L-arginine degradation II (AST pathway)

MetaCyc:AST-PWY

The arginine succinyltransferase pathway converts L-arginine through N(2)-succinyl-L-arginine, N(2)-succinyl-L-ornithine, N-succinyl-L-glutamate 5-semialdehyde, and N-succinyl-L-glutamate to L-glutamate and succinate.

Pathway type

amino acid degradation

Organism scope

Pseudomonas aeruginosa NCBITaxon:287

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Pathway network

35 nodes · 43 asserted directed edges

Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.

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Chemical / cofactor
Protein / complex
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Cell / process context
Solid arrow: mechanistic relation
Dashed arrow: membership, location or cofactor relation

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Pseudomonas aeruginosa `NCBITaxon:287`	taxon
arginine N-succinyltransferase `EC:2.3.1.109`	molecular activity
N-succinylarginine dihydrolase `EC:3.5.3.23`	molecular activity
succinylornithine transaminase `EC:2.6.1.81`	molecular activity
succinylglutamate-semialdehyde dehydrogenase `EC:1.2.1.71`	molecular activity
succinylglutamate desuccinylase `EC:3.5.1.96`	molecular activity
succinyl-CoA `CHEBI:57292`	small molecule
L-arginine `CHEBI:32682`	small molecule
N(2)-succinyl-L-arginine `CHEBI:58241`	small molecule
CoA `CHEBI:57287`	small molecule
H(+) `CHEBI:15378`	small molecule
H2O `CHEBI:15377`	small molecule
N(2)-succinyl-L-ornithine `CHEBI:58514`	small molecule
NH4(+) `CHEBI:28938`	small molecule
CO2 `CHEBI:16526`	small molecule
2-oxoglutarate `CHEBI:16810`	small molecule
N-succinyl-L-glutamate 5-semialdehyde `CHEBI:58520`	small molecule
L-glutamate `CHEBI:29985`	small molecule
NAD(+) `CHEBI:57540`	small molecule
N-succinyl-L-glutamate `CHEBI:58763`	small molecule
NADH `CHEBI:57945`	small molecule
succinate `CHEBI:30031`	small molecule
Succinylornithine transaminase/acetylornithine aminotransferase `UniProtKB:O30508`	protein
cytoplasm `GO:0005737`	cellular component
pyridoxal 5'-phosphate(2-) `CHEBI:597326`	cofactor
N-succinylglutamate 5-semialdehyde dehydrogenase `UniProtKB:O50174`	protein
N-succinylarginine dihydrolase `UniProtKB:O50175`	protein
Succinylglutamate desuccinylase `UniProtKB:O50177`	protein
zinc(2+) `CHEBI:29105`	cofactor
Arginine N-succinyltransferase subunit alpha `UniProtKB:P80357`	protein
Arginine N-succinyltransferase subunit beta `UniProtKB:P80358`	protein
arginine N-succinyltransferase reaction `RHEA:15186`	reaction	left to right
N-succinylarginine dihydrolase reaction `RHEA:19534`	reaction	left to right
succinylornithine transaminase reaction `RHEA:16954`	reaction	left to right
succinylglutamate-semialdehyde dehydrogenase reaction `RHEA:10813`	reaction	left to right
succinylglutamate desuccinylase reaction `RHEA:15170`	reaction	left to right

