xenovulene A
CHEBI:66336 EXACT SEEDED
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
A sesquiterpenoid based on a humulene skeleton. It is isolated from Sarocladium strictum and has been shown to exhibit inhibitory activity against GABA receptor.
Structure
| Standard InChIKey | WDFUVZRTUNQXHC-KVPIFFDFSA-N |
|---|---|
| SMILES | [H][C@]12CO[C@]3([H])[C@@]1([H])C(O[C@]1(C)C\C=C\C(C)(C)C\C=C(C)\CC[C@@]31[H])=C(O)C2=O |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA07151 |
Filing pathway
Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Sarocladium sp. 'schorii' NCBITaxon:2203296 |
SOURCE_ASSERTION | mibig:BGC0001827 | DOI:10.1038/s41467-018-04364-9 |
Occurrences 3
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Sarocladium strictum NCBITaxon:5046 |
LOTUS | DOI:10.1039/A704864E |
| Sarocladium strictum NCBITaxon:5046 |
LOTUS | DOI:10.7164/ANTIBIOTICS.48.568 |
| Sarocladium strictum NCBITaxon:5046 |
CHEBI | PMID:7649852 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001827 | Sarocladium sp. 'schorii' NCBITaxon:2203296 |
CLUSTER_UNSTATED | genbank:MG736817.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
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Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001827 | MIBIG | 3 |
| CHEBI:66336 | CHEBI | 3-star |
This page is generated from data/natural_products/unclassified/xenovulene-a.yaml, which is generated from the committed inventories. Neither is edited by hand.