lipid IV(A) biosynthesis pathway

gomodel:6882d2b800000609

Lipid IV(A) biosynthesis converts UDP-N-acetyl-alpha-D-glucosamine to lipid IV(A) through UDP-3-O-acylated glucosamine, lipid X, and disaccharide intermediates in Escherichia coli K-12.

Pathway type

lipid biosynthesis

Organism scope

Escherichia coli K-12 NCBITaxon:83333

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Pathway network

26 nodes · 33 asserted directed edges

Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.

Reaction / activity
Chemical / cofactor
Protein / complex
Cell / process context
Solid arrow: mechanistic relation
Dashed arrow: membership, location or cofactor relation

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Escherichia coli K-12 `NCBITaxon:83333`	taxon
LpxB Ecol `gomodel:6882d2b800000609/6882d2b800000646`	protein
lipid A biosynthetic process `GO:0009245`	biological process
LpxH Ecol `gomodel:6882d2b800000609/6882d2b800000639`	protein
plasma membrane `GO:0005886`	cellular component
cytoplasm `GO:0005737`	cellular component
2,3,2',3'-tetrakis[(3R)-3-hydroxyacyl]-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate(2-) `CHEBI:176343`	small molecule
UDP-3-O-[(3R)-hydroxyacyl]-alpha-D-glucosamine(1-) `CHEBI:137740`	small molecule
UDP-2,3-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(2-) `CHEBI:78847`	small molecule
lipid X(2-) `CHEBI:57957`	small molecule
LpxA Ecol `gomodel:6882d2b800000609/6882d2b800000611`	protein
UDP-3-O-[(3R)-hydroxyacyl]-N-acetyl-alpha-D-glucosamine(2-) `CHEBI:173225`	small molecule
extrinsic component of plasma membrane `GO:0019897`	cellular component
LpxD Ecol `gomodel:6882d2b800000609/6882d2b800000633`	protein
a lipid IVA(4-) `CHEBI:176425`	small molecule
LpxK Ecol `gomodel:6882d2b800000609/6882d2b800000653`	protein
UDP-N-acetyl-alpha-D-glucosamine `CHEBI:16264`	small molecule
LpxC Ecol `gomodel:6882d2b800000609/6882d2b800000628`	protein
manganese(2+) `CHEBI:29035`	cofactor
zinc(2+) `CHEBI:29105`	cofactor
iron(2+) `CHEBI:29033`	cofactor
acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity `gomodel:6882d2b800000609/6882d2b800000610`	molecular activity
UDP-3-O-acyl-N-acetylglucosamine deacetylase activity `gomodel:6882d2b800000609/6882d2b800000627`	molecular activity
UDP-3-O-[(3R)-3-hydroxyacyl]-glucosamine N-acyltransferase activity `gomodel:6882d2b800000609/6882d2b800000632`	molecular activity
UDP-2,3-diacylglucosamine hydrolase activity `gomodel:6882d2b800000609/6882d2b800000638`	molecular activity
lipid-A-disaccharide synthase activity `gomodel:6882d2b800000609/6882d2b800000645`	molecular activity
lipid-A 4'-kinase activity `gomodel:6882d2b800000609/6882d2b800000652`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
LpxB Ecol `gomodel:6882d2b800000609/6882d2b800000646`	enables	lipid-A-disaccharide synthase activity `gomodel:6882d2b800000609/6882d2b800000645`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000645 RO:0002333 gomodel:6882d2b800000609/6882d2b800000646. Source location `./6882d2b800000609.json#/facts/0; endpoint types: /individuals/31/type; /individuals/32/type`
UDP-2,3-diacylglucosamine hydrolase activity `gomodel:6882d2b800000609/6882d2b800000638`	part_of	lipid A biosynthetic process `GO:0009245`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000638 BFO:0000050 gomodel:6882d2b800000609/6882d2b800000640. Source location `./6882d2b800000609.json#/facts/1; endpoint types: /individuals/24/type; /individuals/26/type`
UDP-3-O-[(3R)-3-hydroxyacyl]-glucosamine N-acyltransferase activity `gomodel:6882d2b800000609/6882d2b800000632`	part_of	lipid A biosynthetic process `GO:0009245`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000632 BFO:0000050 gomodel:6882d2b800000609/6882d2b800000636. Source location `./6882d2b800000609.json#/facts/2; endpoint types: /individuals/18/type; /individuals/22/type`
