pyridoxal 5'-phosphate biosynthesis I

MetaCyc:PYRIDOXSYN-PWY

The DXP-dependent pyridoxal 5'-phosphate biosynthesis I pathway oxidizes D-erythrose 4-phosphate to 4-phospho-D-erythronate, transaminates the resulting keto acid to 4-(phosphooxy)-L-threonine, decarboxylates it to 3-amino-2-oxopropyl phosphate, condenses that intermediate with 1-deoxy-D-xylulose 5-phosphate to form pyridoxine 5'-phosphate, and oxidizes pyridoxine 5'-phosphate to pyridoxal 5'-phosphate.

Pathway type
cofactor biosynthesis
Organism scope

Read the source YAML

Pathway network

47 nodes · 67 asserted directed edges

Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.

Pathway network: pyridoxal 5'-phosphate biosynthesis I 47 nodes · 67 asserted directed edges. Every arrow links to its evidence table row; nodes link to their component details. Isolated declared components are retained. CHEBI:15377 — consumes → RHEA:12057; Evidence: RHEA:12057consumes CHEBI:16897 — consumes → RHEA:12057; Evidence: RHEA:12057consumes CHEBI:57540 — consumes → RHEA:12057; Evidence: RHEA:12057consumes RHEA:12057 — produces → CHEBI:15378; Evidence: RHEA:12057produces RHEA:12057 — produces → CHEBI:57945; Evidence: RHEA:12057produces RHEA:12057 — produces → CHEBI:58766; Evidence: RHEA:12057produces CHEBI:57540 — consumes → RHEA:18830; Evidence: RHEA:18830consumes CHEBI:58766 — consumes → RHEA:18830; Evidence: RHEA:18830consumes RHEA:18830 — produces → CHEBI:15378; Evidence: RHEA:18830produces RHEA:18830 — produces → CHEBI:57945; Evidence: RHEA:18830produces RHEA:18830 — produces → CHEBI:58538; Evidence: RHEA:18830produces CHEBI:29985 — consumes → RHEA:16575; Evidence: RHEA:16575consumes CHEBI:58538 — consumes → RHEA:16575; Evidence: RHEA:16575consumes RHEA:16575 — produces → CHEBI:16810; Evidence: RHEA:16575produces RHEA:16575 — produces → CHEBI:58452; Evidence: RHEA:16575produces CHEBI:57540 — consumes → RHEA:32276; Evidence: RHEA:32276consumes CHEBI:58452 — consumes → RHEA:32276; Evidence: RHEA:32276consumes RHEA:32276 — produces → CHEBI:16526; Evidence: RHEA:32276produces RHEA:32276 — produces → CHEBI:57279; Evidence: RHEA:32276produces RHEA:32276 — produces → CHEBI:57945; Evidence: RHEA:32276produces CHEBI:15361 — consumes → RHEA:12606; Evidence: RHEA:12606consumes CHEBI:15378 — consumes → RHEA:12606; Evidence: RHEA:12606consumes CHEBI:59776 — consumes → RHEA:12606; Evidence: RHEA:12606consumes RHEA:12606 — produces → CHEBI:16526; Evidence: RHEA:12606produces RHEA:12606 — produces → CHEBI:57792; Evidence: RHEA:12606produces CHEBI:57279 — consumes → RHEA:15266; Evidence: RHEA:15266consumes CHEBI:57792 — consumes → RHEA:15266; Evidence: RHEA:15266consumes RHEA:15266 — produces → CHEBI:15377; Evidence: RHEA:15266produces RHEA:15266 — produces → CHEBI:15378; Evidence: RHEA:15266produces RHEA:15266 — produces → CHEBI:43474; Evidence: RHEA:15266produces RHEA:15266 — produces → CHEBI:58589; Evidence: RHEA:15266produces CHEBI:15379 — consumes → RHEA:15150; Evidence: RHEA:15150consumes CHEBI:58589 — consumes → RHEA:15150; Evidence: RHEA:15150consumes RHEA:15150 — produces → CHEBI:16240; Evidence: RHEA:15150produces RHEA:15150 — produces → CHEBI:597326; Evidence: RHEA:15150produces EC:1.2.1.72 — catalyzes → RHEA:12057; Evidence: RHEA:12056catalyzes EC:1.1.1.290 — catalyzes → RHEA:18830; Evidence: RHEA:18829catalyzes EC:2.6.1.52 — catalyzes → RHEA:16575; Evidence: RHEA:16573catalyzes EC:1.1.1.262 — catalyzes → RHEA:32276; Evidence: RHEA:32275catalyzes EC:2.2.1.7 — catalyzes → RHEA:12606; Evidence: RHEA:12605catalyzes EC:2.6.99.2 — catalyzes → RHEA:15266; Evidence: RHEA:15265catalyzes EC:1.4.3.5 — catalyzes → RHEA:15150; Evidence: RHEA:15149catalyzes RHEA:12057 — precedes → RHEA:18830; Evidence: MetaCyc:PYRIDOXSYN-PWYprecedes