TCA cycle - detailed

WikiPathways:WP296

The Saccharomyces cerevisiae WikiPathways TCA cycle diagram connects oxaloacetic acid to citrate, cis-aconitate, D-threo-isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and back to oxaloacetic acid, with supported enzyme and cofactor details from the GPML anchor network.

Pathway type

central carbon metabolism

Organism scope

Saccharomyces cerevisiae NCBITaxon:4932

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Pathway network

58 nodes · 75 asserted directed edges

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Protein / complex
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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae `NCBITaxon:4932`	taxon
succinyl-CoA ligase 1 `SGD:S000005668`	protein
ubiquinone-6 `CHEBI:52971`	small molecule
ADP(3-) `CHEBI:456216`	small molecule
NAD(+) `CHEBI:57540`	small molecule
H+ `CHEBI:15378`	small molecule
oxaloacetic acid `CHEBI:30744`	small molecule
citrate synthase 1 `SGD:S000005284`	protein
cytoplasmic malate dehydrogenase `SGD:S000005486`	protein
cis-aconitate `CHEBI:16383`	small molecule
succinate dehydrogenase 3 `SGD:S000001624`	protein
ATP(4-) `CHEBI:30616`	small molecule
succinate dehydrogenase 1 `SGD:S000001631`	protein
mitochondrial malate dehydrogenase `SGD:S000001568`	protein
citrate synthase 2 `SGD:S000000598`	protein
coenzyme A `CHEBI:15346`	small molecule
aconitase `SGD:S000004295`	protein
isocitrate dehydrogenase 1 `SGD:S000004982`	protein
acetyl-CoA `CHEBI:15351`	small molecule
succinyl-CoA ligase 2 `SGD:S000003476`	protein
fumarate hydratase `SGD:S000006183`	protein
succinyl-CoA `CHEBI:57292`	small molecule
hydrogenphosphate `CHEBI:43474`	small molecule
D-threo-isocitrate `CHEBI:15562`	small molecule
2-oxoglutarate `CHEBI:16810`	small molecule
aconitate hydratase `SGD:S000003736`	protein
isocitrate dehydrogenase 2 `SGD:S000005662`	protein
succinate dehydrogenase 4 `SGD:S000002585`	protein
citrate synthase 3 `SGD:S000006205`	protein
malate dehydrogenase `SGD:S000002236`	protein
2-ketoglutarate dehydrogenase `SGD:S000001387`	protein
dihydrolipoyl transsuccinylase `SGD:S000002555`	protein
succinate dehydrogenase 2 `SGD:S000003964`	protein
citrate `CHEBI:16947`	small molecule
H2O `CHEBI:15377`	small molecule
ubiquinol-6 `CHEBI:52970`	small molecule
CO2 `CHEBI:16526`	small molecule
dihydrolipoamide dehydrogenase `SGD:S000001876`	protein
succinate `CHEBI:30031`	small molecule
fumarate `CHEBI:29806`	small molecule
malate `CHEBI:15589`	small molecule
heme `CHEBI:30413`	cofactor
FAD(3-) `CHEBI:57692`	cofactor
tetra-mu3-sulfido-tetrairon `CHEBI:49883`	cofactor
magnesium(2+) `CHEBI:18420`	cofactor
manganese(2+) `CHEBI:29035`	cofactor
thiamine(1+) diphosphate(3-) `CHEBI:58937`	cofactor
(R)-lipoate `CHEBI:83088`	cofactor
di-mu-sulfido-diiron `CHEBI:190135`	cofactor
tri-mu-sulfido-mu3-sulfido-triiron `CHEBI:21137`	cofactor
succinate to fumarate GPML interaction `WikiPathways:WP296/b7797`	molecular activity	left to right
fumarate to malate GPML interaction `WikiPathways:WP296/bec38`	molecular activity	left to right
malate to oxaloacetic acid GPML interaction `WikiPathways:WP296/c084d`	molecular activity	left to right
cis-aconitate to D-threo-isocitrate GPML interaction `WikiPathways:WP296/id21c76d83`	molecular activity	left to right
2-oxoglutarate to succinyl-CoA GPML interaction `WikiPathways:WP296/id238f9689`	molecular activity	left to right
citrate to cis-aconitate GPML interaction `WikiPathways:WP296/id718be16e`	molecular activity	left to right
oxaloacetic acid to citrate GPML interaction `WikiPathways:WP296/id892d5e82`	molecular activity	left to right
D-threo-isocitrate to 2-oxoglutarate GPML interaction `WikiPathways:WP296/ida3b8a465`	molecular activity	left to right
succinyl-CoA to succinate GPML interaction `WikiPathways:WP296/idaf5b761e`	molecular activity	left to right

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
succinate `CHEBI:30031`	consumes	succinate to fumarate GPML interaction `WikiPathways:WP296/b7797`	WikiPathways:WP296 Source assertion: GPML b7797 connects normalized CHEBI:30031 as an input of interaction b7797. Source location `/Pathway/Interaction[@GraphId='b7797']/Graphics; /Pathway/DataNode[@GraphId='c4f94']`
succinate to fumarate GPML interaction `WikiPathways:WP296/b7797`	produces	fumarate `CHEBI:29806`	WikiPathways:WP296 Source assertion: GPML b7797 connects normalized CHEBI:29806 as an output of interaction b7797. Source location `/Pathway/Interaction[@GraphId='b7797']/Graphics; /Pathway/DataNode[@GraphId='e24e6']`
