UK 63598
CHEBI:87399 EXACT SEEDED antimicrobial unspecified
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
A cyclodepsipeptide antibiotic that is isolated from Streptomyces sp. SNA15896 and also exhibits antitumour activity.
Structure
| Standard InChIKey | HBQDLHJADJTNRK-LIXMYSHJSA-N |
|---|---|
| SMILES | [H][C@]12CS[C@@H](SC)[C@]([H])(N(C)C(=O)[C@H](C)NC(=O)[C@@H](COC(=O)[C@@]3(C[C@@H]3C)N(C)C1=O)NC(=O)C1=C(O)C=C3C=CC=CC3=N1)C(=O)N(C)[C@]1(C[C@@H]1C)C(=O)OC[C@@H](NC(=O)C1=C(O)C=C3C=CC=CC3=N1)C(=O)N[C@@H](C)C(=O)N2C |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA010384 |
Filing pathway
Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces sp. SNA15896 NCBITaxon:497689 |
SOURCE_ASSERTION | mibig:BGC0000434 | PMID:19514719 |
Occurrences 2
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.7164/ANTIBIOTICS.42.206 |
| Streptomyces sp. SNA15896 NCBITaxon:497689 |
CHEBI | PMID:19514719 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000434 | Streptomyces sp. SNA15896 NCBITaxon:497689 |
CLUSTER_UNSTATED | genbank:AB375771.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
Elsewhere in the fleet
- AntibioticMech — CHEBI:87399 (same structure, same inchikey)
Explore across X-Mech
Open questions 1
name-disagreement — ChEBI calls this structure 'UK 63598' and MIBiG calls it 'UK-63598'. They share a Standard InChIKey, so if the names denote different compounds then one upstream record has the wrong structure. Check which.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000434 | MIBIG | 5 |
| CHEBI:87399 | CHEBI | 3-star |
This page is generated from data/natural_products/unclassified/uk-63598.yaml, which is generated from the committed inventories. Neither is edited by hand.