LpxH Ecol `gomodel:6882d2b800000609/6882d2b800000639`	enables	UDP-2,3-diacylglucosamine hydrolase activity `gomodel:6882d2b800000609/6882d2b800000638`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000638 RO:0002333 gomodel:6882d2b800000609/6882d2b800000639. Source location `./6882d2b800000609.json#/facts/3; endpoint types: /individuals/24/type; /individuals/25/type`
lipid-A 4'-kinase activity `gomodel:6882d2b800000609/6882d2b800000652`	occurs_in	plasma membrane `GO:0005886`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000652 BFO:0000066 gomodel:6882d2b800000609/6882d2b800000655. Source location `./6882d2b800000609.json#/facts/4; endpoint types: /individuals/38/type; /individuals/41/type`
UDP-3-O-[(3R)-3-hydroxyacyl]-glucosamine N-acyltransferase activity `gomodel:6882d2b800000609/6882d2b800000632`	occurs_in	cytoplasm `GO:0005737`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000632 BFO:0000066 gomodel:6882d2b800000609/6882d2b800000665. Source location `./6882d2b800000609.json#/facts/5; endpoint types: /individuals/18/type; /individuals/51/type`
UDP-2,3-diacylglucosamine hydrolase activity `gomodel:6882d2b800000609/6882d2b800000638`	occurs_in	plasma membrane `GO:0005886`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000638 BFO:0000066 gomodel:6882d2b800000609/6882d2b800000663. Source location `./6882d2b800000609.json#/facts/6; endpoint types: /individuals/24/type; /individuals/49/type`
acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity `gomodel:6882d2b800000609/6882d2b800000610`	part_of	lipid A biosynthetic process `GO:0009245`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000610 BFO:0000050 gomodel:6882d2b800000609/69c59f8a00000884. Source location `./6882d2b800000609.json#/facts/7; endpoint types: /individuals/10/type; /individuals/67/type`
UDP-3-O-acyl-N-acetylglucosamine deacetylase activity `gomodel:6882d2b800000609/6882d2b800000627`	part_of	lipid A biosynthetic process `GO:0009245`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000627 BFO:0000050 gomodel:6882d2b800000609/6882d2b800000629. Source location `./6882d2b800000609.json#/facts/8; endpoint types: /individuals/13/type; /individuals/15/type`
lipid-A 4'-kinase activity `gomodel:6882d2b800000609/6882d2b800000652`	has_input	2,3,2',3'-tetrakis[(3R)-3-hydroxyacyl]-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate(2-) `CHEBI:176343`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000652 RO:0002233 gomodel:6882d2b800000609/6882d2b800000675. Source location `./6882d2b800000609.json#/facts/9; endpoint types: /individuals/38/type; /individuals/61/type`
UDP-3-O-[(3R)-3-hydroxyacyl]-glucosamine N-acyltransferase activity `gomodel:6882d2b800000609/6882d2b800000632`	has_input	UDP-3-O-[(3R)-hydroxyacyl]-alpha-D-glucosamine(1-) `CHEBI:137740`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000632 RO:0002233 gomodel:6882d2b800000609/6882d2b800000672. Source location `./6882d2b800000609.json#/facts/10; endpoint types: /individuals/18/type; /individuals/58/type`
UDP-3-O-acyl-N-acetylglucosamine deacetylase activity `gomodel:6882d2b800000609/6882d2b800000627`	occurs_in	cytoplasm `GO:0005737`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000627 BFO:0000066 gomodel:6882d2b800000609/6882d2b800000667. Source location `./6882d2b800000609.json#/facts/11; endpoint types: /individuals/13/type; /individuals/53/type`
UDP-3-O-[(3R)-3-hydroxyacyl]-glucosamine N-acyltransferase activity `gomodel:6882d2b800000609/6882d2b800000632`	has_output	UDP-2,3-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(2-) `CHEBI:78847`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000632 RO:0002234 gomodel:6882d2b800000609/6882d2b800000673. Source location `./6882d2b800000609.json#/facts/12; endpoint types: /individuals/18/type; /individuals/59/type`
lipid-A-disaccharide synthase activity `gomodel:6882d2b800000609/6882d2b800000645`	part_of	lipid A biosynthetic process `GO:0009245`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000645 BFO:0000050 gomodel:6882d2b800000609/6882d2b800000647. Source location `./6882d2b800000609.json#/facts/13; endpoint types: /individuals/31/type; /individuals/33/type`