fumarate `CHEBI:29806`	consumes	fumarate to malate GPML interaction `WikiPathways:WP296/bec38`	WikiPathways:WP296 Source assertion: GPML bec38 connects normalized CHEBI:29806 as an input of interaction bec38. Source location `/Pathway/Interaction[@GraphId='bec38']/Graphics; /Pathway/DataNode[@GraphId='e24e6']`
fumarate to malate GPML interaction `WikiPathways:WP296/bec38`	produces	malate `CHEBI:15589`	WikiPathways:WP296 Source assertion: GPML bec38 connects normalized CHEBI:15589 as an output of interaction bec38. Source location `/Pathway/Interaction[@GraphId='bec38']/Graphics; /Pathway/DataNode[@GraphId='e5fa5']`
malate `CHEBI:15589`	consumes	malate to oxaloacetic acid GPML interaction `WikiPathways:WP296/c084d`	WikiPathways:WP296 Source assertion: GPML c084d connects normalized CHEBI:15589 as an input of interaction c084d. Source location `/Pathway/Interaction[@GraphId='c084d']/Graphics; /Pathway/DataNode[@GraphId='e5fa5']`
malate to oxaloacetic acid GPML interaction `WikiPathways:WP296/c084d`	produces	oxaloacetic acid `CHEBI:30744`	WikiPathways:WP296 Source assertion: GPML c084d connects normalized CHEBI:30744 as an output of interaction c084d. Source location `/Pathway/Interaction[@GraphId='c084d']/Graphics; /Pathway/DataNode[@GraphId='aeccb']`
cis-aconitate `CHEBI:16383`	consumes	cis-aconitate to D-threo-isocitrate GPML interaction `WikiPathways:WP296/id21c76d83`	WikiPathways:WP296 Source assertion: GPML id21c76d83 connects normalized CHEBI:16383 as an input of interaction id21c76d83. Source location `/Pathway/Interaction[@GraphId='id21c76d83']/Graphics; /Pathway/DataNode[@GraphId='b0a18']`
cis-aconitate to D-threo-isocitrate GPML interaction `WikiPathways:WP296/id21c76d83`	produces	D-threo-isocitrate `CHEBI:15562`	WikiPathways:WP296 Source assertion: GPML id21c76d83 connects normalized CHEBI:15562 as an output of interaction id21c76d83. Source location `/Pathway/Interaction[@GraphId='id21c76d83']/Graphics; /Pathway/DataNode[@GraphId='e08ee']`
2-oxoglutarate `CHEBI:16810`	consumes	2-oxoglutarate to succinyl-CoA GPML interaction `WikiPathways:WP296/id238f9689`	WikiPathways:WP296 Source assertion: GPML id238f9689 connects normalized CHEBI:16810 as an input of interaction id238f9689. Source location `/Pathway/Interaction[@GraphId='id238f9689']/Graphics; /Pathway/DataNode[@GraphId='e3a7b']`
2-oxoglutarate to succinyl-CoA GPML interaction `WikiPathways:WP296/id238f9689`	produces	succinyl-CoA `CHEBI:57292`	WikiPathways:WP296 Source assertion: GPML id238f9689 connects normalized CHEBI:57292 as an output of interaction id238f9689. Source location `/Pathway/Interaction[@GraphId='id238f9689']/Graphics; /Pathway/DataNode[@GraphId='d87e7']`
citrate `CHEBI:16947`	consumes	citrate to cis-aconitate GPML interaction `WikiPathways:WP296/id718be16e`	WikiPathways:WP296 Source assertion: GPML id718be16e connects normalized CHEBI:16947 as an input of interaction id718be16e. Source location `/Pathway/Interaction[@GraphId='id718be16e']/Graphics; /Pathway/DataNode[@GraphId='ec441']`
citrate to cis-aconitate GPML interaction `WikiPathways:WP296/id718be16e`	produces	cis-aconitate `CHEBI:16383`	WikiPathways:WP296 Source assertion: GPML id718be16e connects normalized CHEBI:16383 as an output of interaction id718be16e. Source location `/Pathway/Interaction[@GraphId='id718be16e']/Graphics; /Pathway/DataNode[@GraphId='b0a18']`
oxaloacetic acid `CHEBI:30744`	consumes	oxaloacetic acid to citrate GPML interaction `WikiPathways:WP296/id892d5e82`	WikiPathways:WP296 Source assertion: GPML id892d5e82 connects normalized CHEBI:30744 as an input of interaction id892d5e82. Source location `/Pathway/Interaction[@GraphId='id892d5e82']/Graphics; /Pathway/DataNode[@GraphId='aeccb']`
oxaloacetic acid to citrate GPML interaction `WikiPathways:WP296/id892d5e82`	produces	citrate `CHEBI:16947`	WikiPathways:WP296 Source assertion: GPML id892d5e82 connects normalized CHEBI:16947 as an output of interaction id892d5e82. Source location `/Pathway/Interaction[@GraphId='id892d5e82']/Graphics; /Pathway/DataNode[@GraphId='ec441']`
D-threo-isocitrate `CHEBI:15562`	consumes	D-threo-isocitrate to 2-oxoglutarate GPML interaction `WikiPathways:WP296/ida3b8a465`	WikiPathways:WP296 Source assertion: GPML ida3b8a465 connects normalized CHEBI:15562 as an input of interaction ida3b8a465. Source location `/Pathway/Interaction[@GraphId='ida3b8a465']/Graphics; /Pathway/DataNode[@GraphId='e08ee']`