RHEA:12606 — precedes → RHEA:15266; Evidence: MetaCyc:PYRIDOXSYN-PWYprecedes RHEA:15266 — precedes → RHEA:15150; Evidence: MetaCyc:PYRIDOXSYN-PWYprecedes RHEA:16575 — precedes → RHEA:32276; Evidence: MetaCyc:PYRIDOXSYN-PWYprecedes RHEA:18830 — precedes → RHEA:16575; Evidence: MetaCyc:PYRIDOXSYN-PWYprecedes RHEA:32276 — precedes → RHEA:15266; Evidence: MetaCyc:PYRIDOXSYN-PWYprecedes UniProtKB:P05459 — enables → RHEA:18830; Evidence: UniProtKB:P05459enables UniProtKB:P05459 — located_in → GO:0005737; Evidence: UniProtKB:P05459located in UniProtKB:P0A794 — enables → RHEA:15266; Evidence: UniProtKB:P0A794enables UniProtKB:P0A794 — located_in → GO:0005737; Evidence: UniProtKB:P0A794located in UniProtKB:P0A9B6 — enables → RHEA:12057; Evidence: UniProtKB:P0A9B6enables UniProtKB:P0A9B6 — located_in → GO:0005737; Evidence: UniProtKB:P0A9B6located in UniProtKB:P0AFI7 — enables → RHEA:15150; Evidence: UniProtKB:P0AFI7enables UniProtKB:P0AFI7 — has_cofactor → CHEBI:58210; Evidence: UniProtKB:P0AFI7has cofactor UniProtKB:P19624 — enables → RHEA:32276; Evidence: UniProtKB:P19624enables UniProtKB:P19624 — located_in → GO:0005737; Evidence: UniProtKB:P19624located in UniProtKB:P19624 — has_cofactor → CHEBI:29105; Evidence: UniProtKB:P19624has cofactor UniProtKB:P19624 — has_cofactor → CHEBI:18420; Evidence: UniProtKB:P19624has cofactor UniProtKB:P19624 — has_cofactor → CHEBI:48828; Evidence: UniProtKB:P19624has cofactor UniProtKB:P23721 — enables → RHEA:16575; Evidence: UniProtKB:P23721enables UniProtKB:P23721 — located_in → GO:0005737; Evidence: UniProtKB:P23721located in UniProtKB:P23721 — has_cofactor → CHEBI:597326; Evidence: UniProtKB:P23721has cofactor UniProtKB:P77488 — enables → RHEA:12606; Evidence: UniProtKB:P77488enables UniProtKB:P77488 — has_cofactor → CHEBI:18420; Evidence: UniProtKB:P77488has cofactor UniProtKB:P77488 — has_cofactor → CHEBI:58937; Evidence: UniProtKB:P77488has cofactor erythrose-4-phosphate dehydrogenase; EC:1.2.1.72; Declared type: molecular_activity molecular activity erythrose-4-phosphate dehydrogenase 4-phosphoerythronate dehydrogenase; EC:1.1.1.290; Declared type: molecular_activity molecular activity 4-phosphoerythronate dehydrogenase phosphoserine transaminase; EC:2.6.1.52; Declared type: molecular_activity molecular activity phosphoserine transaminase 4-hydroxythreonine-4-phosphate dehydrogenase; EC:1.1.1.262; Declared type: molecular_activity molecular activity 4-hydroxythreonine-4- phosphate dehydrogenase 1-deoxy-D-xylulose-5-phosphate synthase; EC:2.2.1.7; Declared type: molecular_activity molecular activity 1-deoxy-D- xylulose-5-phosphate synthase pyridoxine 5'-phosphate synthase; EC:2.6.99.2; Declared type: molecular_activity molecular activity pyridoxine 5'-phosphate synthase pyridoxine 5'-phosphate oxidase; EC:1.4.3.5; Declared type: molecular_activity molecular activity pyridoxine 5'-phosphate oxidase D-erythrose 4-phosphate; CHEBI:16897; Declared type: small_molecule small molecule D-erythrose 4-phosphate NAD(+); CHEBI:57540; Declared type: small_molecule small molecule NAD(+) H2O; CHEBI:15377; Declared type: small_molecule small molecule H2O 4-phospho-D-erythronate; CHEBI:58766; Declared type: small_molecule small molecule 4-phospho-D-erythronate NADH; CHEBI:57945; Declared type: small_molecule small molecule NADH H(+); CHEBI:15378; Declared type: small_molecule small molecule H(+) (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate; CHEBI:58538; Declared type: small_molecule small molecule (R)-3-hydroxy-2-oxo-4- phosphooxybutanoate L-glutamate; CHEBI:29985; Declared type: small_molecule small molecule L-glutamate 4-(phosphooxy)-L-threonine; CHEBI:58452; Declared type: small_molecule small molecule 4-(phosphooxy)-L-threonine 