Peptidoglycan cytoplasmic synthesis and recycling pathways

WikiPathways:WP5060

Peptidoglycan cytoplasmic synthesis and recycling in Escherichia coli links UDP-GlcNAc, UDP-MurNAc peptide intermediates, lipid II, peptidoglycan, and anhydro-N-acetylmuramate recycling reactions in the WP5060 GPML diagram.

Pathway type

cell wall biosynthesis

Organism scope

Escherichia coli NCBITaxon:562

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Pathway network

109 nodes · 127 asserted directed edges

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Escherichia coli `NCBITaxon:562`	taxon
anhMurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala `WikiPathways:WP5060/a45c7`	small molecule
D-alanine `CHEBI:15570`	small molecule
glmS `UniProtKB:P17169`	protein
glmU `UniProtKB:P0ACC7`	protein
glutamine `CHEBI:28300`	small molecule
L-Ala-gamma-D-Glu-meso-DAP-D-Ala `WikiPathways:WP5060/de8b0`	small molecule
glmM `UniProtKB:P31120`	protein
murF `UniProtKB:P11880`	protein
D-glucosamine-6-phosphate `CHEBI:20995`	small molecule
UDP-N-acetylmuramoyl-L-alanine `CHEBI:16932`	small molecule
L-glutamate `CHEBI:29985`	small molecule
D-Ala-D-Ala `CHEBI:16576`	small molecule
meso-2,6-diaminopimelic acid `CHEBI:16488`	small molecule
Penicillin-binding protein 1C `UniProtKB:P76577`	protein
L-alanine `CHEBI:16977`	small molecule
Penicillin-binding protein 1B `UniProtKB:P02919`	protein
Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine `CHEBI:28138`	small molecule
UTP `CHEBI:46398`	small molecule
Undecaprenyl phosphate `CHEBI:16141`	small molecule
Glucosamine-1P `CHEBI:174383`	small molecule
undecaprenyldiphospho-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine `CHEBI:61543`	small molecule
UDP-MurNAc-L-Ala-D-Glu `CHEBI:16970`	small molecule
Undecaprenyl pyrophosphate `CHEBI:17047`	small molecule
Fructose-6-phosphate `CHEBI:15946`	small molecule
D-glutamate `CHEBI:29986`	small molecule
UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP `CHEBI:28639`	small molecule
UDP-GlcNAc `CHEBI:16264`	small molecule
UDP-MurNAc `CHEBI:70765`	small molecule
Undecaprenyl-diphosphatase `UniProtKB:P60932`	protein
UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala-D-Ala `CHEBI:18199`	small molecule
Penicillin-binding protein 1A `UniProtKB:P02918`	protein
phosphoenolpyruvate `CHEBI:58702`	small molecule
UDP-GlcNAc-enolpyruvate `CHEBI:68483`	small molecule
NADPH `CHEBI:16474`	small molecule
N-acetylglucosamine-1-phosphate `CHEBI:16446`	small molecule
Peptidoglycan Layer `CHEBI:8005`	small molecule
acetyl-CoA `CHEBI:15351`	small molecule
N-acetyl-D-glucosamine 6-phosphate `CHEBI:15784`	small molecule
MurNAc 6-phosphate `CHEBI:47968`	small molecule
GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala `WikiPathways:WP5060/e9564`	small molecule
N-acetylmuramic acid `CHEBI:47965`	small molecule
Penicillin-binding protein 2 (Peptidoglycan D,D-transpeptidase MrdA) `UniProtKB:Q2TL65`	protein
Penicillin-binding protein 3 (Peptidoglycan D,D-transpeptidase FtsI) `UniProtKB:P0AD68`	protein
murE `UniProtKB:P22188`	protein
murD `UniProtKB:P14900`	protein
murC `UniProtKB:P17952`	protein
murB `UniProtKB:P08373`	protein
murA `UniProtKB:P0A749`	protein
murG `UniProtKB:P17443`	protein
mraY `UniProtKB:P0A6W3`	protein
ddlB `UniProtKB:P07862`	protein
dadX `UniProtKB:P29012`	protein
alr `UniProtKB:P0A6B4`	protein
murI `UniProtKB:P22634`	protein
ampG `UniProtKB:P0AE16`	protein
mpl `UniProtKB:P37773`	protein
murJ `UniProtKB:P0AF16`	protein
ftsW `UniProtKB:P0ABG4`	protein
mtgA `UniProtKB:P46022`	protein
murP `UniProtKB:P77272`	protein
anmK `UniProtKB:P77570`	protein
murQ `UniProtKB:P76535`	protein
nagA `UniProtKB:P0AF18`	protein
nagB `UniProtKB:P0A759`	protein
nagK `UniProtKB:P75959`	protein
1,6-anhMurNAc `CHEBI:40666`	small molecule
nagZ `UniProtKB:P75949`	protein
GlcNAc `CHEBI:506227`	small molecule
1,6-anhydro-N-acetylmuramyl-L-alanine amidase (AmpD) `UniProtKB:P13016`	protein
L-alanyl-gamma-D-glutamyl-meso-diaminopimelic acid `CHEBI:61564`	small molecule
Murein tetrapeptide carboxypeptidase (LdcA) `UniProtKB:P76008`	protein
magnesium(2+) `CHEBI:18420`	cofactor
cobalt(2+) `CHEBI:48828`	cofactor
FAD(3-) `CHEBI:57692`	cofactor
manganese(2+) `CHEBI:29035`	cofactor
pyridoxal 5'-phosphate(2-) `CHEBI:597326`	cofactor
zinc(2+) `CHEBI:29105`	cofactor
cadmium(2+) `CHEBI:48775`	cofactor
iron(2+) `CHEBI:29033`	cofactor
nickel(2+) `CHEBI:49786`	cofactor
D-glucosamine-6-phosphate to Fructose-6-phosphate GPML interaction `WikiPathways:WP5060/ac9d2`	molecular activity	left to right
UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala-D-Ala to UND-PP-MurNAc-L-Ala-D-Glu-meso-DAP-D-Ala-D-Ala GPML interaction `WikiPathways:WP5060/adda4`	molecular activity	left to right
Fructose-6-phosphate to D-glucosamine-6-phosphate GPML interaction `WikiPathways:WP5060/af0e7`	molecular activity	left to right
1,6-anhMurNAc to MurNAc 6-phosphate GPML interaction `WikiPathways:WP5060/af315`	molecular activity	left to right
WP5060 b423c GPML interaction `WikiPathways:WP5060/b423c`	molecular activity	left to right
WP5060 b5af5 GPML interaction `WikiPathways:WP5060/b5af5`	molecular activity	left to right
UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP to UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala-D-Ala GPML interaction `WikiPathways:WP5060/b8180`	molecular activity	left to right
UDP-GlcNAc-enolpyruvate to UDP-MurNAc GPML interaction `WikiPathways:WP5060/b8d40`	molecular activity	left to right
Glucosamine-1P to N-acetylglucosamine-1-phosphate GPML interaction `WikiPathways:WP5060/bcf55`	molecular activity	left to right
GlcNAc to GlcNAc-6-P GPML interaction `WikiPathways:WP5060/c0f79`	molecular activity	left to right
GlcNAc-6-P to D-glucosamine-6-phosphate GPML interaction `WikiPathways:WP5060/c131c`	molecular activity	left to right
D-alanine to D-Ala-D-Ala GPML interaction `WikiPathways:WP5060/cdc0a`	molecular activity	left to right
UDP-MurNAc to UDP-MurNAc-L-Ala GPML interaction `WikiPathways:WP5060/d013c`	molecular activity	left to right
L-glutamate to D-glutamate GPML interaction `WikiPathways:WP5060/d5182`	molecular activity	reversible
Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine to Peptidoglycan Layer GPML interaction `WikiPathways:WP5060/d89b1`	molecular activity	left to right
UDP-GlcNAc to UDP-GlcNAc-enolpyruvate GPML interaction `WikiPathways:WP5060/e2f23`	molecular activity	left to right
L-Ala-gamma-D-Glu-meso-DAP to UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP GPML interaction `WikiPathways:WP5060/e8b23`	molecular activity	left to right
MurNAc to MurNAc 6-phosphate GPML interaction `WikiPathways:WP5060/eab24`	molecular activity	left to right
UDP-MurNAc-L-Ala to UDP-MurNAc-L-Ala-D-Glu GPML interaction `WikiPathways:WP5060/eb85c`	molecular activity	left to right
D-glucosamine-6-phosphate to Glucosamine-1P GPML interaction `WikiPathways:WP5060/ebc50`	molecular activity	reversible
UDP-MurNAc-L-Ala-D-Glu to UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP GPML interaction `WikiPathways:WP5060/eff80`	molecular activity	left to right
Peptidoglycan Layer to GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala GPML interaction `WikiPathways:WP5060/f4fde`	molecular activity	left to right
UND-PP-MurNAc-L-Ala-D-Glu-meso-DAP-D-Ala-D-Ala to Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine GPML interaction `WikiPathways:WP5060/f53c7`	molecular activity	left to right
N-acetylglucosamine-1-phosphate to UDP-GlcNAc GPML interaction `WikiPathways:WP5060/f628a`	molecular activity	left to right
