Calvin-Benson-Bassham cycle
MetaCyc:CALVIN-PWY
Complete 13-reaction native Calvin–Benson–Bassham cycle, with reduction and full pentose regeneration, scoped to Synechocystis PCC 6803 and separately identified current Kazusa protein annotations. The exact native identity is retained rather than equating the plant-oriented GO:0019253 definition. Rhea charged forms refine native chemical classes, without class-wide exactMatch. Weighted closure fixes three CO2 into one glyceraldehyde 3-phosphate using nine ATP and six NADPH; these are formal stoichiometric weights, not measured culture fluxes. Both aldolase activities, both transketolase activities and both functions of the bifunctional phosphatase are retained. Aldolase isoforms and the additional FBPase are alternatives, not serial requirements. Native parent-strain assemblies are connected to Kazusa accessions only through explicit database component mappings, not assumed culture identity. The erroneous native TPI link to mouse Q95554 is rejected; Q59994 has independent inferred activity evidence. Native TKTASYN and current P73282 remain separately scoped annotations without an asserted equivalence. The 2023 L-erythrulose surrogate-donor assay is not evidence for either canonical transketolase substrate pair. Sequence-matched synthetic CP12 rescue supports conditional system-level regulation in GT PCC6803, not a purified inhibition assay or counted ternary complex. Metal annotations and assay metals remain distinct; AMP-dependent inactive phosphatase assemblies are not treated as invariant active complexes. Carbon uptake, light reactions, photorespiration and biomass synthesis lie outside the native 13-member boundary.
- Pathway type
- carbon fixation
- Organism scope
Pathway network
65 nodes · 118 asserted directed edges
Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.
- Reaction / activity
- Chemical / cofactor
- Protein / complex
- Cell / process context
- Pathway
- Solid arrow: mechanistic relation
- Dashed arrow: membership, location or cofactor relation
Components and activities
| Node | Kind or role | Source direction |
|---|---|---|
Synechocystis sp. PCC 6803NCBITaxon:1148 | taxon | |
Synechocystis sp. PCC 6803 substr. KazusaNCBITaxon:1111708 | taxon | |
aldehydo-D-ribose 5-phosphate(2-)CHEBI:58273 | small molecule | |
D-ribulose 5-phosphate(2-)CHEBI:58121 | small molecule | |
ATP(4-)CHEBI:30616 | small molecule | |
D-ribulose 1,5-bisphosphate(4-)CHEBI:57870 | small molecule | |
ADP(3-)CHEBI:456216 | small molecule | |
hydronCHEBI:15378 | small molecule | |
D-xylulose 5-phosphate(2-)CHEBI:57737 | small molecule | |
sedoheptulose 1,7-bisphosphate(4-)CHEBI:58335 | small molecule | |
waterCHEBI:15377 | small molecule | |
sedoheptulose 7-phosphate(2-)CHEBI:57483 | small molecule | |
hydrogenphosphateCHEBI:43474 | small molecule | |
beta-D-fructofuranose 6-phosphate(2-)CHEBI:57634 | small molecule | |
D-glyceraldehyde 3-phosphate(2-)CHEBI:59776 | small molecule | |
D-erythrose 4-phosphate(2-)CHEBI:16897 | small molecule | |
beta-D-fructofuranose 1,6-bisphosphate(4-)CHEBI:32966 | small molecule | |
glycerone phosphate(2-)CHEBI:57642 | small molecule | |
3-phosphonato-D-glyceroyl phosphate(4-)CHEBI:57604 | small molecule | |
NADPH(4-)CHEBI:57783 | small molecule | |
NADP(3-)CHEBI:58349 | small molecule | |
3-phosphonato-D-glycerate(3-)CHEBI:58272 | small molecule | |
carbon dioxideCHEBI:16526 | small molecule | |
Glyceraldehyde-3-phosphate dehydrogenase 2UniProtKB:P80505 | protein | |
Fructose-bisphosphate aldolase class 2UniProtKB:Q55664 | protein | |
Ribulose-phosphate 3-epimeraseUniProtKB:P74061 | protein | |
Ribulose bisphosphate carboxylase large chainUniProtKB:P54205 | protein | |
D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphataseUniProtKB:P73922 | protein | |
Fructose-1,6-bisphosphatase class 1UniProtKB:P74324 | protein | |
Ribulose bisphosphate carboxylase small subunitUniProtKB:P54206 | protein | |
Ribose-5-phosphate isomerase AUniProtKB:Q55766 | protein | |
Phosphoglycerate kinaseUniProtKB:P74421 | protein | |
Triosephosphate isomeraseUniProtKB:Q59994 | protein | |
Fructose-bisphosphate aldolase class 1UniProtKB:P74309 | protein | |
PhosphoribulokinaseUniProtKB:P37101 | protein | |
TransketolaseUniProtKB:P73282 | protein | |
ribulose bisphosphate carboxylase/oxygenaseMetaCyc:CPLX-105 | complex | |
Cbbl dimerMetaCyc:CPLX-7223 | complex | |
D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphataseMetaCyc:CPLX-162 | complex | |
fructose-1,6-bisphosphatase class 1MetaCyc:CPLX-143 | complex | |
class II fructose-bisphosphate aldolase/sedoheptulose-1,7-bisphosphate aldolaseMetaCyc:CPLX-9465 | complex | |
class I fructose-bisphosphate aldolase/sedoheptulose-1,7-bisphosphate aldolaseMetaCyc:CPLX-9466 | complex | |
transketolaseMetaCyc:TKTASYN-MONOMER | protein | |
magnesium(2+)CHEBI:18420 | cofactor | |
zinc(2+)CHEBI:29105 | cofactor | |
manganese(2+)CHEBI:29035 | cofactor | |
divalent metal cationCHEBI:60240 | cofactor | |
calcium(2+)CHEBI:29108 | cofactor | |
cobalt(2+)CHEBI:48828 | cofactor | |
thiamine(1+) diphosphate(3-)CHEBI:58937 | cofactor | |
adenosine 5'-monophosphate(2-)CHEBI:456215 | small molecule | |
carboxysomeGO:0031470 | cellular component | |
Ssl3364 proteinUniProtKB:P73654 | protein | |
aldehydo-D-ribose 5-phosphate => D-ribulose 5-phosphateRHEA:14658 | reaction | left to right |
D-ribulose 5-phosphate + ATP => D-ribulose 1,5-bisphosphate + ADP + H(+)RHEA:19366 | reaction | left to right |
D-xylulose 5-phosphate => D-ribulose 5-phosphateRHEA:13679 | reaction | right to left |
D-sedoheptulose 1,7-bisphosphate + H2O => D-sedoheptulose 7-phosphate + phosphateRHEA:17462 | reaction | left to right |
beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphateRHEA:27628 | reaction | right to left |
D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphateRHEA:10509 | reaction | left to right |
beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphateRHEA:11065 | reaction | left to right |
D-erythrose 4-phosphate + dihydroxyacetone phosphate => D-sedoheptulose 1,7-bisphosphateRHEA:30168 | reaction | left to right |
D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphateRHEA:14731 | reaction | right to left |
D-glyceraldehyde 3-phosphate => dihydroxyacetone phosphateRHEA:18586 | reaction | left to right |
(2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)RHEA:10298 | reaction | right to left |
(2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADPRHEA:14802 | reaction | left to right |
D-ribulose 1,5-bisphosphate + CO2 + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)RHEA:23126 | reaction | right to left |
Mechanistic edges
| Subject | Predicate and description | Object | Evidence |
|---|---|---|---|
aldehydo-D-ribose 5-phosphate => D-ribulose 5-phosphateRHEA:14658 | part_of Native chemical classes are refined to the displayed Rhea structures; class-wide exact identity is not asserted. | MetaCyc:CALVIN-PWY |
