xenovulene A

CHEBI:66336 EXACT SEEDED

A sesquiterpenoid based on a humulene skeleton. It is isolated from Sarocladium strictum and has been shown to exhibit inhibitory activity against GABA receptor.

Structure

Standard InChIKey	WDFUVZRTUNQXHC-KVPIFFDFSA-N
SMILES	[H][C@]12CO[C@]3([H])[C@@]1([H])C(O[C@]1(C)C\C=C\C(C)(C)C\C=C(C)\CC[C@@]31[H])=C(O)C2=O
Stereochemistry	fully defined
Cross-references	npatlas:NPA07151

Filing pathway

Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Sarocladium sp. 'schorii' NCBITaxon:2203296	SOURCE_ASSERTION	mibig:BGC0001827	DOI:10.1038/s41467-018-04364-9

Occurrences 3

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Sarocladium strictum NCBITaxon:5046	LOTUS	DOI:10.1039/A704864E
Sarocladium strictum NCBITaxon:5046	LOTUS	DOI:10.7164/ANTIBIOTICS.48.568
Sarocladium strictum NCBITaxon:5046	CHEBI	PMID:7649852

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0001827	Sarocladium sp. 'schorii' NCBITaxon:2203296	CLUSTER_UNSTATED	genbank:MG736817.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Provenance

Source concept	Source	Version
BGC0001827	MIBIG	3
CHEBI:66336	CHEBI	3-star

This page is generated from data/natural_products/unclassified/xenovulene-a.yaml, which is generated from the committed inventories. Neither is edited by hand.