2-oxoglutarate; CHEBI:16810; Declared type: small_molecule small molecule 2-oxoglutarate 3-amino-2-oxopropyl phosphate; CHEBI:57279; Declared type: small_molecule small molecule 3-amino-2-oxopropyl phosphate CO2; CHEBI:16526; Declared type: small_molecule small molecule CO2 D-glyceraldehyde 3-phosphate; CHEBI:59776; Declared type: small_molecule small molecule D-glyceraldehyde 3-phosphate pyruvate; CHEBI:15361; Declared type: small_molecule small molecule pyruvate 1-deoxy-D-xylulose 5-phosphate; CHEBI:57792; Declared type: small_molecule small molecule 1-deoxy-D-xylulose 5-phosphate pyridoxine 5'-phosphate; CHEBI:58589; Declared type: small_molecule small molecule pyridoxine 5'-phosphate phosphate; CHEBI:43474; Declared type: small_molecule small molecule phosphate O2; CHEBI:15379; Declared type: small_molecule small molecule O2 pyridoxal 5'-phosphate; CHEBI:597326; Declared type: cofactor cofactor pyridoxal 5'-phosphate H2O2; CHEBI:16240; Declared type: small_molecule small molecule H2O2 Erythronate-4-phosphate dehydrogenase; UniProtKB:P05459; Declared type: protein protein Erythronate-4-phosphate dehydrogenase cytoplasm; GO:0005737; Declared type: cellular_component cellular component cytoplasm Pyridoxine 5'-phosphate synthase; UniProtKB:P0A794; Declared type: protein protein Pyridoxine 5'-phosphate synthase D-erythrose-4-phosphate dehydrogenase; UniProtKB:P0A9B6; Declared type: protein protein D-erythrose-4-phosphate dehydrogenase Pyridoxine/pyridoxamine 5'-phosphate oxidase; UniProtKB:P0AFI7; Declared type: protein protein Pyridoxine/pyridoxamine 5'-phosphate oxidase FMN(3-); CHEBI:58210; Declared type: cofactor cofactor FMN(3-) 4-hydroxythreonine-4-phosphate dehydrogenase; UniProtKB:P19624; Declared type: protein protein 4-hydroxythreonine-4- phosphate dehydrogenase zinc(2+); CHEBI:29105; Declared type: cofactor cofactor zinc(2+) magnesium(2+); CHEBI:18420; Declared type: cofactor cofactor magnesium(2+) cobalt(2+); CHEBI:48828; Declared type: cofactor cofactor cobalt(2+) Phosphoserine aminotransferase; UniProtKB:P23721; Declared type: protein protein Phosphoserine aminotransferase 1-deoxy-D-xylulose-5-phosphate synthase; UniProtKB:P77488; Declared type: protein protein 1-deoxy-D- xylulose-5-phosphate synthase thiamine(1+) diphosphate(3-); CHEBI:58937; Declared type: cofactor cofactor thiamine(1+) diphosphate(3-) erythrose-4-phosphate dehydrogenase reaction; RHEA:12057; Declared type: reaction/activity; Source reaction direction: left_to_right reaction / activity erythrose-4-phosphate dehydrogenase reaction 4-phospho-D-erythronate dehydrogenase reaction; RHEA:18830; Declared type: reaction/activity; Source reaction direction: left_to_right reaction / activity 4-phospho-D-erythronate dehydrogenase reaction phosphoserine transaminase reaction; RHEA:16575; Declared type: reaction/activity; Source reaction direction: right_to_left reaction / activity phosphoserine transaminase reaction 4-hydroxythreonine-4-phosphate dehydrogenase reaction; RHEA:32276; Declared type: reaction/activity; Source reaction direction: left_to_right reaction / activity 4-hydroxythreonine-4- phosphate dehydrogenase reaction 1-deoxy-D-xylulose-5-phosphate synthase reaction; RHEA:12606; Declared type: reaction/activity; Source reaction direction: left_to_right reaction / activity 1-deoxy-D- xylulose-5-phosphate synthase reaction pyridoxine 5'-phosphate synthase reaction; RHEA:15266; Declared type: reaction/activity; Source reaction direction: left_to_right reaction / activity pyridoxine 5'-phosphate synthase reaction pyridoxine 5'-phosphate oxidase reaction; RHEA:15150; Declared type: reaction/activity; Source reaction direction: left_to_right reaction / activity pyridoxine 5'-phosphate oxidase reaction