|
aldehydo-D-ribose 5-phosphate(2-)CHEBI:58273 | consumes Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient. | aldehydo-D-ribose 5-phosphate => D-ribulose 5-phosphateRHEA:14658 |
|
aldehydo-D-ribose 5-phosphate => D-ribulose 5-phosphateRHEA:14658 | produces Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient. | D-ribulose 5-phosphate(2-)CHEBI:58121 |
|
D-ribulose 5-phosphate + ATP => D-ribulose 1,5-bisphosphate + ADP + H(+)RHEA:19366 | part_of Native reaction and displayed chemical structures map to the selected charged directional equation. | MetaCyc:CALVIN-PWY |
|
D-ribulose 5-phosphate(2-)CHEBI:58121 | consumes Coefficient 1 in the selected charged equation; cycle multiplicity 3 is separate from this reaction coefficient. | D-ribulose 5-phosphate + ATP => D-ribulose 1,5-bisphosphate + ADP + H(+)RHEA:19366 |
|
ATP(4-)CHEBI:30616 | consumes Coefficient 1 in the selected charged equation; cycle multiplicity 3 is separate from this reaction coefficient. | D-ribulose 5-phosphate + ATP => D-ribulose 1,5-bisphosphate + ADP + H(+)RHEA:19366 |
|
D-ribulose 5-phosphate + ATP => D-ribulose 1,5-bisphosphate + ADP + H(+)RHEA:19366 | produces Coefficient 1 in the selected charged equation; cycle multiplicity 3 is separate from this reaction coefficient. | D-ribulose 1,5-bisphosphate(4-)CHEBI:57870 |
|
D-ribulose 5-phosphate + ATP => D-ribulose 1,5-bisphosphate + ADP + H(+)RHEA:19366 | produces Coefficient 1 in the selected charged equation; cycle multiplicity 3 is separate from this reaction coefficient. | ADP(3-)CHEBI:456216 |
|
D-ribulose 5-phosphate + ATP => D-ribulose 1,5-bisphosphate + ADP + H(+)RHEA:19366 | produces Coefficient 1 in the selected charged equation; cycle multiplicity 3 is separate from this reaction coefficient. | hydronCHEBI:15378 |
|
D-xylulose 5-phosphate => D-ribulose 5-phosphateRHEA:13679 | part_of Native reaction and displayed chemical structures map to the selected charged directional equation. | MetaCyc:CALVIN-PWY |
|
D-xylulose 5-phosphate(2-)CHEBI:57737 | consumes Coefficient 1 in the selected charged equation; cycle multiplicity 2 is separate from this reaction coefficient. | D-xylulose 5-phosphate => D-ribulose 5-phosphateRHEA:13679 |
|
D-xylulose 5-phosphate => D-ribulose 5-phosphateRHEA:13679 | produces Coefficient 1 in the selected charged equation; cycle multiplicity 2 is separate from this reaction coefficient. | D-ribulose 5-phosphate(2-)CHEBI:58121 |
|
D-sedoheptulose 1,7-bisphosphate + H2O => D-sedoheptulose 7-phosphate + phosphateRHEA:17462 | part_of Native chemical classes are refined to the displayed Rhea structures; class-wide exact identity is not asserted. | MetaCyc:CALVIN-PWY |
|
sedoheptulose 1,7-bisphosphate(4-)CHEBI:58335 | consumes Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient. | D-sedoheptulose 1,7-bisphosphate + H2O => D-sedoheptulose 7-phosphate + phosphateRHEA:17462 |
|
waterCHEBI:15377 | consumes Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient. | D-sedoheptulose 1,7-bisphosphate + H2O => D-sedoheptulose 7-phosphate + phosphateRHEA:17462 |
|
D-sedoheptulose 1,7-bisphosphate + H2O => D-sedoheptulose 7-phosphate + phosphateRHEA:17462 | produces Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient. | sedoheptulose 7-phosphate(2-)CHEBI:57483 |
|
D-sedoheptulose 1,7-bisphosphate + H2O => D-sedoheptulose 7-phosphate + phosphateRHEA:17462 | produces Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient. | hydrogenphosphateCHEBI:43474 |
|
beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphateRHEA:27628 | part_of Native reaction and displayed chemical structures map to the selected charged directional equation. | MetaCyc:CALVIN-PWY |
|
beta-D-fructofuranose 6-phosphate(2-)CHEBI:57634 | consumes Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient. | beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphateRHEA:27628 |
|
D-glyceraldehyde 3-phosphate(2-)CHEBI:59776 | consumes Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient. | beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphateRHEA:27628 |
|
beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphateRHEA:27628 | produces Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient. | D-erythrose 4-phosphate(2-)CHEBI:16897 |
|
beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphateRHEA:27628 | produces Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient. | D-xylulose 5-phosphate(2-)CHEBI:57737 |
|
D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphateRHEA:10509 | part_of Native chemical classes are refined to the displayed Rhea structures; class-wide exact identity is not asserted. | MetaCyc:CALVIN-PWY |
|
sedoheptulose 7-phosphate(2-)CHEBI:57483 | consumes Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient. | D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphateRHEA:10509 |
|
D-glyceraldehyde 3-phosphate(2-)CHEBI:59776 | consumes Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient. | D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphateRHEA:10509 |
|
D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphateRHEA:10509 | produces Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient. | aldehydo-D-ribose 5-phosphate(2-)CHEBI:58273 |
|
D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphateRHEA:10509 | produces Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient. | D-xylulose 5-phosphate(2-)CHEBI:57737 |
|
beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphateRHEA:11065 | part_of Native reaction and displayed chemical structures map to the selected charged directional equation. | MetaCyc:CALVIN-PWY |
|
beta-D-fructofuranose 1,6-bisphosphate(4-)CHEBI:32966 | consumes Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient. | beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphateRHEA:11065 |
|
waterCHEBI:15377 | consumes Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient. | beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphateRHEA:11065 |
|
beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphateRHEA:11065 | produces Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient. | beta-D-fructofuranose 6-phosphate(2-)CHEBI:57634 |
|
beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphateRHEA:11065 | produces Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient. | hydrogenphosphateCHEBI:43474 |
|
D-erythrose 4-phosphate + dihydroxyacetone phosphate => D-sedoheptulose 1,7-bisphosphateRHEA:30168 | part_of Native reaction and displayed chemical structures map to the selected charged directional equation. | MetaCyc:CALVIN-PWY |
|
D-erythrose 4-phosphate(2-)CHEBI:16897 | consumes Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient. | D-erythrose 4-phosphate + dihydroxyacetone phosphate => D-sedoheptulose 1,7-bisphosphateRHEA:30168 |
