2-phenylethanol biosynthesis

WikiPathways:WP5587

2-phenylethanol biosynthesis in Saccharomyces cerevisiae places glucose, phosphoenolpyruvate, erythrose 4-phosphate, 3-deoxy-D-arabino-heptulosonic acid 7-phosphate, shikimate, chorismate, phenylalanine, and 2-phenylethanol in shikimate- and Ehrlich-route reactions in the WP5587 GPML diagram. The graph distinguishes reversible phenylalanine transamination, DAHP condensation and the connected phenylpyruvate-to-phenylacetaldehyde Ehrlich route; collapsed upstream branches represent multiple enzymatic steps.

Pathway type
aromatic alcohol biosynthesis
Organism scope

Read the source YAML

Pathway network

37 nodes · 38 asserted directed edges

Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.

Pathway network: 2-phenylethanol biosynthesis 37 nodes · 38 asserted directed edges. Every arrow links to its evidence table row; nodes link to their component details. Isolated declared components are retained. CHEBI:18150 — consumes → WikiPathways:WP5587/id32159333; Evidence: WikiPathways:WP5587consumes WikiPathways:WP5587/id32159333 — produces → CHEBI:16119; Evidence: WikiPathways:WP5587produces CHEBI:16666 — consumes → WikiPathways:WP5587/id42570815; Evidence: WikiPathways:WP5587consumes WikiPathways:WP5587/id42570815 — produces → CHEBI:18005; Evidence: WikiPathways:WP5587produces CHEBI:4167 — consumes → WikiPathways:WP5587/id5c945cbf; Evidence: WikiPathways:WP5587consumes WikiPathways:WP5587/id5c945cbf — produces → CHEBI:4170; Evidence: WikiPathways:WP5587produces CHEBI:16424 — consumes → WikiPathways:WP5587/id7ed21248; Evidence: WikiPathways:WP5587consumes WikiPathways:WP5587/id7ed21248 — produces → CHEBI:49000; Evidence: WikiPathways:WP5587produces WikiPathways:WP5587/id864096aa — produces → CHEBI:18005; The source has arrowheads on both endpoints; the displayed orientation is one direction of a reversible conversion.; Evidence: WikiPathways:WP5587produces CHEBI:58095 — consumes → WikiPathways:WP5587/id864096aa; The source has arrowheads on both endpoints; the displayed orientation is one direction of a reversible conversion.; Evidence: WikiPathways:WP5587consumes CHEBI:18005 — consumes → WikiPathways:WP5587/id9510c196; Evidence: WikiPathways:WP5587consumes WikiPathways:WP5587/id9510c196 — produces → CHEBI:16424; Evidence: WikiPathways:WP5587produces CHEBI:16119 — consumes → WikiPathways:WP5587/idbd32b592; Evidence: WikiPathways:WP5587consumes WikiPathways:WP5587/idbd32b592 — produces → CHEBI:29748; Evidence: WikiPathways:WP5587produces CHEBI:58702 — consumes → WikiPathways:WP5587/idc5e5e165; Evidence: WikiPathways:WP5587consumes WikiPathways:WP5587/idc5e5e165 — produces → CHEBI:18150; Evidence: WikiPathways:WP5587produces CHEBI:29748 — consumes → WikiPathways:WP5587/idda151004; Evidence: WikiPathways:WP5587consumes WikiPathways:WP5587/idda151004 — produces → CHEBI:16666; Evidence: WikiPathways:WP5587produces CHEBI:4170 — consumes → WikiPathways:WP5587/idf0d0e924; Evidence: WikiPathways:WP5587consumes WikiPathways:WP5587/idf0d0e924 — produces → CHEBI:58702; Evidence: WikiPathways:WP5587produces CHEBI:4170 — consumes → WikiPathways:WP5587/idf107e51d; Evidence: WikiPathways:WP5587consumes WikiPathways:WP5587/idf107e51d — produces → CHEBI:48153; Evidence: WikiPathways:WP5587produces SGD:S000004918 — catalyzes → WikiPathways:WP5587/id7ed21248; Evidence: WikiPathways:WP5587catalyzes SGD:S000005185 — enables → WikiPathways:WP5587/idf107e51d; Evidence: WikiPathways:WP5587enables SGD:S000002534 — enables → WikiPathways:WP5587/id32159333; Evidence: WikiPathways:WP5587enables SGD:S000003424 — enables → WikiPathways:WP5587/idf0d0e924; Evidence: WikiPathways:WP5587enables SGD:S000006264 — catalyzes → WikiPathways:WP5587/idda151004; Evidence: WikiPathways:WP5587catalyzes SGD:S000000453 — catalyzes → WikiPathways:WP5587/idc5e5e165; Evidence: WikiPathways:WP5587catalyzes SGD:S000002788 — catalyzes → WikiPathways:WP5587/id9510c196; Evidence: WikiPathways:WP5587catalyzes SGD:S000005260 — catalyzes → WikiPathways:WP5587/id42570815; Evidence: WikiPathways:WP5587catalyzes SGD:S000003170 — catalyzes → WikiPathways:WP5587/id864096aa; Evidence: WikiPathways:WP5587catalyzes SGD:S000002442 — catalyzes → WikiPathways:WP5587/idc5e5e165; Evidence: WikiPathways:WP5587catalyzes CHEBI:48153 — consumes → WikiPathways:WP5587/idc5e5e165; The two native DAHP input lines represent one condensation reaction.; Evidence: WikiPathways:WP5587consumes SGD:S000002788 — has_cofactor → CHEBI:18420; UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250; Evidence: UniProtKB:Q06408, UniProtKB:Q06408has cofactor SGD:S000002788 — has_cofactor → CHEBI:58937; UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250; Evidence: UniProtKB:Q06408, UniProtKB:Q06408has cofactor SGD:S000002534 — has_cofactor → CHEBI:29105; UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_03143) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000255 (HAMAP-Rule:MF_03143); Evidence: UniProtKB:P08566, UniProtKB:P08566has cofactor SGD:S000004918 — has_cofactor → CHEBI:29105; UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330); Evidence: UniProtKB:P00331, UniProtKB:P00331has cofactor SGD:S000003170 — has_cofactor → CHEBI:597326; UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:23893908); Evidence: UniProtKB:P53090, UniProtKB:P53090has cofactor phenylalanine; CHEBI:58095; Declared type: small_molecule small molecule phenylalanine Shikimate; CHEBI:16119; Declared type: small_molecule small molecule Shikimate ARO4; SGD:S000000453; Declared type: protein protein ARO4 Chorismate; CHEBI:29748; Declared type: small_molecule small molecule Chorismate TDH3; SGD:S000003424; Declared type: protein protein TDH3 ARO3; SGD:S000002442; Declared type: protein protein ARO3 prephenic acid; CHEBI:16666; Declared type: small_molecule small molecule prephenic acid Phosphoenolpyruvate; CHEBI:58702; Declared type: small_molecule small molecule Phosphoenolpyruvate keto-phenylpyruvate; CHEBI:18005; Declared type: small_molecule small molecule keto-phenylpyruvate phenylacetaldehyde; CHEBI:16424; Declared type: small_molecule small molecule phenylacetaldehyde Glucose; CHEBI:4167; Declared type: small_molecule small molecule Glucose ARO10; SGD:S000002788; Declared type: protein protein ARO10 Erythrose-4-phosphate; CHEBI:48153; Declared type: small_molecule small molecule Erythrose-4-phosphate ZWF1; SGD:S000005185; Declared type: protein protein ZWF1 3-Deoxy-D-arabino-heptulosonic acid 7-phosphate; CHEBI:18150; Declared type: small_molecule small molecule 3-Deoxy-D-arabino- heptulosonic acid 7-phosphate 2-phenylethanol; CHEBI:49000; Declared type: small_molecule small molecule 2-phenylethanol