D-threo-isocitrate to 2-oxoglutarate GPML interaction `WikiPathways:WP296/ida3b8a465`	produces	2-oxoglutarate `CHEBI:16810`	WikiPathways:WP296 Source assertion: GPML ida3b8a465 connects normalized CHEBI:16810 as an output of interaction ida3b8a465. Source location `/Pathway/Interaction[@GraphId='ida3b8a465']/Graphics; /Pathway/DataNode[@GraphId='e3a7b']`
succinyl-CoA `CHEBI:57292`	consumes	succinyl-CoA to succinate GPML interaction `WikiPathways:WP296/idaf5b761e`	WikiPathways:WP296 Source assertion: GPML idaf5b761e connects normalized CHEBI:57292 as an input of interaction idaf5b761e. Source location `/Pathway/Interaction[@GraphId='idaf5b761e']/Graphics; /Pathway/DataNode[@GraphId='d87e7']`
succinyl-CoA to succinate GPML interaction `WikiPathways:WP296/idaf5b761e`	produces	succinate `CHEBI:30031`	WikiPathways:WP296 Source assertion: GPML idaf5b761e connects normalized CHEBI:30031 as an output of interaction idaf5b761e. Source location `/Pathway/Interaction[@GraphId='idaf5b761e']/Graphics; /Pathway/DataNode[@GraphId='c4f94']`
citrate to cis-aconitate GPML interaction `WikiPathways:WP296/id718be16e`	produces	H2O `CHEBI:15377`	WikiPathways:WP296 Source assertion: GPML dfb97 connects normalized CHEBI:15377 as an output of interaction id718be16e. Source location `/Pathway/Interaction[@GraphId='dfb97']/Graphics; /Pathway/DataNode[@GraphId='e5e79']`
H2O `CHEBI:15377`	consumes	fumarate to malate GPML interaction `WikiPathways:WP296/bec38`	WikiPathways:WP296 Source assertion: GPML e42b8 connects normalized CHEBI:15377 as an input of interaction bec38. Source location `/Pathway/Interaction[@GraphId='e42b8']/Graphics; /Pathway/DataNode[@GraphId='f5459']`
H2O `CHEBI:15377`	consumes	cis-aconitate to D-threo-isocitrate GPML interaction `WikiPathways:WP296/id21c76d83`	WikiPathways:WP296 Source assertion: GPML f99c8 connects normalized CHEBI:15377 as an input of interaction id21c76d83. Source location `/Pathway/Interaction[@GraphId='f99c8']/Graphics; /Pathway/DataNode[@GraphId='a6e5e']`
oxaloacetic acid to citrate GPML interaction `WikiPathways:WP296/id892d5e82`	produces	coenzyme A `CHEBI:15346`	WikiPathways:WP296 Source assertion: GPML id223de00c connects normalized CHEBI:15346 as an output of interaction id892d5e82. Source location `/Pathway/Interaction[@GraphId='id223de00c']/Graphics; /Pathway/DataNode[@GraphId='c19']`
oxaloacetic acid to citrate GPML interaction `WikiPathways:WP296/id892d5e82`	produces	H+ `CHEBI:15378`	WikiPathways:WP296 Source assertion: GPML id223de00c connects normalized CHEBI:15378 as an output of interaction id892d5e82. Source location `/Pathway/Interaction[@GraphId='id223de00c']/Graphics; /Pathway/DataNode[@GraphId='d16c3']`
aconitate hydratase `SGD:S000003736`	catalyzes	citrate to cis-aconitate GPML interaction `WikiPathways:WP296/id718be16e`	WikiPathways:WP296 Source assertion: GPML id22686f56 connects normalized SGD:S000003736 as a catalyst of interaction id718be16e. Source location `/Pathway/Interaction[@GraphId='id22686f56']/Graphics; /Pathway/DataNode[@GraphId='e64']`
aconitase `SGD:S000004295`	catalyzes	citrate to cis-aconitate GPML interaction `WikiPathways:WP296/id718be16e`	WikiPathways:WP296 Source assertion: GPML id22686f56 connects normalized SGD:S000004295 as a catalyst of interaction id718be16e. Source location `/Pathway/Interaction[@GraphId='id22686f56']/Graphics; /Pathway/DataNode[@GraphId='eb5']`
succinyl-CoA to succinate GPML interaction `WikiPathways:WP296/idaf5b761e`	produces	ATP(4-) `CHEBI:30616`	WikiPathways:WP296 Source assertion: GPML id262ffb89 connects normalized CHEBI:30616 as an output of interaction idaf5b761e. Source location `/Pathway/Interaction[@GraphId='id262ffb89']/Graphics; /Pathway/DataNode[@GraphId='be8']`
succinyl-CoA to succinate GPML interaction `WikiPathways:WP296/idaf5b761e`	produces	coenzyme A `CHEBI:15346`	WikiPathways:WP296 Source assertion: GPML id262ffb89 connects normalized CHEBI:15346 as an output of interaction idaf5b761e. Source location `/Pathway/Interaction[@GraphId='id262ffb89']/Graphics; /Pathway/DataNode[@GraphId='e00']`
citrate synthase 1 `SGD:S000005284`	catalyzes	oxaloacetic acid to citrate GPML interaction `WikiPathways:WP296/id892d5e82`	WikiPathways:WP296 Source assertion: GPML id45ff05f2 connects normalized SGD:S000005284 as a catalyst of interaction id892d5e82. Source location `/Pathway/Interaction[@GraphId='id45ff05f2']/Graphics; /Pathway/DataNode[@GraphId='af1']`
