Glutamate degradation I

WikiPathways:WP556

Glutamate degradation I converts L-glutamate to 4-aminobutanoate, succinate semialdehyde, and then succinate in Saccharomyces cerevisiae.

Pathway type

amino acid degradation

Organism scope

Saccharomyces cerevisiae NCBITaxon:4932

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Pathway network

17 nodes · 19 asserted directed edges

Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.

Reaction / activity
Chemical / cofactor
Protein / complex
Solid arrow: mechanistic relation
Dashed arrow: membership, location or cofactor relation

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae `NCBITaxon:4932`	taxon
water `CHEBI:15377`	small molecule
L-glutamate `CHEBI:29985`	small molecule
UGA2 `SGD:S000000210`	protein
succinate semialdehyde `CHEBI:57706`	small molecule
carbon dioxide `CHEBI:16526`	small molecule
2-oxoglutarate(2-) `CHEBI:16810`	small molecule
NAD(P)H `CHEBI:13392`	small molecule
GAD1 `SGD:S000004862`	protein
4-aminobutanoate `CHEBI:59888`	small molecule
succinate `CHEBI:30031`	small molecule
NAD(P)(+) `CHEBI:13390`	small molecule
UGA1 `SGD:S000003251`	protein
hydron `CHEBI:15378`	small molecule
pyridoxal 5'-phosphate(2-) `CHEBI:597326`	cofactor
succinate semialdehyde to succinate GPML interaction `WikiPathways:WP556/adc8e`	molecular activity	left to right
4-aminobutanoate to succinate semialdehyde GPML interaction `WikiPathways:WP556/b960c`	molecular activity	left to right
L-glutamate to 4-aminobutanoate GPML interaction `WikiPathways:WP556/id1356da06`	molecular activity	left to right