Components and activities

Declared biological components and source reaction directions
NodeKind or roleSource direction
Escherichia coli
NCBITaxon:562		taxon
erythrose-4-phosphate dehydrogenase
EC:1.2.1.72		molecular activity
4-phosphoerythronate dehydrogenase
EC:1.1.1.290		molecular activity
phosphoserine transaminase
EC:2.6.1.52		molecular activity
4-hydroxythreonine-4-phosphate dehydrogenase
EC:1.1.1.262		molecular activity
1-deoxy-D-xylulose-5-phosphate synthase
EC:2.2.1.7		molecular activity
pyridoxine 5'-phosphate synthase
EC:2.6.99.2		molecular activity
pyridoxine 5'-phosphate oxidase
EC:1.4.3.5		molecular activity
D-erythrose 4-phosphate
CHEBI:16897		small molecule
NAD(+)
CHEBI:57540		small molecule
H2O
CHEBI:15377		small molecule
4-phospho-D-erythronate
CHEBI:58766		small molecule
NADH
CHEBI:57945		small molecule
H(+)
CHEBI:15378		small molecule
(R)-3-hydroxy-2-oxo-4-phosphooxybutanoate
CHEBI:58538		small molecule
L-glutamate
CHEBI:29985		small molecule
4-(phosphooxy)-L-threonine
CHEBI:58452		small molecule
2-oxoglutarate
CHEBI:16810		small molecule
3-amino-2-oxopropyl phosphate
CHEBI:57279		small molecule
CO2
CHEBI:16526		small molecule
D-glyceraldehyde 3-phosphate
CHEBI:59776		small molecule
pyruvate
CHEBI:15361		small molecule
1-deoxy-D-xylulose 5-phosphate
CHEBI:57792		small molecule
pyridoxine 5'-phosphate
CHEBI:58589		small molecule
phosphate
CHEBI:43474		small molecule
O2
CHEBI:15379		small molecule
pyridoxal 5'-phosphate
CHEBI:597326		cofactor
H2O2
CHEBI:16240		small molecule
Erythronate-4-phosphate dehydrogenase
UniProtKB:P05459		protein
cytoplasm
GO:0005737		cellular component
Pyridoxine 5'-phosphate synthase
UniProtKB:P0A794		protein
D-erythrose-4-phosphate dehydrogenase
UniProtKB:P0A9B6		protein
Pyridoxine/pyridoxamine 5'-phosphate oxidase
UniProtKB:P0AFI7		protein
FMN(3-)
CHEBI:58210		cofactor
4-hydroxythreonine-4-phosphate dehydrogenase
UniProtKB:P19624		protein
zinc(2+)
CHEBI:29105		cofactor
magnesium(2+)
CHEBI:18420		cofactor
cobalt(2+)
CHEBI:48828		cofactor
Phosphoserine aminotransferase
UniProtKB:P23721		protein
1-deoxy-D-xylulose-5-phosphate synthase
UniProtKB:P77488		protein
thiamine(1+) diphosphate(3-)
CHEBI:58937		cofactor
erythrose-4-phosphate dehydrogenase reaction
RHEA:12057		reactionleft to right
4-phospho-D-erythronate dehydrogenase reaction
RHEA:18830		reactionleft to right
phosphoserine transaminase reaction
RHEA:16575		reactionright to left
4-hydroxythreonine-4-phosphate dehydrogenase reaction
RHEA:32276		reactionleft to right
1-deoxy-D-xylulose-5-phosphate synthase reaction
RHEA:12606		reactionleft to right
pyridoxine 5'-phosphate synthase reaction
RHEA:15266		reactionleft to right
pyridoxine 5'-phosphate oxidase reaction
RHEA:15150		reactionleft to right

Mechanistic edges

Mechanistic edges and their cited evidence
SubjectPredicate and descriptionObjectEvidence
H2O
CHEBI:15377		consumes

erythrose-4-phosphate dehydrogenase reaction
RHEA:12057
  • RHEA:12057

    Source assertion: Rhea lists CHEBI:15377 on the substrates side of RHEA:12057 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/12057']/rh:substrates; rh:contains/rh:compound/rh:accession
D-erythrose 4-phosphate
CHEBI:16897		consumes

erythrose-4-phosphate dehydrogenase reaction
RHEA:12057
  • RHEA:12057

    Source assertion: Rhea lists CHEBI:16897 on the substrates side of RHEA:12057 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/12057']/rh:substrates; rh:contains/rh:compound/rh:accession
NAD(+)
CHEBI:57540		consumes

erythrose-4-phosphate dehydrogenase reaction
RHEA:12057
  • RHEA:12057

    Source assertion: Rhea lists CHEBI:57540 on the substrates side of RHEA:12057 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/12057']/rh:substrates; rh:contains/rh:compound/rh:accession
erythrose-4-phosphate dehydrogenase reaction
RHEA:12057		produces

H(+)
CHEBI:15378
  • RHEA:12057

    Source assertion: Rhea lists CHEBI:15378 on the products side of RHEA:12057 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/12057']/rh:products; rh:contains/rh:compound/rh:accession
erythrose-4-phosphate dehydrogenase reaction
RHEA:12057		produces

NADH
CHEBI:57945
  • RHEA:12057

    Source assertion: Rhea lists CHEBI:57945 on the products side of RHEA:12057 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/12057']/rh:products; rh:contains/rh:compound/rh:accession
erythrose-4-phosphate dehydrogenase reaction
RHEA:12057		produces

4-phospho-D-erythronate
CHEBI:58766
  • RHEA:12057

    Source assertion: Rhea lists CHEBI:58766 on the products side of RHEA:12057 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/12057']/rh:products; rh:contains/rh:compound/rh:accession
NAD(+)
CHEBI:57540		consumes

4-phospho-D-erythronate dehydrogenase reaction
RHEA:18830
  • RHEA:18830

    Source assertion: Rhea lists CHEBI:57540 on the substrates side of RHEA:18830 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/18830']/rh:substrates; rh:contains/rh:compound/rh:accession
4-phospho-D-erythronate
CHEBI:58766		consumes

