L-arginine biosynthesis II (acetyl cycle)

gomodel:YeastPathways_ARGSYNBSUB-PWY

L-arginine biosynthesis II in Saccharomyces cerevisiae S288C uses ARG2, ARG56, ARG8, and ARG7 acetyl-cycle reactions to convert L-glutamate to L-ornithine, then uses CPX-579, ARG3, ARG1, and ARG4 to convert L-ornithine through L-citrulline and argininosuccinate to L-arginine.

Pathway type

amino acid biosynthesis

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

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Pathway network

54 nodes · 91 asserted directed edges

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
L-glutamine zwitterion `CHEBI:58359`	small molecule
ARG3 Scer `SGD:S000003624`	protein
L-arginine biosynthetic process `GO:0006526`	biological process
N-acetyl-L-gamma-glutamyl phosphate(3-) `CHEBI:57936`	small molecule
water `CHEBI:15377`	small molecule
L-argininium(1+) `CHEBI:32682`	small molecule
hydron `CHEBI:15378`	small molecule
NADP(3-) `CHEBI:58349`	small molecule
coenzyme A(4-) `CHEBI:57287`	small molecule
CPX-579 Scer `SGD:S000217863`	complex
CPA2 Scer `SGD:S000003870`	protein
hydrogenphosphate `CHEBI:43474`	small molecule
cytosol `GO:0005829`	cellular component
L-glutamate(1-) `CHEBI:29985`	small molecule
ARG56 Scer `SGD:S000000871`	protein
carbamoyl phosphate(2-) `CHEBI:58228`	small molecule
(N(omega)-L-arginino)succinate(1-) `CHEBI:57472`	small molecule
N(2)-acetyl-L-ornithine zwitterion `CHEBI:57805`	small molecule
L-ornithinium(1+) `CHEBI:46911`	small molecule
L-citrulline zwitterion `CHEBI:57743`	small molecule
diphosphoric acid `CHEBI:29888`	small molecule
adenosine 5'-monophosphate(2-) `CHEBI:456215`	small molecule
2-acetamido-5-oxopentanoate `CHEBI:29123`	small molecule
ARG2 Scer `SGD:S000003607`	protein
N-acetyl-L-glutamate(2-) `CHEBI:44337`	small molecule
L-aspartate(1-) `CHEBI:29991`	small molecule
ARG7 Scer `SGD:S000004666`	protein
ADP(3-) `CHEBI:456216`	small molecule
2-oxoglutarate(2-) `CHEBI:16810`	small molecule
NADPH(4-) `CHEBI:57783`	small molecule
ATP(4-) `CHEBI:30616`	small molecule
fumarate(2-) `CHEBI:29806`	small molecule
ARG4 Scer `SGD:S000001060`	protein
acetyl-CoA(4-) `CHEBI:57288`	small molecule
ARG1 Scer `SGD:S000005419`	protein
ARG8 Scer `SGD:S000005500`	protein
CPA1 Scer `SGD:S000005829`	protein
hydrogencarbonate `CHEBI:17544`	small molecule
cytoplasm `GO:0005737`	cellular component
mitochondrion `GO:0005739`	cellular component
mitochondrial matrix `GO:0005759`	cellular component
magnesium(2+) `CHEBI:18420`	cofactor
manganese(2+) `CHEBI:29035`	cofactor
pyridoxal 5'-phosphate(2-) `CHEBI:597326`	cofactor
acetylglutamate kinase activity `gomodel:ACETYLGLUTKIN-RXN`	molecular activity
N2-acetyl-L-ornithine:2-oxoglutarate 5-transaminase activity `gomodel:ACETYLORNTRANSAM-RXN`	molecular activity
argininosuccinate lyase activity `gomodel:ARGSUCCINLYA-RXN`	molecular activity
argininosuccinate synthase activity `gomodel:ARGSUCCINSYN-RXN`	molecular activity
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity `gomodel:CARBPSYN-RXN`	molecular activity
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor `gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN`	molecular activity
N-acetyl-gamma-glutamyl-phosphate reductase (NADP+) activity `gomodel:N-ACETYLGLUTPREDUCT-RXN`	molecular activity
L-glutamate N-acetyltransferase activity, acetyl-CoA as donor `gomodel:N-ACETYLTRANSFER-RXN`	molecular activity
ornithine carbamoyltransferase activity `gomodel:ORNCARBAMTRANSFER-RXN`	molecular activity
L-glutamate N-acetyltransferase activity, acetyl-CoA as donor `gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity `gomodel:CARBPSYN-RXN`	has_input	L-glutamine zwitterion `CHEBI:58359`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:CARBPSYN-RXN RO:0002233 gomodel:CHEBI_58359_CARBPSYN-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/0; endpoint types: /individuals/4/type; /individuals/43/type`
ARG3 Scer `SGD:S000003624`	enables	ornithine carbamoyltransferase activity `gomodel:ORNCARBAMTRANSFER-RXN`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ORNCARBAMTRANSFER-RXN RO:0002333 gomodel:YJL088W-MONOMER_ORNCARBAMTRANSFER-RXN_controller. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/1; endpoint types: /individuals/48/type; /individuals/55/type`
acetylglutamate kinase activity `gomodel:ACETYLGLUTKIN-RXN`	part_of	L-arginine biosynthetic process `GO:0006526`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ACETYLGLUTKIN-RXN BFO:0000050 gomodel:YeastPathways_ARGSYNBSUB-PWY/YeastPathways_ARGSYNBSUB-PWY. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/2; endpoint types: /individuals/0/type; /individuals/135/type`
acetylglutamate kinase activity `gomodel:ACETYLGLUTKIN-RXN`	has_output	N-acetyl-L-gamma-glutamyl phosphate(3-) `CHEBI:57936`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ACETYLGLUTKIN-RXN RO:0002234 gomodel:CHEBI_57936_ACETYLGLUTKIN-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/3; endpoint types: /individuals/0/type; /individuals/40/type`
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity `gomodel:CARBPSYN-RXN`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:CARBPSYN-RXN RO:0002233 gomodel:CHEBI_15377_CARBPSYN-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/4; endpoint types: /individuals/4/type; /individuals/5/type`