ARO7; SGD:S000006264; Declared type: protein protein ARO7 ARO1; SGD:S000002534; Declared type: protein protein ARO1 PHA2; SGD:S000005260; Declared type: protein protein PHA2 D-glucopyranose 6-phosphate; CHEBI:4170; Declared type: small_molecule small molecule D-glucopyranose 6-phosphate ADH2; SGD:S000004918; Declared type: protein protein ADH2 ARO8; SGD:S000003170; Declared type: protein protein ARO8 magnesium(2+); CHEBI:18420; Declared type: cofactor cofactor magnesium(2+) thiamine(1+) diphosphate(3-); CHEBI:58937; Declared type: cofactor cofactor thiamine(1+) diphosphate(3-) zinc(2+); CHEBI:29105; Declared type: cofactor cofactor zinc(2+) pyridoxal 5'-phosphate(2-); CHEBI:597326; Declared type: cofactor cofactor pyridoxal 5'-phosphate(2-) 3-Deoxy-D-arabino-heptulosonic acid 7-phosphate to Shikimate GPML interaction; WikiPathways:WP5587/id32159333; Declared type: molecular_activity; Source reaction direction: left_to_right molecular activity 3-Deoxy-D-arabino- heptulosonic acid 7-phosphate to Shikimate GPML interaction prephenic acid conversion; WikiPathways:WP5587/id42570815; Declared type: molecular_activity; Source reaction direction: left_to_right molecular activity prephenic acid conversion Glucose to Glucose 6-phosphate GPML interaction; WikiPathways:WP5587/id5c945cbf; Declared type: molecular_activity; Source reaction direction: left_to_right molecular activity Glucose to Glucose 6-phosphate GPML interaction Phenylacetaldehyde to 2-phenylethanol GPML interaction; WikiPathways:WP5587/id7ed21248; Declared type: molecular_activity; Source reaction direction: left_to_right molecular activity Phenylacetaldehyde to 2-phenylethanol GPML interaction phenylpyruvate and phenylalanine reversible GPML interaction; WikiPathways:WP5587/id864096aa; Declared type: molecular_activity; Source reaction direction: reversible molecular activity phenylpyruvate and phenylalanine reversible GPML interaction keto-phenylpyruvate conversion; WikiPathways:WP5587/id9510c196; Declared type: molecular_activity; Source reaction direction: left_to_right molecular activity keto-phenylpyruvate conversion Shikimate to Chorismate GPML interaction; WikiPathways:WP5587/idbd32b592; Declared type: molecular_activity; Source reaction direction: left_to_right molecular activity Shikimate to Chorismate GPML interaction Phosphoenolpyruvate to 3-Deoxy-D-arabino-heptulosonic acid 7-phosphate GPML interaction; WikiPathways:WP5587/idc5e5e165; Declared type: molecular_activity; Source reaction direction: left_to_right molecular activity Phosphoenolpyruvate to 3-Deoxy-D-arabino- heptulosonic acid 7-phosphate GPML interaction Chorismate to Prephenate GPML interaction; WikiPathways:WP5587/idda151004; Declared type: molecular_activity; Source reaction direction: left_to_right molecular activity Chorismate to Prephenate GPML interaction Glucose 6-phosphate to Phosphoenolpyruvate GPML interaction; WikiPathways:WP5587/idf0d0e924; Declared type: molecular_activity; Source reaction direction: left_to_right molecular activity Glucose 6-phosphate to Phosphoenolpyruvate GPML interaction Glucose 6-phosphate to Erythrose-4-phosphate GPML interaction; WikiPathways:WP5587/idf107e51d; Declared type: molecular_activity; Source reaction direction: left_to_right molecular activity Glucose 6-phosphate to Erythrose-4-phosphate GPML interaction