Undecaprenyl pyrophosphate to Undecaprenyl phosphate GPML interaction `WikiPathways:WP5060/fb09e`	molecular activity	left to right
WP5060 ffa50 GPML interaction `WikiPathways:WP5060/ffa50`	molecular activity	left to right
L-alanine to D-alanine GPML interaction `WikiPathways:WP5060/id535c37a4`	molecular activity	reversible
anhMurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala to 1,6-anhMurNAc GPML interaction `WikiPathways:WP5060/id92720196`	molecular activity	left to right
MurNAc 6-phosphate to GlcNAc-6-P GPML interaction `WikiPathways:WP5060/idb435b98e`	molecular activity	left to right

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
D-glucosamine-6-phosphate `CHEBI:20995`	consumes	D-glucosamine-6-phosphate to Fructose-6-phosphate GPML interaction `WikiPathways:WP5060/ac9d2`	WikiPathways:WP5060 Source assertion: GPML ac9d2 connects normalized CHEBI:20995 as an input of interaction ac9d2. Source location `/Pathway/Interaction[@GraphId='ac9d2']/Graphics; /Pathway/DataNode[@GraphId='a5f2a']`
D-glucosamine-6-phosphate to Fructose-6-phosphate GPML interaction `WikiPathways:WP5060/ac9d2`	produces	Fructose-6-phosphate `CHEBI:15946`	WikiPathways:WP5060 Source assertion: GPML ac9d2 connects normalized CHEBI:15946 as an output of interaction ac9d2. Source location `/Pathway/Interaction[@GraphId='ac9d2']/Graphics; /Pathway/DataNode[@GraphId='e83ae']`
UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala-D-Ala `CHEBI:18199`	consumes	UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala-D-Ala to UND-PP-MurNAc-L-Ala-D-Glu-meso-DAP-D-Ala-D-Ala GPML interaction `WikiPathways:WP5060/adda4`	WikiPathways:WP5060 Source assertion: GPML adda4 connects normalized CHEBI:18199 as an input of interaction adda4. Source location `/Pathway/Interaction[@GraphId='adda4']/Graphics; /Pathway/DataNode[@GraphId='e7be7']`
UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala-D-Ala to UND-PP-MurNAc-L-Ala-D-Glu-meso-DAP-D-Ala-D-Ala GPML interaction `WikiPathways:WP5060/adda4`	produces	undecaprenyldiphospho-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine `CHEBI:61543`	WikiPathways:WP5060 Source assertion: GPML adda4 connects normalized CHEBI:61543 as an output of interaction adda4. Source location `/Pathway/Interaction[@GraphId='adda4']/Graphics; /Pathway/DataNode[@GraphId='b5141']`
Fructose-6-phosphate `CHEBI:15946`	consumes	Fructose-6-phosphate to D-glucosamine-6-phosphate GPML interaction `WikiPathways:WP5060/af0e7`	WikiPathways:WP5060 Source assertion: GPML af0e7 connects normalized CHEBI:15946 as an input of interaction af0e7. Source location `/Pathway/Interaction[@GraphId='af0e7']/Graphics; /Pathway/DataNode[@GraphId='e83ae']`
Fructose-6-phosphate to D-glucosamine-6-phosphate GPML interaction `WikiPathways:WP5060/af0e7`	produces	D-glucosamine-6-phosphate `CHEBI:20995`	WikiPathways:WP5060 Source assertion: GPML af0e7 connects normalized CHEBI:20995 as an output of interaction af0e7. Source location `/Pathway/Interaction[@GraphId='af0e7']/Graphics; /Pathway/DataNode[@GraphId='a5f2a']`
1,6-anhMurNAc `CHEBI:40666`	consumes	1,6-anhMurNAc to MurNAc 6-phosphate GPML interaction `WikiPathways:WP5060/af315`	WikiPathways:WP5060 Source assertion: GPML af315 connects normalized CHEBI:40666 as an input of interaction af315. Source location `/Pathway/Interaction[@GraphId='af315']/Graphics; /Pathway/DataNode[@GraphId='a8855']`
1,6-anhMurNAc to MurNAc 6-phosphate GPML interaction `WikiPathways:WP5060/af315`	produces	MurNAc 6-phosphate `CHEBI:47968`	WikiPathways:WP5060 Source assertion: GPML af315 connects normalized CHEBI:47968 as an output of interaction af315. Source location `/Pathway/Interaction[@GraphId='af315']/Graphics; /Pathway/DataNode[@GraphId='f14a1']`
L-Ala-gamma-D-Glu-meso-DAP-D-Ala `WikiPathways:WP5060/de8b0`	consumes	WP5060 b423c GPML interaction `WikiPathways:WP5060/b423c`	WikiPathways:WP5060 Source assertion: GPML b423c connects normalized WikiPathways:WP5060/de8b0 as an input of interaction b423c. Source location `/Pathway/Interaction[@GraphId='b423c']/Graphics; /Pathway/DataNode[@GraphId='de8b0']`
WP5060 b423c GPML interaction `WikiPathways:WP5060/b423c`	produces	L-alanyl-gamma-D-glutamyl-meso-diaminopimelic acid `CHEBI:61564`	WikiPathways:WP5060 Source assertion: GPML b423c connects normalized CHEBI:61564 as an output of interaction b423c. Source location `/Pathway/Interaction[@GraphId='b423c']/Graphics; /Pathway/DataNode[@GraphId='ed65e']`
GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala `WikiPathways:WP5060/e9564`	consumes	WP5060 b5af5 GPML interaction `WikiPathways:WP5060/b5af5`	WikiPathways:WP5060 Source assertion: GPML b5af5 connects normalized WikiPathways:WP5060/e9564 as an input of interaction b5af5. Source location `/Pathway/Interaction[@GraphId='b5af5']/Graphics; /Pathway/DataNode[@GraphId='e9564']`
WP5060 b5af5 GPML interaction `WikiPathways:WP5060/b5af5`	produces	GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala `WikiPathways:WP5060/e9564`	WikiPathways:WP5060 Source assertion: GPML b5af5 connects normalized WikiPathways:WP5060/e9564 as an output of interaction b5af5. Source location `/Pathway/Interaction[@GraphId='b5af5']/Graphics; /Pathway/DataNode[@GraphId='c345c']`
UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP `CHEBI:28639`	consumes	UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP to UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala-D-Ala GPML interaction `WikiPathways:WP5060/b8180`	WikiPathways:WP5060 Source assertion: GPML b8180 connects normalized CHEBI:28639 as an input of interaction b8180. Source location `/Pathway/Interaction[@GraphId='b8180']/Graphics; /Pathway/DataNode[@GraphId='c0dd7']`
UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP to UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala-D-Ala GPML interaction `WikiPathways:WP5060/b8180`	produces	UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala-D-Ala `CHEBI:18199`	WikiPathways:WP5060 Source assertion: GPML b8180 connects normalized CHEBI:18199 as an output of interaction b8180. Source location `/Pathway/Interaction[@GraphId='b8180']/Graphics; /Pathway/DataNode[@GraphId='e7be7']`
UDP-GlcNAc-enolpyruvate `CHEBI:68483`	consumes	UDP-GlcNAc-enolpyruvate to UDP-MurNAc GPML interaction `WikiPathways:WP5060/b8d40`	WikiPathways:WP5060 Source assertion: GPML b8d40 connects normalized CHEBI:68483 as an input of interaction b8d40. Source location `/Pathway/Interaction[@GraphId='b8d40']/Graphics; /Pathway/DataNode[@GraphId='c4246']`
UDP-GlcNAc-enolpyruvate to UDP-MurNAc GPML interaction `WikiPathways:WP5060/b8d40`	produces	UDP-MurNAc `CHEBI:70765`	WikiPathways:WP5060 Source assertion: GPML b8d40 connects normalized CHEBI:70765 as an output of interaction b8d40. Source location `/Pathway/Interaction[@GraphId='b8d40']/Graphics; /Pathway/DataNode[@GraphId='db31c']`
Glucosamine-1P `CHEBI:174383`	consumes	Glucosamine-1P to N-acetylglucosamine-1-phosphate GPML interaction `WikiPathways:WP5060/bcf55`	WikiPathways:WP5060 Source assertion: GPML bcf55 connects normalized CHEBI:174383 as an input of interaction bcf55. Source location `/Pathway/Interaction[@GraphId='bcf55']/Graphics; /Pathway/DataNode[@GraphId='e2e4d']`
Glucosamine-1P to N-acetylglucosamine-1-phosphate GPML interaction `WikiPathways:WP5060/bcf55`	produces	N-acetylglucosamine-1-phosphate `CHEBI:16446`	WikiPathways:WP5060 Source assertion: GPML bcf55 connects normalized CHEBI:16446 as an output of interaction bcf55. Source location `/Pathway/Interaction[@GraphId='bcf55']/Graphics; /Pathway/DataNode[@GraphId='e0ff9']`
