NAD salvage pathway V

WikiPathways:WP171

NAD salvage pathway V in Saccharomyces cerevisiae converts nicotinamide through nicotinate, beta-nicotinate D-ribonucleotide, and nicotinate adenine dinucleotide to regenerate NAD in the WP171 GPML diagram.

Pathway type
cofactor biosynthesis
Organism scope

Read the source YAML

Pathway network

33 nodes · 41 asserted directed edges

Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.

Pathway network: NAD salvage pathway V 33 nodes · 41 asserted directed edges. Every arrow links to its evidence table row; nodes link to their component details. Isolated declared components are retained. CHEBI:17154 — consumes → WikiPathways:WP171/id4b00dac6; Evidence: WikiPathways:WP171consumes WikiPathways:WP171/id4b00dac6 — produces → CHEBI:32544; Evidence: WikiPathways:WP171produces CHEBI:58437 — consumes → WikiPathways:WP171/id58e1978f; Evidence: WikiPathways:WP171consumes WikiPathways:WP171/id58e1978f — produces → CHEBI:15846; Evidence: WikiPathways:WP171produces WikiPathways:WP171/id5b2236e7 — produces → CHEBI:58437; Evidence: WikiPathways:WP171produces CHEBI:57502 — consumes → WikiPathways:WP171/id5b2236e7; Evidence: WikiPathways:WP171consumes CHEBI:32544 — consumes → WikiPathways:WP171/ide26ea2c3; Evidence: WikiPathways:WP171consumes WikiPathways:WP171/ide26ea2c3 — produces → CHEBI:57502; Evidence: WikiPathways:WP171produces CHEBI:15846 — consumes → WikiPathways:WP171/idfac03b17; Evidence: WikiPathways:WP171consumes WikiPathways:WP171/idfac03b17 — produces → CHEBI:17154; Evidence: WikiPathways:WP171produces SGD:S000002200 — catalyzes → WikiPathways:WP171/idfac03b17; Evidence: WikiPathways:WP171catalyzes CHEBI:15377 — consumes → WikiPathways:WP171/ide26ea2c3; Evidence: WikiPathways:WP171consumes CHEBI:58017 — consumes → WikiPathways:WP171/ide26ea2c3; Evidence: WikiPathways:WP171consumes CHEBI:30616 — consumes → WikiPathways:WP171/ide26ea2c3; Evidence: WikiPathways:WP171consumes WikiPathways:WP171/ide26ea2c3 — produces → CHEBI:456216; Evidence: WikiPathways:WP171produces WikiPathways:WP171/ide26ea2c3 — produces → CHEBI:33019; Evidence: WikiPathways:WP171produces WikiPathways:WP171/ide26ea2c3 — produces → CHEBI:43474; Evidence: WikiPathways:WP171produces SGD:S000003005 — catalyzes → WikiPathways:WP171/id4b00dac6; Evidence: WikiPathways:WP171catalyzes WikiPathways:WP171/id4b00dac6 — produces → CHEBI:16134; Evidence: WikiPathways:WP171produces WikiPathways:WP171/idfac03b17 — produces → CHEBI:83767; Evidence: WikiPathways:WP171produces WikiPathways:WP171/idfac03b17 — produces → CHEBI:29967; Evidence: WikiPathways:WP171produces WikiPathways:WP171/id58e1978f — produces → CHEBI:456215; Evidence: WikiPathways:WP171produces WikiPathways:WP171/id58e1978f — produces → CHEBI:29985; Evidence: WikiPathways:WP171produces WikiPathways:WP171/id58e1978f — produces → CHEBI:33019; Evidence: WikiPathways:WP171produces WikiPathways:WP171/id58e1978f — produces → CHEBI:15378; Evidence: WikiPathways:WP171produces SGD:S000005735 — catalyzes → WikiPathways:WP171/ide26ea2c3; Evidence: WikiPathways:WP171catalyzes CHEBI:15378 — consumes → WikiPathways:WP171/id5b2236e7; Evidence: WikiPathways:WP171consumes CHEBI:30616 — consumes → WikiPathways:WP171/id5b2236e7; Evidence: WikiPathways:WP171consumes CHEBI:15377 — consumes → WikiPathways:WP171/id58e1978f; Evidence: WikiPathways:WP171consumes CHEBI:30616 — consumes → WikiPathways:WP171/id58e1978f; Evidence: WikiPathways:WP171consumes CHEBI:58359 — consumes → WikiPathways:WP171/id58e1978f; Evidence: WikiPathways:WP171consumes CHEBI:15377 — consumes → WikiPathways:WP171/id4b00dac6; Evidence: WikiPathways:WP171consumes CHEBI:15377 — consumes → WikiPathways:WP171/idfac03b17; Evidence: WikiPathways:WP171consumes CHEBI:61930 — consumes → WikiPathways:WP171/idfac03b17; Evidence: WikiPathways:WP171consumes SGD:S000001116 — catalyzes → WikiPathways:WP171/id58e1978f; Evidence: WikiPathways:WP171catalyzes SGD:S000004320 — catalyzes → WikiPathways:WP171/id5b2236e7; Evidence: WikiPathways:WP171catalyzes SGD:S000003242 — catalyzes → WikiPathways:WP171/id5b2236e7; Evidence: WikiPathways:WP171catalyzes WikiPathways:WP171/id5b2236e7 — produces → CHEBI:33019; Evidence: WikiPathways:WP171produces SGD:S000004320 — has_cofactor → CHEBI:49786; UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10428462) Divalent metal cation. UniProt note evidence: ECO:0000269 (PubMed:10428462); Evidence: UniProtKB:Q06178, UniProtKB:Q06178has cofactor SGD:S000003242 — has_cofactor → CHEBI:48828; UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:12597897) Divalent metal cation. UniProt note evidence: ECO:0000269 (PubMed:12597897); Evidence: UniProtKB:P53204, UniProtKB:P53204has cofactor SGD:S000002200 — has_cofactor → CHEBI:29105; UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: Historical ADP-ribosyltransferase assignment does not negate the directly evidenced SIR2 zinc annotation. UniProt evidence: ECO:0000269 (PubMed:23307867) Binds 1 zinc ion per subunit. UniProt note evidence: ECO:0000269 (PubMed:23307867); Evidence: UniProtKB:P06700, UniProtKB:P06700has cofactor AMP; CHEBI:456215; Declared type: small_molecule small molecule AMP H2O; CHEBI:15377; Declared type: small_molecule small molecule H2O nicotinate adenine dinucleotide; CHEBI:58437; Declared type: small_molecule small molecule nicotinate adenine dinucleotide beta-nicotinate D-ribonucleotide; CHEBI:57502; Declared type: small_molecule small molecule beta-nicotinate D-ribonucleotide NH3; CHEBI:16134; Declared type: small_molecule small molecule NH3 NAD; CHEBI:15846; Declared type: small_molecule small molecule NAD L-glutamate; CHEBI:29985; Declared type: small_molecule small molecule L-glutamate N(6)-acetyl-L-lysine residue; CHEBI:61930; Declared type: small_molecule small molecule N(6)-acetyl-L-lysine residue ADP(3-); CHEBI:456216; Declared type: small_molecule small molecule ADP(3-) NPT1; SGD:S000005735; Declared type: protein protein NPT1 diphosphate(3-); CHEBI:33019; Declared type: small_molecule small molecule diphosphate(3-) PNC1; SGD:S000003005; Declared type: protein protein PNC1 nicotinamide; CHEBI:17154; Declared type: small_molecule small molecule nicotinamide QNS1; SGD:S000001116; Declared type: protein protein QNS1 nicotinate; CHEBI:32544; Declared type: small_molecule small molecule nicotinate 5-phospho-alpha-D-ribose 1-diphosphate; CHEBI:58017; Declared type: small_molecule small molecule 5-phospho-alpha-D-ribose 1-diphosphate NMA1; SGD:S000004320; Declared type: protein protein NMA1 NMA2; SGD:S000003242; Declared type: protein protein NMA2 hydrogenphosphate; CHEBI:43474; Declared type: small_molecule small molecule hydrogenphosphate ATP(4-); CHEBI:30616; Declared type: small_molecule small molecule ATP(4-) H+; CHEBI:15378; Declared type: small_molecule small molecule H+ L-glutamine; CHEBI:58359; Declared type: small_molecule small molecule L-glutamine SIR2; SGD:S000002200; Declared type: protein protein SIR2 2''-O-acetyl-ADP-ribose; CHEBI:83767; Declared type: small_molecule small molecule 2''-O-acetyl-ADP-ribose L-lysine residue; CHEBI:29967; Declared type: small_molecule small molecule L-lysine residue nickel(2+); CHEBI:49786; Declared type: cofactor cofactor nickel(2+) cobalt(2+); CHEBI:48828; Declared type: cofactor cofactor cobalt(2+) zinc(2+); CHEBI:29105; Declared type: cofactor cofactor zinc(2+) nicotinamide to nicotinate GPML interaction; WikiPathways:WP171/id4b00dac6; Declared type: molecular_activity; Source reaction direction: left_to_right molecular activity nicotinamide to nicotinate GPML interaction nicotinate adenine dinucleotide to NAD GPML interaction; WikiPathways:WP171/id58e1978f; Declared type: molecular_activity; Source reaction direction: left_to_right molecular activity nicotinate adenine dinucleotide to NAD GPML interaction beta-nicotinate D-ribonucleotide to nicotinate adenine dinucleotide GPML interaction; WikiPathways:WP171/id5b2236e7; Declared type: molecular_activity; Source reaction direction: left_to_right molecular activity beta-nicotinate D-ribonucleotide to nicotinate adenine dinucleotide GPML interaction nicotinate to beta-nicotinate D-ribonucleotide GPML interaction; WikiPathways:WP171/ide26ea2c3; Declared type: molecular_activity; Source reaction direction: left_to_right molecular activity nicotinate to beta- nicotinate D-ribonucleotide GPML interaction NAD to nicotinamide GPML interaction; WikiPathways:WP171/idfac03b17; Declared type: molecular_activity; Source reaction direction: left_to_right molecular activity NAD to nicotinamide GPML interaction