citrate synthase 2 `SGD:S000000598`	catalyzes	oxaloacetic acid to citrate GPML interaction `WikiPathways:WP296/id892d5e82`	WikiPathways:WP296 Source assertion: GPML id45ff05f2 connects normalized SGD:S000000598 as a catalyst of interaction id892d5e82. Source location `/Pathway/Interaction[@GraphId='id45ff05f2']/Graphics; /Pathway/DataNode[@GraphId='c15']`
citrate synthase 3 `SGD:S000006205`	catalyzes	oxaloacetic acid to citrate GPML interaction `WikiPathways:WP296/id892d5e82`	WikiPathways:WP296 Source assertion: GPML id45ff05f2 connects normalized SGD:S000006205 as a catalyst of interaction id892d5e82. Source location `/Pathway/Interaction[@GraphId='id45ff05f2']/Graphics; /Pathway/DataNode[@GraphId='eb6']`
isocitrate dehydrogenase 1 `SGD:S000004982`	enables	D-threo-isocitrate to 2-oxoglutarate GPML interaction `WikiPathways:WP296/ida3b8a465`	WikiPathways:WP296 Source assertion: GPML id535a2a81 connects normalized SGD:S000004982 as an enabling enzyme component of interaction ida3b8a465. Source location `/Pathway/Interaction[@GraphId='id535a2a81']/Graphics; /Pathway/DataNode[@GraphId='c5f']`
isocitrate dehydrogenase 2 `SGD:S000005662`	enables	D-threo-isocitrate to 2-oxoglutarate GPML interaction `WikiPathways:WP296/ida3b8a465`	WikiPathways:WP296 Source assertion: GPML id535a2a81 connects normalized SGD:S000005662 as an enabling enzyme component of interaction ida3b8a465. Source location `/Pathway/Interaction[@GraphId='id535a2a81']/Graphics; /Pathway/DataNode[@GraphId='e80']`
succinyl-CoA ligase 1 `SGD:S000005668`	enables	succinyl-CoA to succinate GPML interaction `WikiPathways:WP296/idaf5b761e`	WikiPathways:WP296 Source assertion: GPML id649fabcc connects normalized SGD:S000005668 as an enabling enzyme component of interaction idaf5b761e. Source location `/Pathway/Interaction[@GraphId='id649fabcc']/Graphics; /Pathway/DataNode[@GraphId='a05']`
succinyl-CoA ligase 2 `SGD:S000003476`	enables	succinyl-CoA to succinate GPML interaction `WikiPathways:WP296/idaf5b761e`	WikiPathways:WP296 Source assertion: GPML id649fabcc connects normalized SGD:S000003476 as an enabling enzyme component of interaction idaf5b761e. Source location `/Pathway/Interaction[@GraphId='id649fabcc']/Graphics; /Pathway/DataNode[@GraphId='ca2']`
NAD(+) `CHEBI:57540`	consumes	malate to oxaloacetic acid GPML interaction `WikiPathways:WP296/c084d`	WikiPathways:WP296 Source assertion: GPML id9381d0ea connects normalized CHEBI:57540 as an input of interaction c084d. Source location `/Pathway/Interaction[@GraphId='id9381d0ea']/Graphics; /Pathway/DataNode[@GraphId='aaa85']`
succinate dehydrogenase 3 `SGD:S000001624`	enables	succinate to fumarate GPML interaction `WikiPathways:WP296/b7797`	WikiPathways:WP296 Source assertion: GPML id9d770d61 connects normalized SGD:S000001624 as an enabling enzyme component of interaction b7797. Source location `/Pathway/Interaction[@GraphId='id9d770d61']/Graphics; /Pathway/DataNode[@GraphId='b23']`
succinate dehydrogenase 1 `SGD:S000001631`	enables	succinate to fumarate GPML interaction `WikiPathways:WP296/b7797`	WikiPathways:WP296 Source assertion: GPML id9d770d61 connects normalized SGD:S000001631 as an enabling enzyme component of interaction b7797. Source location `/Pathway/Interaction[@GraphId='id9d770d61']/Graphics; /Pathway/DataNode[@GraphId='bcd']`
succinate dehydrogenase 4 `SGD:S000002585`	enables	succinate to fumarate GPML interaction `WikiPathways:WP296/b7797`	WikiPathways:WP296 Source assertion: GPML id9d770d61 connects normalized SGD:S000002585 as an enabling enzyme component of interaction b7797. Source location `/Pathway/Interaction[@GraphId='id9d770d61']/Graphics; /Pathway/DataNode[@GraphId='e8a']`
succinate dehydrogenase 2 `SGD:S000003964`	enables	succinate to fumarate GPML interaction `WikiPathways:WP296/b7797`	WikiPathways:WP296 Source assertion: GPML id9d770d61 connects normalized SGD:S000003964 as an enabling enzyme component of interaction b7797. Source location `/Pathway/Interaction[@GraphId='id9d770d61']/Graphics; /Pathway/DataNode[@GraphId='f57']`
acetyl-CoA `CHEBI:15351`	consumes	oxaloacetic acid to citrate GPML interaction `WikiPathways:WP296/id892d5e82`	WikiPathways:WP296 Source assertion: GPML ida4bd3f73 connects normalized CHEBI:15351 as an input of interaction id892d5e82. Source location `/Pathway/Interaction[@GraphId='ida4bd3f73']/Graphics; /Pathway/DataNode[@GraphId='c81']`