argininosuccinate lyase activity `gomodel:ARGSUCCINLYA-RXN`	has_output	L-argininium(1+) `CHEBI:32682`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ARGSUCCINLYA-RXN RO:0002234 gomodel:CHEBI_32682_ARGSUCCINLYA-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/5; endpoint types: /individuals/2/type; /individuals/24/type`
L-glutamate N-acetyltransferase activity, acetyl-CoA as donor `gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704 RO:0002234 gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000708. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/6; endpoint types: /individuals/136/type; /individuals/140/type`
N-acetyl-gamma-glutamyl-phosphate reductase (NADP+) activity `gomodel:N-ACETYLGLUTPREDUCT-RXN`	has_output	NADP(3-) `CHEBI:58349`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:N-ACETYLGLUTPREDUCT-RXN RO:0002234 gomodel:CHEBI_58349_N-ACETYLGLUTPREDUCT-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/7; endpoint types: /individuals/46/type; /individuals/42/type`
L-glutamate N-acetyltransferase activity, acetyl-CoA as donor `gomodel:N-ACETYLTRANSFER-RXN`	has_output	coenzyme A(4-) `CHEBI:57287`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:N-ACETYLTRANSFER-RXN RO:0002234 gomodel:CHEBI_57287_N-ACETYLTRANSFER-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/8; endpoint types: /individuals/47/type; /individuals/34/type`
CPX-579 Scer `SGD:S000217863`	has_part	CPA2 Scer `SGD:S000003870`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:CPLX3O-887_CARBPSYN-RXN_controller BFO:0000051 gomodel:SGD_S000003870_CPLX3O-887_component. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/9; endpoint types: /individuals/44/type; /individuals/49/type`
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity `gomodel:CARBPSYN-RXN`	has_output	hydrogenphosphate `CHEBI:43474`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:CARBPSYN-RXN RO:0002234 gomodel:CHEBI_43474_CARBPSYN-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/10; endpoint types: /individuals/4/type; /individuals/25/type`
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor `gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN`	has_input	L-glutamate(1-) `CHEBI:29985`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_29985_GLUTAMATE-N-ACETYLTRANSFERASE-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/12; endpoint types: /individuals/45/type; /individuals/18/type`
ornithine carbamoyltransferase activity `gomodel:ORNCARBAMTRANSFER-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ORNCARBAMTRANSFER-RXN BFO:0000066 gomodel:reaction_ORNCARBAMTRANSFER-RXN_location_lociGO_0005829. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/13; endpoint types: /individuals/48/type; /individuals/134/type`
ARG56 Scer `SGD:S000000871`	enables	N-acetyl-gamma-glutamyl-phosphate reductase (NADP+) activity `gomodel:N-ACETYLGLUTPREDUCT-RXN`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:N-ACETYLGLUTPREDUCT-RXN RO:0002333 gomodel:YER069W-MONOMER_N-ACETYLGLUTPREDUCT-RXN_controller. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/14; endpoint types: /individuals/46/type; /individuals/52/type`
ornithine carbamoyltransferase activity `gomodel:ORNCARBAMTRANSFER-RXN`	has_input	carbamoyl phosphate(2-) `CHEBI:58228`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ORNCARBAMTRANSFER-RXN RO:0002233 gomodel:CHEBI_58228_CARBPSYN-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/15; endpoint types: /individuals/48/type; /individuals/41/type`
argininosuccinate lyase activity `gomodel:ARGSUCCINLYA-RXN`	has_input	(N(omega)-L-arginino)succinate(1-) `CHEBI:57472`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ARGSUCCINLYA-RXN RO:0002233 gomodel:CHEBI_57472_ARGSUCCINSYN-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/16; endpoint types: /individuals/2/type; /individuals/36/type`
N2-acetyl-L-ornithine:2-oxoglutarate 5-transaminase activity `gomodel:ACETYLORNTRANSAM-RXN`	has_output	N(2)-acetyl-L-ornithine zwitterion `CHEBI:57805`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ACETYLORNTRANSAM-RXN RO:0002234 gomodel:CHEBI_57805_ACETYLORNTRANSAM-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/17; endpoint types: /individuals/1/type; /individuals/39/type`
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor `gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN`	causally_upstream_of	acetylglutamate kinase activity `gomodel:ACETYLGLUTKIN-RXN`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN RO:0002411 gomodel:ACETYLGLUTKIN-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/18; endpoint types: /individuals/45/type; /individuals/0/type`
ornithine carbamoyltransferase activity `gomodel:ORNCARBAMTRANSFER-RXN`	has_input	L-ornithinium(1+) `CHEBI:46911`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ORNCARBAMTRANSFER-RXN RO:0002233 gomodel:CHEBI_46911_GLUTAMATE-N-ACETYLTRANSFERASE-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/19; endpoint types: /individuals/48/type; /individuals/33/type`