Components and activities

Declared biological components and source reaction directions
NodeKind or roleSource direction
Saccharomyces cerevisiae
NCBITaxon:4932		taxon
phenylalanine
CHEBI:58095		small molecule
Shikimate
CHEBI:16119		small molecule
ARO4
SGD:S000000453		protein
Chorismate
CHEBI:29748		small molecule
TDH3
SGD:S000003424		protein
ARO3
SGD:S000002442		protein
prephenic acid
CHEBI:16666		small molecule
Phosphoenolpyruvate
CHEBI:58702		small molecule
keto-phenylpyruvate
CHEBI:18005		small molecule
phenylacetaldehyde
CHEBI:16424		small molecule
Glucose
CHEBI:4167		small molecule
ARO10
SGD:S000002788		protein
Erythrose-4-phosphate
CHEBI:48153		small molecule
ZWF1
SGD:S000005185		protein
3-Deoxy-D-arabino-heptulosonic acid 7-phosphate
CHEBI:18150		small molecule
2-phenylethanol
CHEBI:49000		small molecule
ARO7
SGD:S000006264		protein
ARO1
SGD:S000002534		protein
PHA2
SGD:S000005260		protein
D-glucopyranose 6-phosphate
CHEBI:4170		small molecule
ADH2
SGD:S000004918		protein
ARO8
SGD:S000003170		protein
magnesium(2+)
CHEBI:18420		cofactor
thiamine(1+) diphosphate(3-)
CHEBI:58937		cofactor
zinc(2+)
CHEBI:29105		cofactor
pyridoxal 5'-phosphate(2-)
CHEBI:597326		cofactor
3-Deoxy-D-arabino-heptulosonic acid 7-phosphate to Shikimate GPML interaction
WikiPathways:WP5587/id32159333		molecular activityleft to right
prephenic acid conversion
WikiPathways:WP5587/id42570815		molecular activityleft to right
Glucose to Glucose 6-phosphate GPML interaction
WikiPathways:WP5587/id5c945cbf		molecular activityleft to right
Phenylacetaldehyde to 2-phenylethanol GPML interaction
WikiPathways:WP5587/id7ed21248		molecular activityleft to right
phenylpyruvate and phenylalanine reversible GPML interaction
WikiPathways:WP5587/id864096aa		molecular activityreversible
keto-phenylpyruvate conversion
WikiPathways:WP5587/id9510c196		molecular activityleft to right
Shikimate to Chorismate GPML interaction
WikiPathways:WP5587/idbd32b592		molecular activityleft to right
Phosphoenolpyruvate to 3-Deoxy-D-arabino-heptulosonic acid 7-phosphate GPML interaction
WikiPathways:WP5587/idc5e5e165		molecular activityleft to right
Chorismate to Prephenate GPML interaction
WikiPathways:WP5587/idda151004		molecular activityleft to right
Glucose 6-phosphate to Phosphoenolpyruvate GPML interaction
WikiPathways:WP5587/idf0d0e924		molecular activityleft to right
Glucose 6-phosphate to Erythrose-4-phosphate GPML interaction
WikiPathways:WP5587/idf107e51d		molecular activityleft to right

Mechanistic edges

Mechanistic edges and their cited evidence
SubjectPredicate and descriptionObjectEvidence
3-Deoxy-D-arabino-heptulosonic acid 7-phosphate
CHEBI:18150		consumes

3-Deoxy-D-arabino-heptulosonic acid 7-phosphate to Shikimate GPML interaction
WikiPathways:WP5587/id32159333
  • WikiPathways:WP5587

    Source assertion: GPML id32159333 connects normalized CHEBI:18150 as an input of interaction id32159333.

    Source location/Pathway/Interaction[@GraphId='id32159333']/Graphics; /Pathway/DataNode[@GraphId='e43bf']
3-Deoxy-D-arabino-heptulosonic acid 7-phosphate to Shikimate GPML interaction
WikiPathways:WP5587/id32159333		produces

Shikimate
CHEBI:16119
  • WikiPathways:WP5587

    Source assertion: GPML id32159333 connects normalized CHEBI:16119 as an output of interaction id32159333.

    Source location/Pathway/Interaction[@GraphId='id32159333']/Graphics; /Pathway/DataNode[@GraphId='ad2cf']
prephenic acid
CHEBI:16666		consumes

prephenic acid conversion
WikiPathways:WP5587/id42570815
  • WikiPathways:WP5587

    Source assertion: GPML id42570815 connects normalized CHEBI:16666 as an input of interaction id42570815.

    Source location/Pathway/Interaction[@GraphId='id42570815']/Graphics; /Pathway/DataNode[@GraphId='bca0f']
prephenic acid conversion
WikiPathways:WP5587/id42570815		produces

keto-phenylpyruvate
CHEBI:18005
  • WikiPathways:WP5587

    Source assertion: GPML id42570815 connects normalized CHEBI:18005 as an output of interaction id42570815.