Components and activities

Declared biological components and source reaction directions
NodeKind or roleSource direction
Saccharomyces cerevisiae
NCBITaxon:4932		taxon
AMP
CHEBI:456215		small molecule
H2O
CHEBI:15377		small molecule
nicotinate adenine dinucleotide
CHEBI:58437		small molecule
beta-nicotinate D-ribonucleotide
CHEBI:57502		small molecule
NH3
CHEBI:16134		small molecule
NAD
CHEBI:15846		small molecule
L-glutamate
CHEBI:29985		small molecule
N(6)-acetyl-L-lysine residue
CHEBI:61930		small molecule
ADP(3-)
CHEBI:456216		small molecule
NPT1
SGD:S000005735		protein
diphosphate(3-)
CHEBI:33019		small molecule
PNC1
SGD:S000003005		protein
nicotinamide
CHEBI:17154		small molecule
QNS1
SGD:S000001116		protein
nicotinate
CHEBI:32544		small molecule
5-phospho-alpha-D-ribose 1-diphosphate
CHEBI:58017		small molecule
NMA1
SGD:S000004320		protein
NMA2
SGD:S000003242		protein
hydrogenphosphate
CHEBI:43474		small molecule
ATP(4-)
CHEBI:30616		small molecule
H+
CHEBI:15378		small molecule
L-glutamine
CHEBI:58359		small molecule
SIR2
SGD:S000002200		protein
2''-O-acetyl-ADP-ribose
CHEBI:83767		small molecule
L-lysine residue
CHEBI:29967		small molecule
nickel(2+)
CHEBI:49786		cofactor
cobalt(2+)
CHEBI:48828		cofactor
zinc(2+)
CHEBI:29105		cofactor
nicotinamide to nicotinate GPML interaction
WikiPathways:WP171/id4b00dac6		molecular activityleft to right
nicotinate adenine dinucleotide to NAD GPML interaction
WikiPathways:WP171/id58e1978f		molecular activityleft to right
beta-nicotinate D-ribonucleotide to nicotinate adenine dinucleotide GPML interaction
WikiPathways:WP171/id5b2236e7		molecular activityleft to right
nicotinate to beta-nicotinate D-ribonucleotide GPML interaction
WikiPathways:WP171/ide26ea2c3		molecular activityleft to right
NAD to nicotinamide GPML interaction
WikiPathways:WP171/idfac03b17		molecular activityleft to right