GlcNAc `CHEBI:506227`	consumes	GlcNAc to GlcNAc-6-P GPML interaction `WikiPathways:WP5060/c0f79`	WikiPathways:WP5060 Source assertion: GPML c0f79 connects normalized CHEBI:506227 as an input of interaction c0f79. Source location `/Pathway/Interaction[@GraphId='c0f79']/Graphics; /Pathway/DataNode[@GraphId='c45e3']`
GlcNAc to GlcNAc-6-P GPML interaction `WikiPathways:WP5060/c0f79`	produces	N-acetyl-D-glucosamine 6-phosphate `CHEBI:15784`	WikiPathways:WP5060 Source assertion: GPML c0f79 connects normalized CHEBI:15784 as an output of interaction c0f79. Source location `/Pathway/Interaction[@GraphId='c0f79']/Graphics; /Pathway/DataNode[@GraphId='b0b99']`
N-acetyl-D-glucosamine 6-phosphate `CHEBI:15784`	consumes	GlcNAc-6-P to D-glucosamine-6-phosphate GPML interaction `WikiPathways:WP5060/c131c`	WikiPathways:WP5060 Source assertion: GPML c131c connects normalized CHEBI:15784 as an input of interaction c131c. Source location `/Pathway/Interaction[@GraphId='c131c']/Graphics; /Pathway/DataNode[@GraphId='b0b99']`
GlcNAc-6-P to D-glucosamine-6-phosphate GPML interaction `WikiPathways:WP5060/c131c`	produces	D-glucosamine-6-phosphate `CHEBI:20995`	WikiPathways:WP5060 Source assertion: GPML c131c connects normalized CHEBI:20995 as an output of interaction c131c. Source location `/Pathway/Interaction[@GraphId='c131c']/Graphics; /Pathway/DataNode[@GraphId='a5f2a']`
D-alanine `CHEBI:15570`	consumes	D-alanine to D-Ala-D-Ala GPML interaction `WikiPathways:WP5060/cdc0a`	WikiPathways:WP5060 Source assertion: GPML cdc0a connects normalized CHEBI:15570 as an input of interaction cdc0a. Source location `/Pathway/Interaction[@GraphId='cdc0a']/Graphics; /Pathway/DataNode[@GraphId='ce380']`
D-alanine to D-Ala-D-Ala GPML interaction `WikiPathways:WP5060/cdc0a`	produces	D-Ala-D-Ala `CHEBI:16576`	WikiPathways:WP5060 Source assertion: GPML cdc0a connects normalized CHEBI:16576 as an output of interaction cdc0a. Source location `/Pathway/Interaction[@GraphId='cdc0a']/Graphics; /Pathway/DataNode[@GraphId='abc1f']`
UDP-MurNAc `CHEBI:70765`	consumes	UDP-MurNAc to UDP-MurNAc-L-Ala GPML interaction `WikiPathways:WP5060/d013c`	WikiPathways:WP5060 Source assertion: GPML d013c connects normalized CHEBI:70765 as an input of interaction d013c. Source location `/Pathway/Interaction[@GraphId='d013c']/Graphics; /Pathway/DataNode[@GraphId='db31c']`
UDP-MurNAc to UDP-MurNAc-L-Ala GPML interaction `WikiPathways:WP5060/d013c`	produces	UDP-N-acetylmuramoyl-L-alanine `CHEBI:16932`	WikiPathways:WP5060 Source assertion: GPML d013c connects normalized CHEBI:16932 as an output of interaction d013c. Source location `/Pathway/Interaction[@GraphId='d013c']/Graphics; /Pathway/DataNode[@GraphId='a6683']`
L-glutamate `CHEBI:29985`	consumes The source has arrowheads on both endpoints; the displayed orientation is one direction of a reversible conversion.	L-glutamate to D-glutamate GPML interaction `WikiPathways:WP5060/d5182`	WikiPathways:WP5060 Source assertion: GPML d5182 connects normalized CHEBI:29985 as an input of interaction d5182. Source location `/Pathway/Interaction[@GraphId='d5182']/Graphics; /Pathway/DataNode[@GraphId='ff05c']`
L-glutamate to D-glutamate GPML interaction `WikiPathways:WP5060/d5182`	produces The source has arrowheads on both endpoints; the displayed orientation is one direction of a reversible conversion.	D-glutamate `CHEBI:29986`	WikiPathways:WP5060 Source assertion: GPML d5182 connects normalized CHEBI:29986 as an output of interaction d5182. Source location `/Pathway/Interaction[@GraphId='d5182']/Graphics; /Pathway/DataNode[@GraphId='b18c7']`
Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine `CHEBI:28138`	consumes	Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine to Peptidoglycan Layer GPML interaction `WikiPathways:WP5060/d89b1`	WikiPathways:WP5060 Source assertion: GPML d89b1 connects normalized CHEBI:28138 as an input of interaction d89b1. Source location `/Pathway/Interaction[@GraphId='d89b1']/Graphics; /Pathway/DataNode[@GraphId='d1db8']`
Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine to Peptidoglycan Layer GPML interaction `WikiPathways:WP5060/d89b1`	produces	Peptidoglycan Layer `CHEBI:8005`	WikiPathways:WP5060 Source assertion: GPML d89b1 connects normalized CHEBI:8005 as an output of interaction d89b1. Source location `/Pathway/Interaction[@GraphId='d89b1']/Graphics; /Pathway/DataNode[@GraphId='b806f']`
UDP-GlcNAc `CHEBI:16264`	consumes	UDP-GlcNAc to UDP-GlcNAc-enolpyruvate GPML interaction `WikiPathways:WP5060/e2f23`	WikiPathways:WP5060 Source assertion: GPML e2f23 connects normalized CHEBI:16264 as an input of interaction e2f23. Source location `/Pathway/Interaction[@GraphId='e2f23']/Graphics; /Pathway/DataNode[@GraphId='b6d47']`
UDP-GlcNAc to UDP-GlcNAc-enolpyruvate GPML interaction `WikiPathways:WP5060/e2f23`	produces	UDP-GlcNAc-enolpyruvate `CHEBI:68483`	WikiPathways:WP5060 Source assertion: GPML e2f23 connects normalized CHEBI:68483 as an output of interaction e2f23. Source location `/Pathway/Interaction[@GraphId='e2f23']/Graphics; /Pathway/DataNode[@GraphId='c4246']`
L-alanyl-gamma-D-glutamyl-meso-diaminopimelic acid `CHEBI:61564`	consumes	L-Ala-gamma-D-Glu-meso-DAP to UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP GPML interaction `WikiPathways:WP5060/e8b23`	WikiPathways:WP5060 Source assertion: GPML e8b23 connects normalized CHEBI:61564 as an input of interaction e8b23. Source location `/Pathway/Interaction[@GraphId='e8b23']/Graphics; /Pathway/DataNode[@GraphId='ed65e']`
L-Ala-gamma-D-Glu-meso-DAP to UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP GPML interaction `WikiPathways:WP5060/e8b23`	produces	UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP `CHEBI:28639`	WikiPathways:WP5060 Source assertion: GPML e8b23 connects normalized CHEBI:28639 as an output of interaction e8b23. Source location `/Pathway/Interaction[@GraphId='e8b23']/Graphics; /Pathway/DataNode[@GraphId='c0dd7']`
N-acetylmuramic acid `CHEBI:47965`	consumes	MurNAc to MurNAc 6-phosphate GPML interaction `WikiPathways:WP5060/eab24`	WikiPathways:WP5060 Source assertion: GPML eab24 connects normalized CHEBI:47965 as an input of interaction eab24. Source location `/Pathway/Interaction[@GraphId='eab24']/Graphics; /Pathway/DataNode[@GraphId='a0d71']`
MurNAc to MurNAc 6-phosphate GPML interaction `WikiPathways:WP5060/eab24`	produces	MurNAc 6-phosphate `CHEBI:47968`	WikiPathways:WP5060 Source assertion: GPML eab24 connects normalized CHEBI:47968 as an output of interaction eab24. Source location `/Pathway/Interaction[@GraphId='eab24']/Graphics; /Pathway/DataNode[@GraphId='f14a1']`
UDP-N-acetylmuramoyl-L-alanine `CHEBI:16932`	consumes	UDP-MurNAc-L-Ala to UDP-MurNAc-L-Ala-D-Glu GPML interaction `WikiPathways:WP5060/eb85c`	WikiPathways:WP5060 Source assertion: GPML eb85c connects normalized CHEBI:16932 as an input of interaction eb85c. Source location `/Pathway/Interaction[@GraphId='eb85c']/Graphics; /Pathway/DataNode[@GraphId='a6683']`
UDP-MurNAc-L-Ala to UDP-MurNAc-L-Ala-D-Glu GPML interaction `WikiPathways:WP5060/eb85c`	produces	UDP-MurNAc-L-Ala-D-Glu `CHEBI:16970`	WikiPathways:WP5060 Source assertion: GPML eb85c connects normalized CHEBI:16970 as an output of interaction eb85c. Source location `/Pathway/Interaction[@GraphId='eb85c']/Graphics; /Pathway/DataNode[@GraphId='b2fd6']`
D-glucosamine-6-phosphate `CHEBI:20995`	consumes The source has arrowheads on both endpoints; the displayed orientation is one direction of a reversible conversion.	D-glucosamine-6-phosphate to Glucosamine-1P GPML interaction `WikiPathways:WP5060/ebc50`	WikiPathways:WP5060 Source assertion: GPML ebc50 connects normalized CHEBI:20995 as an input of interaction ebc50. Source location `/Pathway/Interaction[@GraphId='ebc50']/Graphics; /Pathway/DataNode[@GraphId='a5f2a']`