H2O `CHEBI:15377`	consumes	oxaloacetic acid to citrate GPML interaction `WikiPathways:WP296/id892d5e82`	WikiPathways:WP296 Source assertion: GPML ida4bd3f73 connects normalized CHEBI:15377 as an input of interaction id892d5e82. Source location `/Pathway/Interaction[@GraphId='ida4bd3f73']/Graphics; /Pathway/DataNode[@GraphId='aa687']`
cytoplasmic malate dehydrogenase `SGD:S000005486`	catalyzes	malate to oxaloacetic acid GPML interaction `WikiPathways:WP296/c084d`	WikiPathways:WP296 Source assertion: GPML ida80523b connects normalized SGD:S000005486 as a catalyst of interaction c084d. Source location `/Pathway/Interaction[@GraphId='ida80523b']/Graphics; /Pathway/DataNode[@GraphId='afc']`
mitochondrial malate dehydrogenase `SGD:S000001568`	catalyzes	malate to oxaloacetic acid GPML interaction `WikiPathways:WP296/c084d`	WikiPathways:WP296 Source assertion: GPML ida80523b connects normalized SGD:S000001568 as a catalyst of interaction c084d. Source location `/Pathway/Interaction[@GraphId='ida80523b']/Graphics; /Pathway/DataNode[@GraphId='bda']`
malate dehydrogenase `SGD:S000002236`	catalyzes	malate to oxaloacetic acid GPML interaction `WikiPathways:WP296/c084d`	WikiPathways:WP296 Source assertion: GPML ida80523b connects normalized SGD:S000002236 as a catalyst of interaction c084d. Source location `/Pathway/Interaction[@GraphId='ida80523b']/Graphics; /Pathway/DataNode[@GraphId='edb']`
fumarate hydratase `SGD:S000006183`	catalyzes	fumarate to malate GPML interaction `WikiPathways:WP296/bec38`	WikiPathways:WP296 Source assertion: GPML idab038033 connects normalized SGD:S000006183 as a catalyst of interaction bec38. Source location `/Pathway/Interaction[@GraphId='idab038033']/Graphics; /Pathway/DataNode[@GraphId='d74']`
ubiquinone-6 `CHEBI:52971`	consumes	succinate to fumarate GPML interaction `WikiPathways:WP296/b7797`	WikiPathways:WP296 Source assertion: GPML idabc4f331 connects normalized CHEBI:52971 as an input of interaction b7797. Source location `/Pathway/Interaction[@GraphId='idabc4f331']/Graphics; /Pathway/DataNode[@GraphId='a7e']`
ADP(3-) `CHEBI:456216`	consumes	succinyl-CoA to succinate GPML interaction `WikiPathways:WP296/idaf5b761e`	WikiPathways:WP296 Source assertion: GPML idb56de142 connects normalized CHEBI:456216 as an input of interaction idaf5b761e. Source location `/Pathway/Interaction[@GraphId='idb56de142']/Graphics; /Pathway/DataNode[@GraphId='a89']`
hydrogenphosphate `CHEBI:43474`	consumes	succinyl-CoA to succinate GPML interaction `WikiPathways:WP296/idaf5b761e`	WikiPathways:WP296 Source assertion: GPML idb56de142 connects normalized CHEBI:43474 as an input of interaction idaf5b761e. Source location `/Pathway/Interaction[@GraphId='idb56de142']/Graphics; /Pathway/DataNode[@GraphId='f96']`
NAD(+) `CHEBI:57540`	consumes	2-oxoglutarate to succinyl-CoA GPML interaction `WikiPathways:WP296/id238f9689`	WikiPathways:WP296 Source assertion: GPML idb9cd3a1e connects normalized CHEBI:57540 as an input of interaction id238f9689. Source location `/Pathway/Interaction[@GraphId='idb9cd3a1e']/Graphics; /Pathway/DataNode[@GraphId='aa36a']`
coenzyme A `CHEBI:15346`	consumes	2-oxoglutarate to succinyl-CoA GPML interaction `WikiPathways:WP296/id238f9689`	WikiPathways:WP296 Source assertion: GPML idb9cd3a1e connects normalized CHEBI:15346 as an input of interaction id238f9689. Source location `/Pathway/Interaction[@GraphId='idb9cd3a1e']/Graphics; /Pathway/DataNode[@GraphId='b80e7']`
aconitase `SGD:S000004295`	catalyzes	cis-aconitate to D-threo-isocitrate GPML interaction `WikiPathways:WP296/id21c76d83`	WikiPathways:WP296 Source assertion: GPML idc9944f47 connects normalized SGD:S000004295 as a catalyst of interaction id21c76d83. Source location `/Pathway/Interaction[@GraphId='idc9944f47']/Graphics; /Pathway/DataNode[@GraphId='c39']`
NAD(+) `CHEBI:57540`	consumes	D-threo-isocitrate to 2-oxoglutarate GPML interaction `WikiPathways:WP296/ida3b8a465`	WikiPathways:WP296 Source assertion: GPML idd2c371cf connects normalized CHEBI:57540 as an input of interaction ida3b8a465. Source location `/Pathway/Interaction[@GraphId='idd2c371cf']/Graphics; /Pathway/DataNode[@GraphId='f2838']`
2-oxoglutarate to succinyl-CoA GPML interaction `WikiPathways:WP296/id238f9689`	produces	CO2 `CHEBI:16526`	WikiPathways:WP296 Source assertion: GPML iddb7a89c2 connects normalized CHEBI:16526 as an output of interaction id238f9689. Source location `/Pathway/Interaction[@GraphId='iddb7a89c2']/Graphics; /Pathway/DataNode[@GraphId='bb18d']`