Mechanistic edges

Mechanistic edges and their cited evidence
SubjectPredicate and descriptionObjectEvidence
nicotinamide
CHEBI:17154		consumes

nicotinamide to nicotinate GPML interaction
WikiPathways:WP171/id4b00dac6
  • WikiPathways:WP171

    Source assertion: GPML id4b00dac6 connects normalized CHEBI:17154 as an input of interaction id4b00dac6.

    Source location/Pathway/Interaction[@GraphId='id4b00dac6']/Graphics; /Pathway/DataNode[@GraphId='d1d']
nicotinamide to nicotinate GPML interaction
WikiPathways:WP171/id4b00dac6		produces

nicotinate
CHEBI:32544
  • WikiPathways:WP171

    Source assertion: GPML id4b00dac6 connects normalized CHEBI:32544 as an output of interaction id4b00dac6.

    Source location/Pathway/Interaction[@GraphId='id4b00dac6']/Graphics; /Pathway/DataNode[@GraphId='dd772']
nicotinate adenine dinucleotide
CHEBI:58437		consumes

nicotinate adenine dinucleotide to NAD GPML interaction
WikiPathways:WP171/id58e1978f
  • WikiPathways:WP171

    Source assertion: GPML id58e1978f connects normalized CHEBI:58437 as an input of interaction id58e1978f.

    Source location/Pathway/Interaction[@GraphId='id58e1978f']/Graphics; /Pathway/DataNode[@GraphId='c5365']
nicotinate adenine dinucleotide to NAD GPML interaction
WikiPathways:WP171/id58e1978f		produces

NAD
CHEBI:15846
  • WikiPathways:WP171

    Source assertion: GPML id58e1978f connects normalized CHEBI:15846 as an output of interaction id58e1978f.

    Source location/Pathway/Interaction[@GraphId='id58e1978f']/Graphics; /Pathway/DataNode[@GraphId='dc20f']
beta-nicotinate D-ribonucleotide to nicotinate adenine dinucleotide GPML interaction
WikiPathways:WP171/id5b2236e7		produces

nicotinate adenine dinucleotide
CHEBI:58437
  • WikiPathways:WP171

    Source assertion: GPML id5b2236e7 connects normalized CHEBI:58437 as an output of interaction id5b2236e7.

    Source location/Pathway/Interaction[@GraphId='id5b2236e7']/Graphics; /Pathway/DataNode[@GraphId='c5365']
beta-nicotinate D-ribonucleotide
CHEBI:57502		consumes

beta-nicotinate D-ribonucleotide to nicotinate adenine dinucleotide GPML interaction
WikiPathways:WP171/id5b2236e7
  • WikiPathways:WP171

    Source assertion: GPML id5b2236e7 connects normalized CHEBI:57502 as an input of interaction id5b2236e7.

    Source location/Pathway/Interaction[@GraphId='id5b2236e7']/Graphics; /Pathway/DataNode[@GraphId='d3af6']
nicotinate
CHEBI:32544		consumes

nicotinate to beta-nicotinate D-ribonucleotide GPML interaction
WikiPathways:WP171/ide26ea2c3
  • WikiPathways:WP171

    Source assertion: GPML ide26ea2c3 connects normalized CHEBI:32544 as an input of interaction ide26ea2c3.