UDP-3-O-acyl-N-acetylglucosamine deacetylase activity `gomodel:6882d2b800000609/6882d2b800000627`	has_output	UDP-3-O-[(3R)-hydroxyacyl]-alpha-D-glucosamine(1-) `CHEBI:137740`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000627 RO:0002234 gomodel:6882d2b800000609/6882d2b800000672. Source location `./6882d2b800000609.json#/facts/14; endpoint types: /individuals/13/type; /individuals/58/type`
lipid-A-disaccharide synthase activity `gomodel:6882d2b800000609/6882d2b800000645`	has_input	lipid X(2-) `CHEBI:57957`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000645 RO:0002233 gomodel:6882d2b800000609/6882d2b800000674. Source location `./6882d2b800000609.json#/facts/15; endpoint types: /individuals/31/type; /individuals/60/type`
LpxA Ecol `gomodel:6882d2b800000609/6882d2b800000611`	enables	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity `gomodel:6882d2b800000609/6882d2b800000610`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000610 RO:0002333 gomodel:6882d2b800000609/6882d2b800000611. Source location `./6882d2b800000609.json#/facts/16; endpoint types: /individuals/10/type; /individuals/11/type`
lipid-A 4'-kinase activity `gomodel:6882d2b800000609/6882d2b800000652`	part_of	lipid A biosynthetic process `GO:0009245`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000652 BFO:0000050 gomodel:6882d2b800000609/6882d2b800000654. Source location `./6882d2b800000609.json#/facts/17; endpoint types: /individuals/38/type; /individuals/40/type`
UDP-3-O-acyl-N-acetylglucosamine deacetylase activity `gomodel:6882d2b800000609/6882d2b800000627`	has_input	UDP-3-O-[(3R)-hydroxyacyl]-N-acetyl-alpha-D-glucosamine(2-) `CHEBI:173225`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000627 RO:0002233 gomodel:6882d2b800000609/6882d2b800000671. Source location `./6882d2b800000609.json#/facts/18; endpoint types: /individuals/13/type; /individuals/57/type`
lipid-A-disaccharide synthase activity `gomodel:6882d2b800000609/6882d2b800000645`	occurs_in	extrinsic component of plasma membrane `GO:0019897`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000645 BFO:0000066 gomodel:6882d2b800000609/6882d2b800000661. Source location `./6882d2b800000609.json#/facts/19; endpoint types: /individuals/31/type; /individuals/47/type`
lipid-A-disaccharide synthase activity `gomodel:6882d2b800000609/6882d2b800000645`	has_output	2,3,2',3'-tetrakis[(3R)-3-hydroxyacyl]-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate(2-) `CHEBI:176343`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000645 RO:0002234 gomodel:6882d2b800000609/6882d2b800000675. Source location `./6882d2b800000609.json#/facts/20; endpoint types: /individuals/31/type; /individuals/61/type`
UDP-2,3-diacylglucosamine hydrolase activity `gomodel:6882d2b800000609/6882d2b800000638`	has_output	lipid X(2-) `CHEBI:57957`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000638 RO:0002234 gomodel:6882d2b800000609/6882d2b800000674. Source location `./6882d2b800000609.json#/facts/21; endpoint types: /individuals/24/type; /individuals/60/type`
LpxD Ecol `gomodel:6882d2b800000609/6882d2b800000633`	enables	UDP-3-O-[(3R)-3-hydroxyacyl]-glucosamine N-acyltransferase activity `gomodel:6882d2b800000609/6882d2b800000632`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000632 RO:0002333 gomodel:6882d2b800000609/6882d2b800000633. Source location `./6882d2b800000609.json#/facts/22; endpoint types: /individuals/18/type; /individuals/19/type`
lipid-A 4'-kinase activity `gomodel:6882d2b800000609/6882d2b800000652`	has_output	a lipid IVA(4-) `CHEBI:176425`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000652 RO:0002234 gomodel:6882d2b800000609/6882d2b800000678. Source location `./6882d2b800000609.json#/facts/23; endpoint types: /individuals/38/type; /individuals/62/type`
LpxK Ecol `gomodel:6882d2b800000609/6882d2b800000653`	enables	lipid-A 4'-kinase activity `gomodel:6882d2b800000609/6882d2b800000652`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000652 RO:0002333 gomodel:6882d2b800000609/6882d2b800000653. Source location `./6882d2b800000609.json#/facts/24; endpoint types: /individuals/38/type; /individuals/39/type`