D-glucosamine-6-phosphate to Glucosamine-1P GPML interaction `WikiPathways:WP5060/ebc50`	produces The source has arrowheads on both endpoints; the displayed orientation is one direction of a reversible conversion.	Glucosamine-1P `CHEBI:174383`	WikiPathways:WP5060 Source assertion: GPML ebc50 connects normalized CHEBI:174383 as an output of interaction ebc50. Source location `/Pathway/Interaction[@GraphId='ebc50']/Graphics; /Pathway/DataNode[@GraphId='e2e4d']`
UDP-MurNAc-L-Ala-D-Glu `CHEBI:16970`	consumes	UDP-MurNAc-L-Ala-D-Glu to UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP GPML interaction `WikiPathways:WP5060/eff80`	WikiPathways:WP5060 Source assertion: GPML eff80 connects normalized CHEBI:16970 as an input of interaction eff80. Source location `/Pathway/Interaction[@GraphId='eff80']/Graphics; /Pathway/DataNode[@GraphId='b2fd6']`
UDP-MurNAc-L-Ala-D-Glu to UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP GPML interaction `WikiPathways:WP5060/eff80`	produces	UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP `CHEBI:28639`	WikiPathways:WP5060 Source assertion: GPML eff80 connects normalized CHEBI:28639 as an output of interaction eff80. Source location `/Pathway/Interaction[@GraphId='eff80']/Graphics; /Pathway/DataNode[@GraphId='c0dd7']`
Peptidoglycan Layer `CHEBI:8005`	consumes	Peptidoglycan Layer to GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala GPML interaction `WikiPathways:WP5060/f4fde`	WikiPathways:WP5060 Source assertion: GPML f4fde connects normalized CHEBI:8005 as an input of interaction f4fde. Source location `/Pathway/Interaction[@GraphId='f4fde']/Graphics; /Pathway/DataNode[@GraphId='b806f']`
Peptidoglycan Layer to GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala GPML interaction `WikiPathways:WP5060/f4fde`	produces	GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala `WikiPathways:WP5060/e9564`	WikiPathways:WP5060 Source assertion: GPML f4fde connects normalized WikiPathways:WP5060/e9564 as an output of interaction f4fde. Source location `/Pathway/Interaction[@GraphId='f4fde']/Graphics; /Pathway/DataNode[@GraphId='e9564']`
undecaprenyldiphospho-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine `CHEBI:61543`	consumes	UND-PP-MurNAc-L-Ala-D-Glu-meso-DAP-D-Ala-D-Ala to Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine GPML interaction `WikiPathways:WP5060/f53c7`	WikiPathways:WP5060 Source assertion: GPML f53c7 connects normalized CHEBI:61543 as an input of interaction f53c7. Source location `/Pathway/Interaction[@GraphId='f53c7']/Graphics; /Pathway/DataNode[@GraphId='b5141']`
UND-PP-MurNAc-L-Ala-D-Glu-meso-DAP-D-Ala-D-Ala to Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine GPML interaction `WikiPathways:WP5060/f53c7`	produces	Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine `CHEBI:28138`	WikiPathways:WP5060 Source assertion: GPML f53c7 connects normalized CHEBI:28138 as an output of interaction f53c7. Source location `/Pathway/Interaction[@GraphId='f53c7']/Graphics; /Pathway/DataNode[@GraphId='d1db8']`
N-acetylglucosamine-1-phosphate `CHEBI:16446`	consumes	N-acetylglucosamine-1-phosphate to UDP-GlcNAc GPML interaction `WikiPathways:WP5060/f628a`	WikiPathways:WP5060 Source assertion: GPML f628a connects normalized CHEBI:16446 as an input of interaction f628a. Source location `/Pathway/Interaction[@GraphId='f628a']/Graphics; /Pathway/DataNode[@GraphId='e0ff9']`
N-acetylglucosamine-1-phosphate to UDP-GlcNAc GPML interaction `WikiPathways:WP5060/f628a`	produces	UDP-GlcNAc `CHEBI:16264`	WikiPathways:WP5060 Source assertion: GPML f628a connects normalized CHEBI:16264 as an output of interaction f628a. Source location `/Pathway/Interaction[@GraphId='f628a']/Graphics; /Pathway/DataNode[@GraphId='b6d47']`
Undecaprenyl pyrophosphate `CHEBI:17047`	consumes	Undecaprenyl pyrophosphate to Undecaprenyl phosphate GPML interaction `WikiPathways:WP5060/fb09e`	WikiPathways:WP5060 Source assertion: GPML fb09e connects normalized CHEBI:17047 as an input of interaction fb09e. Source location `/Pathway/Interaction[@GraphId='fb09e']/Graphics; /Pathway/DataNode[@GraphId='ebd59']`
Undecaprenyl pyrophosphate to Undecaprenyl phosphate GPML interaction `WikiPathways:WP5060/fb09e`	produces	Undecaprenyl phosphate `CHEBI:16141`	WikiPathways:WP5060 Source assertion: GPML fb09e connects normalized CHEBI:16141 as an output of interaction fb09e. Source location `/Pathway/Interaction[@GraphId='fb09e']/Graphics; /Pathway/DataNode[@GraphId='fb1b0']`
GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala `WikiPathways:WP5060/e9564`	consumes	WP5060 ffa50 GPML interaction `WikiPathways:WP5060/ffa50`	WikiPathways:WP5060 Source assertion: GPML ffa50 connects normalized WikiPathways:WP5060/e9564 as an input of interaction ffa50. Source location `/Pathway/Interaction[@GraphId='ffa50']/Graphics; /Pathway/DataNode[@GraphId='c345c']`
WP5060 ffa50 GPML interaction `WikiPathways:WP5060/ffa50`	produces	anhMurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala `WikiPathways:WP5060/a45c7`	WikiPathways:WP5060 Source assertion: GPML ffa50 connects normalized WikiPathways:WP5060/a45c7 as an output of interaction ffa50. Source location `/Pathway/Interaction[@GraphId='ffa50']/Graphics; /Pathway/DataNode[@GraphId='a45c7']`
L-alanine `CHEBI:16977`	consumes The source has arrowheads on both endpoints; the displayed orientation is one direction of a reversible conversion.	L-alanine to D-alanine GPML interaction `WikiPathways:WP5060/id535c37a4`	WikiPathways:WP5060 Source assertion: GPML id535c37a4 connects normalized CHEBI:16977 as an input of interaction id535c37a4. Source location `/Pathway/Interaction[@GraphId='id535c37a4']/Graphics; /Pathway/DataNode[@GraphId='eb48f']`
L-alanine to D-alanine GPML interaction `WikiPathways:WP5060/id535c37a4`	produces The source has arrowheads on both endpoints; the displayed orientation is one direction of a reversible conversion.	D-alanine `CHEBI:15570`	WikiPathways:WP5060 Source assertion: GPML id535c37a4 connects normalized CHEBI:15570 as an output of interaction id535c37a4. Source location `/Pathway/Interaction[@GraphId='id535c37a4']/Graphics; /Pathway/DataNode[@GraphId='ce380']`
anhMurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala `WikiPathways:WP5060/a45c7`	consumes	anhMurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala to 1,6-anhMurNAc GPML interaction `WikiPathways:WP5060/id92720196`	WikiPathways:WP5060 Source assertion: GPML id92720196 connects normalized WikiPathways:WP5060/a45c7 as an input of interaction id92720196. Source location `/Pathway/Interaction[@GraphId='id92720196']/Graphics; /Pathway/DataNode[@GraphId='a45c7']`
anhMurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala to 1,6-anhMurNAc GPML interaction `WikiPathways:WP5060/id92720196`	produces	1,6-anhMurNAc `CHEBI:40666`	WikiPathways:WP5060 Source assertion: GPML id92720196 connects normalized CHEBI:40666 as an output of interaction id92720196. Source location `/Pathway/Interaction[@GraphId='id92720196']/Graphics; /Pathway/DataNode[@GraphId='a8855']`
MurNAc 6-phosphate `CHEBI:47968`	consumes	MurNAc 6-phosphate to GlcNAc-6-P GPML interaction `WikiPathways:WP5060/idb435b98e`	WikiPathways:WP5060 Source assertion: GPML idb435b98e connects normalized CHEBI:47968 as an input of interaction idb435b98e. Source location `/Pathway/Interaction[@GraphId='idb435b98e']/Graphics; /Pathway/DataNode[@GraphId='f14a1']`