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor `gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN`	has_input	N(2)-acetyl-L-ornithine zwitterion `CHEBI:57805`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_57805_ACETYLORNTRANSAM-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/20; endpoint types: /individuals/45/type; /individuals/39/type`
ornithine carbamoyltransferase activity `gomodel:ORNCARBAMTRANSFER-RXN`	part_of	L-arginine biosynthetic process `GO:0006526`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ORNCARBAMTRANSFER-RXN BFO:0000050 gomodel:YeastPathways_ARGSYNBSUB-PWY/YeastPathways_ARGSYNBSUB-PWY. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/21; endpoint types: /individuals/48/type; /individuals/135/type`
argininosuccinate synthase activity `gomodel:ARGSUCCINSYN-RXN`	has_input	L-citrulline zwitterion `CHEBI:57743`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ARGSUCCINSYN-RXN RO:0002233 gomodel:CHEBI_57743_ORNCARBAMTRANSFER-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/22; endpoint types: /individuals/3/type; /individuals/37/type`
L-glutamate N-acetyltransferase activity, acetyl-CoA as donor `gomodel:N-ACETYLTRANSFER-RXN`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:N-ACETYLTRANSFER-RXN RO:0002234 gomodel:CHEBI_15378_N-ACETYLTRANSFER-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/23; endpoint types: /individuals/47/type; /individuals/9/type`
argininosuccinate synthase activity `gomodel:ARGSUCCINSYN-RXN`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ARGSUCCINSYN-RXN RO:0002234 gomodel:CHEBI_15378_ARGSUCCINSYN-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/24; endpoint types: /individuals/3/type; /individuals/6/type`
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity `gomodel:CARBPSYN-RXN`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:CARBPSYN-RXN RO:0002234 gomodel:CHEBI_15378_CARBPSYN-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/25; endpoint types: /individuals/4/type; /individuals/7/type`
N-acetyl-gamma-glutamyl-phosphate reductase (NADP+) activity `gomodel:N-ACETYLGLUTPREDUCT-RXN`	has_output	hydrogenphosphate `CHEBI:43474`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:N-ACETYLGLUTPREDUCT-RXN RO:0002234 gomodel:CHEBI_43474_N-ACETYLGLUTPREDUCT-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/26; endpoint types: /individuals/46/type; /individuals/26/type`
argininosuccinate synthase activity `gomodel:ARGSUCCINSYN-RXN`	has_output	diphosphoric acid `CHEBI:29888`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ARGSUCCINSYN-RXN RO:0002234 gomodel:CHEBI_29888_ARGSUCCINSYN-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/27; endpoint types: /individuals/3/type; /individuals/15/type`
argininosuccinate synthase activity `gomodel:ARGSUCCINSYN-RXN`	has_output	adenosine 5'-monophosphate(2-) `CHEBI:456215`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ARGSUCCINSYN-RXN RO:0002234 gomodel:CHEBI_456215_ARGSUCCINSYN-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/28; endpoint types: /individuals/3/type; /individuals/30/type`
N-acetyl-gamma-glutamyl-phosphate reductase (NADP+) activity `gomodel:N-ACETYLGLUTPREDUCT-RXN`	has_output	2-acetamido-5-oxopentanoate `CHEBI:29123`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:N-ACETYLGLUTPREDUCT-RXN RO:0002234 gomodel:CHEBI_29123_N-ACETYLGLUTPREDUCT-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/29; endpoint types: /individuals/46/type; /individuals/13/type`
N2-acetyl-L-ornithine:2-oxoglutarate 5-transaminase activity `gomodel:ACETYLORNTRANSAM-RXN`	part_of	L-arginine biosynthetic process `GO:0006526`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ACETYLORNTRANSAM-RXN BFO:0000050 gomodel:YeastPathways_ARGSYNBSUB-PWY/YeastPathways_ARGSYNBSUB-PWY. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/30; endpoint types: /individuals/1/type; /individuals/135/type`
ARG2 Scer `SGD:S000003607`	enables	L-glutamate N-acetyltransferase activity, acetyl-CoA as donor `gomodel:N-ACETYLTRANSFER-RXN`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:N-ACETYLTRANSFER-RXN RO:0002333 gomodel:YJL071W-MONOMER_N-ACETYLTRANSFER-RXN_controller. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/31; endpoint types: /individuals/47/type; /individuals/54/type` UniProtKB:P40360 Source assertion: UniProtKB:P40360 annotates acetyl-CoA-dependent L-glutamate N-acetylation (RHEA:24292); this corrects the imported methionine-activity label. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/1707/comments/1/reaction`
L-glutamate N-acetyltransferase activity, acetyl-CoA as donor `gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704`	has_output	N-acetyl-L-glutamate(2-) `CHEBI:44337`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704 RO:0002234 gomodel:CHEBI_44337_N-ACETYLTRANSFER-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/32; endpoint types: /individuals/136/type; /individuals/29/type`
ARG56 Scer `SGD:S000000871`	enables	acetylglutamate kinase activity `gomodel:ACETYLGLUTKIN-RXN`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ACETYLGLUTKIN-RXN RO:0002333 gomodel:YER069W-MONOMER_ACETYLGLUTKIN-RXN_controller. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/35; endpoint types: /individuals/0/type; /individuals/51/type`
