L-fucose degradation I
MetaCyc:FUCCAT-PWY
L-fucose degradation I epimerizes beta-L-fucose to alpha-L-fucose, isomerizes L-fucose to L-fuculose, phosphorylates L-fuculose with ATP, and cleaves L-fuculose 1-phosphate to (S)-lactaldehyde and dihydroxyacetone phosphate.
- Pathway type
- carbohydrate degradation
- Organism scope
Pathway network
18 nodes · 19 asserted directed edges
Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.
- Reaction / activity
- Chemical / cofactor
- Other participant
- Solid arrow: mechanistic relation
- Dashed arrow: membership, location or cofactor relation
Components and activities
| Node | Kind or role | Source direction |
|---|---|---|
Escherichia coli str. K-12 substr. MG1655NCBITaxon:511145 | taxon | |
L-fucose mutarotaseEC:5.1.3.29 | molecular activity | |
L-fucose isomeraseEC:5.3.1.25 | molecular activity | |
L-fuculokinaseEC:2.7.1.51 | molecular activity | |
L-fuculose-phosphate aldolaseEC:4.1.2.17 | molecular activity | |
beta-L-fucoseCHEBI:42589 | small molecule | |
alpha-L-fucoseCHEBI:42548 | small molecule | |
L-fucoseCHEBI:2181 | small molecule | |
L-fuculoseCHEBI:17617 | small molecule | |
ATPCHEBI:30616 | small molecule | |
L-fuculose 1-phosphateCHEBI:57846 | small molecule | |
ADPCHEBI:456216 | small molecule | |
H(+)CHEBI:15378 | small molecule | |
(S)-lactaldehydeCHEBI:18041 | small molecule | |
dihydroxyacetone phosphateCHEBI:57642 | small molecule | |
L-fuculokinase reactionRHEA:12377 | reaction | left to right |
L-fuculose-phosphate aldolase reactionRHEA:12934 | reaction | left to right |
L-fucose mutarotase reactionRHEA:25582 | reaction | right to left |
L-fucose isomerase reactionRHEA:17234 | reaction | left to right |
Mechanistic edges
| Subject | Predicate and description | Object | Evidence |
|---|---|---|---|
L-fuculoseCHEBI:17617 | consumes | L-fuculokinase reactionRHEA:12377 |
|
ATPCHEBI:30616 | consumes | L-fuculokinase reactionRHEA:12377 |
|
L-fuculokinase reactionRHEA:12377 | produces | H(+)CHEBI:15378 |
|
L-fuculokinase reactionRHEA:12377 | produces | ADPCHEBI:456216 |
|
L-fuculokinase reactionRHEA:12377 | produces | L-fuculose 1-phosphateCHEBI:57846 |
|
L-fuculose 1-phosphateCHEBI:57846 | consumes | L-fuculose-phosphate aldolase reactionRHEA:12934 |
|
L-fuculose-phosphate aldolase reactionRHEA:12934 | produces | (S)-lactaldehydeCHEBI:18041 |
|
L-fuculose-phosphate aldolase reactionRHEA:12934 | produces | dihydroxyacetone phosphateCHEBI:57642 |
|
beta-L-fucoseCHEBI:42589 | consumes | L-fucose mutarotase reactionRHEA:25582 |
|
L-fucose mutarotase reactionRHEA:25582 | produces | alpha-L-fucoseCHEBI:42548 |
|
L-fucoseCHEBI:2181 | consumes | L-fucose isomerase reactionRHEA:17234 |
|
L-fucose isomerase reactionRHEA:17234 | produces | L-fuculoseCHEBI:17617 |
|
L-fucose mutarotaseEC:5.1.3.29 | catalyzes | L-fucose mutarotase reactionRHEA:25582 |
|
L-fucose isomeraseEC:5.3.1.25 | catalyzes | L-fucose isomerase reactionRHEA:17234 |
|
L-fuculokinaseEC:2.7.1.51 | catalyzes | L-fuculokinase reactionRHEA:12377 |
|
L-fuculose-phosphate aldolaseEC:4.1.2.17 | catalyzes | L-fuculose-phosphate aldolase reactionRHEA:12934 |
|
L-fuculokinase reactionRHEA:12377 | precedes | L-fuculose-phosphate aldolase reactionRHEA:12934 |
|
L-fucose isomerase reactionRHEA:17234 | precedes | L-fuculokinase reactionRHEA:12377 |
|
L-fucose mutarotase reactionRHEA:25582 | precedes | L-fucose isomerase reactionRHEA:17234 |
|
References
MetaCyc:FUCCAT-PWYMetaCyc L-fucose degradation I (source version: 22.5)RHEA:25580Rhea L-fucose mutarotase reaction (source version: 139)RHEA:25583Rhea bidirectional L-fucose mutarotase reaction (source version: 139)RHEA:17233Rhea L-fucose isomerase reaction (source version: 139)RHEA:17236Rhea bidirectional L-fucose isomerase reaction (source version: 139)RHEA:12376Rhea L-fuculokinase reaction (source version: 139)RHEA:12377Rhea L-fuculose-1-phosphate-forming direction (source version: 139)RHEA:12933Rhea L-fuculose-phosphate aldolase reaction (source version: 139)RHEA:12934Rhea L-fuculose-1-phosphate-cleaving direction (source version: 139)RHEA:25582RHEA:25582 authority record (source version: 139)RHEA:17234RHEA:17234 authority record (source version: 139)
Curation history
- codex
- EDIT — Align NCBITaxon:511145 label with the pinned authority
Corrected the taxon label from Escherichia coli K-12 substr. MG1655 to Escherichia coli str. K-12 substr. MG1655, matching the independently extracted NCBITaxon 2026-05-13 canonical label in data/identifier_authorities/ontology.json. The identifier and biological scope are unchanged. Discovered by the blocking identifier gate for issue #229; tracked by #243.
- EDIT — Align NCBITaxon:511145 label with the pinned authority
- codex
- EDIT — Review causal chemistry and add sourced molecular context
Reviewed the entire record against MetaCyc 22.5 native pathway XML (including nested pathways), Rhea 139 explicit sides and directions, ENZYME 02-Sep-2026, PubMed records, and reviewed UniProt 2026_03 annotations within the record's taxon scope. Replaced generated structured-source quotations with source_assertion and source_locator. Typed molecular activities and participants. Reaction count 4 to 4; 2 directed-ID corrections; 0 protein annotations, 0 cofactor annotations and 0 sourced locations. All Rhea reaction substrate/product sets checked against independent Rhea authority; native pathway leaf coverage and source exceptions recorded in reports/causal_graph_review/metacyc-review.json. Full source URLs, versions and byte hashes are in metacyc-sources.json. All 50 MetaCyc records passed native schema validation; six targeted chemistry/evidence regression tests passed. Missing protein or cofactor annotations are not treated as biological absence; qualifications and exclusions are preserved in the ledger.
- EDIT — Review causal chemistry and add sourced molecular context