2-ketoglutarate dehydrogenase `SGD:S000001387`	enables	2-oxoglutarate to succinyl-CoA GPML interaction `WikiPathways:WP296/id238f9689`	WikiPathways:WP296 Source assertion: GPML iddbe3f305 connects normalized SGD:S000001387 as an enabling enzyme component of interaction id238f9689. Source location `/Pathway/Interaction[@GraphId='iddbe3f305']/Graphics; /Pathway/DataNode[@GraphId='efb']`
dihydrolipoyl transsuccinylase `SGD:S000002555`	enables	2-oxoglutarate to succinyl-CoA GPML interaction `WikiPathways:WP296/id238f9689`	WikiPathways:WP296 Source assertion: GPML iddbe3f305 connects normalized SGD:S000002555 as an enabling enzyme component of interaction id238f9689. Source location `/Pathway/Interaction[@GraphId='iddbe3f305']/Graphics; /Pathway/DataNode[@GraphId='f0f']`
dihydrolipoamide dehydrogenase `SGD:S000001876`	enables	2-oxoglutarate to succinyl-CoA GPML interaction `WikiPathways:WP296/id238f9689`	WikiPathways:WP296 Source assertion: GPML iddbe3f305 connects normalized SGD:S000001876 as an enabling enzyme component of interaction id238f9689. Source location `/Pathway/Interaction[@GraphId='iddbe3f305']/Graphics; /Pathway/DataNode[@GraphId='dd9dc']`
D-threo-isocitrate to 2-oxoglutarate GPML interaction `WikiPathways:WP296/ida3b8a465`	produces	CO2 `CHEBI:16526`	WikiPathways:WP296 Source assertion: GPML ided1baecb connects normalized CHEBI:16526 as an output of interaction ida3b8a465. Source location `/Pathway/Interaction[@GraphId='ided1baecb']/Graphics; /Pathway/DataNode[@GraphId='dcc2e']`
malate to oxaloacetic acid GPML interaction `WikiPathways:WP296/c084d`	produces	H+ `CHEBI:15378`	WikiPathways:WP296 Source assertion: GPML idfe360565 connects normalized CHEBI:15378 as an output of interaction c084d. Source location `/Pathway/Interaction[@GraphId='idfe360565']/Graphics; /Pathway/DataNode[@GraphId='ee3bd']`
succinate to fumarate GPML interaction `WikiPathways:WP296/b7797`	produces	ubiquinol-6 `CHEBI:52970`	WikiPathways:WP296 Source assertion: GPML f1909 connects normalized CHEBI:52970 as an output of interaction b7797. Source location `/Pathway/Interaction[@GraphId='f1909']/Graphics; /Pathway/DataNode[@GraphId='e4bd2']`
succinate dehydrogenase 3 `SGD:S000001624`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified The heme is bound between the two transmembrane subunits.	heme `CHEBI:30413`	UniProtKB:P33421 Source assertion: UniProtKB:P33421 annotates CHEBI:30413 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1091/comments/0/cofactors/0; /results/1091/comments/0/note` UniProtKB:P33421 Source assertion: UniProtKB:P33421 has the exact SGD cross-reference SGD:S000001624. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1091/uniProtKBCrossReferences/0`
succinate dehydrogenase 1 `SGD:S000001631`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:Q0QF01)	FAD(3-) `CHEBI:57692`	UniProtKB:Q00711 Source assertion: UniProtKB:Q00711 annotates CHEBI:57692 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2374/comments/0/cofactors/0` UniProtKB:Q00711 Source assertion: UniProtKB:Q00711 has the exact SGD cross-reference SGD:S000001631. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2374/uniProtKBCrossReferences/0`
aconitase `SGD:S000004295`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:27738674) Binds 1 [4Fe-4S] cluster per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P20004)	tetra-mu3-sulfido-tetrairon `CHEBI:49883`	UniProtKB:P19414 Source assertion: UniProtKB:P19414 annotates CHEBI:49883 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/497/comments/0/cofactors/0; /results/497/comments/0/note` UniProtKB:P19414 Source assertion: UniProtKB:P19414 has the exact SGD cross-reference SGD:S000004295. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/497/uniProtKBCrossReferences/0`
isocitrate dehydrogenase 1 `SGD:S000004982`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 Mg(2+) or Mn(2+) ion per subunit. UniProt note evidence: ECO:0000250	magnesium(2+) `CHEBI:18420`	UniProtKB:P28834 Source assertion: UniProtKB:P28834 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/803/comments/0/cofactors/0; /results/803/comments/0/note` UniProtKB:P28834 Source assertion: UniProtKB:P28834 has the exact SGD cross-reference SGD:S000004982. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/803/uniProtKBCrossReferences/0`
