid:19 assay NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line evidence reference pubchem.aid:19 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 19, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line	ACTIVE	Not recorded	pubchem.aid:139 assay NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line evidence reference pubchem.aid:139 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 139, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the BT-549 Breast cell line	ACTIVE	Not recorded	pubchem.aid:89 assay NCI human tumor cell line growth inhibition assay. Data for the BT-549 Breast cell line evidence reference pubchem.aid:89 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 89, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Renal cell line	ACTIVE	Not recorded	pubchem.aid:131 assay NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Renal cell line evidence reference pubchem.aid:131 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 131, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell line	ACTIVE	Not recorded	pubchem.aid:119 assay NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell line evidence reference pubchem.aid:119 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 119, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line	ACTIVE	Not recorded	pubchem.aid:43 assay NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line evidence reference pubchem.aid:43 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 43, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HCC-2998 Colon cell line	ACTIVE	Not recorded	pubchem.aid:77 assay NCI human tumor cell line growth inhibition assay. Data for the HCC-2998 Colon cell line evidence reference pubchem.aid:77 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 77, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Colon cell line	ACTIVE	Not recorded	pubchem.aid:79 assay NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Colon cell line evidence reference pubchem.aid:79 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 79, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HCT-15 Colon cell line	ACTIVE	Not recorded	pubchem.aid:71 assay NCI human tumor cell line growth inhibition assay. Data for the HCT-15 Colon cell line evidence reference pubchem.aid:71 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 71, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line	ACTIVE	Not recorded	pubchem.aid:125 assay NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line evidence reference pubchem.aid:125 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 125, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HOP-62 Non-Small Cell Lung cell line	ACTIVE	Not recorded	pubchem.aid:9 assay NCI human tumor cell line growth inhibition assay. Data for the HOP-62 Non-Small Cell Lung cell line evidence reference pubchem.aid:9 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 9, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line	ACTIVE	Not recorded	pubchem.aid:13 assay NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line evidence reference pubchem.aid:13 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 13, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HS 578T Breast cell line	ACTIVE	Not recorded	pubchem.aid:97 assay NCI human tumor cell line growth inhibition assay. Data for the HS 578T Breast cell line evidence reference pubchem.aid:97 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 97, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HT29 Colon cell line	ACTIVE	Not recorded	pubchem.aid:65 assay NCI human tumor cell line growth inhibition assay. Data for the HT29 Colon cell line evidence reference pubchem.aid:65 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 65, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC notes 42 further PubChem assay results are in data/raw/pubchem_bioassay.tsv but not written here.