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor `gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN`	has_output	N-acetyl-L-glutamate(2-) `CHEBI:44337`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_44337_GLUTAMATE-N-ACETYLTRANSFERASE-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/36; endpoint types: /individuals/45/type; /individuals/28/type`
argininosuccinate synthase activity `gomodel:ARGSUCCINSYN-RXN`	has_input	L-aspartate(1-) `CHEBI:29991`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ARGSUCCINSYN-RXN RO:0002233 gomodel:CHEBI_29991_ARGSUCCINSYN-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/37; endpoint types: /individuals/3/type; /individuals/20/type`
N2-acetyl-L-ornithine:2-oxoglutarate 5-transaminase activity `gomodel:ACETYLORNTRANSAM-RXN`	has_input	L-glutamate(1-) `CHEBI:29985`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ACETYLORNTRANSAM-RXN RO:0002233 gomodel:CHEBI_29985_ACETYLORNTRANSAM-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/38; endpoint types: /individuals/1/type; /individuals/16/type`
ARG7 Scer `SGD:S000004666`	enables	L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor `gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN RO:0002333 gomodel:YMR062C-MONOMER_GLUTAMATE-N-ACETYLTRANSFERASE-RXN_controller. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/39; endpoint types: /individuals/45/type; /individuals/56/type`
ARG7 Scer `SGD:S000004666`	enables	L-glutamate N-acetyltransferase activity, acetyl-CoA as donor `gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704 RO:0002333 gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000709. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/40; endpoint types: /individuals/136/type; /individuals/141/type` UniProtKB:Q04728 Source assertion: UniProtKB:Q04728 annotates acetyl-CoA-dependent L-glutamate N-acetylation (RHEA:24292); this corrects the imported methionine-activity label. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2639/comments/2/reaction`
N2-acetyl-L-ornithine:2-oxoglutarate 5-transaminase activity `gomodel:ACETYLORNTRANSAM-RXN`	has_input	2-acetamido-5-oxopentanoate `CHEBI:29123`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ACETYLORNTRANSAM-RXN RO:0002233 gomodel:CHEBI_29123_N-ACETYLGLUTPREDUCT-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/41; endpoint types: /individuals/1/type; /individuals/13/type`
ornithine carbamoyltransferase activity `gomodel:ORNCARBAMTRANSFER-RXN`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ORNCARBAMTRANSFER-RXN RO:0002234 gomodel:CHEBI_15378_ORNCARBAMTRANSFER-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/42; endpoint types: /individuals/48/type; /individuals/10/type`
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity `gomodel:CARBPSYN-RXN`	has_output	ADP(3-) `CHEBI:456216`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:CARBPSYN-RXN RO:0002234 gomodel:CHEBI_456216_CARBPSYN-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/43; endpoint types: /individuals/4/type; /individuals/32/type`
acetylglutamate kinase activity `gomodel:ACETYLGLUTKIN-RXN`	has_input	N-acetyl-L-glutamate(2-) `CHEBI:44337`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ACETYLGLUTKIN-RXN RO:0002233 gomodel:CHEBI_44337_N-ACETYLTRANSFER-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/44; endpoint types: /individuals/0/type; /individuals/29/type`
ornithine carbamoyltransferase activity `gomodel:ORNCARBAMTRANSFER-RXN`	has_output	hydrogenphosphate `CHEBI:43474`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ORNCARBAMTRANSFER-RXN RO:0002234 gomodel:CHEBI_43474_ORNCARBAMTRANSFER-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/45; endpoint types: /individuals/48/type; /individuals/27/type`
N2-acetyl-L-ornithine:2-oxoglutarate 5-transaminase activity `gomodel:ACETYLORNTRANSAM-RXN`	has_output	2-oxoglutarate(2-) `CHEBI:16810`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ACETYLORNTRANSAM-RXN RO:0002234 gomodel:CHEBI_16810_ACETYLORNTRANSAM-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/46; endpoint types: /individuals/1/type; /individuals/11/type`
N-acetyl-gamma-glutamyl-phosphate reductase (NADP+) activity `gomodel:N-ACETYLGLUTPREDUCT-RXN`	has_input	N-acetyl-L-gamma-glutamyl phosphate(3-) `CHEBI:57936`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:N-ACETYLGLUTPREDUCT-RXN RO:0002233 gomodel:CHEBI_57936_ACETYLGLUTKIN-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/47; endpoint types: /individuals/46/type; /individuals/40/type`
L-glutamate N-acetyltransferase activity, acetyl-CoA as donor `gomodel:N-ACETYLTRANSFER-RXN`	has_output	N-acetyl-L-glutamate(2-) `CHEBI:44337`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:N-ACETYLTRANSFER-RXN RO:0002234 gomodel:CHEBI_44337_N-ACETYLTRANSFER-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/48; endpoint types: /individuals/47/type; /individuals/29/type`
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity `gomodel:CARBPSYN-RXN`	has_output	carbamoyl phosphate(2-) `CHEBI:58228`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:CARBPSYN-RXN RO:0002234 gomodel:CHEBI_58228_CARBPSYN-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/50; endpoint types: /individuals/4/type; /individuals/41/type`