    Source location/Pathway/Interaction[@GraphId='ide26ea2c3']/Graphics; /Pathway/DataNode[@GraphId='dd772']
nicotinate to beta-nicotinate D-ribonucleotide GPML interaction
WikiPathways:WP171/ide26ea2c3		produces

beta-nicotinate D-ribonucleotide
CHEBI:57502
  • WikiPathways:WP171

    Source assertion: GPML ide26ea2c3 connects normalized CHEBI:57502 as an output of interaction ide26ea2c3.

    Source location/Pathway/Interaction[@GraphId='ide26ea2c3']/Graphics; /Pathway/DataNode[@GraphId='d3af6']
NAD
CHEBI:15846		consumes

NAD to nicotinamide GPML interaction
WikiPathways:WP171/idfac03b17
  • WikiPathways:WP171

    Source assertion: GPML idfac03b17 connects normalized CHEBI:15846 as an input of interaction idfac03b17.

    Source location/Pathway/Interaction[@GraphId='idfac03b17']/Graphics; /Pathway/DataNode[@GraphId='dc20f']
NAD to nicotinamide GPML interaction
WikiPathways:WP171/idfac03b17		produces

nicotinamide
CHEBI:17154
  • WikiPathways:WP171

    Source assertion: GPML idfac03b17 connects normalized CHEBI:17154 as an output of interaction idfac03b17.

    Source location/Pathway/Interaction[@GraphId='idfac03b17']/Graphics; /Pathway/DataNode[@GraphId='d1d']
SIR2
SGD:S000002200		catalyzes

NAD to nicotinamide GPML interaction
WikiPathways:WP171/idfac03b17
  • WikiPathways:WP171

    Source assertion: GPML id163e27f0 connects normalized SGD:S000002200 as a catalyst of interaction idfac03b17.

    Source location/Pathway/Interaction[@GraphId='id163e27f0']/Graphics; /Pathway/DataNode[@GraphId='ccc28']
H2O
CHEBI:15377		consumes

nicotinate to beta-nicotinate D-ribonucleotide GPML interaction
WikiPathways:WP171/ide26ea2c3
  • WikiPathways:WP171

    Source assertion: GPML id281439dd connects normalized CHEBI:15377 as an input of interaction ide26ea2c3.

    Source location/Pathway/Interaction[@GraphId='id281439dd']/Graphics; /Pathway/DataNode[@GraphId='d44']
5-phospho-alpha-D-ribose 1-diphosphate
CHEBI:58017		consumes

nicotinate to beta-nicotinate D-ribonucleotide GPML interaction
WikiPathways:WP171/ide26ea2c3
  • WikiPathways:WP171

    Source assertion: GPML id281439dd connects normalized CHEBI:58017 as an input of interaction ide26ea2c3.

    Source location/Pathway/Interaction[@GraphId='id281439dd']/Graphics; /Pathway/DataNode[@GraphId='e33']
ATP(4-)
CHEBI:30616		consumes

nicotinate to beta-nicotinate D-ribonucleotide GPML interaction
WikiPathways:WP171/ide26ea2c3
  • WikiPathways:WP171

    Source assertion: GPML id281439dd connects normalized CHEBI:30616 as an input of interaction ide26ea2c3.

    Source location/Pathway/Interaction[@GraphId='id281439dd']/Graphics; /Pathway/DataNode[@GraphId='f6f']
nicotinate to beta-nicotinate D-ribonucleotide GPML interaction
WikiPathways:WP171/ide26ea2c3		produces

ADP(3-)
CHEBI:456216
  • WikiPathways:WP171

    Source assertion: GPML id2d1dd000 connects normalized CHEBI:456216 as an output of interaction ide26ea2c3.

    Source location/Pathway/Interaction[@GraphId='id2d1dd000']/Graphics; /Pathway/DataNode[@GraphId='a4d']
nicotinate to beta-nicotinate D-ribonucleotide GPML interaction
WikiPathways:WP171/ide26ea2c3		produces

diphosphate(3-)
CHEBI:33019
  • WikiPathways:WP171

    Source assertion: GPML id2d1dd000 connects normalized CHEBI:33019 as an output of interaction ide26ea2c3.