MurNAc 6-phosphate to GlcNAc-6-P GPML interaction `WikiPathways:WP5060/idb435b98e`	produces	N-acetyl-D-glucosamine 6-phosphate `CHEBI:15784`	WikiPathways:WP5060 Source assertion: GPML idb435b98e connects normalized CHEBI:15784 as an output of interaction idb435b98e. Source location `/Pathway/Interaction[@GraphId='idb435b98e']/Graphics; /Pathway/DataNode[@GraphId='b0b99']`
Murein tetrapeptide carboxypeptidase (LdcA) `UniProtKB:P76008`	catalyzes	WP5060 b423c GPML interaction `WikiPathways:WP5060/b423c`	WikiPathways:WP5060 Source assertion: GPML id366132eb connects normalized UniProtKB:P76008 as a catalyst of interaction b423c. Source location `/Pathway/Interaction[@GraphId='id366132eb']/Graphics; /Pathway/DataNode[@GraphId='fe081']`
alr `UniProtKB:P0A6B4`	catalyzes	L-alanine to D-alanine GPML interaction `WikiPathways:WP5060/id535c37a4`	WikiPathways:WP5060 Source assertion: GPML id486e1789 connects normalized UniProtKB:P0A6B4 as a catalyst of interaction id535c37a4. Source location `/Pathway/Interaction[@GraphId='id486e1789']/Graphics; /Pathway/DataNode[@GraphId='f66da']`
nagZ `UniProtKB:P75949`	catalyzes	WP5060 ffa50 GPML interaction `WikiPathways:WP5060/ffa50`	WikiPathways:WP5060 Source assertion: GPML id5e9b20de connects normalized UniProtKB:P75949 as a catalyst of interaction ffa50. Source location `/Pathway/Interaction[@GraphId='id5e9b20de']/Graphics; /Pathway/DataNode[@GraphId='a415b']`
anhMurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala to 1,6-anhMurNAc GPML interaction `WikiPathways:WP5060/id92720196`	produces	L-Ala-gamma-D-Glu-meso-DAP-D-Ala `WikiPathways:WP5060/de8b0`	WikiPathways:WP5060 Source assertion: GPML id61d3aad3 connects normalized WikiPathways:WP5060/de8b0 as an output of interaction id92720196. Source location `/Pathway/Interaction[@GraphId='id61d3aad3']/Graphics; /Pathway/DataNode[@GraphId='de8b0']`
1,6-anhydro-N-acetylmuramyl-L-alanine amidase (AmpD) `UniProtKB:P13016`	catalyzes	anhMurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala to 1,6-anhMurNAc GPML interaction `WikiPathways:WP5060/id92720196`	WikiPathways:WP5060 Source assertion: GPML id62b52135 connects normalized UniProtKB:P13016 as a catalyst of interaction id92720196. Source location `/Pathway/Interaction[@GraphId='id62b52135']/Graphics; /Pathway/DataNode[@GraphId='d25a8']`
Penicillin-binding protein 2 (Peptidoglycan D,D-transpeptidase MrdA) `UniProtKB:Q2TL65`	catalyzes	Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine to Peptidoglycan Layer GPML interaction `WikiPathways:WP5060/d89b1`	WikiPathways:WP5060 Source assertion: GPML id95f5144b connects normalized UniProtKB:Q2TL65 as a catalyst of interaction d89b1. Source location `/Pathway/Interaction[@GraphId='id95f5144b']/Graphics; /Pathway/DataNode[@GraphId='cce2b']`
UDP-MurNAc `CHEBI:70765`	consumes	L-Ala-gamma-D-Glu-meso-DAP to UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP GPML interaction `WikiPathways:WP5060/e8b23`	WikiPathways:WP5060 Source assertion: GPML idb83aac52 connects normalized CHEBI:70765 as an input of interaction e8b23. Source location `/Pathway/Interaction[@GraphId='idb83aac52']/Graphics; /Pathway/DataNode[@GraphId='db31c']`
glutamine `CHEBI:28300`	consumes	Fructose-6-phosphate to D-glucosamine-6-phosphate GPML interaction `WikiPathways:WP5060/af0e7`	WikiPathways:WP5060 Source assertion: GPML idc67f0bc2 connects normalized CHEBI:28300 as an input of interaction af0e7. Source location `/Pathway/Interaction[@GraphId='idc67f0bc2']/Graphics; /Pathway/DataNode[@GraphId='d4cbd']`
WP5060 ffa50 GPML interaction `WikiPathways:WP5060/ffa50`	produces	GlcNAc `CHEBI:506227`	WikiPathways:WP5060 Source assertion: GPML idcd2e130d connects normalized CHEBI:506227 as an output of interaction ffa50. Source location `/Pathway/Interaction[@GraphId='idcd2e130d']/Graphics; /Pathway/DataNode[@GraphId='c45e3']`
Penicillin-binding protein 3 (Peptidoglycan D,D-transpeptidase FtsI) `UniProtKB:P0AD68`	catalyzes	Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine to Peptidoglycan Layer GPML interaction `WikiPathways:WP5060/d89b1`	WikiPathways:WP5060 Source assertion: GPML iddc402d25 connects normalized UniProtKB:P0AD68 as a catalyst of interaction d89b1. Source location `/Pathway/Interaction[@GraphId='iddc402d25']/Graphics; /Pathway/DataNode[@GraphId='d937f']`
glmS `UniProtKB:P17169`	catalyzes	Fructose-6-phosphate to D-glucosamine-6-phosphate GPML interaction `WikiPathways:WP5060/af0e7`	WikiPathways:WP5060 Source assertion: GPML a73c0 connects normalized UniProtKB:P17169 as a catalyst of interaction af0e7. Source location `/Pathway/Interaction[@GraphId='a73c0']/Graphics; /Pathway/DataNode[@GraphId='abfd4']`
mraY `UniProtKB:P0A6W3`	catalyzes	UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala-D-Ala to UND-PP-MurNAc-L-Ala-D-Glu-meso-DAP-D-Ala-D-Ala GPML interaction `WikiPathways:WP5060/adda4`	WikiPathways:WP5060 Source assertion: GPML e5322 connects normalized UniProtKB:P0A6W3 as a catalyst of interaction adda4. Source location `/Pathway/Interaction[@GraphId='e5322']/Graphics; /Pathway/DataNode[@GraphId='a7bb4']`
UTP `CHEBI:46398`	consumes	N-acetylglucosamine-1-phosphate to UDP-GlcNAc GPML interaction `WikiPathways:WP5060/f628a`	WikiPathways:WP5060 Source assertion: GPML e8fbc connects normalized CHEBI:46398 as an input of interaction f628a. Source location `/Pathway/Interaction[@GraphId='e8fbc']/Graphics; /Pathway/DataNode[@GraphId='b9b67']`
meso-2,6-diaminopimelic acid `CHEBI:16488`	consumes	UDP-MurNAc-L-Ala-D-Glu to UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP GPML interaction `WikiPathways:WP5060/eff80`	WikiPathways:WP5060 Source assertion: GPML eac8f connects normalized CHEBI:16488 as an input of interaction eff80. Source location `/Pathway/Interaction[@GraphId='eac8f']/Graphics; /Pathway/DataNode[@GraphId='eb5c4']`
L-alanine `CHEBI:16977`	consumes	UDP-MurNAc to UDP-MurNAc-L-Ala GPML interaction `WikiPathways:WP5060/d013c`	WikiPathways:WP5060 Source assertion: GPML d076f connects normalized CHEBI:16977 as an input of interaction d013c. Source location `/Pathway/Interaction[@GraphId='d076f']/Graphics; /Pathway/DataNode[@GraphId='f7d60']`
ddlB `UniProtKB:P07862`	catalyzes	D-alanine to D-Ala-D-Ala GPML interaction `WikiPathways:WP5060/cdc0a`	WikiPathways:WP5060 Source assertion: GPML e8b24 connects normalized UniProtKB:P07862 as a catalyst of interaction cdc0a. Source location `/Pathway/Interaction[@GraphId='e8b24']/Graphics; /Pathway/DataNode[@GraphId='ee00f']`
murJ `UniProtKB:P0AF16`	enables	Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine to Peptidoglycan Layer GPML interaction `WikiPathways:WP5060/d89b1`	WikiPathways:WP5060 Source assertion: GPML b80a0 connects normalized UniProtKB:P0AF16 as an enabling enzyme component of interaction d89b1. Source location `/Pathway/Interaction[@GraphId='b80a0']/Graphics; /Pathway/DataNode[@GraphId='c74ae']`
Undecaprenyl phosphate `CHEBI:16141`	consumes	UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala-D-Ala to UND-PP-MurNAc-L-Ala-D-Glu-meso-DAP-D-Ala-D-Ala GPML interaction `WikiPathways:WP5060/adda4`	WikiPathways:WP5060 Source assertion: GPML f27ff connects normalized CHEBI:16141 as an input of interaction adda4. Source location `/Pathway/Interaction[@GraphId='f27ff']/Graphics; /Pathway/DataNode[@GraphId='fb1b0']`