4-phospho-D-erythronate dehydrogenase reaction
RHEA:18830
  • RHEA:18830

    Source assertion: Rhea lists CHEBI:58766 on the substrates side of RHEA:18830 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/18830']/rh:substrates; rh:contains/rh:compound/rh:accession
4-phospho-D-erythronate dehydrogenase reaction
RHEA:18830		produces

H(+)
CHEBI:15378
  • RHEA:18830

    Source assertion: Rhea lists CHEBI:15378 on the products side of RHEA:18830 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/18830']/rh:products; rh:contains/rh:compound/rh:accession
4-phospho-D-erythronate dehydrogenase reaction
RHEA:18830		produces

NADH
CHEBI:57945
  • RHEA:18830

    Source assertion: Rhea lists CHEBI:57945 on the products side of RHEA:18830 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/18830']/rh:products; rh:contains/rh:compound/rh:accession
4-phospho-D-erythronate dehydrogenase reaction
RHEA:18830		produces

(R)-3-hydroxy-2-oxo-4-phosphooxybutanoate
CHEBI:58538
  • RHEA:18830

    Source assertion: Rhea lists CHEBI:58538 on the products side of RHEA:18830 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/18830']/rh:products; rh:contains/rh:compound/rh:accession
L-glutamate
CHEBI:29985		consumes

phosphoserine transaminase reaction
RHEA:16575
  • RHEA:16575

    Source assertion: Rhea lists CHEBI:29985 on the substrates side of RHEA:16575 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/16575']/rh:substrates; rh:contains/rh:compound/rh:accession
(R)-3-hydroxy-2-oxo-4-phosphooxybutanoate
CHEBI:58538		consumes

phosphoserine transaminase reaction
RHEA:16575
  • RHEA:16575

    Source assertion: Rhea lists CHEBI:58538 on the substrates side of RHEA:16575 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/16575']/rh:substrates; rh:contains/rh:compound/rh:accession
phosphoserine transaminase reaction
RHEA:16575		produces

2-oxoglutarate
CHEBI:16810
  • RHEA:16575

    Source assertion: Rhea lists CHEBI:16810 on the products side of RHEA:16575 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/16575']/rh:products; rh:contains/rh:compound/rh:accession
phosphoserine transaminase reaction
RHEA:16575		produces

4-(phosphooxy)-L-threonine
CHEBI:58452
  • RHEA:16575

    Source assertion: Rhea lists CHEBI:58452 on the products side of RHEA:16575 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/16575']/rh:products; rh:contains/rh:compound/rh:accession
NAD(+)
CHEBI:57540		consumes

4-hydroxythreonine-4-phosphate dehydrogenase reaction
RHEA:32276
  • RHEA:32276

    Source assertion: Rhea lists CHEBI:57540 on the substrates side of RHEA:32276 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/32276']/rh:substrates; rh:contains/rh:compound/rh:accession
4-(phosphooxy)-L-threonine
CHEBI:58452		consumes

4-hydroxythreonine-4-phosphate dehydrogenase reaction
RHEA:32276
  • RHEA:32276

    Source assertion: Rhea lists CHEBI:58452 on the substrates side of RHEA:32276 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/32276']/rh:substrates; rh:contains/rh:compound/rh:accession
4-hydroxythreonine-4-phosphate dehydrogenase reaction
RHEA:32276		produces

CO2
CHEBI:16526
  • RHEA:32276

    Source assertion: Rhea lists CHEBI:16526 on the products side of RHEA:32276 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/32276']/rh:products; rh:contains/rh:compound/rh:accession
4-hydroxythreonine-4-phosphate dehydrogenase reaction
RHEA:32276		produces

3-amino-2-oxopropyl phosphate
CHEBI:57279
  • RHEA:32276

    Source assertion: Rhea lists CHEBI:57279 on the products side of RHEA:32276 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/32276']/rh:products; rh:contains/rh:compound/rh:accession
4-hydroxythreonine-4-phosphate dehydrogenase reaction
RHEA:32276		produces

NADH
CHEBI:57945
  • RHEA:32276

    Source assertion: Rhea lists CHEBI:57945 on the products side of RHEA:32276 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/32276']/rh:products; rh:contains/rh:compound/rh:accession
pyruvate
CHEBI:15361		consumes

1-deoxy-D-xylulose-5-phosphate synthase reaction
RHEA:12606
  • RHEA:12606

    Source assertion: Rhea lists CHEBI:15361 on the substrates side of RHEA:12606 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/12606']/rh:substrates; rh:contains/rh:compound/rh:accession
H(+)
CHEBI:15378		consumes

1-deoxy-D-xylulose-5-phosphate synthase reaction
RHEA:12606
  • RHEA:12606

    Source assertion: Rhea lists CHEBI:15378 on the substrates side of RHEA:12606 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/12606']/rh:substrates; rh:contains/rh:compound/rh:accession
D-glyceraldehyde 3-phosphate
CHEBI:59776		consumes

1-deoxy-D-xylulose-5-phosphate synthase reaction
RHEA:12606
  • RHEA:12606

    Source assertion: Rhea lists CHEBI:59776 on the substrates side of RHEA:12606 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/12606']/rh:substrates; rh:contains/rh:compound/rh:accession
1-deoxy-D-xylulose-5-phosphate synthase reaction
RHEA:12606		produces