    Source location/Pathway/Interaction[@GraphId='id42570815']/Graphics; /Pathway/DataNode[@GraphId='c3273']
Glucose
CHEBI:4167		consumes

Glucose to Glucose 6-phosphate GPML interaction
WikiPathways:WP5587/id5c945cbf
  • WikiPathways:WP5587

    Source assertion: GPML id5c945cbf connects normalized CHEBI:4167 as an input of interaction id5c945cbf.

    Source location/Pathway/Interaction[@GraphId='id5c945cbf']/Graphics; /Pathway/DataNode[@GraphId='cac7e']
Glucose to Glucose 6-phosphate GPML interaction
WikiPathways:WP5587/id5c945cbf		produces

D-glucopyranose 6-phosphate
CHEBI:4170
  • WikiPathways:WP5587

    Source assertion: GPML id5c945cbf connects normalized CHEBI:4170 as an output of interaction id5c945cbf.

    Source location/Pathway/Interaction[@GraphId='id5c945cbf']/Graphics; /Pathway/DataNode[@GraphId='f3b4d']
phenylacetaldehyde
CHEBI:16424		consumes

Phenylacetaldehyde to 2-phenylethanol GPML interaction
WikiPathways:WP5587/id7ed21248
  • WikiPathways:WP5587

    Source assertion: GPML id7ed21248 connects normalized CHEBI:16424 as an input of interaction id7ed21248.

    Source location/Pathway/Interaction[@GraphId='id7ed21248']/Graphics; /Pathway/DataNode[@GraphId='c6b39']
Phenylacetaldehyde to 2-phenylethanol GPML interaction
WikiPathways:WP5587/id7ed21248		produces

2-phenylethanol
CHEBI:49000
  • WikiPathways:WP5587

    Source assertion: GPML id7ed21248 connects normalized CHEBI:49000 as an output of interaction id7ed21248.

    Source location/Pathway/Interaction[@GraphId='id7ed21248']/Graphics; /Pathway/DataNode[@GraphId='e6b13']
phenylpyruvate and phenylalanine reversible GPML interaction
WikiPathways:WP5587/id864096aa		produces

The source has arrowheads on both endpoints; the displayed orientation is one direction of a reversible conversion.

keto-phenylpyruvate
CHEBI:18005
  • WikiPathways:WP5587

    Source assertion: GPML id864096aa connects normalized CHEBI:18005 as an output of interaction id864096aa.

    Source location/Pathway/Interaction[@GraphId='id864096aa']/Graphics; /Pathway/DataNode[@GraphId='c3273']
phenylalanine
CHEBI:58095		consumes

The source has arrowheads on both endpoints; the displayed orientation is one direction of a reversible conversion.

phenylpyruvate and phenylalanine reversible GPML interaction
WikiPathways:WP5587/id864096aa
  • WikiPathways:WP5587

    Source assertion: GPML id864096aa connects normalized CHEBI:58095 as an input of interaction id864096aa.

    Source location/Pathway/Interaction[@GraphId='id864096aa']/Graphics; /Pathway/DataNode[@GraphId='a9433']
keto-phenylpyruvate
CHEBI:18005		consumes

keto-phenylpyruvate conversion
WikiPathways:WP5587/id9510c196
  • WikiPathways:WP5587

    Source assertion: GPML id9510c196 connects normalized CHEBI:18005 as an input of interaction id9510c196.

    Source location/Pathway/Interaction[@GraphId='id9510c196']/Graphics; /Pathway/DataNode[@GraphId='c3273']
keto-phenylpyruvate conversion
WikiPathways:WP5587/id9510c196		produces

phenylacetaldehyde
CHEBI:16424
  • WikiPathways:WP5587

    Source assertion: GPML id9510c196 connects normalized CHEBI:16424 as an output of interaction id9510c196.

    Source location/Pathway/Interaction[@GraphId='id9510c196']/Graphics; /Pathway/DataNode[@GraphId='c6b39']
Shikimate
CHEBI:16119		consumes

Shikimate to Chorismate GPML interaction
WikiPathways:WP5587/idbd32b592
  • WikiPathways:WP5587

    Source assertion: GPML idbd32b592 connects normalized CHEBI:16119 as an input of interaction idbd32b592.