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
L-arginine `CHEBI:32682`	consumes	arginine N-succinyltransferase reaction `RHEA:15186`	RHEA:15186 Source assertion: Rhea lists CHEBI:32682 on the substrates side of RHEA:15186 in this directed reaction. Source location `rdf:Description[@rdf:about='http://rdf.rhea-db.org/15186']/rh:substrates; rh:contains/rh:compound/rh:accession`
succinyl-CoA `CHEBI:57292`	consumes	arginine N-succinyltransferase reaction `RHEA:15186`	RHEA:15186 Source assertion: Rhea lists CHEBI:57292 on the substrates side of RHEA:15186 in this directed reaction. Source location `rdf:Description[@rdf:about='http://rdf.rhea-db.org/15186']/rh:substrates; rh:contains/rh:compound/rh:accession`
arginine N-succinyltransferase reaction `RHEA:15186`	produces	H(+) `CHEBI:15378`	RHEA:15186 Source assertion: Rhea lists CHEBI:15378 on the products side of RHEA:15186 in this directed reaction. Source location `rdf:Description[@rdf:about='http://rdf.rhea-db.org/15186']/rh:products; rh:contains/rh:compound/rh:accession`
arginine N-succinyltransferase reaction `RHEA:15186`	produces	CoA `CHEBI:57287`	RHEA:15186 Source assertion: Rhea lists CHEBI:57287 on the products side of RHEA:15186 in this directed reaction. Source location `rdf:Description[@rdf:about='http://rdf.rhea-db.org/15186']/rh:products; rh:contains/rh:compound/rh:accession`
arginine N-succinyltransferase reaction `RHEA:15186`	produces	N(2)-succinyl-L-arginine `CHEBI:58241`	RHEA:15186 Source assertion: Rhea lists CHEBI:58241 on the products side of RHEA:15186 in this directed reaction. Source location `rdf:Description[@rdf:about='http://rdf.rhea-db.org/15186']/rh:products; rh:contains/rh:compound/rh:accession`
H2O `CHEBI:15377`	consumes	N-succinylarginine dihydrolase reaction `RHEA:19534`	RHEA:19534 Source assertion: Rhea lists CHEBI:15377 on the substrates side of RHEA:19534 in this directed reaction. Source location `rdf:Description[@rdf:about='http://rdf.rhea-db.org/19534']/rh:substrates; rh:contains/rh:compound/rh:accession`
H(+) `CHEBI:15378`	consumes	N-succinylarginine dihydrolase reaction `RHEA:19534`	RHEA:19534 Source assertion: Rhea lists CHEBI:15378 on the substrates side of RHEA:19534 in this directed reaction. Source location `rdf:Description[@rdf:about='http://rdf.rhea-db.org/19534']/rh:substrates; rh:contains/rh:compound/rh:accession`
N(2)-succinyl-L-arginine `CHEBI:58241`	consumes	N-succinylarginine dihydrolase reaction `RHEA:19534`	RHEA:19534 Source assertion: Rhea lists CHEBI:58241 on the substrates side of RHEA:19534 in this directed reaction. Source location `rdf:Description[@rdf:about='http://rdf.rhea-db.org/19534']/rh:substrates; rh:contains/rh:compound/rh:accession`
N-succinylarginine dihydrolase reaction `RHEA:19534`	produces	CO2 `CHEBI:16526`	RHEA:19534 Source assertion: Rhea lists CHEBI:16526 on the products side of RHEA:19534 in this directed reaction. Source location `rdf:Description[@rdf:about='http://rdf.rhea-db.org/19534']/rh:products; rh:contains/rh:compound/rh:accession`
N-succinylarginine dihydrolase reaction `RHEA:19534`	produces	NH4(+) `CHEBI:28938`	RHEA:19534 Source assertion: Rhea lists CHEBI:28938 on the products side of RHEA:19534 in this directed reaction. Source location `rdf:Description[@rdf:about='http://rdf.rhea-db.org/19534']/rh:products; rh:contains/rh:compound/rh:accession`
N-succinylarginine dihydrolase reaction `RHEA:19534`	produces	N(2)-succinyl-L-ornithine `CHEBI:58514`	RHEA:19534 Source assertion: Rhea lists CHEBI:58514 on the products side of RHEA:19534 in this directed reaction. Source location `rdf:Description[@rdf:about='http://rdf.rhea-db.org/19534']/rh:products; rh:contains/rh:compound/rh:accession`
2-oxoglutarate `CHEBI:16810`	consumes	succinylornithine transaminase reaction `RHEA:16954`	RHEA:16954 Source assertion: Rhea lists CHEBI:16810 on the substrates side of RHEA:16954 in this directed reaction. Source location `rdf:Description[@rdf:about='http://rdf.rhea-db.org/16954']/rh:substrates; rh:contains/rh:compound/rh:accession`
