linearmycin A and related metabolites biosynthetic gene cluster

MIBiG:BGC0002072

The Streptomyces sp. Mg1 linearmycin gene cluster produces linearmycins A, B and C. Deletion and complementation establish LnyI as required for production. The graph records experimentally observed products and genetic dependence; detailed starter-unit chemistry and modular chain-extension assignments remain proposed.

Pathway type

biosynthetic gene cluster

Organism scope

Streptomyces sp. Mg1 NCBITaxon:465541

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Pathway network

5 nodes · 4 asserted directed edges

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Chemical / cofactor
Protein / complex
Pathway
Solid arrow: mechanistic relation
Dashed arrow: membership, location or cofactor relation

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Streptomyces sp. Mg1 `NCBITaxon:465541`	taxon
LnyI `NCBIProtein:AKL64828.1`	protein
Linearmycin A `CHEBI:202459`	small molecule
Linearmycin B `CHEBI:202416`	small molecule
Linearmycin C `CHEBI:210490`	small molecule

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
LnyI `NCBIProtein:AKL64828.1`	enables Genetic requirement for pathway output; this does not assert a specific starter-substrate reaction.	linearmycin A and related metabolites biosynthetic gene cluster `MIBiG:BGC0002072`	PMID:28919037 Source assertion: Deleting lnyI eliminates detectable linearmycins A, B and C; complementation restores production. Source location `Results: lnyI deletion and complementation; HPLC profiles`
linearmycin A and related metabolites biosynthetic gene cluster `MIBiG:BGC0002072`	produces	Linearmycin A `CHEBI:202459`	PMID:28919037 Source assertion: Linearmycin A was detected among Streptomyces sp. Mg1 linearmycin products in the production and mutant experiments. Source location `Results: linearmycin identification and lnyI mutant/complement HPLC profiles`
linearmycin A and related metabolites biosynthetic gene cluster `MIBiG:BGC0002072`	produces	Linearmycin B `CHEBI:202416`	PMID:28919037 Source assertion: Linearmycin B was detected among Streptomyces sp. Mg1 linearmycin products in the production and mutant experiments. Source location `Results: linearmycin identification and lnyI mutant/complement HPLC profiles`
linearmycin A and related metabolites biosynthetic gene cluster `MIBiG:BGC0002072`	produces	Linearmycin C `CHEBI:210490`	PMID:28919037 Source assertion: Linearmycin C was detected among Streptomyces sp. Mg1 linearmycin products in the production and mutant experiments. Source location `Results: linearmycin identification and lnyI mutant/complement HPLC profiles`

Biosynthetic gene clusters

linearmycin A and related metabolites biosynthetic gene clusterMIBiG:BGC0002072
- Products: linearmycin A, linearmycin B, linearmycin C
- Classes: PKS:Type I
- Loci: CP011664.1
- Genes: 10

References

PMID:29348524 MIBiG literature reference PMID:29348524
MIBiG:BGC0002072 mibig-4.0 native structured pathway source (source version: 4.0)
PMID:28919037 A Link between Linearmycin Biosynthesis and Extracellular Vesicle Genesis Connects Specialized Metabolism and Bacterial Membrane Physiology

Curation history

2026-10-05T06:16:46Z Codex
- EDIT — Review complete causal graph against native sources and correct unsupported or omitted relationships
  Reconstructed experimentally grounded LnyI dependence and three observed products; duplicated source linearmycin C is one entity. Proposed arginine-derived starter and PKS module skipping remain unasserted. Removed unrelated PMID32964081 (cigarette-smoking dataset). ChEBI product names, formulas and chain lengths checked against native structures. Every native record was inspected; see reports/causal-graph-diagram-review.json for native-object counts, exclusions and identity corrections. Semantic validation and native GraphId locator checks passed; authority snapshots and full corpus gates are coordinated separately.
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2026-10-05T19:14:27Z codex
- EDIT — Remove repeated MIBiG namespace in the generated description
  Removed only the repeated MIBiG word before the existing MIBiG:BGC0002072 identifier. Cluster metadata, references, organisms and mechanistic edges remain unchanged. Updated the MIBiG importer template to prevent recurrence; regenerated the site and validated the record.
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