N-acetyl-gamma-glutamyl-phosphate reductase (NADP+) activity `gomodel:N-ACETYLGLUTPREDUCT-RXN`	has_input	NADPH(4-) `CHEBI:57783`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:N-ACETYLGLUTPREDUCT-RXN RO:0002233 gomodel:CHEBI_57783_N-ACETYLGLUTPREDUCT-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/51; endpoint types: /individuals/46/type; /individuals/38/type`
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity `gomodel:CARBPSYN-RXN`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:CARBPSYN-RXN RO:0002233 gomodel:CHEBI_30616_CARBPSYN-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/52; endpoint types: /individuals/4/type; /individuals/23/type`
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity `gomodel:CARBPSYN-RXN`	has_output	L-glutamate(1-) `CHEBI:29985`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:CARBPSYN-RXN RO:0002234 gomodel:CHEBI_29985_CARBPSYN-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/53; endpoint types: /individuals/4/type; /individuals/17/type`
argininosuccinate lyase activity `gomodel:ARGSUCCINLYA-RXN`	has_output	fumarate(2-) `CHEBI:29806`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ARGSUCCINLYA-RXN RO:0002234 gomodel:CHEBI_29806_ARGSUCCINLYA-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/54; endpoint types: /individuals/2/type; /individuals/14/type`
N-acetyl-gamma-glutamyl-phosphate reductase (NADP+) activity `gomodel:N-ACETYLGLUTPREDUCT-RXN`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:N-ACETYLGLUTPREDUCT-RXN RO:0002233 gomodel:CHEBI_15378_N-ACETYLGLUTPREDUCT-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/57; endpoint types: /individuals/46/type; /individuals/8/type`
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor `gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN`	part_of	L-arginine biosynthetic process `GO:0006526`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN BFO:0000050 gomodel:YeastPathways_ARGSYNBSUB-PWY/YeastPathways_ARGSYNBSUB-PWY. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/58; endpoint types: /individuals/45/type; /individuals/135/type`
L-glutamate N-acetyltransferase activity, acetyl-CoA as donor `gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704`	has_output	coenzyme A(4-) `CHEBI:57287`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704 RO:0002234 gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000707. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/59; endpoint types: /individuals/136/type; /individuals/139/type`
argininosuccinate synthase activity `gomodel:ARGSUCCINSYN-RXN`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ARGSUCCINSYN-RXN RO:0002233 gomodel:CHEBI_30616_ARGSUCCINSYN-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/60; endpoint types: /individuals/3/type; /individuals/22/type`
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity `gomodel:CARBPSYN-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:CARBPSYN-RXN BFO:0000066 gomodel:reaction_CARBPSYN-RXN_location_lociGO_0005829. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/61; endpoint types: /individuals/4/type; /individuals/130/type`
L-glutamate N-acetyltransferase activity, acetyl-CoA as donor `gomodel:N-ACETYLTRANSFER-RXN`	has_input	L-glutamate(1-) `CHEBI:29985`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:N-ACETYLTRANSFER-RXN RO:0002233 gomodel:CHEBI_29985_N-ACETYLTRANSFER-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/62; endpoint types: /individuals/47/type; /individuals/19/type`
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor `gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN`	has_output	L-ornithinium(1+) `CHEBI:46911`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_46911_GLUTAMATE-N-ACETYLTRANSFERASE-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/63; endpoint types: /individuals/45/type; /individuals/33/type`
acetylglutamate kinase activity `gomodel:ACETYLGLUTKIN-RXN`	has_output	ADP(3-) `CHEBI:456216`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ACETYLGLUTKIN-RXN RO:0002234 gomodel:CHEBI_456216_ACETYLGLUTKIN-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/64; endpoint types: /individuals/0/type; /individuals/31/type`
argininosuccinate lyase activity `gomodel:ARGSUCCINLYA-RXN`	part_of	L-arginine biosynthetic process `GO:0006526`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ARGSUCCINLYA-RXN BFO:0000050 gomodel:YeastPathways_ARGSYNBSUB-PWY/YeastPathways_ARGSYNBSUB-PWY. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/65; endpoint types: /individuals/2/type; /individuals/135/type`
ARG4 Scer `SGD:S000001060`	enables	argininosuccinate lyase activity `gomodel:ARGSUCCINLYA-RXN`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ARGSUCCINLYA-RXN RO:0002333 gomodel:YHR018C-MONOMER_ARGSUCCINLYA-RXN_controller. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/66; endpoint types: /individuals/2/type; /individuals/53/type`