N(2)-succinyl-L-ornithine `CHEBI:58514`	consumes	succinylornithine transaminase reaction `RHEA:16954`	RHEA:16954 Source assertion: Rhea lists CHEBI:58514 on the substrates side of RHEA:16954 in this directed reaction. Source location `rdf:Description[@rdf:about='http://rdf.rhea-db.org/16954']/rh:substrates; rh:contains/rh:compound/rh:accession`
succinylornithine transaminase reaction `RHEA:16954`	produces	L-glutamate `CHEBI:29985`	RHEA:16954 Source assertion: Rhea lists CHEBI:29985 on the products side of RHEA:16954 in this directed reaction. Source location `rdf:Description[@rdf:about='http://rdf.rhea-db.org/16954']/rh:products; rh:contains/rh:compound/rh:accession`
succinylornithine transaminase reaction `RHEA:16954`	produces	N-succinyl-L-glutamate 5-semialdehyde `CHEBI:58520`	RHEA:16954 Source assertion: Rhea lists CHEBI:58520 on the products side of RHEA:16954 in this directed reaction. Source location `rdf:Description[@rdf:about='http://rdf.rhea-db.org/16954']/rh:products; rh:contains/rh:compound/rh:accession`
H2O `CHEBI:15377`	consumes	succinylglutamate-semialdehyde dehydrogenase reaction `RHEA:10813`	RHEA:10813 Source assertion: Rhea lists CHEBI:15377 on the substrates side of RHEA:10813 in this directed reaction. Source location `rdf:Description[@rdf:about='http://rdf.rhea-db.org/10813']/rh:substrates; rh:contains/rh:compound/rh:accession`
NAD(+) `CHEBI:57540`	consumes	succinylglutamate-semialdehyde dehydrogenase reaction `RHEA:10813`	RHEA:10813 Source assertion: Rhea lists CHEBI:57540 on the substrates side of RHEA:10813 in this directed reaction. Source location `rdf:Description[@rdf:about='http://rdf.rhea-db.org/10813']/rh:substrates; rh:contains/rh:compound/rh:accession`
N-succinyl-L-glutamate 5-semialdehyde `CHEBI:58520`	consumes	succinylglutamate-semialdehyde dehydrogenase reaction `RHEA:10813`	RHEA:10813 Source assertion: Rhea lists CHEBI:58520 on the substrates side of RHEA:10813 in this directed reaction. Source location `rdf:Description[@rdf:about='http://rdf.rhea-db.org/10813']/rh:substrates; rh:contains/rh:compound/rh:accession`
succinylglutamate-semialdehyde dehydrogenase reaction `RHEA:10813`	produces	H(+) `CHEBI:15378`	RHEA:10813 Source assertion: Rhea lists CHEBI:15378 on the products side of RHEA:10813 in this directed reaction. Source location `rdf:Description[@rdf:about='http://rdf.rhea-db.org/10813']/rh:products; rh:contains/rh:compound/rh:accession`
succinylglutamate-semialdehyde dehydrogenase reaction `RHEA:10813`	produces	NADH `CHEBI:57945`	RHEA:10813 Source assertion: Rhea lists CHEBI:57945 on the products side of RHEA:10813 in this directed reaction. Source location `rdf:Description[@rdf:about='http://rdf.rhea-db.org/10813']/rh:products; rh:contains/rh:compound/rh:accession`
succinylglutamate-semialdehyde dehydrogenase reaction `RHEA:10813`	produces	N-succinyl-L-glutamate `CHEBI:58763`	RHEA:10813 Source assertion: Rhea lists CHEBI:58763 on the products side of RHEA:10813 in this directed reaction. Source location `rdf:Description[@rdf:about='http://rdf.rhea-db.org/10813']/rh:products; rh:contains/rh:compound/rh:accession`
H2O `CHEBI:15377`	consumes	succinylglutamate desuccinylase reaction `RHEA:15170`	RHEA:15170 Source assertion: Rhea lists CHEBI:15377 on the substrates side of RHEA:15170 in this directed reaction. Source location `rdf:Description[@rdf:about='http://rdf.rhea-db.org/15170']/rh:substrates; rh:contains/rh:compound/rh:accession`
N-succinyl-L-glutamate `CHEBI:58763`	consumes	succinylglutamate desuccinylase reaction `RHEA:15170`	RHEA:15170 Source assertion: Rhea lists CHEBI:58763 on the substrates side of RHEA:15170 in this directed reaction. Source location `rdf:Description[@rdf:about='http://rdf.rhea-db.org/15170']/rh:substrates; rh:contains/rh:compound/rh:accession`