    Source location/Pathway/Interaction[@GraphId='id2d1dd000']/Graphics; /Pathway/DataNode[@GraphId='b8c']
nicotinate to beta-nicotinate D-ribonucleotide GPML interaction
WikiPathways:WP171/ide26ea2c3		produces

hydrogenphosphate
CHEBI:43474
  • WikiPathways:WP171

    Source assertion: GPML id2d1dd000 connects normalized CHEBI:43474 as an output of interaction ide26ea2c3.

    Source location/Pathway/Interaction[@GraphId='id2d1dd000']/Graphics; /Pathway/DataNode[@GraphId='f29']
PNC1
SGD:S000003005		catalyzes

nicotinamide to nicotinate GPML interaction
WikiPathways:WP171/id4b00dac6
  • WikiPathways:WP171

    Source assertion: GPML id32f0a3f9 connects normalized SGD:S000003005 as a catalyst of interaction id4b00dac6.

    Source location/Pathway/Interaction[@GraphId='id32f0a3f9']/Graphics; /Pathway/DataNode[@GraphId='be0']
nicotinamide to nicotinate GPML interaction
WikiPathways:WP171/id4b00dac6		produces

NH3
CHEBI:16134
  • WikiPathways:WP171

    Source assertion: GPML id3b06e24 connects normalized CHEBI:16134 as an output of interaction id4b00dac6.

    Source location/Pathway/Interaction[@GraphId='id3b06e24']/Graphics; /Pathway/DataNode[@GraphId='d8e']
NAD to nicotinamide GPML interaction
WikiPathways:WP171/idfac03b17		produces

2''-O-acetyl-ADP-ribose
CHEBI:83767
  • WikiPathways:WP171

    Source assertion: GPML id3b401140 connects normalized CHEBI:83767 as an output of interaction idfac03b17.

    Source location/Pathway/Interaction[@GraphId='id3b401140']/Graphics; /Pathway/DataNode[@GraphId='e89b1']
NAD to nicotinamide GPML interaction
WikiPathways:WP171/idfac03b17		produces

L-lysine residue
CHEBI:29967
  • WikiPathways:WP171

    Source assertion: GPML id3b401140 connects normalized CHEBI:29967 as an output of interaction idfac03b17.

    Source location/Pathway/Interaction[@GraphId='id3b401140']/Graphics; /Pathway/DataNode[@GraphId='fbed5']
nicotinate adenine dinucleotide to NAD GPML interaction
WikiPathways:WP171/id58e1978f		produces

AMP
CHEBI:456215
  • WikiPathways:WP171

    Source assertion: GPML id492d684f connects normalized CHEBI:456215 as an output of interaction id58e1978f.

    Source location/Pathway/Interaction[@GraphId='id492d684f']/Graphics; /Pathway/DataNode[@GraphId='a8b']
nicotinate adenine dinucleotide to NAD GPML interaction
WikiPathways:WP171/id58e1978f		produces

L-glutamate
CHEBI:29985
  • WikiPathways:WP171

    Source assertion: GPML id492d684f connects normalized CHEBI:29985 as an output of interaction id58e1978f.

    Source location/Pathway/Interaction[@GraphId='id492d684f']/Graphics; /Pathway/DataNode[@GraphId='dcf']
nicotinate adenine dinucleotide to NAD GPML interaction
WikiPathways:WP171/id58e1978f		produces

diphosphate(3-)
CHEBI:33019
  • WikiPathways:WP171

    Source assertion: GPML id492d684f connects normalized CHEBI:33019 as an output of interaction id58e1978f.

    Source location/Pathway/Interaction[@GraphId='id492d684f']/Graphics; /Pathway/DataNode[@GraphId='ae062']
nicotinate adenine dinucleotide to NAD GPML interaction
WikiPathways:WP171/id58e1978f		produces

H+
CHEBI:15378
  • WikiPathways:WP171

    Source assertion: GPML id492d684f connects normalized CHEBI:15378 as an output of interaction id58e1978f.

