Glutathione-glutaredoxin redox reaction

WikiPathways:WP392

Glutathione-glutaredoxin redox reaction in Saccharomyces cerevisiae links glutathione/glutathione disulfide recycling through GLR1 to glutathione consumption by GTT1/GTT2 and GPX1/GPX2/HYR1-catalyzed glutathione oxidation in the WP392 GPML diagram. The unresolved glutaredoxin redox partner is not specified; peroxidase assignments retain the diagram scope and do not establish glutathione as the exclusive physiological donor.

Pathway type
glutathione redox
Organism scope

Read the source YAML

Pathway network

18 nodes · 18 asserted directed edges

Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.

Pathway network: Glutathione-glutaredoxin redox reaction 18 nodes · 18 asserted directed edges. Every arrow links to its evidence table row; nodes link to their component details. Isolated declared components are retained. CHEBI:58297 — consumes → WikiPathways:WP392/id3206f739; Evidence: WikiPathways:WP392consumes WikiPathways:WP392/id3206f739 — produces → CHEBI:57925; Evidence: WikiPathways:WP392produces CHEBI:57925 — consumes → WikiPathways:WP392/id8cc08cdf; Evidence: WikiPathways:WP392consumes WikiPathways:WP392/id8cc08cdf — produces → CHEBI:17021; Evidence: WikiPathways:WP392produces CHEBI:57925 — consumes → WikiPathways:WP392/idb13bbbe; Evidence: WikiPathways:WP392consumes WikiPathways:WP392/idb13bbbe — produces → CHEBI:58297; Evidence: WikiPathways:WP392produces SGD:S000006012 — catalyzes → WikiPathways:WP392/id3206f739; Evidence: WikiPathways:WP392catalyzes SGD:S000001509 — catalyzes → WikiPathways:WP392/idb13bbbe; Evidence: WikiPathways:WP392catalyzes SGD:S000000448 — catalyzes → WikiPathways:WP392/idb13bbbe; Evidence: WikiPathways:WP392catalyzes SGD:S000001476 — catalyzes → WikiPathways:WP392/idb13bbbe; Evidence: WikiPathways:WP392catalyzes WikiPathways:WP392/idb13bbbe — produces → CHEBI:15377; Evidence: WikiPathways:WP392produces SGD:S000003983 — catalyzes → WikiPathways:WP392/id8cc08cdf; Evidence: WikiPathways:WP392catalyzes SGD:S000001477 — catalyzes → WikiPathways:WP392/id8cc08cdf; Evidence: WikiPathways:WP392catalyzes WikiPathways:WP392/id3206f739 — produces → CHEBI:58349; Evidence: WikiPathways:WP392produces CHEBI:16474 — consumes → WikiPathways:WP392/id3206f739; Direction resolved from the source pathway redox description, not an unheaded line alone.; Evidence: WikiPathways:WP392consumes CHEBI:15378 — consumes → WikiPathways:WP392/id3206f739; Direction resolved from the source pathway redox description, not an unheaded line alone.; Evidence: WikiPathways:WP392consumes CHEBI:16240 — consumes → WikiPathways:WP392/idb13bbbe; Direction resolved from the source pathway redox description, not an unheaded line alone.; Evidence: WikiPathways:WP392consumes SGD:S000006012 — has_cofactor → CHEBI:57692; UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:17554778) Binds 1 FAD per subunit. UniProt note evidence: ECO:0000269 (PubMed:17554778); Evidence: UniProtKB:P41921, UniProtKB:P41921has cofactor glutathione; CHEBI:57925; Declared type: small_molecule small molecule glutathione H2O2; CHEBI:16240; Declared type: small_molecule small molecule H2O2 NADP(3-); CHEBI:58349; Declared type: small_molecule small molecule NADP(3-) water; CHEBI:15377; Declared type: small_molecule small molecule water glutathione disulfide; CHEBI:58297; Declared type: small_molecule small molecule glutathione disulfide S-substituted glutathione; CHEBI:17021; Declared type: small_molecule small molecule S-substituted glutathione GTT2; SGD:S000003983; Declared type: protein protein GTT2 GTT1; SGD:S000001477; Declared type: protein protein GTT1 GPX1; SGD:S000001509; Declared type: protein protein GPX1 GPX2; SGD:S000000448; Declared type: protein protein GPX2 GLR1; SGD:S000006012; Declared type: protein protein GLR1 HYR1; SGD:S000001476; Declared type: protein protein HYR1 NADPH; CHEBI:16474; Declared type: small_molecule small molecule NADPH hydron; CHEBI:15378; Declared type: small_molecule small molecule hydron FAD(3-); CHEBI:57692; Declared type: cofactor cofactor FAD(3-) glutathione disulfide to glutathione GPML interaction; WikiPathways:WP392/id3206f739; Declared type: molecular_activity; Source reaction direction: left_to_right molecular activity glutathione disulfide to glutathione GPML interaction glutathione to glutathione-S-conjugate GPML interaction; WikiPathways:WP392/id8cc08cdf; Declared type: molecular_activity; Source reaction direction: left_to_right molecular activity glutathione to glutathione- S-conjugate GPML interaction glutathione to glutathione disulfide GPML interaction; WikiPathways:WP392/idb13bbbe; Declared type: molecular_activity; Source reaction direction: left_to_right molecular activity glutathione to glutathione disulfide GPML interaction