UDP-2,3-diacylglucosamine hydrolase activity `gomodel:6882d2b800000609/6882d2b800000638`	has_input	UDP-2,3-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(2-) `CHEBI:78847`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000638 RO:0002233 gomodel:6882d2b800000609/6882d2b800000673. Source location `./6882d2b800000609.json#/facts/25; endpoint types: /individuals/24/type; /individuals/59/type`
acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity `gomodel:6882d2b800000609/6882d2b800000610`	has_input	UDP-N-acetyl-alpha-D-glucosamine `CHEBI:16264`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000610 RO:0002233 gomodel:6882d2b800000609/6882d2b800000681. Source location `./6882d2b800000609.json#/facts/26; endpoint types: /individuals/10/type; /individuals/65/type`
acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity `gomodel:6882d2b800000609/6882d2b800000610`	has_output	UDP-3-O-[(3R)-hydroxyacyl]-N-acetyl-alpha-D-glucosamine(2-) `CHEBI:173225`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000610 RO:0002234 gomodel:6882d2b800000609/6882d2b800000671. Source location `./6882d2b800000609.json#/facts/27; endpoint types: /individuals/10/type; /individuals/57/type`
acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity `gomodel:6882d2b800000609/6882d2b800000610`	occurs_in	cytoplasm `GO:0005737`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000610 BFO:0000066 gomodel:6882d2b800000609/6882d2b800000669. Source location `./6882d2b800000609.json#/facts/28; endpoint types: /individuals/10/type; /individuals/55/type`
LpxC Ecol `gomodel:6882d2b800000609/6882d2b800000628`	enables	UDP-3-O-acyl-N-acetylglucosamine deacetylase activity `gomodel:6882d2b800000609/6882d2b800000627`	gomodel:6882d2b800000609 Source assertion: The model asserts gomodel:6882d2b800000609/6882d2b800000627 RO:0002333 gomodel:6882d2b800000609/6882d2b800000628. Source location `./6882d2b800000609.json#/facts/29; endpoint types: /individuals/13/type; /individuals/14/type`
LpxH Ecol `gomodel:6882d2b800000609/6882d2b800000639`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_00575); ECO:0000305 (PubMed:12000770) Binds 2 Mn(2+) ions per subunit in a binuclear metal center. UniProt note evidence: ECO:0000255 (HAMAP-Rule:MF_00575)	manganese(2+) `CHEBI:29035`	UniProtKB:P43341 Source assertion: UniProtKB:P43341 annotates CHEBI:29035 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A83333+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_biocyc%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:754f9ed81673546fc431e009c1b979e9ce6db9cd2cc9b24ef62b5fdd1c3204e7] #/results/1299/comments/0/cofactors/0; /results/1299/comments/0/note` gomodel:6882d2b800000609 Source assertion: The native individual gomodel:6882d2b800000609/6882d2b800000639 has type EcoCyc:EG12666-MONOMER. Source location `./6882d2b800000609.json#/individuals/25/type/0` UniProtKB:P43341 Source assertion: Reviewed UniProtKB:P43341 has the exact BioCyc cross-reference EcoCyc:EG12666-MONOMER; this joins the native model protein to its cofactor annotation. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A83333+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_biocyc%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:754f9ed81673546fc431e009c1b979e9ce6db9cd2cc9b24ef62b5fdd1c3204e7] #/results/1299/uniProtKBCrossReferences/0`