    Source location/Pathway/Interaction[@GraphId='id492d684f']/Graphics; /Pathway/DataNode[@GraphId='a7470']
NPT1
SGD:S000005735		catalyzes

nicotinate to beta-nicotinate D-ribonucleotide GPML interaction
WikiPathways:WP171/ide26ea2c3
  • WikiPathways:WP171

    Source assertion: GPML id503ead connects normalized SGD:S000005735 as a catalyst of interaction ide26ea2c3.

    Source location/Pathway/Interaction[@GraphId='id503ead']/Graphics; /Pathway/DataNode[@GraphId='b46']
H+
CHEBI:15378		consumes

beta-nicotinate D-ribonucleotide to nicotinate adenine dinucleotide GPML interaction
WikiPathways:WP171/id5b2236e7
  • WikiPathways:WP171

    Source assertion: GPML id515f4de5 connects normalized CHEBI:15378 as an input of interaction id5b2236e7.

    Source location/Pathway/Interaction[@GraphId='id515f4de5']/Graphics; /Pathway/DataNode[@GraphId='bda45']
ATP(4-)
CHEBI:30616		consumes

beta-nicotinate D-ribonucleotide to nicotinate adenine dinucleotide GPML interaction
WikiPathways:WP171/id5b2236e7
  • WikiPathways:WP171

    Source assertion: GPML id515f4de5 connects normalized CHEBI:30616 as an input of interaction id5b2236e7.

    Source location/Pathway/Interaction[@GraphId='id515f4de5']/Graphics; /Pathway/DataNode[@GraphId='dba6f']
H2O
CHEBI:15377		consumes

nicotinate adenine dinucleotide to NAD GPML interaction
WikiPathways:WP171/id58e1978f
  • WikiPathways:WP171

    Source assertion: GPML id5c00a7af connects normalized CHEBI:15377 as an input of interaction id58e1978f.

    Source location/Pathway/Interaction[@GraphId='id5c00a7af']/Graphics; /Pathway/DataNode[@GraphId='e99']
ATP(4-)
CHEBI:30616		consumes

nicotinate adenine dinucleotide to NAD GPML interaction
WikiPathways:WP171/id58e1978f
  • WikiPathways:WP171

    Source assertion: GPML id5c00a7af connects normalized CHEBI:30616 as an input of interaction id58e1978f.

    Source location/Pathway/Interaction[@GraphId='id5c00a7af']/Graphics; /Pathway/DataNode[@GraphId='d8269']
L-glutamine
CHEBI:58359		consumes

nicotinate adenine dinucleotide to NAD GPML interaction
WikiPathways:WP171/id58e1978f
  • WikiPathways:WP171

    Source assertion: GPML id5c00a7af connects normalized CHEBI:58359 as an input of interaction id58e1978f.

    Source location/Pathway/Interaction[@GraphId='id5c00a7af']/Graphics; /Pathway/DataNode[@GraphId='ec262']
H2O
CHEBI:15377		consumes

nicotinamide to nicotinate GPML interaction
WikiPathways:WP171/id4b00dac6
  • WikiPathways:WP171

    Source assertion: GPML id5df52837 connects normalized CHEBI:15377 as an input of interaction id4b00dac6.

    Source location/Pathway/Interaction[@GraphId='id5df52837']/Graphics; /Pathway/DataNode[@GraphId='bfb']
H2O
CHEBI:15377		consumes

NAD to nicotinamide GPML interaction
WikiPathways:WP171/idfac03b17
  • WikiPathways:WP171

    Source assertion: GPML id5e896944 connects normalized CHEBI:15377 as an input of interaction idfac03b17.

    Source location/Pathway/Interaction[@GraphId='id5e896944']/Graphics; /Pathway/DataNode[@GraphId='d7d']
N(6)-acetyl-L-lysine residue
CHEBI:61930		consumes

NAD to nicotinamide GPML interaction
WikiPathways:WP171/idfac03b17
  • WikiPathways:WP171

    Source assertion: GPML id5e896944 connects normalized CHEBI:61930 as an input of interaction idfac03b17.

