Phospholipids degradation

WikiPathways:WP71

Phospholipids degradation in Saccharomyces cerevisiae covers the WikiPathways phospholipase D branch that hydrolyzes phosphatidylcholine to phosphatidate and choline through SPO14.

Pathway type

phospholipid degradation

Organism scope

Saccharomyces cerevisiae NCBITaxon:4932

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Pathway network

7 nodes · 6 asserted directed edges

Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.

Reaction / activity
Chemical / cofactor
Protein / complex
Solid arrow: mechanistic relation
Dashed arrow: membership, location or cofactor relation

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae `NCBITaxon:4932`	taxon
hydron `CHEBI:15378`	small molecule
SPO14 `SGD:S000001739`	protein
water `CHEBI:15377`	small molecule
phosphatidylcholine `CHEBI:16110`	lipid
1,2-diacyl-sn-glycerol 3-phosphate `CHEBI:29089`	lipid
choline `CHEBI:15354`	small molecule
phosphatidylcholine to phosphatidate and choline `WikiPathways:WP71/id3a707ae4`	molecular activity	left to right

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
phosphatidylcholine `CHEBI:16110`	consumes	phosphatidylcholine to phosphatidate and choline `WikiPathways:WP71/id3a707ae4`	WikiPathways:WP71 Source assertion: GPML id3a707ae4 connects normalized CHEBI:16110 as an input of interaction id3a707ae4. Source location `/Pathway/Interaction[@GraphId='id3a707ae4']/Graphics; /Pathway/DataNode[@GraphId='ee13a']`
phosphatidylcholine to phosphatidate and choline `WikiPathways:WP71/id3a707ae4`	produces	1,2-diacyl-sn-glycerol 3-phosphate `CHEBI:29089`	WikiPathways:WP71 Source assertion: GPML id3a707ae4 connects normalized CHEBI:29089 as an output of interaction id3a707ae4. Source location `/Pathway/Interaction[@GraphId='id3a707ae4']/Graphics; /Pathway/DataNode[@GraphId='c42d6']`
phosphatidylcholine to phosphatidate and choline `WikiPathways:WP71/id3a707ae4`	produces	choline `CHEBI:15354`	WikiPathways:WP71 Source assertion: GPML id153723c8 connects normalized CHEBI:15354 as an output of interaction id3a707ae4. Source location `/Pathway/Interaction[@GraphId='id153723c8']/Graphics; /Pathway/DataNode[@GraphId='ad11f']`
phosphatidylcholine to phosphatidate and choline `WikiPathways:WP71/id3a707ae4`	produces	hydron `CHEBI:15378`	WikiPathways:WP71 Source assertion: GPML id153723c8 connects normalized CHEBI:15378 as an output of interaction id3a707ae4. Source location `/Pathway/Interaction[@GraphId='id153723c8']/Graphics; /Pathway/DataNode[@GraphId='ca3e3']`
SPO14 `SGD:S000001739`	catalyzes	phosphatidylcholine to phosphatidate and choline `WikiPathways:WP71/id3a707ae4`	WikiPathways:WP71 Source assertion: GPML id8293ebf6 connects normalized SGD:S000001739 as a catalyst of interaction id3a707ae4. Source location `/Pathway/Interaction[@GraphId='id8293ebf6']/Graphics; /Pathway/DataNode[@GraphId='e31']`
water `CHEBI:15377`	consumes	phosphatidylcholine to phosphatidate and choline `WikiPathways:WP71/id3a707ae4`	WikiPathways:WP71 Source assertion: GPML idb1638a08 connects normalized CHEBI:15377 as an input of interaction id3a707ae4. Source location `/Pathway/Interaction[@GraphId='idb1638a08']/Graphics; /Pathway/DataNode[@GraphId='bc483']`

References

WikiPathways:WP71 WP71 native structured pathway source (source version: WP71_r20260926102110)

Curation history

2026-10-05T19:29:52Z Codex; adversarial-scientific-correction; Corrected choline CHEBI:15354 to small_molecule using ChEBI release 255 structural classification; biochemical edges and original source assertions are unchanged.
2026-10-05T06:17:05Z Codex
- EDIT — Review complete causal graph against native sources and correct unsupported or omitted relationships
  Retained the explicitly scoped SPO14 phospholipase D branch. Excluded ISC1 phosphatidylcholine claim contradicted by the source comment; PLC1 branch is outside this record scope. Every native record was inspected; see reports/causal-graph-diagram-review.json for native-object counts, exclusions and identity corrections. Semantic validation and native GraphId locator checks passed; authority snapshots and full corpus gates are coordinated separately.
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2026-10-05T19:31:04Z Codex
- EDIT — Corrected choline CHEBI:15354 to small_molecule using ChEBI release 255 structural classification; biochemical edges and original source assertions are unchanged.
  Corrected choline CHEBI:15354 to small_molecule using ChEBI release 255 structural classification; biochemical edges and original source assertions are unchanged. Original source assertions and review scope are preserved in reports/causal_graph_review/adversarial-scientific-corrections.json. Validated the changed record against the closed schema and added focused regression checks; repository-wide validation and generated artifacts are handled in the integration step.
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