    Source location/Pathway/Interaction[@GraphId='idbd32b592']/Graphics; /Pathway/DataNode[@GraphId='ad2cf']
Shikimate to Chorismate GPML interaction
WikiPathways:WP5587/idbd32b592		produces

Chorismate
CHEBI:29748
  • WikiPathways:WP5587

    Source assertion: GPML idbd32b592 connects normalized CHEBI:29748 as an output of interaction idbd32b592.

    Source location/Pathway/Interaction[@GraphId='idbd32b592']/Graphics; /Pathway/DataNode[@GraphId='b4aee']
Phosphoenolpyruvate
CHEBI:58702		consumes

Phosphoenolpyruvate to 3-Deoxy-D-arabino-heptulosonic acid 7-phosphate GPML interaction
WikiPathways:WP5587/idc5e5e165
  • WikiPathways:WP5587

    Source assertion: GPML idc5e5e165 connects normalized CHEBI:58702 as an input of interaction idc5e5e165.

    Source location/Pathway/Interaction[@GraphId='idc5e5e165']/Graphics; /Pathway/DataNode[@GraphId='bd7fc']
Phosphoenolpyruvate to 3-Deoxy-D-arabino-heptulosonic acid 7-phosphate GPML interaction
WikiPathways:WP5587/idc5e5e165		produces

3-Deoxy-D-arabino-heptulosonic acid 7-phosphate
CHEBI:18150
  • WikiPathways:WP5587

    Source assertion: GPML idc5e5e165 connects normalized CHEBI:18150 as an output of interaction idc5e5e165.

    Source location/Pathway/Interaction[@GraphId='idc5e5e165']/Graphics; /Pathway/DataNode[@GraphId='e43bf']
Chorismate
CHEBI:29748		consumes

Chorismate to Prephenate GPML interaction
WikiPathways:WP5587/idda151004
  • WikiPathways:WP5587

    Source assertion: GPML idda151004 connects normalized CHEBI:29748 as an input of interaction idda151004.

    Source location/Pathway/Interaction[@GraphId='idda151004']/Graphics; /Pathway/DataNode[@GraphId='b4aee']
Chorismate to Prephenate GPML interaction
WikiPathways:WP5587/idda151004		produces

prephenic acid
CHEBI:16666
  • WikiPathways:WP5587

    Source assertion: GPML idda151004 connects normalized CHEBI:16666 as an output of interaction idda151004.

    Source location/Pathway/Interaction[@GraphId='idda151004']/Graphics; /Pathway/DataNode[@GraphId='bca0f']
D-glucopyranose 6-phosphate
CHEBI:4170		consumes

Glucose 6-phosphate to Phosphoenolpyruvate GPML interaction
WikiPathways:WP5587/idf0d0e924
  • WikiPathways:WP5587

    Source assertion: GPML idf0d0e924 connects normalized CHEBI:4170 as an input of interaction idf0d0e924.

    Source location/Pathway/Interaction[@GraphId='idf0d0e924']/Graphics; /Pathway/DataNode[@GraphId='f3b4d']
Glucose 6-phosphate to Phosphoenolpyruvate GPML interaction
WikiPathways:WP5587/idf0d0e924		produces

Phosphoenolpyruvate
CHEBI:58702
  • WikiPathways:WP5587

    Source assertion: GPML idf0d0e924 connects normalized CHEBI:58702 as an output of interaction idf0d0e924.

    Source location/Pathway/Interaction[@GraphId='idf0d0e924']/Graphics; /Pathway/DataNode[@GraphId='bd7fc']
D-glucopyranose 6-phosphate
CHEBI:4170		consumes

Glucose 6-phosphate to Erythrose-4-phosphate GPML interaction
WikiPathways:WP5587/idf107e51d
  • WikiPathways:WP5587

    Source assertion: GPML idf107e51d connects normalized CHEBI:4170 as an input of interaction idf107e51d.

    Source location/Pathway/Interaction[@GraphId='idf107e51d']/Graphics; /Pathway/DataNode[@GraphId='f3b4d']
Glucose 6-phosphate to Erythrose-4-phosphate GPML interaction
WikiPathways:WP5587/idf107e51d		produces

Erythrose-4-phosphate
CHEBI:48153
  • WikiPathways:WP5587

    Source assertion: GPML idf107e51d connects normalized CHEBI:48153 as an output of interaction idf107e51d.