succinylglutamate desuccinylase reaction `RHEA:15170`	produces	L-glutamate `CHEBI:29985`	RHEA:15170 Source assertion: Rhea lists CHEBI:29985 on the products side of RHEA:15170 in this directed reaction. Source location `rdf:Description[@rdf:about='http://rdf.rhea-db.org/15170']/rh:products; rh:contains/rh:compound/rh:accession`
succinylglutamate desuccinylase reaction `RHEA:15170`	produces	succinate `CHEBI:30031`	RHEA:15170 Source assertion: Rhea lists CHEBI:30031 on the products side of RHEA:15170 in this directed reaction. Source location `rdf:Description[@rdf:about='http://rdf.rhea-db.org/15170']/rh:products; rh:contains/rh:compound/rh:accession`
arginine N-succinyltransferase `EC:2.3.1.109`	catalyzes	arginine N-succinyltransferase reaction `RHEA:15186`	RHEA:15185 Source assertion: Rhea associates EC:2.3.1.109 with the reaction family containing RHEA:15186. Source location `rh:ec` PMID:9393691 the aruF and aruG genes encode the subunits (AruAI and AruAII) of arginine and ornithine N2-succinyltransferases Source location `PubMed Abstract`
N-succinylarginine dihydrolase `EC:3.5.3.23`	catalyzes	N-succinylarginine dihydrolase reaction `RHEA:19534`	RHEA:19533 Source assertion: Rhea associates EC:3.5.3.23 with the reaction family containing RHEA:19534. Source location `rh:ec` PMID:9393691 The aruR, aruC, aruD, aruB, and aruE genes specify the ArgR regulatory protein, N2-succinylornithine 5-aminotransferase, N-succinylglutamate 5-semialdehyde dehydrogenase, N2-succinylarginine dihydrolase, and N-succinylglutamate desuccinylase, respectively Source location `PubMed Abstract`
succinylornithine transaminase `EC:2.6.1.81`	catalyzes	succinylornithine transaminase reaction `RHEA:16954`	RHEA:16953 Source assertion: Rhea associates EC:2.6.1.81 with the reaction family containing RHEA:16954. Source location `rh:ec` PMID:9393691 The aruR, aruC, aruD, aruB, and aruE genes specify the ArgR regulatory protein, N2-succinylornithine 5-aminotransferase, N-succinylglutamate 5-semialdehyde dehydrogenase, N2-succinylarginine dihydrolase, and N-succinylglutamate desuccinylase, respectively Source location `PubMed Abstract`
succinylglutamate-semialdehyde dehydrogenase `EC:1.2.1.71`	catalyzes	succinylglutamate-semialdehyde dehydrogenase reaction `RHEA:10813`	RHEA:10812 Source assertion: Rhea associates EC:1.2.1.71 with the reaction family containing RHEA:10813. Source location `rh:ec` PMID:9393691 The aruR, aruC, aruD, aruB, and aruE genes specify the ArgR regulatory protein, N2-succinylornithine 5-aminotransferase, N-succinylglutamate 5-semialdehyde dehydrogenase, N2-succinylarginine dihydrolase, and N-succinylglutamate desuccinylase, respectively Source location `PubMed Abstract`
succinylglutamate desuccinylase `EC:3.5.1.96`	catalyzes	succinylglutamate desuccinylase reaction `RHEA:15170`	RHEA:15169 Source assertion: Rhea associates EC:3.5.1.96 with the reaction family containing RHEA:15170. Source location `rh:ec` PMID:9393691 The aruR, aruC, aruD, aruB, and aruE genes specify the ArgR regulatory protein, N2-succinylornithine 5-aminotransferase, N-succinylglutamate 5-semialdehyde dehydrogenase, N2-succinylarginine dihydrolase, and N-succinylglutamate desuccinylase, respectively Source location `PubMed Abstract`
succinylglutamate-semialdehyde dehydrogenase reaction `RHEA:10813`	precedes	succinylglutamate desuccinylase reaction `RHEA:15170`	MetaCyc:AST-PWY Source assertion: MetaCyc pathway ordering places RHEA:10813 before RHEA:15170 in this pathway. Shared intermediate: CHEBI:58763. Source location `Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references`
arginine N-succinyltransferase reaction `RHEA:15186`	precedes	N-succinylarginine dihydrolase reaction `RHEA:19534`	MetaCyc:AST-PWY Source assertion: MetaCyc pathway ordering places RHEA:15186 before RHEA:19534 in this pathway. Shared intermediate: CHEBI:58241. Source location `Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references`