Components and activities

Declared biological components and source reaction directions
NodeKind or roleSource direction
Saccharomyces cerevisiae
NCBITaxon:4932		taxon
glutathione
CHEBI:57925		small molecule
H2O2
CHEBI:16240		small molecule
NADP(3-)
CHEBI:58349		small molecule
water
CHEBI:15377		small molecule
glutathione disulfide
CHEBI:58297		small molecule
S-substituted glutathione
CHEBI:17021		small molecule
GTT2
SGD:S000003983		protein
GTT1
SGD:S000001477		protein
GPX1
SGD:S000001509		protein
GPX2
SGD:S000000448		protein
GLR1
SGD:S000006012		protein
HYR1
SGD:S000001476		protein
NADPH
CHEBI:16474		small molecule
hydron
CHEBI:15378		small molecule
FAD(3-)
CHEBI:57692		cofactor
glutathione disulfide to glutathione GPML interaction
WikiPathways:WP392/id3206f739		molecular activityleft to right
glutathione to glutathione-S-conjugate GPML interaction
WikiPathways:WP392/id8cc08cdf		molecular activityleft to right
glutathione to glutathione disulfide GPML interaction
WikiPathways:WP392/idb13bbbe		molecular activityleft to right

Mechanistic edges

Mechanistic edges and their cited evidence
SubjectPredicate and descriptionObjectEvidence
glutathione disulfide
CHEBI:58297		consumes

glutathione disulfide to glutathione GPML interaction
WikiPathways:WP392/id3206f739
  • WikiPathways:WP392

    Source assertion: GPML id3206f739 connects normalized CHEBI:58297 as an input of interaction id3206f739.

    Source location/Pathway/Interaction[@GraphId='id3206f739']/Graphics; /Pathway/DataNode[@GraphId='fc211']
glutathione disulfide to glutathione GPML interaction
WikiPathways:WP392/id3206f739		produces

glutathione
CHEBI:57925
  • WikiPathways:WP392

    Source assertion: GPML id3206f739 connects normalized CHEBI:57925 as an output of interaction id3206f739.

    Source location/Pathway/Interaction[@GraphId='id3206f739']/Graphics; /Pathway/DataNode[@GraphId='a20fb']
glutathione
CHEBI:57925		consumes

glutathione to glutathione-S-conjugate GPML interaction
WikiPathways:WP392/id8cc08cdf
  • WikiPathways:WP392

    Source assertion: GPML id8cc08cdf connects normalized CHEBI:57925 as an input of interaction id8cc08cdf.

    Source location/Pathway/Interaction[@GraphId='id8cc08cdf']/Graphics; /Pathway/DataNode[@GraphId='a20fb']
glutathione to glutathione-S-conjugate GPML interaction
WikiPathways:WP392/id8cc08cdf		produces

S-substituted glutathione
CHEBI:17021
  • WikiPathways:WP392

    Source assertion: GPML id8cc08cdf connects normalized CHEBI:17021 as an output of interaction id8cc08cdf.

    Source location/Pathway/Interaction[@GraphId='id8cc08cdf']/Graphics; /Pathway/DataNode[@GraphId='a3d26']
glutathione
CHEBI:57925		consumes

glutathione to glutathione disulfide GPML interaction
WikiPathways:WP392/idb13bbbe
  • WikiPathways:WP392

    Source assertion: GPML idb13bbbe connects normalized CHEBI:57925 as an input of interaction idb13bbbe.

    Source location/Pathway/Interaction[@GraphId='idb13bbbe']/Graphics; /Pathway/DataNode[@GraphId='a20fb']
glutathione to glutathione disulfide GPML interaction
WikiPathways:WP392/idb13bbbe		produces

glutathione disulfide
CHEBI:58297
  • WikiPathways:WP392

    Source assertion: GPML idb13bbbe connects normalized CHEBI:58297 as an output of interaction idb13bbbe.

    Source location/Pathway/Interaction[@GraphId='idb13bbbe']/Graphics; /Pathway/DataNode[@GraphId='fc211']
GLR1
SGD:S000006012		catalyzes

glutathione disulfide to glutathione GPML interaction
WikiPathways:WP392/id3206f739
  • WikiPathways:WP392

    Source assertion: GPML id7dd40452 connects normalized SGD:S000006012 as a catalyst of interaction id3206f739.

    Source location/Pathway/Interaction[@GraphId='id7dd40452']/Graphics; /Pathway/DataNode[@GraphId='f19']
GPX1
SGD:S000001509		catalyzes

glutathione to glutathione disulfide GPML interaction
WikiPathways:WP392/idb13bbbe
  • WikiPathways:WP392

    Source assertion: GPML ida03687f connects normalized SGD:S000001509 as a catalyst of interaction idb13bbbe.