Penicillin-binding protein 1A `UniProtKB:P02918`	catalyzes	Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine to Peptidoglycan Layer GPML interaction `WikiPathways:WP5060/d89b1`	WikiPathways:WP5060 Source assertion: GPML eaf5c connects normalized UniProtKB:P02918 as a catalyst of interaction d89b1. Source location `/Pathway/Interaction[@GraphId='eaf5c']/Graphics; /Pathway/DataNode[@GraphId='f3e57']`
murD `UniProtKB:P14900`	catalyzes	UDP-MurNAc-L-Ala to UDP-MurNAc-L-Ala-D-Glu GPML interaction `WikiPathways:WP5060/eb85c`	WikiPathways:WP5060 Source assertion: GPML c3287 connects normalized UniProtKB:P14900 as a catalyst of interaction eb85c. Source location `/Pathway/Interaction[@GraphId='c3287']/Graphics; /Pathway/DataNode[@GraphId='c490a']`
murC `UniProtKB:P17952`	catalyzes	UDP-MurNAc to UDP-MurNAc-L-Ala GPML interaction `WikiPathways:WP5060/d013c`	WikiPathways:WP5060 Source assertion: GPML c5421 connects normalized UniProtKB:P17952 as a catalyst of interaction d013c. Source location `/Pathway/Interaction[@GraphId='c5421']/Graphics; /Pathway/DataNode[@GraphId='be995']`
murA `UniProtKB:P0A749`	catalyzes	UDP-GlcNAc to UDP-GlcNAc-enolpyruvate GPML interaction `WikiPathways:WP5060/e2f23`	WikiPathways:WP5060 Source assertion: GPML d5859 connects normalized UniProtKB:P0A749 as a catalyst of interaction e2f23. Source location `/Pathway/Interaction[@GraphId='d5859']/Graphics; /Pathway/DataNode[@GraphId='b957f']`
murB `UniProtKB:P08373`	catalyzes	UDP-GlcNAc-enolpyruvate to UDP-MurNAc GPML interaction `WikiPathways:WP5060/b8d40`	WikiPathways:WP5060 Source assertion: GPML a1f97 connects normalized UniProtKB:P08373 as a catalyst of interaction b8d40. Source location `/Pathway/Interaction[@GraphId='a1f97']/Graphics; /Pathway/DataNode[@GraphId='ccbe3']`
D-glutamate `CHEBI:29986`	consumes	UDP-MurNAc-L-Ala to UDP-MurNAc-L-Ala-D-Glu GPML interaction `WikiPathways:WP5060/eb85c`	WikiPathways:WP5060 Source assertion: GPML a2a7d connects normalized CHEBI:29986 as an input of interaction eb85c. Source location `/Pathway/Interaction[@GraphId='a2a7d']/Graphics; /Pathway/DataNode[@GraphId='b18c7']`
murI `UniProtKB:P22634`	catalyzes	L-glutamate to D-glutamate GPML interaction `WikiPathways:WP5060/d5182`	WikiPathways:WP5060 Source assertion: GPML e65f6 connects normalized UniProtKB:P22634 as a catalyst of interaction d5182. Source location `/Pathway/Interaction[@GraphId='e65f6']/Graphics; /Pathway/DataNode[@GraphId='f39e3']`
murE `UniProtKB:P22188`	catalyzes	UDP-MurNAc-L-Ala-D-Glu to UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP GPML interaction `WikiPathways:WP5060/eff80`	WikiPathways:WP5060 Source assertion: GPML b5eed connects normalized UniProtKB:P22188 as a catalyst of interaction eff80. Source location `/Pathway/Interaction[@GraphId='b5eed']/Graphics; /Pathway/DataNode[@GraphId='f7f2e']`
D-Ala-D-Ala `CHEBI:16576`	consumes	UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP to UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala-D-Ala GPML interaction `WikiPathways:WP5060/b8180`	WikiPathways:WP5060 Source assertion: GPML ca472 connects normalized CHEBI:16576 as an input of interaction b8180. Source location `/Pathway/Interaction[@GraphId='ca472']/Graphics; /Pathway/DataNode[@GraphId='abc1f']`
Undecaprenyl-diphosphatase `UniProtKB:P60932`	catalyzes	Undecaprenyl pyrophosphate to Undecaprenyl phosphate GPML interaction `WikiPathways:WP5060/fb09e`	WikiPathways:WP5060 Source assertion: GPML e1c23 connects normalized UniProtKB:P60932 as a catalyst of interaction fb09e. Source location `/Pathway/Interaction[@GraphId='e1c23']/Graphics; /Pathway/DataNode[@GraphId='baff9']`
murG `UniProtKB:P17443`	catalyzes	UND-PP-MurNAc-L-Ala-D-Glu-meso-DAP-D-Ala-D-Ala to Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine GPML interaction `WikiPathways:WP5060/f53c7`	WikiPathways:WP5060 Source assertion: GPML e2e96 connects normalized UniProtKB:P17443 as a catalyst of interaction f53c7. Source location `/Pathway/Interaction[@GraphId='e2e96']/Graphics; /Pathway/DataNode[@GraphId='f9f7a']`
Penicillin-binding protein 1C `UniProtKB:P76577`	catalyzes	Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine to Peptidoglycan Layer GPML interaction `WikiPathways:WP5060/d89b1`	WikiPathways:WP5060 Source assertion: GPML f68a1 connects normalized UniProtKB:P76577 as a catalyst of interaction d89b1. Source location `/Pathway/Interaction[@GraphId='f68a1']/Graphics; /Pathway/DataNode[@GraphId='abaac']`
glmU `UniProtKB:P0ACC7`	catalyzes	N-acetylglucosamine-1-phosphate to UDP-GlcNAc GPML interaction `WikiPathways:WP5060/f628a`	WikiPathways:WP5060 Source assertion: GPML cfa25 connects normalized UniProtKB:P0ACC7 as a catalyst of interaction f628a. Source location `/Pathway/Interaction[@GraphId='cfa25']/Graphics; /Pathway/DataNode[@GraphId='d088e']`
acetyl-CoA `CHEBI:15351`	consumes	Glucosamine-1P to N-acetylglucosamine-1-phosphate GPML interaction `WikiPathways:WP5060/bcf55`	WikiPathways:WP5060 Source assertion: GPML d0579 connects normalized CHEBI:15351 as an input of interaction bcf55. Source location `/Pathway/Interaction[@GraphId='d0579']/Graphics; /Pathway/DataNode[@GraphId='c9312']`
phosphoenolpyruvate `CHEBI:58702`	consumes	UDP-GlcNAc to UDP-GlcNAc-enolpyruvate GPML interaction `WikiPathways:WP5060/e2f23`	WikiPathways:WP5060 Source assertion: GPML f3504 connects normalized CHEBI:58702 as an input of interaction e2f23. Source location `/Pathway/Interaction[@GraphId='f3504']/Graphics; /Pathway/DataNode[@GraphId='b9c50']`
mtgA `UniProtKB:P46022`	catalyzes	Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine to Peptidoglycan Layer GPML interaction `WikiPathways:WP5060/d89b1`	WikiPathways:WP5060 Source assertion: GPML bebbb connects normalized UniProtKB:P46022 as a catalyst of interaction d89b1. Source location `/Pathway/Interaction[@GraphId='bebbb']/Graphics; /Pathway/DataNode[@GraphId='ccfb0']`
murF `UniProtKB:P11880`	catalyzes	UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP to UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala-D-Ala GPML interaction `WikiPathways:WP5060/b8180`	WikiPathways:WP5060 Source assertion: GPML ca145 connects normalized UniProtKB:P11880 as a catalyst of interaction b8180. Source location `/Pathway/Interaction[@GraphId='ca145']/Graphics; /Pathway/DataNode[@GraphId='e1e13']`
ftsW `UniProtKB:P0ABG4`	catalyzes	Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine to Peptidoglycan Layer GPML interaction `WikiPathways:WP5060/d89b1`	WikiPathways:WP5060 Source assertion: GPML ea2ce connects normalized UniProtKB:P0ABG4 as a catalyst of interaction d89b1. Source location `/Pathway/Interaction[@GraphId='ea2ce']/Graphics; /Pathway/DataNode[@GraphId='efb9c']`
Penicillin-binding protein 1B `UniProtKB:P02919`	catalyzes	Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine to Peptidoglycan Layer GPML interaction `WikiPathways:WP5060/d89b1`	WikiPathways:WP5060 Source assertion: GPML d24b8 connects normalized UniProtKB:P02919 as a catalyst of interaction d89b1. Source location `/Pathway/Interaction[@GraphId='d24b8']/Graphics; /Pathway/DataNode[@GraphId='bba64']`
NADPH `CHEBI:16474`	consumes	UDP-GlcNAc-enolpyruvate to UDP-MurNAc GPML interaction `WikiPathways:WP5060/b8d40`	WikiPathways:WP5060 Source assertion: GPML ccc5e connects normalized CHEBI:16474 as an input of interaction b8d40. Source location `/Pathway/Interaction[@GraphId='ccc5e']/Graphics; /Pathway/DataNode[@GraphId='f223e']`
glmM `UniProtKB:P31120`	catalyzes	D-glucosamine-6-phosphate to Glucosamine-1P GPML interaction `WikiPathways:WP5060/ebc50`	WikiPathways:WP5060 Source assertion: GPML c9642 connects normalized UniProtKB:P31120 as a catalyst of interaction ebc50. Source location `/Pathway/Interaction[@GraphId='c9642']/Graphics; /Pathway/DataNode[@GraphId='e1221']`