isocitrate dehydrogenase 1 `SGD:S000004982`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 Mg(2+) or Mn(2+) ion per subunit. UniProt note evidence: ECO:0000250	manganese(2+) `CHEBI:29035`	UniProtKB:P28834 Source assertion: UniProtKB:P28834 annotates CHEBI:29035 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/803/comments/0/cofactors/1; /results/803/comments/0/note` UniProtKB:P28834 Source assertion: UniProtKB:P28834 has the exact SGD cross-reference SGD:S000004982. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/803/uniProtKBCrossReferences/0`
succinyl-CoA ligase 2 `SGD:S000003476`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_03219) Binds 1 Mg(2+) ion per subunit. UniProt note evidence: ECO:0000255 (HAMAP-Rule:MF_03219)	magnesium(2+) `CHEBI:18420`	UniProtKB:P53312 Source assertion: UniProtKB:P53312 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3976/comments/0/cofactors/0; /results/3976/comments/0/note` UniProtKB:P53312 Source assertion: UniProtKB:P53312 has the exact SGD cross-reference SGD:S000003476. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3976/uniProtKBCrossReferences/0`
aconitate hydratase `SGD:S000003736`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P20004) Binds 1 [4Fe-4S] cluster per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P20004)	tetra-mu3-sulfido-tetrairon `CHEBI:49883`	UniProtKB:P39533 Source assertion: UniProtKB:P39533 annotates CHEBI:49883 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1568/comments/0/cofactors/0; /results/1568/comments/0/note` UniProtKB:P39533 Source assertion: UniProtKB:P39533 has the exact SGD cross-reference SGD:S000003736. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1568/uniProtKBCrossReferences/0`
isocitrate dehydrogenase 2 `SGD:S000005662`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 Mg(2+) or Mn(2+) ion per subunit. UniProt note evidence: ECO:0000250	magnesium(2+) `CHEBI:18420`	UniProtKB:P28241 Source assertion: UniProtKB:P28241 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/784/comments/0/cofactors/0; /results/784/comments/0/note` UniProtKB:P28241 Source assertion: UniProtKB:P28241 has the exact SGD cross-reference SGD:S000005662. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/784/uniProtKBCrossReferences/0`
isocitrate dehydrogenase 2 `SGD:S000005662`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 Mg(2+) or Mn(2+) ion per subunit. UniProt note evidence: ECO:0000250	manganese(2+) `CHEBI:29035`	UniProtKB:P28241 Source assertion: UniProtKB:P28241 annotates CHEBI:29035 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/784/comments/0/cofactors/1; /results/784/comments/0/note` UniProtKB:P28241 Source assertion: UniProtKB:P28241 has the exact SGD cross-reference SGD:S000005662. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/784/uniProtKBCrossReferences/0`
2-ketoglutarate dehydrogenase `SGD:S000001387`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	thiamine(1+) diphosphate(3-) `CHEBI:58937`	UniProtKB:P20967 Source assertion: UniProtKB:P20967 annotates CHEBI:58937 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/538/comments/0/cofactors/0` UniProtKB:P20967 Source assertion: UniProtKB:P20967 has the exact SGD cross-reference SGD:S000001387. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/538/uniProtKBCrossReferences/0`
2-ketoglutarate dehydrogenase `SGD:S000001387`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:Q02218)	magnesium(2+) `CHEBI:18420`	UniProtKB:P20967 Source assertion: UniProtKB:P20967 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/538/comments/0/cofactors/1` UniProtKB:P20967 Source assertion: UniProtKB:P20967 has the exact SGD cross-reference SGD:S000001387. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/538/uniProtKBCrossReferences/0`
dihydrolipoyl transsuccinylase `SGD:S000002555`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The source describes a covalently attached cofactor moiety. Keep that bound-state qualification; no free cosubstrate consumption is inferred. UniProt evidence: not specified Binds 1 lipoyl cofactor covalently.	(R)-lipoate `CHEBI:83088`	UniProtKB:P19262 Source assertion: UniProtKB:P19262 annotates CHEBI:83088 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/494/comments/0/cofactors/0; /results/494/comments/0/note` UniProtKB:P19262 Source assertion: UniProtKB:P19262 has the exact SGD cross-reference SGD:S000002555. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/494/uniProtKBCrossReferences/0`