succinylornithine transaminase reaction `RHEA:16954`	precedes	succinylglutamate-semialdehyde dehydrogenase reaction `RHEA:10813`	MetaCyc:AST-PWY Source assertion: MetaCyc pathway ordering places RHEA:16954 before RHEA:10813 in this pathway. Shared intermediate: CHEBI:58520. Source location `Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references`
N-succinylarginine dihydrolase reaction `RHEA:19534`	precedes	succinylornithine transaminase reaction `RHEA:16954`	MetaCyc:AST-PWY Source assertion: MetaCyc pathway ordering places RHEA:19534 before RHEA:16954 in this pathway. Shared intermediate: CHEBI:58514. Source location `Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references`
Succinylornithine transaminase/acetylornithine aminotransferase `UniProtKB:O30508`	enables	succinylornithine transaminase reaction `RHEA:16954`	UniProtKB:O30508 Source assertion: UniProt annotates UniProtKB:O30508 with catalytic activity for the reaction family of RHEA:16954. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:208964. Source location `comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences`
Succinylornithine transaminase/acetylornithine aminotransferase `UniProtKB:O30508`	located_in	cytoplasm `GO:0005737`	UniProtKB:O30508 Source assertion: UniProt locates UniProtKB:O30508 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305. Source location `comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping`
Succinylornithine transaminase/acetylornithine aminotransferase `UniProtKB:O30508`	has_cofactor	pyridoxal 5'-phosphate(2-) `CHEBI:597326`	UniProtKB:O30508 Source assertion: UniProt lists CHEBI:597326 as a cofactor of UniProtKB:O30508 (evidence: ECO:0000250). Binds 1 pyridoxal phosphate per subunit. Source location `comments[commentType='COFACTOR'].cofactors and note`
N-succinylglutamate 5-semialdehyde dehydrogenase `UniProtKB:O50174`	enables	succinylglutamate-semialdehyde dehydrogenase reaction `RHEA:10813`	UniProtKB:O50174 Source assertion: UniProt annotates UniProtKB:O50174 with catalytic activity for the reaction family of RHEA:10813. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:208964. Source location `comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences`
N-succinylarginine dihydrolase `UniProtKB:O50175`	enables	N-succinylarginine dihydrolase reaction `RHEA:19534`	UniProtKB:O50175 Source assertion: UniProt annotates UniProtKB:O50175 with catalytic activity for the reaction family of RHEA:19534. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:208964. Source location `comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences`
Succinylglutamate desuccinylase `UniProtKB:O50177`	enables	succinylglutamate desuccinylase reaction `RHEA:15170`	UniProtKB:O50177 Source assertion: UniProt annotates UniProtKB:O50177 with catalytic activity for the reaction family of RHEA:15170. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:208964. Source location `comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences`
Succinylglutamate desuccinylase `UniProtKB:O50177`	has_cofactor	zinc(2+) `CHEBI:29105`	UniProtKB:O50177 Source assertion: UniProt lists CHEBI:29105 as a cofactor of UniProtKB:O50177 (evidence: ECO:0000255). Binds 1 zinc ion per subunit. Source location `comments[commentType='COFACTOR'].cofactors and note`
Arginine N-succinyltransferase subunit alpha `UniProtKB:P80357`	enables	arginine N-succinyltransferase reaction `RHEA:15186`	UniProtKB:P80357 Source assertion: UniProt annotates UniProtKB:P80357 with catalytic activity for the reaction family of RHEA:15186. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:208964. Source location `comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences`
Arginine N-succinyltransferase subunit beta `UniProtKB:P80358`	enables	arginine N-succinyltransferase reaction `RHEA:15186`	UniProtKB:P80358 Source assertion: UniProt annotates UniProtKB:P80358 with catalytic activity for the reaction family of RHEA:15186. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:208964. Source location `comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences`