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
succinate semialdehyde `CHEBI:57706`	consumes	succinate semialdehyde to succinate GPML interaction `WikiPathways:WP556/adc8e`	WikiPathways:WP556 Source assertion: GPML adc8e connects normalized CHEBI:57706 as an input of interaction adc8e. Source location `/Pathway/Interaction[@GraphId='adc8e']/Graphics; /Pathway/DataNode[@GraphId='a723b']`
succinate semialdehyde to succinate GPML interaction `WikiPathways:WP556/adc8e`	produces	succinate `CHEBI:30031`	WikiPathways:WP556 Source assertion: GPML adc8e connects normalized CHEBI:30031 as an output of interaction adc8e. Source location `/Pathway/Interaction[@GraphId='adc8e']/Graphics; /Pathway/DataNode[@GraphId='da8fc']`
4-aminobutanoate `CHEBI:59888`	consumes	4-aminobutanoate to succinate semialdehyde GPML interaction `WikiPathways:WP556/b960c`	WikiPathways:WP556 Source assertion: GPML b960c connects normalized CHEBI:59888 as an input of interaction b960c. Source location `/Pathway/Interaction[@GraphId='b960c']/Graphics; /Pathway/DataNode[@GraphId='d8b29']`
4-aminobutanoate to succinate semialdehyde GPML interaction `WikiPathways:WP556/b960c`	produces	succinate semialdehyde `CHEBI:57706`	WikiPathways:WP556 Source assertion: GPML b960c connects normalized CHEBI:57706 as an output of interaction b960c. Source location `/Pathway/Interaction[@GraphId='b960c']/Graphics; /Pathway/DataNode[@GraphId='a723b']`
L-glutamate `CHEBI:29985`	consumes	L-glutamate to 4-aminobutanoate GPML interaction `WikiPathways:WP556/id1356da06`	WikiPathways:WP556 Source assertion: GPML id1356da06 connects normalized CHEBI:29985 as an input of interaction id1356da06. Source location `/Pathway/Interaction[@GraphId='id1356da06']/Graphics; /Pathway/DataNode[@GraphId='dd2e6']`
L-glutamate to 4-aminobutanoate GPML interaction `WikiPathways:WP556/id1356da06`	produces	4-aminobutanoate `CHEBI:59888`	WikiPathways:WP556 Source assertion: GPML id1356da06 connects normalized CHEBI:59888 as an output of interaction id1356da06. Source location `/Pathway/Interaction[@GraphId='id1356da06']/Graphics; /Pathway/DataNode[@GraphId='d8b29']`
water `CHEBI:15377`	consumes	succinate semialdehyde to succinate GPML interaction `WikiPathways:WP556/adc8e`	WikiPathways:WP556 Source assertion: GPML id38174c4f connects normalized CHEBI:15377 as an input of interaction adc8e. Source location `/Pathway/Interaction[@GraphId='id38174c4f']/Graphics; /Pathway/DataNode[@GraphId='a17a6']`
NAD(P)(+) `CHEBI:13390`	consumes	succinate semialdehyde to succinate GPML interaction `WikiPathways:WP556/adc8e`	WikiPathways:WP556 Source assertion: GPML id38174c4f connects normalized CHEBI:13390 as an input of interaction adc8e. Source location `/Pathway/Interaction[@GraphId='id38174c4f']/Graphics; /Pathway/DataNode[@GraphId='de987']`
L-glutamate to 4-aminobutanoate GPML interaction `WikiPathways:WP556/id1356da06`	produces	carbon dioxide `CHEBI:16526`	WikiPathways:WP556 Source assertion: GPML id5fc21733 connects normalized CHEBI:16526 as an output of interaction id1356da06. Source location `/Pathway/Interaction[@GraphId='id5fc21733']/Graphics; /Pathway/DataNode[@GraphId='c50ae']`
2-oxoglutarate(2-) `CHEBI:16810`	consumes	4-aminobutanoate to succinate semialdehyde GPML interaction `WikiPathways:WP556/b960c`	WikiPathways:WP556 Source assertion: GPML id76efa8ad connects normalized CHEBI:16810 as an input of interaction b960c. Source location `/Pathway/Interaction[@GraphId='id76efa8ad']/Graphics; /Pathway/DataNode[@GraphId='c7eed']`
UGA1 `SGD:S000003251`	catalyzes	4-aminobutanoate to succinate semialdehyde GPML interaction `WikiPathways:WP556/b960c`	WikiPathways:WP556 Source assertion: GPML id77422312 connects normalized SGD:S000003251 as a catalyst of interaction b960c. Source location `/Pathway/Interaction[@GraphId='id77422312']/Graphics; /Pathway/DataNode[@GraphId='e9564']`
hydron `CHEBI:15378`	consumes	L-glutamate to 4-aminobutanoate GPML interaction `WikiPathways:WP556/id1356da06`	WikiPathways:WP556 Source assertion: GPML idad51913f connects normalized CHEBI:15378 as an input of interaction id1356da06. Source location `/Pathway/Interaction[@GraphId='idad51913f']/Graphics; /Pathway/DataNode[@GraphId='f9274']`
UGA2 `SGD:S000000210`	catalyzes	succinate semialdehyde to succinate GPML interaction `WikiPathways:WP556/adc8e`	WikiPathways:WP556 Source assertion: GPML idc91f98e3 connects normalized SGD:S000000210 as a catalyst of interaction adc8e. Source location `/Pathway/Interaction[@GraphId='idc91f98e3']/Graphics; /Pathway/DataNode[@GraphId='a67d0']`
4-aminobutanoate to succinate semialdehyde GPML interaction `WikiPathways:WP556/b960c`	produces	L-glutamate `CHEBI:29985`	WikiPathways:WP556 Source assertion: GPML ide9dea94f connects normalized CHEBI:29985 as an output of interaction b960c. Source location `/Pathway/Interaction[@GraphId='ide9dea94f']/Graphics; /Pathway/DataNode[@GraphId='a55ec']`
GAD1 `SGD:S000004862`	catalyzes	L-glutamate to 4-aminobutanoate GPML interaction `WikiPathways:WP556/id1356da06`	WikiPathways:WP556 Source assertion: GPML idf2f34343 connects normalized SGD:S000004862 as a catalyst of interaction id1356da06. Source location `/Pathway/Interaction[@GraphId='idf2f34343']/Graphics; /Pathway/DataNode[@GraphId='d1e']`
succinate semialdehyde to succinate GPML interaction `WikiPathways:WP556/adc8e`	produces	NAD(P)H `CHEBI:13392`	WikiPathways:WP556 Source assertion: GPML e831d connects normalized CHEBI:13392 as an output of interaction adc8e. Source location `/Pathway/Interaction[@GraphId='e831d']/Graphics; /Pathway/DataNode[@GraphId='cb0a1']`
succinate semialdehyde to succinate GPML interaction `WikiPathways:WP556/adc8e`	produces	hydron `CHEBI:15378`	WikiPathways:WP556 Source assertion: GPML e831d connects normalized CHEBI:15378 as an output of interaction adc8e. Source location `/Pathway/Interaction[@GraphId='e831d']/Graphics; /Pathway/DataNode[@GraphId='c9d82']; /Pathway/DataNode[@GraphId='f708d']`
GAD1 `SGD:S000004862`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250	pyridoxal 5'-phosphate(2-) `CHEBI:597326`	UniProtKB:Q04792 Source assertion: UniProtKB:Q04792 annotates CHEBI:597326 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4938/comments/0/cofactors/0` UniProtKB:Q04792 Source assertion: UniProtKB:Q04792 has the exact SGD cross-reference SGD:S000004862. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4938/uniProtKBCrossReferences/0`
UGA1 `SGD:S000003251`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:17355287)	pyridoxal 5'-phosphate(2-) `CHEBI:597326`	UniProtKB:P17649 Source assertion: UniProtKB:P17649 annotates CHEBI:597326 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/468/comments/0/cofactors/0` UniProtKB:P17649 Source assertion: UniProtKB:P17649 has the exact SGD cross-reference SGD:S000003251. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/468/uniProtKBCrossReferences/0`

References

WikiPathways:WP556 WP556 native structured pathway source (source version: WP556_r140475)
UniProtKB:Q04792 UniProtKB Q04792 cofactor annotations (source version: 2026_03)
UniProtKB:P17649 UniProtKB P17649 cofactor annotations (source version: 2026_03)

Curation history

2026-10-05T06:16:34Z Codex
- EDIT — Review complete causal graph against native sources and correct unsupported or omitted relationships
  Restored GAD1, UGA1, UGA2, proton/CO2, 2-oxoglutarate/glutamate, water and NAD(P) redox pair from native anchors. Every native record was inspected; see reports/causal-graph-diagram-review.json for native-object counts, exclusions and identity corrections. Semantic validation and native GraphId locator checks passed; authority snapshots and full corpus gates are coordinated separately.
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