    Source location/Pathway/Interaction[@GraphId='idf107e51d']/Graphics; /Pathway/DataNode[@GraphId='d8ea8']
ADH2
SGD:S000004918		catalyzes

Phenylacetaldehyde to 2-phenylethanol GPML interaction
WikiPathways:WP5587/id7ed21248
  • WikiPathways:WP5587

    Source assertion: GPML id1c0fc9d0 connects normalized SGD:S000004918 as a catalyst of interaction id7ed21248.

    Source location/Pathway/Interaction[@GraphId='id1c0fc9d0']/Graphics; /Pathway/DataNode[@GraphId='f7cdd']
ZWF1
SGD:S000005185		enables

Glucose 6-phosphate to Erythrose-4-phosphate GPML interaction
WikiPathways:WP5587/idf107e51d
  • WikiPathways:WP5587

    Source assertion: GPML id20ec62a connects normalized SGD:S000005185 as an enabling enzyme component of interaction idf107e51d.

    Source location/Pathway/Interaction[@GraphId='id20ec62a']/Graphics; /Pathway/DataNode[@GraphId='e2d53']
ARO1
SGD:S000002534		enables

3-Deoxy-D-arabino-heptulosonic acid 7-phosphate to Shikimate GPML interaction
WikiPathways:WP5587/id32159333
  • WikiPathways:WP5587

    Source assertion: GPML id38a08c22 connects normalized SGD:S000002534 as an enabling enzyme component of interaction id32159333.

    Source location/Pathway/Interaction[@GraphId='id38a08c22']/Graphics; /Pathway/DataNode[@GraphId='ebf5e']
TDH3
SGD:S000003424		enables

Glucose 6-phosphate to Phosphoenolpyruvate GPML interaction
WikiPathways:WP5587/idf0d0e924
  • WikiPathways:WP5587

    Source assertion: GPML id59c08d8c connects normalized SGD:S000003424 as an enabling enzyme component of interaction idf0d0e924.

    Source location/Pathway/Interaction[@GraphId='id59c08d8c']/Graphics; /Pathway/DataNode[@GraphId='b7ee6']
ARO7
SGD:S000006264		catalyzes

Chorismate to Prephenate GPML interaction
WikiPathways:WP5587/idda151004
  • WikiPathways:WP5587

    Source assertion: GPML id80e48618 connects normalized SGD:S000006264 as a catalyst of interaction idda151004.

    Source location/Pathway/Interaction[@GraphId='id80e48618']/Graphics; /Pathway/DataNode[@GraphId='e7b42']
ARO4
SGD:S000000453		catalyzes

Phosphoenolpyruvate to 3-Deoxy-D-arabino-heptulosonic acid 7-phosphate GPML interaction
WikiPathways:WP5587/idc5e5e165
  • WikiPathways:WP5587

    Source assertion: GPML ida5d852b5 connects normalized SGD:S000000453 as a catalyst of interaction idc5e5e165.

    Source location/Pathway/Interaction[@GraphId='ida5d852b5']/Graphics; /Pathway/DataNode[@GraphId='b38f0']
ARO10
SGD:S000002788		catalyzes

keto-phenylpyruvate conversion
WikiPathways:WP5587/id9510c196
  • WikiPathways:WP5587

    Source assertion: GPML iddc9137a7 connects normalized SGD:S000002788 as a catalyst of interaction id9510c196.

    Source location/Pathway/Interaction[@GraphId='iddc9137a7']/Graphics; /Pathway/DataNode[@GraphId='d76fd']
PHA2
SGD:S000005260		catalyzes

prephenic acid conversion
WikiPathways:WP5587/id42570815
  • WikiPathways:WP5587

    Source assertion: GPML ide507376c connects normalized SGD:S000005260 as a catalyst of interaction id42570815.

    Source location/Pathway/Interaction[@GraphId='ide507376c']/Graphics; /Pathway/DataNode[@GraphId='eccf3']
ARO8
SGD:S000003170		catalyzes

phenylpyruvate and phenylalanine reversible GPML interaction
WikiPathways:WP5587/id864096aa
  • WikiPathways:WP5587

    Source assertion: GPML ide836cb7e connects normalized SGD:S000003170 as a catalyst of interaction id864096aa.