argininosuccinate lyase activity `gomodel:ARGSUCCINLYA-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ARGSUCCINLYA-RXN BFO:0000066 gomodel:reaction_ARGSUCCINLYA-RXN_location_lociGO_0005829. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/67; endpoint types: /individuals/2/type; /individuals/128/type`
L-glutamate N-acetyltransferase activity, acetyl-CoA as donor `gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704`	part_of	L-arginine biosynthetic process `GO:0006526`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704 BFO:0000050 gomodel:YeastPathways_ARGSYNBSUB-PWY/YeastPathways_ARGSYNBSUB-PWY. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/68; endpoint types: /individuals/136/type; /individuals/135/type`
L-glutamate N-acetyltransferase activity, acetyl-CoA as donor `gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704`	has_input	acetyl-CoA(4-) `CHEBI:57288`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704 RO:0002233 gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000706. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/69; endpoint types: /individuals/136/type; /individuals/138/type`
ARG1 Scer `SGD:S000005419`	enables	argininosuccinate synthase activity `gomodel:ARGSUCCINSYN-RXN`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ARGSUCCINSYN-RXN RO:0002333 gomodel:YOL058W-MONOMER_ARGSUCCINSYN-RXN_controller. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/70; endpoint types: /individuals/3/type; /individuals/57/type`
L-glutamate N-acetyltransferase activity, acetyl-CoA as donor `gomodel:N-ACETYLTRANSFER-RXN`	part_of	L-arginine biosynthetic process `GO:0006526`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:N-ACETYLTRANSFER-RXN BFO:0000050 gomodel:YeastPathways_ARGSYNBSUB-PWY/YeastPathways_ARGSYNBSUB-PWY. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/71; endpoint types: /individuals/47/type; /individuals/135/type`
L-glutamate N-acetyltransferase activity, acetyl-CoA as donor `gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704`	has_input	L-glutamate(1-) `CHEBI:29985`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704 RO:0002233 gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000705. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/72; endpoint types: /individuals/136/type; /individuals/137/type`
argininosuccinate synthase activity `gomodel:ARGSUCCINSYN-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ARGSUCCINSYN-RXN BFO:0000066 gomodel:reaction_ARGSUCCINSYN-RXN_location_lociGO_0005829. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/73; endpoint types: /individuals/3/type; /individuals/129/type`
CPX-579 Scer `SGD:S000217863`	enables	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity `gomodel:CARBPSYN-RXN`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:CARBPSYN-RXN RO:0002333 gomodel:CPLX3O-887_CARBPSYN-RXN_controller. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/74; endpoint types: /individuals/4/type; /individuals/44/type`
acetylglutamate kinase activity `gomodel:ACETYLGLUTKIN-RXN`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ACETYLGLUTKIN-RXN RO:0002233 gomodel:CHEBI_30616_ACETYLGLUTKIN-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/75; endpoint types: /individuals/0/type; /individuals/21/type`
N-acetyl-gamma-glutamyl-phosphate reductase (NADP+) activity `gomodel:N-ACETYLGLUTPREDUCT-RXN`	part_of	L-arginine biosynthetic process `GO:0006526`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:N-ACETYLGLUTPREDUCT-RXN BFO:0000050 gomodel:YeastPathways_ARGSYNBSUB-PWY/YeastPathways_ARGSYNBSUB-PWY. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/76; endpoint types: /individuals/46/type; /individuals/135/type`
ARG8 Scer `SGD:S000005500`	enables	N2-acetyl-L-ornithine:2-oxoglutarate 5-transaminase activity `gomodel:ACETYLORNTRANSAM-RXN`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ACETYLORNTRANSAM-RXN RO:0002333 gomodel:YOL140W-MONOMER_ACETYLORNTRANSAM-RXN_controller. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/77; endpoint types: /individuals/1/type; /individuals/58/type`
CPX-579 Scer `SGD:S000217863`	has_part	CPA1 Scer `SGD:S000005829`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:CPLX3O-887_CARBPSYN-RXN_controller BFO:0000051 gomodel:SGD_S000005829_CPLX3O-887_component. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/78; endpoint types: /individuals/44/type; /individuals/50/type`
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity `gomodel:CARBPSYN-RXN`	part_of	L-arginine biosynthetic process `GO:0006526`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:CARBPSYN-RXN BFO:0000050 gomodel:YeastPathways_ARGSYNBSUB-PWY/YeastPathways_ARGSYNBSUB-PWY. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/79; endpoint types: /individuals/4/type; /individuals/135/type`
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity `gomodel:CARBPSYN-RXN`	has_input	hydrogencarbonate `CHEBI:17544`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:CARBPSYN-RXN RO:0002233 gomodel:CHEBI_17544_CARBPSYN-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/80; endpoint types: /individuals/4/type; /individuals/12/type`