CO2
CHEBI:16526
  • RHEA:12606

    Source assertion: Rhea lists CHEBI:16526 on the products side of RHEA:12606 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/12606']/rh:products; rh:contains/rh:compound/rh:accession
1-deoxy-D-xylulose-5-phosphate synthase reaction
RHEA:12606		produces

1-deoxy-D-xylulose 5-phosphate
CHEBI:57792
  • RHEA:12606

    Source assertion: Rhea lists CHEBI:57792 on the products side of RHEA:12606 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/12606']/rh:products; rh:contains/rh:compound/rh:accession
3-amino-2-oxopropyl phosphate
CHEBI:57279		consumes

pyridoxine 5'-phosphate synthase reaction
RHEA:15266
  • RHEA:15266

    Source assertion: Rhea lists CHEBI:57279 on the substrates side of RHEA:15266 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/15266']/rh:substrates; rh:contains/rh:compound/rh:accession
1-deoxy-D-xylulose 5-phosphate
CHEBI:57792		consumes

pyridoxine 5'-phosphate synthase reaction
RHEA:15266
  • RHEA:15266

    Source assertion: Rhea lists CHEBI:57792 on the substrates side of RHEA:15266 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/15266']/rh:substrates; rh:contains/rh:compound/rh:accession
pyridoxine 5'-phosphate synthase reaction
RHEA:15266		produces

H2O
CHEBI:15377
  • RHEA:15266

    Source assertion: Rhea lists CHEBI:15377 on the products side of RHEA:15266 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/15266']/rh:products; rh:contains/rh:compound/rh:accession
pyridoxine 5'-phosphate synthase reaction
RHEA:15266		produces

H(+)
CHEBI:15378
  • RHEA:15266

    Source assertion: Rhea lists CHEBI:15378 on the products side of RHEA:15266 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/15266']/rh:products; rh:contains/rh:compound/rh:accession
pyridoxine 5'-phosphate synthase reaction
RHEA:15266		produces

phosphate
CHEBI:43474
  • RHEA:15266

    Source assertion: Rhea lists CHEBI:43474 on the products side of RHEA:15266 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/15266']/rh:products; rh:contains/rh:compound/rh:accession
pyridoxine 5'-phosphate synthase reaction
RHEA:15266		produces

pyridoxine 5'-phosphate
CHEBI:58589
  • RHEA:15266

    Source assertion: Rhea lists CHEBI:58589 on the products side of RHEA:15266 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/15266']/rh:products; rh:contains/rh:compound/rh:accession
O2
CHEBI:15379		consumes

pyridoxine 5'-phosphate oxidase reaction
RHEA:15150
  • RHEA:15150

    Source assertion: Rhea lists CHEBI:15379 on the substrates side of RHEA:15150 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/15150']/rh:substrates; rh:contains/rh:compound/rh:accession
pyridoxine 5'-phosphate
CHEBI:58589		consumes

pyridoxine 5'-phosphate oxidase reaction
RHEA:15150
  • RHEA:15150

    Source assertion: Rhea lists CHEBI:58589 on the substrates side of RHEA:15150 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/15150']/rh:substrates; rh:contains/rh:compound/rh:accession
pyridoxine 5'-phosphate oxidase reaction
RHEA:15150		produces

H2O2
CHEBI:16240
  • RHEA:15150

    Source assertion: Rhea lists CHEBI:16240 on the products side of RHEA:15150 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/15150']/rh:products; rh:contains/rh:compound/rh:accession
pyridoxine 5'-phosphate oxidase reaction
RHEA:15150		produces

pyridoxal 5'-phosphate
CHEBI:597326
  • RHEA:15150

    Source assertion: Rhea lists CHEBI:597326 on the products side of RHEA:15150 in this directed reaction.

    Source locationrdf:Description[@rdf:about='http://rdf.rhea-db.org/15150']/rh:products; rh:contains/rh:compound/rh:accession
erythrose-4-phosphate dehydrogenase
EC:1.2.1.72		catalyzes

erythrose-4-phosphate dehydrogenase reaction
RHEA:12057
  • RHEA:12056

    Source assertion: Rhea associates EC:1.2.1.72 with the reaction family containing RHEA:12057.

    Source locationrh:ec
4-phosphoerythronate dehydrogenase
EC:1.1.1.290		catalyzes

4-phospho-D-erythronate dehydrogenase reaction
RHEA:18830
  • RHEA:18829

    Source assertion: Rhea associates EC:1.1.1.290 with the reaction family containing RHEA:18830.

    Source locationrh:ec
phosphoserine transaminase
EC:2.6.1.52		catalyzes

phosphoserine transaminase reaction
RHEA:16575
  • RHEA:16573

    Source assertion: Rhea associates EC:2.6.1.52 with the reaction family containing RHEA:16575.

    Source locationrh:ec
4-hydroxythreonine-4-phosphate dehydrogenase
EC:1.1.1.262		catalyzes

4-hydroxythreonine-4-phosphate dehydrogenase reaction
RHEA:32276
  • RHEA:32275

    Source assertion: Rhea associates EC:1.1.1.262 with the reaction family containing RHEA:32276.