    Source location/Pathway/Interaction[@GraphId='ide836cb7e']/Graphics; /Pathway/DataNode[@GraphId='fa3b6']
ARO3
SGD:S000002442		catalyzes

Phosphoenolpyruvate to 3-Deoxy-D-arabino-heptulosonic acid 7-phosphate GPML interaction
WikiPathways:WP5587/idc5e5e165
  • WikiPathways:WP5587

    Source assertion: GPML idebc2a294 connects normalized SGD:S000002442 as a catalyst of interaction idc5e5e165.

    Source location/Pathway/Interaction[@GraphId='idebc2a294']/Graphics; /Pathway/DataNode[@GraphId='bb8b7']
Erythrose-4-phosphate
CHEBI:48153		consumes

The two native DAHP input lines represent one condensation reaction.

Phosphoenolpyruvate to 3-Deoxy-D-arabino-heptulosonic acid 7-phosphate GPML interaction
WikiPathways:WP5587/idc5e5e165
  • WikiPathways:WP5587

    Source assertion: GPML id88645eca connects normalized CHEBI:48153 as an input of interaction idc5e5e165.

    Source location/Pathway/Interaction[@GraphId='id88645eca']/Graphics; /Pathway/DataNode[@GraphId='d8ea8']
ARO10
SGD:S000002788		has_cofactor

UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250

magnesium(2+)
CHEBI:18420
  • UniProtKB:Q06408

    Source assertion: UniProtKB:Q06408 annotates CHEBI:18420 as a cofactor of this protein.

    Source locationhttps://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/comments/0/cofactors/0; /results/2752/comments/0/note
  • UniProtKB:Q06408

    Source assertion: UniProtKB:Q06408 has the exact SGD cross-reference SGD:S000002788.

    Source locationhttps://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/uniProtKBCrossReferences/0
ARO10
SGD:S000002788		has_cofactor

UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250

thiamine(1+) diphosphate(3-)
CHEBI:58937
  • UniProtKB:Q06408

    Source assertion: UniProtKB:Q06408 annotates CHEBI:58937 as a cofactor of this protein.

    Source locationhttps://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/comments/1/cofactors/0; /results/2752/comments/1/note
  • UniProtKB:Q06408

    Source assertion: UniProtKB:Q06408 has the exact SGD cross-reference SGD:S000002788.

    Source locationhttps://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/uniProtKBCrossReferences/0
ARO1
SGD:S000002534		has_cofactor

UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_03143) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000255 (HAMAP-Rule:MF_03143)

zinc(2+)
CHEBI:29105
  • UniProtKB:P08566

    Source assertion: UniProtKB:P08566 annotates CHEBI:29105 as a cofactor of this protein.

    Source locationhttps://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/213/comments/0/cofactors/0; /results/213/comments/0/note
  • UniProtKB:P08566

    Source assertion: UniProtKB:P08566 has the exact SGD cross-reference SGD:S000002534.

    Source locationhttps://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/213/uniProtKBCrossReferences/0
ADH2
SGD:S000004918		has_cofactor

UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)

zinc(2+)
CHEBI:29105
  • UniProtKB:P00331

    Source assertion: UniProtKB:P00331 annotates CHEBI:29105 as a cofactor of this protein.

    Source locationhttps://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/23/comments/0/cofactors/0; /results/23/comments/0/note
  • UniProtKB:P00331

    Source assertion: UniProtKB:P00331 has the exact SGD cross-reference SGD:S000004918.

    Source locationhttps://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/23/uniProtKBCrossReferences/0
ARO8
SGD:S000003170		has_cofactor

UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:23893908)

pyridoxal 5'-phosphate(2-)
CHEBI:597326
  • UniProtKB:P53090

    Source assertion: UniProtKB:P53090 annotates CHEBI:597326 as a cofactor of this protein.

    Source locationhttps://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2112/comments/0/cofactors/0
  • UniProtKB:P53090

    Source assertion: UniProtKB:P53090 has the exact SGD cross-reference SGD:S000003170.

    Source locationhttps://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2112/uniProtKBCrossReferences/0

References

Curation history