argininosuccinate synthase activity `gomodel:ARGSUCCINSYN-RXN`	has_output	(N(omega)-L-arginino)succinate(1-) `CHEBI:57472`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ARGSUCCINSYN-RXN RO:0002234 gomodel:CHEBI_57472_ARGSUCCINSYN-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/81; endpoint types: /individuals/3/type; /individuals/36/type`
argininosuccinate synthase activity `gomodel:ARGSUCCINSYN-RXN`	part_of	L-arginine biosynthetic process `GO:0006526`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ARGSUCCINSYN-RXN BFO:0000050 gomodel:YeastPathways_ARGSYNBSUB-PWY/YeastPathways_ARGSYNBSUB-PWY. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/82; endpoint types: /individuals/3/type; /individuals/135/type`
L-glutamate N-acetyltransferase activity, acetyl-CoA as donor `gomodel:N-ACETYLTRANSFER-RXN`	has_input	acetyl-CoA(4-) `CHEBI:57288`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:N-ACETYLTRANSFER-RXN RO:0002233 gomodel:CHEBI_57288_N-ACETYLTRANSFER-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/83; endpoint types: /individuals/47/type; /individuals/35/type`
ornithine carbamoyltransferase activity `gomodel:ORNCARBAMTRANSFER-RXN`	has_output	L-citrulline zwitterion `CHEBI:57743`	gomodel:YeastPathways_ARGSYNBSUB-PWY Source assertion: The model asserts gomodel:ORNCARBAMTRANSFER-RXN RO:0002234 gomodel:CHEBI_57743_ORNCARBAMTRANSFER-RXN. Source location `./YeastPathways_ARGSYNBSUB-PWY.json#/facts/84; endpoint types: /individuals/48/type; /individuals/37/type`
CPX-579 Scer `SGD:S000217863`	located_in Complex location from the independent composition source; original GO-CAM activity locations are retained with their own provenance.	cytoplasm `GO:0005737`	SGD:S000217863 Source assertion: Complex Portal CPX-579 records cellular location GO:0005737 (cytoplasm); its evidence classification is ECO:0000353: physical interaction evidence. Source location `Complex Portal JSON #/crossReferences/9; /evidenceType`
ARG3 Scer `SGD:S000003624`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source	cytoplasm `GO:0005737`	UniProtKB:P05150 Source assertion: UniProtKB:P05150 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/100/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P05150 Source assertion: UniProtKB:P05150 has the exact SGD cross-reference SGD:S000003624. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/100/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
CPA2 Scer `SGD:S000003870`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:200419); ECO:0000269 (PubMed:205532)	cytoplasm `GO:0005737`	UniProtKB:P03965 Source assertion: UniProtKB:P03965 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/75/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P03965 Source assertion: UniProtKB:P03965 has the exact SGD cross-reference SGD:S000003870. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/75/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ARG56 Scer `SGD:S000000871`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source	mitochondrion `GO:0005739`	UniProtKB:Q01217 Source assertion: UniProtKB:Q01217 annotates location Mitochondrion (SL-0173). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2384/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q01217 Source assertion: UniProtKB:Q01217 has the exact SGD cross-reference SGD:S000000871. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2384/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ARG2 Scer `SGD:S000003607`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:205532)	mitochondrion `GO:0005739`	UniProtKB:P40360 Source assertion: UniProtKB:P40360 annotates location Mitochondrion (SL-0173). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1707/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P40360 Source assertion: UniProtKB:P40360 has the exact SGD cross-reference SGD:S000003607. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1707/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ARG7 Scer `SGD:S000004666`	located_in Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03124); ECO:0000269 (PubMed:14576278)	mitochondrial matrix `GO:0005759`	UniProtKB:Q04728 Source assertion: UniProtKB:Q04728 annotates location Mitochondrion matrix (SL-0170). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2639/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q04728 Source assertion: UniProtKB:Q04728 has the exact SGD cross-reference SGD:S000004666. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2639/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ARG1 Scer `SGD:S000005419`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:205532)	cytoplasm `GO:0005737`	UniProtKB:P22768 Source assertion: UniProtKB:P22768 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/599/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P22768 Source assertion: UniProtKB:P22768 has the exact SGD cross-reference SGD:S000005419. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/599/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ARG8 Scer `SGD:S000005500`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:205532)	mitochondrial matrix `GO:0005759`	UniProtKB:P18544 Source assertion: UniProtKB:P18544 annotates location Mitochondrion matrix (SL-0170). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3317/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P18544 Source assertion: UniProtKB:P18544 has the exact SGD cross-reference SGD:S000005500. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3317/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
