viridicatumtoxin

CHEBI:85616 EXACT SEEDED antimicrobial unspecified

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

A tetracycline-like polyketide antibiotic that is produced by several species of Penicillium and Aspergillus.

Structure

Standard InChIKey	SUWQGLGDFGHZNH-WBWZXODPSA-N
SMILES	COC1=C2C3=C(C(O)=C1)C(O)=C1C(=O)[C@]4(O)C(=O)C(C(N)=O)=C(O)C[C@]4(O)[C@@H](O)C1=C3C[C@]21C(C)=CCCC1(C)C
Stereochemistry	fully defined
Cross-references	npatlas:NPA03651, pubchem:54679209

Filing pathway

Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Penicillium aethiopicum NCBITaxon:36650	BGC_CHARACTERIZED	mibig:BGC0000168	DOI:10.1016/j.chembiol.2010.03.015

Occurrences 9

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Penicillium brasilianum NCBITaxon:104259	LOTUS	DOI:10.1038/JA.2012.83
Penicillium brasilianum NCBITaxon:104259	CHEBI	PMID:23168407
Aspergillus ustus NCBITaxon:40382	LOTUS	DOI:10.1371/JOURNAL.PONE.0116089
Aspergillus ustus NCBITaxon:40382	CHEBI	PMID:25706180
Aspergillus unilateralis NCBITaxon:41057	LOTUS	DOI:10.1002/CHIN.200523199
Eupenicillium NCBITaxon:5073	LOTUS	DOI:10.1021/NP500111W
Penicillium aethiopicum NCBITaxon:36650	LOTUS	DOI:10.1016/J.CHEMBIOL.2010.03.015
Penicillium aethiopicum NCBITaxon:36650	LOTUS	DOI:10.1021/JA3028636
Penicillium aethiopicum NCBITaxon:36650	CHEBI	PMID:22590971

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0000168	Penicillium aethiopicum NCBITaxon:36650	CLUSTER_DEMONSTRATED	genbank:GU574477.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 1

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
HERG Channel Activity	ACTIVE	Not recorded	pubchem.aid:376 assay HERG Channel Activity evidence reference pubchem.aid:376 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 376, deposited by PDSP; assay type Other. Target accession NP_000229 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE

Elsewhere in the fleet

AntibioticMech — CHEBI:85616 (same structure, same inchikey)

Explore across X-Mech

AntibioticMech (viridicatumtoxin) ↗ MediaIngredientMech (CHEBI:85616) ↗ TaxonMech: Penicillium aethiopicum (NCBITaxon:36650) ↗ PathwayMech (mibig:BGC0000168) ↗

Provenance

Source concept	Source	Version
BGC0000168	MIBIG	5
CHEBI:85616	CHEBI	3-star

This page is generated from data/natural_products/unclassified/viridicatumtoxin.yaml, which is generated from the committed inventories. Neither is edited by hand.