|
glycerone phosphate(2-)CHEBI:57642 | consumes Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient. | D-erythrose 4-phosphate + dihydroxyacetone phosphate => D-sedoheptulose 1,7-bisphosphateRHEA:30168 |
|
D-erythrose 4-phosphate + dihydroxyacetone phosphate => D-sedoheptulose 1,7-bisphosphateRHEA:30168 | produces Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient. | sedoheptulose 1,7-bisphosphate(4-)CHEBI:58335 |
|
D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphateRHEA:14731 | part_of Native reaction and displayed chemical structures map to the selected charged directional equation. | MetaCyc:CALVIN-PWY |
|
D-glyceraldehyde 3-phosphate(2-)CHEBI:59776 | consumes Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient. | D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphateRHEA:14731 |
|
glycerone phosphate(2-)CHEBI:57642 | consumes Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient. | D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphateRHEA:14731 |
|
D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphateRHEA:14731 | produces Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient. | beta-D-fructofuranose 1,6-bisphosphate(4-)CHEBI:32966 |
|
D-glyceraldehyde 3-phosphate => dihydroxyacetone phosphateRHEA:18586 | part_of Native reaction and displayed chemical structures map to the selected charged directional equation. | MetaCyc:CALVIN-PWY |
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D-glyceraldehyde 3-phosphate(2-)CHEBI:59776 | consumes Coefficient 1 in the selected charged equation; cycle multiplicity 2 is separate from this reaction coefficient. | D-glyceraldehyde 3-phosphate => dihydroxyacetone phosphateRHEA:18586 |
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D-glyceraldehyde 3-phosphate => dihydroxyacetone phosphateRHEA:18586 | produces Coefficient 1 in the selected charged equation; cycle multiplicity 2 is separate from this reaction coefficient. | glycerone phosphate(2-)CHEBI:57642 |
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(2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)RHEA:10298 | part_of Native reaction and displayed chemical structures map to the selected charged directional equation. | MetaCyc:CALVIN-PWY |
|
3-phosphonato-D-glyceroyl phosphate(4-)CHEBI:57604 | consumes Coefficient 1 in the selected charged equation; cycle multiplicity 6 is separate from this reaction coefficient. | (2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)RHEA:10298 |
|
NADPH(4-)CHEBI:57783 | consumes Coefficient 1 in the selected charged equation; cycle multiplicity 6 is separate from this reaction coefficient. | (2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)RHEA:10298 |
|
hydronCHEBI:15378 | consumes Coefficient 1 in the selected charged equation; cycle multiplicity 6 is separate from this reaction coefficient. | (2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)RHEA:10298 |
|
(2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)RHEA:10298 | produces Coefficient 1 in the selected charged equation; cycle multiplicity 6 is separate from this reaction coefficient. | D-glyceraldehyde 3-phosphate(2-)CHEBI:59776 |
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(2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)RHEA:10298 | produces Coefficient 1 in the selected charged equation; cycle multiplicity 6 is separate from this reaction coefficient. | hydrogenphosphateCHEBI:43474 |
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(2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)RHEA:10298 | produces Coefficient 1 in the selected charged equation; cycle multiplicity 6 is separate from this reaction coefficient. | NADP(3-)CHEBI:58349 |
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(2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADPRHEA:14802 | part_of Native reaction and displayed chemical structures map to the selected charged directional equation. | MetaCyc:CALVIN-PWY |
|
3-phosphonato-D-glycerate(3-)CHEBI:58272 | consumes Coefficient 1 in the selected charged equation; cycle multiplicity 6 is separate from this reaction coefficient. | (2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADPRHEA:14802 |
|
ATP(4-)CHEBI:30616 | consumes Coefficient 1 in the selected charged equation; cycle multiplicity 6 is separate from this reaction coefficient. | (2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADPRHEA:14802 |
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(2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADPRHEA:14802 | produces Coefficient 1 in the selected charged equation; cycle multiplicity 6 is separate from this reaction coefficient. | 3-phosphonato-D-glyceroyl phosphate(4-)CHEBI:57604 |
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(2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADPRHEA:14802 | produces Coefficient 1 in the selected charged equation; cycle multiplicity 6 is separate from this reaction coefficient. | ADP(3-)CHEBI:456216 |
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D-ribulose 1,5-bisphosphate + CO2 + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)RHEA:23126 | part_of Native reaction and displayed chemical structures map to the selected charged directional equation. | MetaCyc:CALVIN-PWY |
|
D-ribulose 1,5-bisphosphate(4-)CHEBI:57870 | consumes Coefficient 1 in the selected charged equation; cycle multiplicity 3 is separate from this reaction coefficient. | D-ribulose 1,5-bisphosphate + CO2 + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)RHEA:23126 |
|
carbon dioxideCHEBI:16526 | consumes Coefficient 1 in the selected charged equation; cycle multiplicity 3 is separate from this reaction coefficient. | D-ribulose 1,5-bisphosphate + CO2 + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)RHEA:23126 |
|
waterCHEBI:15377 | consumes Coefficient 1 in the selected charged equation; cycle multiplicity 3 is separate from this reaction coefficient. | D-ribulose 1,5-bisphosphate + CO2 + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)RHEA:23126 |
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D-ribulose 1,5-bisphosphate + CO2 + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)RHEA:23126 | produces Coefficient 2 in the selected charged equation; cycle multiplicity 3 is separate from this reaction coefficient. | 3-phosphonato-D-glycerate(3-)CHEBI:58272 |
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D-ribulose 1,5-bisphosphate + CO2 + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)RHEA:23126 | produces Coefficient 2 in the selected charged equation; cycle multiplicity 3 is separate from this reaction coefficient. | hydronCHEBI:15378 |