CPA1 Scer `SGD:S000005829`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:200419); ECO:0000269 (PubMed:205532)	cytoplasm `GO:0005737`	UniProtKB:P07258 Source assertion: UniProtKB:P07258 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/169/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P07258 Source assertion: UniProtKB:P07258 has the exact SGD cross-reference SGD:S000005829. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/169/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
CPA2 Scer `SGD:S000003870`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (PROSITE-ProRule:PRU00409) Binds 4 Mg(2+) or Mn(2+) ions per subunit. UniProt note evidence: ECO:0000255 (PROSITE-ProRule:PRU00409)	magnesium(2+) `CHEBI:18420`	UniProtKB:P03965 Source assertion: UniProtKB:P03965 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/75/comments/0/cofactors/0; /results/75/comments/0/note` UniProtKB:P03965 Source assertion: UniProtKB:P03965 has the exact SGD cross-reference SGD:S000003870. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/75/uniProtKBCrossReferences/0`
CPA2 Scer `SGD:S000003870`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (PROSITE-ProRule:PRU00409) Binds 4 Mg(2+) or Mn(2+) ions per subunit. UniProt note evidence: ECO:0000255 (PROSITE-ProRule:PRU00409)	manganese(2+) `CHEBI:29035`	UniProtKB:P03965 Source assertion: UniProtKB:P03965 annotates CHEBI:29035 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/75/comments/0/cofactors/1; /results/75/comments/0/note` UniProtKB:P03965 Source assertion: UniProtKB:P03965 has the exact SGD cross-reference SGD:S000003870. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/75/uniProtKBCrossReferences/0`
ARG8 Scer `SGD:S000005500`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	pyridoxal 5'-phosphate(2-) `CHEBI:597326`	UniProtKB:P18544 Source assertion: UniProtKB:P18544 annotates CHEBI:597326 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3317/comments/0/cofactors/0` UniProtKB:P18544 Source assertion: UniProtKB:P18544 has the exact SGD cross-reference SGD:S000005500. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3317/uniProtKBCrossReferences/0`

References

gomodel:YeastPathways_ARGSYNBSUB-PWY GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY (source version: Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json)
SGD:S000217863 Complex Portal CPX-579: Carbamoyl-phosphate synthase arginine-specific (source version: Inspected API snapshot 2026-10-05; release dates 2014-10-16)
UniProtKB:P07258 Reviewed UniProtKB P07258 SGD cross-reference (source version: UniProt release 2026_03)
UniProtKB:P03965 Reviewed UniProtKB P03965 SGD cross-reference (source version: UniProt release 2026_03)
UniProtKB:P05150 Reviewed UniProtKB P05150 location annotations (source version: UniProt release 2026_03)
UniProtKB:Q01217 Reviewed UniProtKB Q01217 location annotations (source version: UniProt release 2026_03)
UniProtKB:P40360 Reviewed UniProtKB P40360 location annotations (source version: UniProt release 2026_03)
UniProtKB:Q04728 Reviewed UniProtKB Q04728 location annotations (source version: UniProt release 2026_03)
UniProtKB:P22768 Reviewed UniProtKB P22768 location annotations (source version: UniProt release 2026_03)
UniProtKB:P18544 Reviewed UniProtKB P18544 location annotations (source version: UniProt release 2026_03)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger. Reviewed exact Complex Portal composition, source evidence grades, and independent physical complex locations.
2026-10-05T06:17:04Z Codex; review-complex-composition; Reviewed exact Complex Portal composition, source evidence grades, and independent physical complex locations; reused existing proteins through reviewed UniProt SGD cross-references.
2026-10-05T07:05:25Z Codex; edited; Correct ARG2/ARG7 activity labels; chemical sides and enzyme identities retained.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 10 activity location assignments and 9 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 8 independently supported location edges and quarantined 6 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
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2026-10-05T07:05:25Z Codex
- EDIT — Correct ARG2/ARG7 activity labels; chemical sides and enzyme identities retained.
  User-authorized full causal graph curation. Correct ARG2/ARG7 activity labels; chemical sides and enzyme identities retained. Independent UniProt release2026_03 annotations, Rhea139 and ChEBI255 were inspected; primary literature was checked for the taxon/function distinctions. Exact source pointers and superseded edge assertions are retained in reports/causal_graph_review/gocam-chemical-corrections.json. Native schema validation and focused biochemical regression tests were run. Shared final rendering and full gates are performed by the coordinating agent.
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