    Source locationrh:ec
1-deoxy-D-xylulose-5-phosphate synthase
EC:2.2.1.7		catalyzes

1-deoxy-D-xylulose-5-phosphate synthase reaction
RHEA:12606
  • RHEA:12605

    Source assertion: Rhea associates EC:2.2.1.7 with the reaction family containing RHEA:12606.

    Source locationrh:ec
pyridoxine 5'-phosphate synthase
EC:2.6.99.2		catalyzes

pyridoxine 5'-phosphate synthase reaction
RHEA:15266
  • RHEA:15265

    Source assertion: Rhea associates EC:2.6.99.2 with the reaction family containing RHEA:15266.

    Source locationrh:ec
pyridoxine 5'-phosphate oxidase
EC:1.4.3.5		catalyzes

pyridoxine 5'-phosphate oxidase reaction
RHEA:15150
  • RHEA:15149

    Source assertion: Rhea associates EC:1.4.3.5 with the reaction family containing RHEA:15150.

    Source locationrh:ec
erythrose-4-phosphate dehydrogenase reaction
RHEA:12057		precedes

4-phospho-D-erythronate dehydrogenase reaction
RHEA:18830
  • MetaCyc:PYRIDOXSYN-PWY

    Source assertion: MetaCyc pathway ordering places RHEA:12057 before RHEA:18830 in this pathway. Shared intermediate: CHEBI:58766.

    Source locationPathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references
1-deoxy-D-xylulose-5-phosphate synthase reaction
RHEA:12606		precedes

pyridoxine 5'-phosphate synthase reaction
RHEA:15266
  • MetaCyc:PYRIDOXSYN-PWY

    Source assertion: MetaCyc pathway ordering places RHEA:12606 before RHEA:15266 in this pathway. Shared intermediate: CHEBI:57792.

    Source locationPathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references
pyridoxine 5'-phosphate synthase reaction
RHEA:15266		precedes

pyridoxine 5'-phosphate oxidase reaction
RHEA:15150
  • MetaCyc:PYRIDOXSYN-PWY

    Source assertion: MetaCyc pathway ordering places RHEA:15266 before RHEA:15150 in this pathway. Shared intermediate: CHEBI:58589.

    Source locationPathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references
phosphoserine transaminase reaction
RHEA:16575		precedes

4-hydroxythreonine-4-phosphate dehydrogenase reaction
RHEA:32276
  • MetaCyc:PYRIDOXSYN-PWY

    Source assertion: MetaCyc pathway ordering places RHEA:16575 before RHEA:32276 in this pathway. Shared intermediate: CHEBI:58452.

    Source locationPathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references
4-phospho-D-erythronate dehydrogenase reaction
RHEA:18830		precedes

phosphoserine transaminase reaction
RHEA:16575
  • MetaCyc:PYRIDOXSYN-PWY

    Source assertion: MetaCyc pathway ordering places RHEA:18830 before RHEA:16575 in this pathway. Shared intermediate: CHEBI:58538.

    Source locationPathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references
4-hydroxythreonine-4-phosphate dehydrogenase reaction
RHEA:32276		precedes

pyridoxine 5'-phosphate synthase reaction
RHEA:15266
  • MetaCyc:PYRIDOXSYN-PWY

    Source assertion: MetaCyc pathway ordering places RHEA:32276 before RHEA:15266 in this pathway. Shared intermediate: CHEBI:57279.

    Source locationPathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references
Erythronate-4-phosphate dehydrogenase
UniProtKB:P05459		enables

4-phospho-D-erythronate dehydrogenase reaction
RHEA:18830
  • UniProtKB:P05459

    Source assertion: UniProt annotates UniProtKB:P05459 with catalytic activity for the reaction family of RHEA:18830. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:83333.

    Source locationcomments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences
Erythronate-4-phosphate dehydrogenase
UniProtKB:P05459		located_in

cytoplasm
GO:0005737
  • UniProtKB:P05459

    Source assertion: UniProt locates UniProtKB:P05459 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255.

    Source locationcomments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping
Pyridoxine 5'-phosphate synthase
UniProtKB:P0A794		enables

pyridoxine 5'-phosphate synthase reaction
RHEA:15266
  • UniProtKB:P0A794

    Source assertion: UniProt annotates UniProtKB:P0A794 with catalytic activity for the reaction family of RHEA:15266. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333.

    Source locationcomments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences
Pyridoxine 5'-phosphate synthase
UniProtKB:P0A794		located_in

cytoplasm
GO:0005737
  • UniProtKB:P0A794

    Source assertion: UniProt locates UniProtKB:P0A794 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: curated source annotation.

    Source locationcomments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping
D-erythrose-4-phosphate dehydrogenase
UniProtKB:P0A9B6		enables

erythrose-4-phosphate dehydrogenase reaction
RHEA:12057
  • UniProtKB:P0A9B6

    Source assertion: UniProt annotates UniProtKB:P0A9B6 with catalytic activity for the reaction family of RHEA:12057. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333.