References

MetaCyc:AST-PWY MetaCyc L-arginine degradation II pathway (source version: 22.5)
RHEA:15185 Rhea arginine N-succinyltransferase reaction (source version: 139)
RHEA:15186 Rhea N(2)-succinyl-L-arginine-forming direction (source version: 139)
RHEA:19533 Rhea N-succinylarginine dihydrolase reaction (source version: 139)
RHEA:19534 Rhea N(2)-succinyl-L-ornithine-forming direction (source version: 139)
RHEA:16953 Rhea succinylornithine transaminase reaction (source version: 139)
RHEA:16954 Rhea N-succinyl-L-glutamate 5-semialdehyde-forming direction (source version: 139)
RHEA:10812 Rhea succinylglutamate-semialdehyde dehydrogenase reaction (source version: 139)
RHEA:10813 Rhea N-succinyl-L-glutamate-forming direction (source version: 139)
RHEA:15169 Rhea succinylglutamate desuccinylase reaction (source version: 139)
RHEA:15170 Rhea L-glutamate- and succinate-forming direction (source version: 139)
PMID:16593724 Jann et al., Proceedings of the National Academy of Sciences, 1986
PMID:9393691 Itoh, Journal of Bacteriology, 1997
UniProtKB:O30508 UniProtKB:O30508 authority record (source version: 2026_03)
UniProtKB:O50174 UniProtKB:O50174 authority record (source version: 2026_03)
UniProtKB:O50175 UniProtKB:O50175 authority record (source version: 2026_03)
UniProtKB:O50177 UniProtKB:O50177 authority record (source version: 2026_03)
UniProtKB:P80357 UniProtKB:P80357 authority record (source version: 2026_03)
UniProtKB:P80358 UniProtKB:P80358 authority record (source version: 2026_03)

Curation history

2026-10-05T06:25:52Z codex
- EDIT — Review causal chemistry and add sourced molecular context
  Reviewed the entire record against MetaCyc 22.5 native pathway XML (including nested pathways), Rhea 139 explicit sides and directions, ENZYME 02-Sep-2026, PubMed records, and reviewed UniProt 2026_03 annotations within the record's taxon scope. Replaced generated structured-source quotations with source_assertion and source_locator. Typed molecular activities and participants. Reaction count 5 to 5; 0 directed-ID corrections; 6 protein annotations, 2 cofactor annotations and 1 sourced locations. All Rhea reaction substrate/product sets checked against independent Rhea authority; native pathway leaf coverage and source exceptions recorded in reports/causal_graph_review/metacyc-review.json. Full source URLs, versions and byte hashes are in metacyc-sources.json. All 50 MetaCyc records passed native schema validation; six targeted chemistry/evidence regression tests passed. Missing protein or cofactor annotations are not treated as biological absence; qualifications and exclusions are preserved in the ledger.
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