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aldehydo-D-ribose 5-phosphate => D-ribulose 5-phosphateRHEA:14658 | provides_input_for Chemical continuity through CHEBI:58121. This does not assert equal flux through every cycle edge. | D-ribulose 5-phosphate + ATP => D-ribulose 1,5-bisphosphate + ADP + H(+)RHEA:19366 |
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D-ribulose 5-phosphate + ATP => D-ribulose 1,5-bisphosphate + ADP + H(+)RHEA:19366 | provides_input_for Chemical continuity through CHEBI:57870. This does not assert equal flux through every cycle edge. | D-ribulose 1,5-bisphosphate + CO2 + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)RHEA:23126 |
|
D-xylulose 5-phosphate => D-ribulose 5-phosphateRHEA:13679 | provides_input_for Chemical continuity through CHEBI:58121. This does not assert equal flux through every cycle edge. | D-ribulose 5-phosphate + ATP => D-ribulose 1,5-bisphosphate + ADP + H(+)RHEA:19366 |
|
D-sedoheptulose 1,7-bisphosphate + H2O => D-sedoheptulose 7-phosphate + phosphateRHEA:17462 | provides_input_for Chemical continuity through CHEBI:57483. This does not assert equal flux through every cycle edge. | D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphateRHEA:10509 |
|
beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphateRHEA:27628 | provides_input_for Chemical continuity through CHEBI:57737. This does not assert equal flux through every cycle edge. | D-xylulose 5-phosphate => D-ribulose 5-phosphateRHEA:13679 |
|
beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphateRHEA:27628 | provides_input_for Chemical continuity through CHEBI:16897. This does not assert equal flux through every cycle edge. | D-erythrose 4-phosphate + dihydroxyacetone phosphate => D-sedoheptulose 1,7-bisphosphateRHEA:30168 |
|
D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphateRHEA:10509 | provides_input_for Chemical continuity through CHEBI:58273. This does not assert equal flux through every cycle edge. | aldehydo-D-ribose 5-phosphate => D-ribulose 5-phosphateRHEA:14658 |
|
D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphateRHEA:10509 | provides_input_for Chemical continuity through CHEBI:57737. This does not assert equal flux through every cycle edge. | D-xylulose 5-phosphate => D-ribulose 5-phosphateRHEA:13679 |
|
beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphateRHEA:11065 | provides_input_for Chemical continuity through CHEBI:57634. This does not assert equal flux through every cycle edge. | beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphateRHEA:27628 |
|
D-erythrose 4-phosphate + dihydroxyacetone phosphate => D-sedoheptulose 1,7-bisphosphateRHEA:30168 | provides_input_for Chemical continuity through CHEBI:58335. This does not assert equal flux through every cycle edge. | D-sedoheptulose 1,7-bisphosphate + H2O => D-sedoheptulose 7-phosphate + phosphateRHEA:17462 |
|
D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphateRHEA:14731 | provides_input_for Chemical continuity through CHEBI:32966. This does not assert equal flux through every cycle edge. | beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphateRHEA:11065 |
|
D-glyceraldehyde 3-phosphate => dihydroxyacetone phosphateRHEA:18586 | provides_input_for Chemical continuity through CHEBI:57642. This does not assert equal flux through every cycle edge. | D-erythrose 4-phosphate + dihydroxyacetone phosphate => D-sedoheptulose 1,7-bisphosphateRHEA:30168 |
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D-glyceraldehyde 3-phosphate => dihydroxyacetone phosphateRHEA:18586 | provides_input_for Chemical continuity through CHEBI:57642. This does not assert equal flux through every cycle edge. | D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphateRHEA:14731 |
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(2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)RHEA:10298 | provides_input_for Chemical continuity through CHEBI:59776. This does not assert equal flux through every cycle edge. | beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphateRHEA:27628 |
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(2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)RHEA:10298 | provides_input_for Chemical continuity through CHEBI:59776. This does not assert equal flux through every cycle edge. | D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphateRHEA:10509 |
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(2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)RHEA:10298 | provides_input_for Chemical continuity through CHEBI:59776. This does not assert equal flux through every cycle edge. | D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphateRHEA:14731 |
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(2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)RHEA:10298 | provides_input_for Chemical continuity through CHEBI:59776. This does not assert equal flux through every cycle edge. | D-glyceraldehyde 3-phosphate => dihydroxyacetone phosphateRHEA:18586 |
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(2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADPRHEA:14802 | provides_input_for Chemical continuity through CHEBI:57604. This does not assert equal flux through every cycle edge. | (2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)RHEA:10298 |
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D-ribulose 1,5-bisphosphate + CO2 + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)RHEA:23126 | provides_input_for Chemical continuity through CHEBI:58272. This does not assert equal flux through every cycle edge. | (2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADPRHEA:14802 |
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ribulose bisphosphate carboxylase/oxygenaseMetaCyc:CPLX-105 | has_part Native coefficient 8; current accession is connected by an explicit native unification cross-reference. Parent PCC6803 and current Kazusa strain are not made identical. Assembly is the source-described state, not invariant under every condition. | Ribulose bisphosphate carboxylase small subunitUniProtKB:P54206 |
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Cbbl dimerMetaCyc:CPLX-7223 | has_part Native coefficient 2; current accession is connected by an explicit native unification cross-reference. Parent PCC6803 and current Kazusa strain are not made identical. Assembly is the source-described state, not invariant under every condition. | Ribulose bisphosphate carboxylase large chainUniProtKB:P54205 |
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D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphataseMetaCyc:CPLX-162 | has_part Native coefficient 4; current accession is connected by an explicit native unification cross-reference. Parent PCC6803 and current Kazusa strain are not made identical. Assembly is the source-described state, not invariant under every condition. | D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphataseUniProtKB:P73922 |