succinate dehydrogenase 2 `SGD:S000003964`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 [2Fe-2S] cluster. UniProt note evidence: ECO:0000250	di-mu-sulfido-diiron `CHEBI:190135`	UniProtKB:P21801 Source assertion: UniProtKB:P21801 annotates CHEBI:190135 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/560/comments/0/cofactors/0; /results/560/comments/0/note` UniProtKB:P21801 Source assertion: UniProtKB:P21801 has the exact SGD cross-reference SGD:S000003964. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/560/uniProtKBCrossReferences/0`
succinate dehydrogenase 2 `SGD:S000003964`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 [3Fe-4S] cluster. UniProt note evidence: ECO:0000250	tri-mu-sulfido-mu3-sulfido-triiron `CHEBI:21137`	UniProtKB:P21801 Source assertion: UniProtKB:P21801 annotates CHEBI:21137 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/560/comments/1/cofactors/0; /results/560/comments/1/note` UniProtKB:P21801 Source assertion: UniProtKB:P21801 has the exact SGD cross-reference SGD:S000003964. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/560/uniProtKBCrossReferences/0`
succinate dehydrogenase 2 `SGD:S000003964`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 [4Fe-4S] cluster. UniProt note evidence: ECO:0000250	tetra-mu3-sulfido-tetrairon `CHEBI:49883`	UniProtKB:P21801 Source assertion: UniProtKB:P21801 annotates CHEBI:49883 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/560/comments/2/cofactors/0; /results/560/comments/2/note` UniProtKB:P21801 Source assertion: UniProtKB:P21801 has the exact SGD cross-reference SGD:S000003964. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/560/uniProtKBCrossReferences/0`
dihydrolipoamide dehydrogenase `SGD:S000001876`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:9538259); ECO:0000269 (Reference:Ref.13) Binds 1 FAD per subunit. UniProt note evidence: ECO:0000269 (PubMed:9538259); ECO:0000269 (Reference:Ref.13)	FAD(3-) `CHEBI:57692`	UniProtKB:P09624 Source assertion: UniProtKB:P09624 annotates CHEBI:57692 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/227/comments/0/cofactors/0; /results/227/comments/0/note` UniProtKB:P09624 Source assertion: UniProtKB:P09624 has the exact SGD cross-reference SGD:S000001876. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/227/uniProtKBCrossReferences/0`

References

CHEBI:30744 ChEBI oxaloacetic acid JSON API record
WikiPathways:WP296 WP296 native structured pathway source (source version: WP296_r20260922081654)
UniProtKB:P33421 UniProtKB P33421 cofactor annotations (source version: 2026_03)
UniProtKB:Q00711 UniProtKB Q00711 cofactor annotations (source version: 2026_03)
UniProtKB:P19414 UniProtKB P19414 cofactor annotations (source version: 2026_03)
UniProtKB:P28834 UniProtKB P28834 cofactor annotations (source version: 2026_03)
UniProtKB:P53312 UniProtKB P53312 cofactor annotations (source version: 2026_03)
UniProtKB:P39533 UniProtKB P39533 cofactor annotations (source version: 2026_03)
UniProtKB:P28241 UniProtKB P28241 cofactor annotations (source version: 2026_03)
UniProtKB:P20967 UniProtKB P20967 cofactor annotations (source version: 2026_03)
UniProtKB:P19262 UniProtKB P19262 cofactor annotations (source version: 2026_03)
UniProtKB:P21801 UniProtKB P21801 cofactor annotations (source version: 2026_03)
UniProtKB:P09624 UniProtKB P09624 cofactor annotations (source version: 2026_03)

Curation history

2026-10-05T06:17:07Z Codex
- EDIT — Review complete causal graph against native sources and correct unsupported or omitted relationships
  Restored supported anchor cofactors and enzyme components; multisubunit groups enable the reaction instead of each subunit being independently catalytic. Q6 replaces the native Q9 cross-reference; source ATP and CoA CAS crossrefs incorrectly identify dATP and F420 and are corrected by reaction context and named chemical identity. Anaplerotic pyruvate branch is outside the retained TCA-cycle scope. Every native record was inspected; see reports/causal-graph-diagram-review.json for native-object counts, exclusions and identity corrections. Semantic validation and native GraphId locator checks passed; authority snapshots and full corpus gates are coordinated separately.
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