LpxC Ecol `gomodel:6882d2b800000609/6882d2b800000628`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_00388); ECO:0000269 (PubMed:10026271); ECO:0000269 (PubMed:20709752) Can use either Fe(2+) or Zn(2+). The metal cofactor can switch between Fe(2+) and Zn(2+) in response to metal availability. Metal switching may be important for regulating the LpxC activity upon changes in environmental conditions. Has a significantly higher affinity for Zn(2+), but exhibits higher activity with Fe(2+) (PubMed:20136146, PubMed:20709752). Can also use Co(2+), Ni(2+) and, to a lesser extent, Mn(2+) (PubMed:10026271). UniProt note evidence: ECO:0000269 (PubMed:10026271); ECO:0000269 (PubMed:20136146); ECO:0000269 (PubMed:20709752)	zinc(2+) `CHEBI:29105`	UniProtKB:P0A725 Source assertion: UniProtKB:P0A725 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A83333+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_biocyc%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:754f9ed81673546fc431e009c1b979e9ce6db9cd2cc9b24ef62b5fdd1c3204e7] #/results/258/comments/0/cofactors/0; /results/258/comments/0/note` gomodel:6882d2b800000609 Source assertion: The native individual gomodel:6882d2b800000609/6882d2b800000628 has type EcoCyc:UDPACYLGLCNACDEACETYL-MONOMER. Source location `./6882d2b800000609.json#/individuals/14/type/0` UniProtKB:P0A725 Source assertion: Reviewed UniProtKB:P0A725 has the exact BioCyc cross-reference EcoCyc:UDPACYLGLCNACDEACETYL-MONOMER; this joins the native model protein to its cofactor annotation. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A83333+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_biocyc%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:754f9ed81673546fc431e009c1b979e9ce6db9cd2cc9b24ef62b5fdd1c3204e7] #/results/258/uniProtKBCrossReferences/0`
LpxC Ecol `gomodel:6882d2b800000609/6882d2b800000628`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:20136146); ECO:0000269 (PubMed:20709752) Can use either Fe(2+) or Zn(2+). The metal cofactor can switch between Fe(2+) and Zn(2+) in response to metal availability. Metal switching may be important for regulating the LpxC activity upon changes in environmental conditions. Has a significantly higher affinity for Zn(2+), but exhibits higher activity with Fe(2+) (PubMed:20136146, PubMed:20709752). Can also use Co(2+), Ni(2+) and, to a lesser extent, Mn(2+) (PubMed:10026271). UniProt note evidence: ECO:0000269 (PubMed:10026271); ECO:0000269 (PubMed:20136146); ECO:0000269 (PubMed:20709752)	iron(2+) `CHEBI:29033`	UniProtKB:P0A725 Source assertion: UniProtKB:P0A725 annotates CHEBI:29033 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A83333+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_biocyc%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:754f9ed81673546fc431e009c1b979e9ce6db9cd2cc9b24ef62b5fdd1c3204e7] #/results/258/comments/0/cofactors/1; /results/258/comments/0/note` gomodel:6882d2b800000609 Source assertion: The native individual gomodel:6882d2b800000609/6882d2b800000628 has type EcoCyc:UDPACYLGLCNACDEACETYL-MONOMER. Source location `./6882d2b800000609.json#/individuals/14/type/0` UniProtKB:P0A725 Source assertion: Reviewed UniProtKB:P0A725 has the exact BioCyc cross-reference EcoCyc:UDPACYLGLCNACDEACETYL-MONOMER; this joins the native model protein to its cofactor annotation. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A83333+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_biocyc%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:754f9ed81673546fc431e009c1b979e9ce6db9cd2cc9b24ef62b5fdd1c3204e7] #/results/258/uniProtKBCrossReferences/0`

References

gomodel:6882d2b800000609 GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609 (source version: Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json)
UniProtKB:P43341 UniProtKB P43341 cofactor annotations (source version: 2026_03)
UniProtKB:P0A725 UniProtKB P0A725 cofactor annotations (source version: 2026_03)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T04:21:18Z codex
- EDIT — Align CHEBI:176425 label with the pinned authority
  Changed the participant label from lipid IVA(4-) to a lipid IVA(4-), matching the independently extracted ChEBI release 255 canonical label. The identifier and biological scope are unchanged. This canonical label discrepancy was exposed during identifier-gate implementation for #229 and is tracked with the other canonical-label corrections in #243.
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