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fructose-1,6-bisphosphatase class 1MetaCyc:CPLX-143 | has_part Native coefficient 4; current accession is connected by an explicit native unification cross-reference. Parent PCC6803 and current Kazusa strain are not made identical. Assembly is the source-described state, not invariant under every condition. | Fructose-1,6-bisphosphatase class 1UniProtKB:P74324 |
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class II fructose-bisphosphate aldolase/sedoheptulose-1,7-bisphosphate aldolaseMetaCyc:CPLX-9465 | has_part Native coefficient 8; current accession is connected by an explicit native unification cross-reference. Parent PCC6803 and current Kazusa strain are not made identical. Assembly is the source-described state, not invariant under every condition. | Fructose-bisphosphate aldolase class 2UniProtKB:Q55664 |
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class I fructose-bisphosphate aldolase/sedoheptulose-1,7-bisphosphate aldolaseMetaCyc:CPLX-9466 | has_part Native coefficient 2; current accession is connected by an explicit native unification cross-reference. Parent PCC6803 and current Kazusa strain are not made identical. Assembly is the source-described state, not invariant under every condition. | Fructose-bisphosphate aldolase class 1UniProtKB:P74309 |
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ribulose bisphosphate carboxylase/oxygenaseMetaCyc:CPLX-105 | has_part Four large-chain dimers plus eight small chains constitute the native Rubisco assembly convention. | Cbbl dimerMetaCyc:CPLX-7223 |
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ribulose bisphosphate carboxylase/oxygenaseMetaCyc:CPLX-105 | catalyzes Native enzyme/activity association; cycle direction follows the pathway layout and original Rhea sides. Alternative bifunctional isoforms are not serial requirements. | D-ribulose 1,5-bisphosphate + CO2 + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)RHEA:23126 |
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D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphataseMetaCyc:CPLX-162 | catalyzes Native enzyme/activity association; cycle direction follows the pathway layout and original Rhea sides. Alternative bifunctional isoforms are not serial requirements. | D-sedoheptulose 1,7-bisphosphate + H2O => D-sedoheptulose 7-phosphate + phosphateRHEA:17462 |
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D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphataseMetaCyc:CPLX-162 | catalyzes Native enzyme/activity association; cycle direction follows the pathway layout and original Rhea sides. Alternative bifunctional isoforms are not serial requirements. | beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphateRHEA:11065 |
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fructose-1,6-bisphosphatase class 1MetaCyc:CPLX-143 | catalyzes Native enzyme/activity association; cycle direction follows the pathway layout and original Rhea sides. Alternative bifunctional isoforms are not serial requirements. | beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphateRHEA:11065 |
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class II fructose-bisphosphate aldolase/sedoheptulose-1,7-bisphosphate aldolaseMetaCyc:CPLX-9465 | catalyzes Native enzyme/activity association; cycle direction follows the pathway layout and original Rhea sides. Alternative bifunctional isoforms are not serial requirements. | D-erythrose 4-phosphate + dihydroxyacetone phosphate => D-sedoheptulose 1,7-bisphosphateRHEA:30168 |
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class II fructose-bisphosphate aldolase/sedoheptulose-1,7-bisphosphate aldolaseMetaCyc:CPLX-9465 | catalyzes Native enzyme/activity association; cycle direction follows the pathway layout and original Rhea sides. Alternative bifunctional isoforms are not serial requirements. | D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphateRHEA:14731 |
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class I fructose-bisphosphate aldolase/sedoheptulose-1,7-bisphosphate aldolaseMetaCyc:CPLX-9466 | catalyzes Native enzyme/activity association; cycle direction follows the pathway layout and original Rhea sides. Alternative bifunctional isoforms are not serial requirements. | D-erythrose 4-phosphate + dihydroxyacetone phosphate => D-sedoheptulose 1,7-bisphosphateRHEA:30168 |
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class I fructose-bisphosphate aldolase/sedoheptulose-1,7-bisphosphate aldolaseMetaCyc:CPLX-9466 | catalyzes Native enzyme/activity association; cycle direction follows the pathway layout and original Rhea sides. Alternative bifunctional isoforms are not serial requirements. | D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphateRHEA:14731 |
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transketolaseMetaCyc:TKTASYN-MONOMER | catalyzes Native transketolase activity only. Its exact mapping to current P73282 remains unestablished; the 2023 surrogate-donor assay does not demonstrate this canonical substrate pair. | D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphateRHEA:10509 |
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transketolaseMetaCyc:TKTASYN-MONOMER | catalyzes Native transketolase activity only. Its exact mapping to current P73282 remains unestablished; the 2023 surrogate-donor assay does not demonstrate this canonical substrate pair. | beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphateRHEA:27628 |
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PhosphoribulokinaseUniProtKB:P37101 | enables Current curated catalytic annotation has no experimental evidence code on this block. Functional protein-level participation does not invent an ungrounded assembly identifier. | D-ribulose 5-phosphate + ATP => D-ribulose 1,5-bisphosphate + ADP + H(+)RHEA:19366 |
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Phosphoglycerate kinaseUniProtKB:P74421 | enables Current catalytic annotation; monomer assignment is ECO:0000250 similarity. Functional protein-level participation does not invent an ungrounded assembly identifier. | (2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADPRHEA:14802 |
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Glyceraldehyde-3-phosphate dehydrogenase 2UniProtKB:P80505 | enables Current activity is ECO:0000269/PMID9226260; the native cycle uses the reductive NADPH direction. Homotetramer and dual-cofactor evidence remain preparation-scoped. Functional protein-level participation does not invent an ungrounded assembly identifier. | (2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)RHEA:10298 |