    Source location/Pathway/Interaction[@GraphId='id5e896944']/Graphics; /Pathway/DataNode[@GraphId='a42ba']
QNS1
SGD:S000001116		catalyzes

nicotinate adenine dinucleotide to NAD GPML interaction
WikiPathways:WP171/id58e1978f
  • WikiPathways:WP171

    Source assertion: GPML id88c19e21 connects normalized SGD:S000001116 as a catalyst of interaction id58e1978f.

    Source location/Pathway/Interaction[@GraphId='id88c19e21']/Graphics; /Pathway/DataNode[@GraphId='d67']
NMA1
SGD:S000004320		catalyzes

beta-nicotinate D-ribonucleotide to nicotinate adenine dinucleotide GPML interaction
WikiPathways:WP171/id5b2236e7
  • WikiPathways:WP171

    Source assertion: GPML id90fd8be connects normalized SGD:S000004320 as a catalyst of interaction id5b2236e7.

    Source location/Pathway/Interaction[@GraphId='id90fd8be']/Graphics; /Pathway/DataNode[@GraphId='e3b']
NMA2
SGD:S000003242		catalyzes

beta-nicotinate D-ribonucleotide to nicotinate adenine dinucleotide GPML interaction
WikiPathways:WP171/id5b2236e7
  • WikiPathways:WP171

    Source assertion: GPML id90fd8be connects normalized SGD:S000003242 as a catalyst of interaction id5b2236e7.

    Source location/Pathway/Interaction[@GraphId='id90fd8be']/Graphics; /Pathway/DataNode[@GraphId='e71']
beta-nicotinate D-ribonucleotide to nicotinate adenine dinucleotide GPML interaction
WikiPathways:WP171/id5b2236e7		produces

diphosphate(3-)
CHEBI:33019
  • WikiPathways:WP171

    Source assertion: GPML idb811c195 connects normalized CHEBI:33019 as an output of interaction id5b2236e7.

    Source location/Pathway/Interaction[@GraphId='idb811c195']/Graphics; /Pathway/DataNode[@GraphId='dc83f']
NMA1
SGD:S000004320		has_cofactor

UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10428462) Divalent metal cation. UniProt note evidence: ECO:0000269 (PubMed:10428462)

nickel(2+)
CHEBI:49786
  • UniProtKB:Q06178

    Source assertion: UniProtKB:Q06178 annotates CHEBI:49786 as a cofactor of this protein.

    Source locationhttps://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2726/comments/0/cofactors/0; /results/2726/comments/0/note
  • UniProtKB:Q06178

    Source assertion: UniProtKB:Q06178 has the exact SGD cross-reference SGD:S000004320.

    Source locationhttps://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2726/uniProtKBCrossReferences/0
NMA2
SGD:S000003242		has_cofactor

UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:12597897) Divalent metal cation. UniProt note evidence: ECO:0000269 (PubMed:12597897)

cobalt(2+)
CHEBI:48828
  • UniProtKB:P53204

    Source assertion: UniProtKB:P53204 annotates CHEBI:48828 as a cofactor of this protein.

    Source locationhttps://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2159/comments/0/cofactors/0; /results/2159/comments/0/note
  • UniProtKB:P53204

    Source assertion: UniProtKB:P53204 has the exact SGD cross-reference SGD:S000003242.

    Source locationhttps://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2159/uniProtKBCrossReferences/0
SIR2
SGD:S000002200		has_cofactor

UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: Historical ADP-ribosyltransferase assignment does not negate the directly evidenced SIR2 zinc annotation. UniProt evidence: ECO:0000269 (PubMed:23307867) Binds 1 zinc ion per subunit. UniProt note evidence: ECO:0000269 (PubMed:23307867)

zinc(2+)
CHEBI:29105
  • UniProtKB:P06700

    Source assertion: UniProtKB:P06700 annotates CHEBI:29105 as a cofactor of this protein.

    Source locationhttps://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/136/comments/0/cofactors/0; /results/136/comments/0/note
  • UniProtKB:P06700

    Source assertion: UniProtKB:P06700 has the exact SGD cross-reference SGD:S000002200.

    Source locationhttps://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/136/uniProtKBCrossReferences/0

References

Curation history