    Source location/Pathway/Interaction[@GraphId='ida03687f']/Graphics; /Pathway/DataNode[@GraphId='dc7']
GPX2
SGD:S000000448		catalyzes

glutathione to glutathione disulfide GPML interaction
WikiPathways:WP392/idb13bbbe
  • WikiPathways:WP392

    Source assertion: GPML ida03687f connects normalized SGD:S000000448 as a catalyst of interaction idb13bbbe.

    Source location/Pathway/Interaction[@GraphId='ida03687f']/Graphics; /Pathway/DataNode[@GraphId='e13']
HYR1
SGD:S000001476		catalyzes

glutathione to glutathione disulfide GPML interaction
WikiPathways:WP392/idb13bbbe
  • WikiPathways:WP392

    Source assertion: GPML ida03687f connects normalized SGD:S000001476 as a catalyst of interaction idb13bbbe.

    Source location/Pathway/Interaction[@GraphId='ida03687f']/Graphics; /Pathway/DataNode[@GraphId='fb3']
glutathione to glutathione disulfide GPML interaction
WikiPathways:WP392/idb13bbbe		produces

water
CHEBI:15377
  • WikiPathways:WP392

    Source assertion: GPML idc27704ba connects normalized CHEBI:15377 as an output of interaction idb13bbbe.

    Source location/Pathway/Interaction[@GraphId='idc27704ba']/Graphics; /Pathway/DataNode[@GraphId='f6c66']
GTT2
SGD:S000003983		catalyzes

glutathione to glutathione-S-conjugate GPML interaction
WikiPathways:WP392/id8cc08cdf
  • WikiPathways:WP392

    Source assertion: GPML idd278a2e5 connects normalized SGD:S000003983 as a catalyst of interaction id8cc08cdf.

    Source location/Pathway/Interaction[@GraphId='idd278a2e5']/Graphics; /Pathway/DataNode[@GraphId='bfc']
GTT1
SGD:S000001477		catalyzes

glutathione to glutathione-S-conjugate GPML interaction
WikiPathways:WP392/id8cc08cdf
  • WikiPathways:WP392

    Source assertion: GPML idd278a2e5 connects normalized SGD:S000001477 as a catalyst of interaction id8cc08cdf.

    Source location/Pathway/Interaction[@GraphId='idd278a2e5']/Graphics; /Pathway/DataNode[@GraphId='c00']
glutathione disulfide to glutathione GPML interaction
WikiPathways:WP392/id3206f739		produces

NADP(3-)
CHEBI:58349
  • WikiPathways:WP392

    Source assertion: GPML idd919a6a connects normalized CHEBI:58349 as an output of interaction id3206f739.

    Source location/Pathway/Interaction[@GraphId='idd919a6a']/Graphics; /Pathway/DataNode[@GraphId='e4820']
NADPH
CHEBI:16474		consumes

Direction resolved from the source pathway redox description, not an unheaded line alone.

glutathione disulfide to glutathione GPML interaction
WikiPathways:WP392/id3206f739
  • WikiPathways:WP392

    Source assertion: GPML id50af4865 connects normalized CHEBI:16474 as an input of interaction id3206f739.

    Source location/Pathway/Interaction[@GraphId='id50af4865']/Graphics; /Pathway/DataNode[@GraphId='fe0']
hydron
CHEBI:15378		consumes

Direction resolved from the source pathway redox description, not an unheaded line alone.

glutathione disulfide to glutathione GPML interaction
WikiPathways:WP392/id3206f739
  • WikiPathways:WP392

    Source assertion: GPML id50af4865 connects normalized CHEBI:15378 as an input of interaction id3206f739.

    Source location/Pathway/Interaction[@GraphId='id50af4865']/Graphics; /Pathway/DataNode[@GraphId='efa82']
H2O2
CHEBI:16240		consumes

Direction resolved from the source pathway redox description, not an unheaded line alone.

glutathione to glutathione disulfide GPML interaction
WikiPathways:WP392/idb13bbbe
  • WikiPathways:WP392

    Source assertion: GPML id3cdb2e84 connects normalized CHEBI:16240 as an input of interaction idb13bbbe.

    Source location/Pathway/Interaction[@GraphId='id3cdb2e84']/Graphics; /Pathway/DataNode[@GraphId='d804d']
GLR1
SGD:S000006012		has_cofactor

UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:17554778) Binds 1 FAD per subunit. UniProt note evidence: ECO:0000269 (PubMed:17554778)

FAD(3-)
CHEBI:57692
  • UniProtKB:P41921

    Source assertion: UniProtKB:P41921 annotates CHEBI:57692 as a cofactor of this protein.

    Source locationhttps://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1831/comments/0/cofactors/0; /results/1831/comments/0/note
  • UniProtKB:P41921

    Source assertion: UniProtKB:P41921 has the exact SGD cross-reference SGD:S000006012.

    Source locationhttps://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1831/uniProtKBCrossReferences/0

References

Curation history