glmU `UniProtKB:P0ACC7`	catalyzes	Glucosamine-1P to N-acetylglucosamine-1-phosphate GPML interaction `WikiPathways:WP5060/bcf55`	WikiPathways:WP5060 Source assertion: GPML eb928 connects normalized UniProtKB:P0ACC7 as a catalyst of interaction bcf55. Source location `/Pathway/Interaction[@GraphId='eb928']/Graphics; /Pathway/DataNode[@GraphId='d2a68']`
ampG `UniProtKB:P0AE16`	catalyzes	WP5060 b5af5 GPML interaction `WikiPathways:WP5060/b5af5`	WikiPathways:WP5060 Source assertion: GPML c0868 connects normalized UniProtKB:P0AE16 as a catalyst of interaction b5af5. Source location `/Pathway/Interaction[@GraphId='c0868']/Graphics; /Pathway/DataNode[@GraphId='ce1e6']`
nagA `UniProtKB:P0AF18`	catalyzes	GlcNAc-6-P to D-glucosamine-6-phosphate GPML interaction `WikiPathways:WP5060/c131c`	WikiPathways:WP5060 Source assertion: GPML df53a connects normalized UniProtKB:P0AF18 as a catalyst of interaction c131c. Source location `/Pathway/Interaction[@GraphId='df53a']/Graphics; /Pathway/DataNode[@GraphId='f1e91']`
murQ `UniProtKB:P76535`	catalyzes	MurNAc 6-phosphate to GlcNAc-6-P GPML interaction `WikiPathways:WP5060/idb435b98e`	WikiPathways:WP5060 Source assertion: GPML e6b4e connects normalized UniProtKB:P76535 as a catalyst of interaction idb435b98e. Source location `/Pathway/Interaction[@GraphId='e6b4e']/Graphics; /Pathway/DataNode[@GraphId='a4c89']`
anmK `UniProtKB:P77570`	catalyzes	1,6-anhMurNAc to MurNAc 6-phosphate GPML interaction `WikiPathways:WP5060/af315`	WikiPathways:WP5060 Source assertion: GPML f671e connects normalized UniProtKB:P77570 as a catalyst of interaction af315. Source location `/Pathway/Interaction[@GraphId='f671e']/Graphics; /Pathway/DataNode[@GraphId='d3c21']`
murP `UniProtKB:P77272`	catalyzes	MurNAc to MurNAc 6-phosphate GPML interaction `WikiPathways:WP5060/eab24`	WikiPathways:WP5060 Source assertion: GPML c18d0 connects normalized UniProtKB:P77272 as a catalyst of interaction eab24. Source location `/Pathway/Interaction[@GraphId='c18d0']/Graphics; /Pathway/DataNode[@GraphId='adec4']`
nagK `UniProtKB:P75959`	catalyzes	GlcNAc to GlcNAc-6-P GPML interaction `WikiPathways:WP5060/c0f79`	WikiPathways:WP5060 Source assertion: GPML f1a29 connects normalized UniProtKB:P75959 as a catalyst of interaction c0f79. Source location `/Pathway/Interaction[@GraphId='f1a29']/Graphics; /Pathway/DataNode[@GraphId='d5433']`
nagB `UniProtKB:P0A759`	catalyzes	D-glucosamine-6-phosphate to Fructose-6-phosphate GPML interaction `WikiPathways:WP5060/ac9d2`	WikiPathways:WP5060 Source assertion: GPML ecc1f connects normalized UniProtKB:P0A759 as a catalyst of interaction ac9d2. Source location `/Pathway/Interaction[@GraphId='ecc1f']/Graphics; /Pathway/DataNode[@GraphId='ca4dd']`
mpl `UniProtKB:P37773`	catalyzes	L-Ala-gamma-D-Glu-meso-DAP to UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP GPML interaction `WikiPathways:WP5060/e8b23`	WikiPathways:WP5060 Source assertion: GPML d6bb0 connects normalized UniProtKB:P37773 as a catalyst of interaction e8b23. Source location `/Pathway/Interaction[@GraphId='d6bb0']/Graphics; /Pathway/DataNode[@GraphId='a948d']`
dadX `UniProtKB:P29012`	catalyzes	L-alanine to D-alanine GPML interaction `WikiPathways:WP5060/id535c37a4`	WikiPathways:WP5060 Source assertion: GPML b569e connects normalized UniProtKB:P29012 as a catalyst of interaction id535c37a4. Source location `/Pathway/Interaction[@GraphId='b569e']/Graphics; /Pathway/DataNode[@GraphId='a7a3b']`
WP5060 b423c GPML interaction `WikiPathways:WP5060/b423c`	produces	D-alanine `CHEBI:15570`	WikiPathways:WP5060 Source assertion: GPML de69c connects normalized CHEBI:15570 as an output of interaction b423c. Source location `/Pathway/Interaction[@GraphId='de69c']/Graphics; /Pathway/DataNode[@GraphId='a68a3']`
glmU `UniProtKB:P0ACC7`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:17473010) Binds 1 Mg(2+) ion per subunit (PubMed:17473010). Can also use Co(2+) ion to a lesser extent (PubMed:11329257). UniProt note evidence: ECO:0000269 (PubMed:11329257); ECO:0000269 (PubMed:17473010)	magnesium(2+) `CHEBI:18420`	UniProtKB:P0ACC7 Source assertion: UniProtKB:P0ACC7 annotates CHEBI:18420 as a cofactor of this protein. Source location https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/10/comments/0/cofactors/0; /results/10/comments/0/note
glmU `UniProtKB:P0ACC7`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:11329257) Binds 1 Mg(2+) ion per subunit (PubMed:17473010). Can also use Co(2+) ion to a lesser extent (PubMed:11329257). UniProt note evidence: ECO:0000269 (PubMed:11329257); ECO:0000269 (PubMed:17473010)	cobalt(2+) `CHEBI:48828`	UniProtKB:P0ACC7 Source assertion: UniProtKB:P0ACC7 annotates CHEBI:48828 as a cofactor of this protein. Source location https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/10/comments/0/cofactors/1; /results/10/comments/0/note
glmM `UniProtKB:P31120`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 Mg(2+) ion per subunit. UniProt note evidence: ECO:0000250	magnesium(2+) `CHEBI:18420`	UniProtKB:P31120 Source assertion: UniProtKB:P31120 annotates CHEBI:18420 as a cofactor of this protein. Source location https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/22/comments/0/cofactors/0; /results/22/comments/0/note
murE `UniProtKB:P22188`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_00208)	magnesium(2+) `CHEBI:18420`	UniProtKB:P22188 Source assertion: UniProtKB:P22188 annotates CHEBI:18420 as a cofactor of this protein. Source location https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/20/comments/0/cofactors/0
murD `UniProtKB:P14900`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000305 (PubMed:1765076)	magnesium(2+) `CHEBI:18420`	UniProtKB:P14900 Source assertion: UniProtKB:P14900 annotates CHEBI:18420 as a cofactor of this protein. Source location https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/16/comments/0/cofactors/0
murB `UniProtKB:P08373`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	FAD(3-) `CHEBI:57692`	UniProtKB:P08373 Source assertion: UniProtKB:P08373 annotates CHEBI:57692 as a cofactor of this protein. Source location https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/4/comments/0/cofactors/0
mraY `UniProtKB:P0A6W3`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_00038); ECO:0000269 (PubMed:215212) Replacement of Mg(2+) by Mn(2+) restores only 10% of the activity. UniProt note evidence: ECO:0000269 (PubMed:215212)	magnesium(2+) `CHEBI:18420`	UniProtKB:P0A6W3 Source assertion: UniProtKB:P0A6W3 annotates CHEBI:18420 as a cofactor of this protein. Source location https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/6/comments/0/cofactors/0; /results/6/comments/0/note
ddlB `UniProtKB:P07862`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 2 magnesium or manganese ions per subunit. UniProt note evidence: ECO:0000250	magnesium(2+) `CHEBI:18420`	UniProtKB:P07862 Source assertion: UniProtKB:P07862 annotates CHEBI:18420 as a cofactor of this protein. Source location https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/3/comments/0/cofactors/0; /results/3/comments/0/note
ddlB `UniProtKB:P07862`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 2 magnesium or manganese ions per subunit. UniProt note evidence: ECO:0000250	manganese(2+) `CHEBI:29035`	UniProtKB:P07862 Source assertion: UniProtKB:P07862 annotates CHEBI:29035 as a cofactor of this protein. Source location https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/3/comments/0/cofactors/1; /results/3/comments/0/note