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Triosephosphate isomeraseUniProtKB:Q59994 | enables HAMAP ECO:0000255 activity and homodimer inference. Native TPIASYN-MONOMER points to unrelated mouse Q95554, so no native-complex equivalence is used. Functional protein-level participation does not invent an ungrounded assembly identifier. | D-glyceraldehyde 3-phosphate => dihydroxyacetone phosphateRHEA:18586 |
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Ribose-5-phosphate isomerase AUniProtKB:Q55766 | enables HAMAP ECO:0000255 activity and homodimer inference; aldehydo substrate is a refinement of the native ribose-phosphate class. Functional protein-level participation does not invent an ungrounded assembly identifier. | aldehydo-D-ribose 5-phosphate => D-ribulose 5-phosphateRHEA:14658 |
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Ribulose-phosphate 3-epimeraseUniProtKB:P74061 | enables HAMAP ECO:0000255 activity; homohexamer annotation separately cites PMID15333955. Functional protein-level participation does not invent an ungrounded assembly identifier. The inspected primary abstract reports a crystallographic asymmetric-unit hexamer, not an invariant solution assembly. | D-xylulose 5-phosphate => D-ribulose 5-phosphateRHEA:13679 |
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TransketolaseUniProtKB:P73282 | enables Unreviewed ARBA/RuleBase ECO:0000256 activity. This is a current annotation, not proof of native TKTASYN identity or of the second canonical substrate pair. Functional protein-level participation does not invent an ungrounded assembly identifier. | D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphateRHEA:10509 |
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Ribulose bisphosphate carboxylase large chainUniProtKB:P54205 | has_cofactor HAMAP ECO:0000255; one magnesium ion per large subunit. | magnesium(2+)CHEBI:18420 |
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Fructose-bisphosphate aldolase class 2UniProtKB:Q55664 | has_cofactor ECO:0000250 similarity: two Zn ions per subunit. The 2003 primary assay instead used CoCl2; this is not direct physiological Zn determination. | zinc(2+)CHEBI:29105 |
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D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphataseUniProtKB:P73922 | has_cofactor ECO:0000250 similarity manganese annotation. Later recombinant assays used magnesium; neither assay condition proves exclusive physiological metal choice. | manganese(2+)CHEBI:29035 |
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Fructose-1,6-bisphosphatase class 1UniProtKB:P74324 | has_cofactor HAMAP ECO:0000255; two magnesium ions per subunit. | magnesium(2+)CHEBI:18420 |
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Ribulose-phosphate 3-epimeraseUniProtKB:P74061 | has_cofactor HAMAP ECO:0000255; one generic divalent metal cation per subunit, not a resolved metal identity. | divalent metal cationCHEBI:60240 |
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TransketolaseUniProtKB:P73282 | has_cofactor ECO:0000256 RuleBase annotation: magnesium and alternative calcium, manganese or cobalt, not simultaneous obligatory occupancy. | magnesium(2+)CHEBI:18420 |
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TransketolaseUniProtKB:P73282 | has_cofactor ECO:0000256 RuleBase annotation: magnesium and alternative calcium, manganese or cobalt, not simultaneous obligatory occupancy. | calcium(2+)CHEBI:29108 |
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TransketolaseUniProtKB:P73282 | has_cofactor ECO:0000256 RuleBase annotation: magnesium and alternative calcium, manganese or cobalt, not simultaneous obligatory occupancy. | manganese(2+)CHEBI:29035 |
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TransketolaseUniProtKB:P73282 | has_cofactor ECO:0000256 RuleBase annotation: magnesium and alternative calcium, manganese or cobalt, not simultaneous obligatory occupancy. | cobalt(2+)CHEBI:48828 |
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TransketolaseUniProtKB:P73282 | has_cofactor ECO:0000256 PIRSR annotation; one thiamine diphosphate per subunit. | thiamine(1+) diphosphate(3-)CHEBI:58937 |
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adenosine 5'-monophosphate(2-)CHEBI:456215 | inhibits AMP inhibition of both native activities is a database assertion; charged AMP is a model normalization. Active and AMP-bound inactive tetramers are condition-dependent, not one invariant catalytic state. | D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphataseMetaCyc:CPLX-162 |
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magnesium(2+)CHEBI:18420 | activates Native allosteric activation annotation; no new concentration-response experiment is inferred. | ribulose bisphosphate carboxylase/oxygenaseMetaCyc:CPLX-105 |
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ribulose bisphosphate carboxylase/oxygenaseMetaCyc:CPLX-105 | located_in Native PCC6803 Rubisco is associated with carboxysome interior and shell fractions. This does not place the entire 13-member cycle inside carboxysomes. | carboxysomeGO:0031470 |
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Ssl3364 proteinUniProtKB:P73654 | regulates Conditional system-level genetic/physiological inference from sequence-matched WT complementation in GT PCC6803. CP12-dependent PRK/GapDH2 foci, metabolite pools and pooled NAD(P)H kinetics do not measure purified inhibition, exact complex stoichiometry, NADPH-specific flux or native Kazusa physiology. | MetaCyc:CALVIN-PWY |
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References
MetaCyc:CALVIN-PWYCalvin-Benson-Bassham cycle (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)RHEA:14658aldehydo-D-ribose 5-phosphate => D-ribulose 5-phosphate (source version: Rhea 142 original complete compressed RDF; approved directional reaction and exact sides)MetaCyc:RIB5PISOM-RXNRIB5PISOM-RXN (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)CHEBI:58273aldehydo-D-ribose 5-phosphate(2-) (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)CHEBI:58121D-ribulose 5-phosphate(2-) (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)RHEA:19366D-ribulose 5-phosphate + ATP => D-ribulose 1,5-bisphosphate + ADP + H(+) (source version: Rhea 142 original complete compressed RDF; approved directional reaction and exact sides)MetaCyc:PHOSPHORIBULOKINASE-RXNPHOSPHORIBULOKINASE-RXN (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)CHEBI:30616ATP(4-) (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)CHEBI:57870D-ribulose 1,5-bisphosphate(4-) (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)CHEBI:456216ADP(3-) (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)CHEBI:15378hydron (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)RHEA:13679D-xylulose 5-phosphate => D-ribulose 5-phosphate (source version: Rhea 142 original complete compressed RDF; approved directional reaction and exact sides)MetaCyc:RIBULP3EPIM-RXNRIBULP3EPIM-RXN (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)CHEBI:57737D-xylulose 5-phosphate(2-) (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)RHEA:17462D-sedoheptulose 1,7-bisphosphate + H2O => D-sedoheptulose 7-phosphate + phosphate (source version: Rhea 142 original complete compressed RDF; approved directional reaction and exact sides)MetaCyc:SEDOHEPTULOSE-BISPHOSPHATASE-RXNSEDOHEPTULOSE-BISPHOSPHATASE-RXN (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)CHEBI:58335sedoheptulose 1,7-bisphosphate(4-) (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)CHEBI:15377water (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)CHEBI:57483sedoheptulose 7-phosphate(2-) (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)CHEBI:43474hydrogenphosphate (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)RHEA:27628beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphate (source version: Rhea 142 original complete compressed RDF; approved directional reaction and exact sides)MetaCyc:2TRANSKETO-RXN2TRANSKETO-RXN (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)CHEBI:57634beta-D-fructofuranose 6-phosphate(2-) (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)CHEBI:59776D-glyceraldehyde 3-phosphate(2-) (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)CHEBI:16897D-erythrose 4-phosphate(2-) (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)RHEA:10509D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate (source version: Rhea 142 original complete compressed RDF; approved directional reaction and exact sides)MetaCyc:1TRANSKETO-RXN1TRANSKETO-RXN (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)RHEA:11065beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate (source version: Rhea 142 original complete compressed RDF; approved directional reaction and exact sides)MetaCyc:F16BDEPHOS-RXNF16BDEPHOS-RXN (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)CHEBI:32966beta-D-fructofuranose 1,6-bisphosphate(4-) (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)RHEA:30168D-erythrose 4-phosphate + dihydroxyacetone phosphate => D-sedoheptulose 1,7-bisphosphate (source version: Rhea 142 original complete compressed RDF; approved directional reaction and exact sides)MetaCyc:SEDOBISALDOL-RXNSEDOBISALDOL-RXN (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)CHEBI:57642glycerone phosphate(2-) (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)RHEA:14731D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphate (source version: Rhea 142 original complete compressed RDF; approved directional reaction and exact sides)MetaCyc:F16ALDOLASE-RXNF16ALDOLASE-RXN (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)RHEA:18586D-glyceraldehyde 3-phosphate => dihydroxyacetone phosphate (source version: Rhea 142 original complete compressed RDF; approved directional reaction and exact sides)MetaCyc:TRIOSEPISOMERIZATION-RXNTRIOSEPISOMERIZATION-RXN (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)RHEA:10298(2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+) (source version: Rhea 142 original complete compressed RDF; approved directional reaction and exact sides)MetaCyc:1.2.1.13-RXN1.2.1.13-RXN (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)CHEBI:576043-phosphonato-D-glyceroyl phosphate(4-) (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)CHEBI:57783NADPH(4-) (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)CHEBI:58349NADP(3-) (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)RHEA:14802(2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADP (source version: Rhea 142 original complete compressed RDF; approved directional reaction and exact sides)MetaCyc:PHOSGLYPHOS-RXNPHOSGLYPHOS-RXN (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)CHEBI:582723-phosphonato-D-glycerate(3-) (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)RHEA:23126D-ribulose 1,5-bisphosphate + CO2 + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+) (source version: Rhea 142 original complete compressed RDF; approved directional reaction and exact sides)MetaCyc:RIBULOSE-BISPHOSPHATE-CARBOXYLASE-RXNRIBULOSE-BISPHOSPHATE-CARBOXYLASE-RXN (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)CHEBI:16526carbon dioxide (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)MetaCyc:CPLX-105ribulose bisphosphate carboxylase/oxygenase (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)MetaCyc:CPLX-7223Cbbl dimer (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)MetaCyc:CPLX-162D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphatase (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)MetaCyc:CPLX-143fructose-1,6-bisphosphatase class 1 (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)MetaCyc:CPLX-9465class II fructose-bisphosphate aldolase/sedoheptulose-1,7-bisphosphate aldolase (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)MetaCyc:CPLX-9466class I fructose-bisphosphate aldolase/sedoheptulose-1,7-bisphosphate aldolase (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)MetaCyc:TKTASYN-MONOMERtransketolase (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)MetaCyc:MONOMER-751CbbS (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)MetaCyc:MONOMER-750CbbL (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)MetaCyc:FBPSBP-MONOMERfructose bisphosphatase F-I monomer (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)MetaCyc:FBPSYN-MONOMERFbp (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)MetaCyc:FBAASYN-MONOMERclass II fructose-bisphosphate aldolase/sedoheptulose-1,7-bisphosphate aldolase monomer (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)MetaCyc:FBABSYN-MONOMERclass I fructose-bisphosphate aldolase/sedoheptulose-1,7-bisphosphate aldolase monomer (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)MetaCyc:ENZRXN-122ribulose bisphosphate carboxylase (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)MetaCyc:ENZRXN-182sedoheptulose bisphosphatase (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)MetaCyc:ENZRXN-183fructose 1,6-bisphosphatase (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)MetaCyc:ENZRXN-169fructose 1,6-bisphosphatase (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)MetaCyc:ENZRXN-163sedoheptulose-1,7-bisphosphate aldolase (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)MetaCyc:ENZRXN-164fructose-bisphosphate aldolase (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)MetaCyc:ENZRXN-165sedoheptulose-1,7-bisphosphate aldolase (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)MetaCyc:ENZRXN-166fructose-bisphosphate aldolase (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)MetaCyc:ENZRXN-168sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycoaldehyde transferase (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)MetaCyc:ENZRXN-167D-fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)UniProtKB:P37101Phosphoribulokinase (source version: Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained)UniProtKB:P74421Phosphoglycerate kinase (source version: Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained)UniProtKB:P80505Glyceraldehyde-3-phosphate dehydrogenase 2 (source version: Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained)UniProtKB:Q59994Triosephosphate isomerase (source version: Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained)UniProtKB:Q55766Ribose-5-phosphate isomerase A (source version: Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained)UniProtKB:P74061Ribulose-phosphate 3-epimerase (source version: Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained)UniProtKB:P73282Transketolase (source version: Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained)CHEBI:18420magnesium(2+) (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)UniProtKB:P54205Ribulose bisphosphate carboxylase large chain (source version: Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained)CHEBI:29105zinc(2+) (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)UniProtKB:Q55664Fructose-bisphosphate aldolase class 2 (source version: Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained)CHEBI:29035manganese(2+) (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)UniProtKB:P73922D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphatase (source version: Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained)UniProtKB:P74324Fructose-1,6-bisphosphatase class 1 (source version: Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained)CHEBI:60240divalent metal cation (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)CHEBI:29108calcium(2+) (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)CHEBI:48828cobalt(2+) (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)CHEBI:58937thiamine(1+) diphosphate(3-) (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)CHEBI:456215adenosine 5'-monophosphate(2-) (source version: ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity)MetaCyc:REG-8538REG-8538 (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)MetaCyc:REG-8539REG-8539 (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)MetaCyc:REG-10188REG-10188 (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)GO:0031470carboxysome (source version: Pinned original GO Semantic SQL; exact cellular-component identity)PMID:17993516A Multiprotein Bicarbonate Dehydration Complex Essential to Carboxysome Function in Cyanobacteria (source version: Original full primary HTML; parent PCC6803 cultures, not a Kazusa-specific preparation)PMID:12668779Purification and Characterization of Class-I and Class-II Fructose-1,6-bisphosphate Aldolases from the Cyanobacterium Synechocystis sp. PCC 6803 (source version: Full original article inspected in author-uploaded ResearchGate web rendering; official local PDF returned 403. No full-text byte hash or offline article replay is claimed)PMID:24286336Structural and biochemical characterization of fructose-1,6/sedoheptulose-1,7-bisphosphatase from the cyanobacterium Synechocystis strain 6803 (source version: Full original official article inspected through web; local response 403 retained separately. No full-text byte hash or offline article replay is claimed)DOI:10.2210/pdb3RPL/pdb3RPL polymer entity 1: engineered PCC6803 FBP/SBPase (source version: Original RCSB polymer_entity/3RPL/1 JSON; sequence and source fields only, not the full paper or assembly endpoint)PMID:9226260Functional complementation of an Escherichia coli gap mutant supports an amphibolic role for NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase of Synechocystis sp. strain PCC 6803. (source version: Original primary abstract HTML inspected; PDF request returned preparation HTML, not a retained full primary PDF)UniProtKB:Q95554Major histocompatibility complex antigen H-2Kbm29 (source version: Original current unreviewed mouse fragment JSON; inspected solely to reject a wrong reciprocal native cross-reference)PMID:15333955Structure of D-ribulose 5-phosphate 3-epimerase from Synechocystis to 1.6 A resolution. (source version: Original Europe PMC indexed primary abstract in a retained metadata batch; no full article inspection is claimed)PMID:37723200Metabolite interactions in the bacterial Calvin cycle and implications for flux regulation (source version: Original full primary JATS; native PCC6803 genomic construct and surrogate-donor assay distinguished)MetaCyc:TPIASYN-MONOMERTpiA (source version: MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained)UniProtKB:P73654Ssl3364 protein (source version: Original UniProt batch JSON, results[0] P73654; canonical label and full 74-aa Kazusa sequence, not a direct functional annotation)PMID:36330266CP12 fine-tunes the Calvin-Benson cycle and carbohydrate metabolism in cyanobacteria (source version: Original full primary JATS; glucose-tolerant PCC6803 with unspecified GT substrain; genetic/physiological scope)DOI:10.3389/fpls.2022.1028794CP12 fine-tunes the Calvin-Benson cycle and carbohydrate metabolism in cyanobacteria — supplementary DataSheet_1.pdf (source version: Original publisher supplementary PDF extracted from the retained Europe PMC ZIP; digest covers the PDF member, not the ZIP)
Curation history
- codex
- CREATE — Add the complete native Calvin cycle with scoped microbial mechanism evidence
Added MetaCyc:CALVIN-PWY with all 13 native reactions, 51 participants, 118 edges, 216 evidence blocks and 106 references. Canonical authorities add 10 original source inputs, 22 source terms and 12 ontology terms while preserving prior entries and policy. The independent external whole-record review found two page locators under issue413 and an external replay input-binding defect under issue414; the corrected successor and its independent positive/negative replay are accepted before this CREATE. research/pathway_additions/2026-10-11-next-220 retains selected immutable original findings, corrected projections, independent dispositions and authority receipts. Exact target hash e5b770e60e481068b847e7dfe60b3f85681e36f25952f2c4308f82b0133d05a9. Formal cycle balance is not physiological flux; current protein annotations, experimental constructs and culture scopes remain distinct. Two primary web full texts lack retained full-body hashes and abstract-only limits remain explicit. The source manifest binds105 originals; the historical correction scalar104 is qualified in the successor. Duplicate searches included ignored/hidden files and relevant symlinks. Maintained rendering, repository gates, graph acceptance and canonical review will follow; this event does not claim their completion.
- CREATE — Add the complete native Calvin cycle with scoped microbial mechanism evidence