    Source locationcomments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences
D-erythrose-4-phosphate dehydrogenase
UniProtKB:P0A9B6		located_in

cytoplasm
GO:0005737
  • UniProtKB:P0A9B6

    Source assertion: UniProt locates UniProtKB:P0A9B6 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: curated source annotation.

    Source locationcomments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping
Pyridoxine/pyridoxamine 5'-phosphate oxidase
UniProtKB:P0AFI7		enables

pyridoxine 5'-phosphate oxidase reaction
RHEA:15150
  • UniProtKB:P0AFI7

    Source assertion: UniProt annotates UniProtKB:P0AFI7 with catalytic activity for the reaction family of RHEA:15150. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333.

    Source locationcomments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences
Pyridoxine/pyridoxamine 5'-phosphate oxidase
UniProtKB:P0AFI7		has_cofactor

FMN(3-)
CHEBI:58210
  • UniProtKB:P0AFI7

    Source assertion: UniProt lists CHEBI:58210 as a cofactor of UniProtKB:P0AFI7 (evidence: ECO:0000269). Binds 1 FMN per subunit.

    Source locationcomments[commentType='COFACTOR'].cofactors and note
4-hydroxythreonine-4-phosphate dehydrogenase
UniProtKB:P19624		enables

4-hydroxythreonine-4-phosphate dehydrogenase reaction
RHEA:32276
  • UniProtKB:P19624

    Source assertion: UniProt annotates UniProtKB:P19624 with catalytic activity for the reaction family of RHEA:32276. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333.

    Source locationcomments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences
4-hydroxythreonine-4-phosphate dehydrogenase
UniProtKB:P19624		located_in

cytoplasm
GO:0005737
  • UniProtKB:P19624

    Source assertion: UniProt locates UniProtKB:P19624 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255.

    Source locationcomments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping
4-hydroxythreonine-4-phosphate dehydrogenase
UniProtKB:P19624		has_cofactor

zinc(2+)
CHEBI:29105
  • UniProtKB:P19624

    Source assertion: UniProt lists CHEBI:29105 as a cofactor of UniProtKB:P19624 (evidence: ECO:0000255, ECO:0000269). Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).

    Source locationcomments[commentType='COFACTOR'].cofactors and note
4-hydroxythreonine-4-phosphate dehydrogenase
UniProtKB:P19624		has_cofactor

magnesium(2+)
CHEBI:18420
  • UniProtKB:P19624

    Source assertion: UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P19624 (evidence: ECO:0000255, ECO:0000269). Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).

    Source locationcomments[commentType='COFACTOR'].cofactors and note
4-hydroxythreonine-4-phosphate dehydrogenase
UniProtKB:P19624		has_cofactor

cobalt(2+)
CHEBI:48828
  • UniProtKB:P19624

    Source assertion: UniProt lists CHEBI:48828 as a cofactor of UniProtKB:P19624 (evidence: ECO:0000255, ECO:0000269). Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).

    Source locationcomments[commentType='COFACTOR'].cofactors and note
Phosphoserine aminotransferase
UniProtKB:P23721		enables

phosphoserine transaminase reaction
RHEA:16575
  • UniProtKB:P23721

    Source assertion: UniProt annotates UniProtKB:P23721 with catalytic activity for the reaction family of RHEA:16575. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333.

    Source locationcomments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences
Phosphoserine aminotransferase
UniProtKB:P23721		located_in

cytoplasm
GO:0005737
  • UniProtKB:P23721

    Source assertion: UniProt locates UniProtKB:P23721 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: curated source annotation.

    Source locationcomments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping
Phosphoserine aminotransferase
UniProtKB:P23721		has_cofactor

pyridoxal 5'-phosphate
CHEBI:597326
  • UniProtKB:P23721

    Source assertion: UniProt lists CHEBI:597326 as a cofactor of UniProtKB:P23721 (evidence: ECO:0000269). Binds 1 pyridoxal phosphate per subunit.

    Source locationcomments[commentType='COFACTOR'].cofactors and note
1-deoxy-D-xylulose-5-phosphate synthase
UniProtKB:P77488		enables

1-deoxy-D-xylulose-5-phosphate synthase reaction
RHEA:12606
  • UniProtKB:P77488

    Source assertion: UniProt annotates UniProtKB:P77488 with catalytic activity for the reaction family of RHEA:12606. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333.

    Source locationcomments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences
1-deoxy-D-xylulose-5-phosphate synthase
UniProtKB:P77488		has_cofactor

magnesium(2+)
CHEBI:18420
  • UniProtKB:P77488

    Source assertion: UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P77488 (evidence: ECO:0000269). Binds 1 Mg(2+) ion per subunit.

    Source locationcomments[commentType='COFACTOR'].cofactors and note
1-deoxy-D-xylulose-5-phosphate synthase
UniProtKB:P77488		has_cofactor

thiamine(1+) diphosphate(3-)
CHEBI:58937
  • UniProtKB:P77488

    Source assertion: UniProt lists CHEBI:58937 as a cofactor of UniProtKB:P77488 (evidence: ECO:0000269). Binds 1 thiamine pyrophosphate per subunit.

    Source locationcomments[commentType='COFACTOR'].cofactors and note

References

Curation history