dadX `UniProtKB:P29012`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250	pyridoxal 5'-phosphate(2-) `CHEBI:597326`	UniProtKB:P29012 Source assertion: UniProtKB:P29012 annotates CHEBI:597326 as a cofactor of this protein. Source location https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/43/comments/0/cofactors/0
alr `UniProtKB:P0A6B4`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:18434499)	pyridoxal 5'-phosphate(2-) `CHEBI:597326`	UniProtKB:P0A6B4 Source assertion: UniProtKB:P0A6B4 annotates CHEBI:597326 as a cofactor of this protein. Source location https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/5/comments/0/cofactors/0
mpl `UniProtKB:P37773`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_02020); ECO:0000269 (PubMed:17384195)	magnesium(2+) `CHEBI:18420`	UniProtKB:P37773 Source assertion: UniProtKB:P37773 annotates CHEBI:18420 as a cofactor of this protein. Source location https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/23/comments/0/cofactors/0
nagA `UniProtKB:P0AF18`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:16630633); ECO:0000269 (PubMed:17567047); ECO:0000269 (PubMed:17567048) Binds 1 divalent metal cation per subunit. The highest efficient metals are Zn(2+) and Co(2+), followed by Mn(2+), Cd(2+), Fe(2+) and Ni(2+). UniProt note evidence: ECO:0000269 (PubMed:16630633); ECO:0000269 (PubMed:17567047); ECO:0000269 (PubMed:17567048)	zinc(2+) `CHEBI:29105`	UniProtKB:P0AF18 Source assertion: UniProtKB:P0AF18 annotates CHEBI:29105 as a cofactor of this protein. Source location https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/14/comments/0/cofactors/0; /results/14/comments/0/note
nagA `UniProtKB:P0AF18`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:16630633); ECO:0000269 (PubMed:17567047); ECO:0000269 (PubMed:17567048) Binds 1 divalent metal cation per subunit. The highest efficient metals are Zn(2+) and Co(2+), followed by Mn(2+), Cd(2+), Fe(2+) and Ni(2+). UniProt note evidence: ECO:0000269 (PubMed:16630633); ECO:0000269 (PubMed:17567047); ECO:0000269 (PubMed:17567048)	cobalt(2+) `CHEBI:48828`	UniProtKB:P0AF18 Source assertion: UniProtKB:P0AF18 annotates CHEBI:48828 as a cofactor of this protein. Source location https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/14/comments/0/cofactors/1; /results/14/comments/0/note
nagA `UniProtKB:P0AF18`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:16630633); ECO:0000269 (PubMed:17567047); ECO:0000269 (PubMed:17567048) Binds 1 divalent metal cation per subunit. The highest efficient metals are Zn(2+) and Co(2+), followed by Mn(2+), Cd(2+), Fe(2+) and Ni(2+). UniProt note evidence: ECO:0000269 (PubMed:16630633); ECO:0000269 (PubMed:17567047); ECO:0000269 (PubMed:17567048)	manganese(2+) `CHEBI:29035`	UniProtKB:P0AF18 Source assertion: UniProtKB:P0AF18 annotates CHEBI:29035 as a cofactor of this protein. Source location https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/14/comments/0/cofactors/2; /results/14/comments/0/note
nagA `UniProtKB:P0AF18`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:16630633); ECO:0000269 (PubMed:17567047); ECO:0000269 (PubMed:17567048) Binds 1 divalent metal cation per subunit. The highest efficient metals are Zn(2+) and Co(2+), followed by Mn(2+), Cd(2+), Fe(2+) and Ni(2+). UniProt note evidence: ECO:0000269 (PubMed:16630633); ECO:0000269 (PubMed:17567047); ECO:0000269 (PubMed:17567048)	cadmium(2+) `CHEBI:48775`	UniProtKB:P0AF18 Source assertion: UniProtKB:P0AF18 annotates CHEBI:48775 as a cofactor of this protein. Source location https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/14/comments/0/cofactors/3; /results/14/comments/0/note
nagA `UniProtKB:P0AF18`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:16630633); ECO:0000269 (PubMed:17567047); ECO:0000269 (PubMed:17567048) Binds 1 divalent metal cation per subunit. The highest efficient metals are Zn(2+) and Co(2+), followed by Mn(2+), Cd(2+), Fe(2+) and Ni(2+). UniProt note evidence: ECO:0000269 (PubMed:16630633); ECO:0000269 (PubMed:17567047); ECO:0000269 (PubMed:17567048)	iron(2+) `CHEBI:29033`	UniProtKB:P0AF18 Source assertion: UniProtKB:P0AF18 annotates CHEBI:29033 as a cofactor of this protein. Source location https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/14/comments/0/cofactors/4; /results/14/comments/0/note
nagA `UniProtKB:P0AF18`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:16630633); ECO:0000269 (PubMed:17567047); ECO:0000269 (PubMed:17567048) Binds 1 divalent metal cation per subunit. The highest efficient metals are Zn(2+) and Co(2+), followed by Mn(2+), Cd(2+), Fe(2+) and Ni(2+). UniProt note evidence: ECO:0000269 (PubMed:16630633); ECO:0000269 (PubMed:17567047); ECO:0000269 (PubMed:17567048)	nickel(2+) `CHEBI:49786`	UniProtKB:P0AF18 Source assertion: UniProtKB:P0AF18 annotates CHEBI:49786 as a cofactor of this protein. Source location https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/14/comments/0/cofactors/5; /results/14/comments/0/note
1,6-anhydro-N-acetylmuramyl-L-alanine amidase (AmpD) `UniProtKB:P13016`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P82974) Zn(2+) is required for amidase activity. UniProt note evidence: ECO:0000250 (UniProtKB:P82974)	zinc(2+) `CHEBI:29105`	UniProtKB:P13016 Source assertion: UniProtKB:P13016 annotates CHEBI:29105 as a cofactor of this protein. Source location https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/35/comments/0/cofactors/0; /results/35/comments/0/note

References

PMID:31296364 Bacteria's different ways to recycle their own cell wall
PMID:18266853 Cytoplasmic steps of peptidoglycan biosynthesis
WikiPathways:WP5060 WP5060 native structured pathway source (source version: WP5060_r142449)
UniProtKB:P0ACC7 UniProtKB P0ACC7 cofactor annotations (source version: 2026_03)
UniProtKB:P31120 UniProtKB P31120 cofactor annotations (source version: 2026_03)
UniProtKB:P22188 UniProtKB P22188 cofactor annotations (source version: 2026_03)
UniProtKB:P14900 UniProtKB P14900 cofactor annotations (source version: 2026_03)
UniProtKB:P08373 UniProtKB P08373 cofactor annotations (source version: 2026_03)
UniProtKB:P0A6W3 UniProtKB P0A6W3 cofactor annotations (source version: 2026_03)
UniProtKB:P07862 UniProtKB P07862 cofactor annotations (source version: 2026_03)
UniProtKB:P29012 UniProtKB P29012 cofactor annotations (source version: 2026_03)
UniProtKB:P0A6B4 UniProtKB P0A6B4 cofactor annotations (source version: 2026_03)
UniProtKB:P37773 UniProtKB P37773 cofactor annotations (source version: 2026_03)
UniProtKB:P0AF18 UniProtKB P0AF18 cofactor annotations (source version: 2026_03)
UniProtKB:P13016 UniProtKB P13016 cofactor annotations (source version: 2026_03)

Curation history

2026-10-05T06:17:02Z Codex
- EDIT — Review complete causal graph against native sources and correct unsupported or omitted relationships
  Restored missing cosubstrates where exact identity is available; reversed-arrow racemases and phosphoglucosamine mutase marked reversible. MurJ is transport support rather than an enzyme that polymerizes peptidoglycan. Cytoplasmic source is explicitly incomplete for membrane/periplasm steps; no omitted DNA/RNA nodes inferred. Every native record was inspected; see reports/causal-graph-diagram-review.json for native-object counts, exclusions and identity corrections. Semantic validation and native GraphId locator checks passed; authority snapshots and full corpus gates are coordinated separately.
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