asparagine degradation

gomodel:YeastPathways_ASPARAGINE-DEG2-PWY

Asparagine degradation hydrolyzes L-asparagine to L-aspartate and ammonium through ASP1/ASP3 activities and then transaminates L-aspartate to oxaloacetate through AAT1/AAT2 in Saccharomyces cerevisiae S288C.

Pathway type

amino acid degradation

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

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Pathway network

29 nodes · 58 asserted directed edges

Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.

Reaction / activity
Chemical / cofactor
Protein / complex
Cell / process context
Solid arrow: mechanistic relation
Dashed arrow: membership, location or cofactor relation

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
ammonium `CHEBI:28938`	small molecule
L-aspartate(1-) `CHEBI:29991`	small molecule
cytosol `GO:0005829`	cellular component
ASP1 Scer `SGD:S000002729`	protein
water `CHEBI:15377`	small molecule
AAT2 Scer `SGD:S000004017`	protein
L-asparagine catabolic process `GO:0006530`	biological process
oxaloacetate(2-) `CHEBI:16452`	small molecule
ASP3-2 Scer `SGD:S000004147`	protein
ASP3-4 Scer `SGD:S000004150`	protein
L-asparagine zwitterion `CHEBI:58048`	small molecule
ASP3-3 Scer `SGD:S000004148`	protein
AAT1 Scer `SGD:S000001589`	protein
L-glutamate(1-) `CHEBI:29985`	small molecule
2-oxoglutarate(2-) `CHEBI:16810`	small molecule
ASP3-1 Scer `SGD:S000004145`	protein
cytoplasm `GO:0005737`	cellular component
peroxisome `GO:0005777`	cellular component
extracellular region `GO:0005576`	cellular component
periplasmic space `GO:0042597`	cellular component
mitochondrial matrix `GO:0005759`	cellular component
pyridoxal 5'-phosphate(2-) `CHEBI:597326`	cofactor
L-aspartate:2-oxoglutarate transaminase activity `gomodel:ASPAMINOTRANS-RXN`	molecular activity
asparaginase activity `gomodel:ASPARAGHYD-RXN`	molecular activity
L-aspartate:2-oxoglutarate transaminase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808`	molecular activity
asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002822`	molecular activity
asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002839`	molecular activity
asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002855`	molecular activity
asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002870`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002870`	has_output	ammonium `CHEBI:28938`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002870 RO:0002234 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002873. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/0; endpoint types: /individuals/78/type; /individuals/81/type`
asparaginase activity `gomodel:ASPARAGHYD-RXN`	has_output	L-aspartate(1-) `CHEBI:29991`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:ASPARAGHYD-RXN RO:0002234 gomodel:CHEBI_29991_ASPARAGHYD-RXN. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/1; endpoint types: /individuals/1/type; /individuals/7/type`
L-aspartate:2-oxoglutarate transaminase activity `gomodel:ASPAMINOTRANS-RXN`	has_input	L-aspartate(1-) `CHEBI:29991`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:ASPAMINOTRANS-RXN RO:0002233 gomodel:CHEBI_29991_ASPARAGHYD-RXN. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/2; endpoint types: /individuals/0/type; /individuals/7/type`
L-aspartate:2-oxoglutarate transaminase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808 BFO:0000066 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002814. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/3; endpoint types: /individuals/26/type; /individuals/31/type`
ASP1 Scer `SGD:S000002729`	enables	asparaginase activity `gomodel:ASPARAGHYD-RXN`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:ASPARAGHYD-RXN RO:0002333 gomodel:YDR321W-MONOMER_ASPARAGHYD-RXN_controller. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/4; endpoint types: /individuals/1/type; /individuals/9/type`
asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002839`	has_output	ammonium `CHEBI:28938`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002839 RO:0002234 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002842. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/5; endpoint types: /individuals/52/type; /individuals/55/type`
asparaginase activity `gomodel:ASPARAGHYD-RXN`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:ASPARAGHYD-RXN RO:0002233 gomodel:CHEBI_15377_ASPARAGHYD-RXN. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/6; endpoint types: /individuals/1/type; /individuals/2/type`
AAT2 Scer `SGD:S000004017`	enables	L-aspartate:2-oxoglutarate transaminase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808 RO:0002333 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002813. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/7; endpoint types: /individuals/26/type; /individuals/30/type`
L-aspartate:2-oxoglutarate transaminase activity `gomodel:ASPAMINOTRANS-RXN`	part_of	L-asparagine catabolic process `GO:0006530`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:ASPAMINOTRANS-RXN BFO:0000050 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/YeastPathways_ASPARAGINE-DEG2-PWY. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/8; endpoint types: /individuals/0/type; /individuals/25/type`
asparaginase activity `gomodel:ASPARAGHYD-RXN`	has_output	ammonium `CHEBI:28938`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:ASPARAGHYD-RXN RO:0002234 gomodel:CHEBI_28938_ASPARAGHYD-RXN. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/9; endpoint types: /individuals/1/type; /individuals/5/type`
asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002839`	part_of	L-asparagine catabolic process `GO:0006530`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002839 BFO:0000050 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/YeastPathways_ASPARAGINE-DEG2-PWY. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/10; endpoint types: /individuals/52/type; /individuals/25/type`
L-aspartate:2-oxoglutarate transaminase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808`	has_output	oxaloacetate(2-) `CHEBI:16452`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808 RO:0002234 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002811. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/11; endpoint types: /individuals/26/type; /individuals/29/type`
ASP3-2 Scer `SGD:S000004147`	enables	asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002839`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002839 RO:0002333 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002844. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/12; endpoint types: /individuals/52/type; /individuals/56/type`
asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002822`	has_output	L-aspartate(1-) `CHEBI:29991`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002822 RO:0002234 gomodel:CHEBI_29991_ASPARAGHYD-RXN. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/13; endpoint types: /individuals/39/type; /individuals/7/type`
ASP3-4 Scer `SGD:S000004150`	enables	asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002855`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002855 RO:0002333 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002860. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/14; endpoint types: /individuals/65/type; /individuals/69/type`
L-aspartate:2-oxoglutarate transaminase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808`	part_of	L-asparagine catabolic process `GO:0006530`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808 BFO:0000050 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/YeastPathways_ASPARAGINE-DEG2-PWY. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/15; endpoint types: /individuals/26/type; /individuals/25/type`
asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002822`	part_of	L-asparagine catabolic process `GO:0006530`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002822 BFO:0000050 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/YeastPathways_ASPARAGINE-DEG2-PWY. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/16; endpoint types: /individuals/39/type; /individuals/25/type`
asparaginase activity `gomodel:ASPARAGHYD-RXN`	has_input	L-asparagine zwitterion `CHEBI:58048`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:ASPARAGHYD-RXN RO:0002233 gomodel:CHEBI_58048_ASPARAGHYD-RXN. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/17; endpoint types: /individuals/1/type; /individuals/8/type`
asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002870`	part_of	L-asparagine catabolic process `GO:0006530`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002870 BFO:0000050 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/YeastPathways_ASPARAGINE-DEG2-PWY. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/18; endpoint types: /individuals/78/type; /individuals/25/type`
ASP3-3 Scer `SGD:S000004148`	enables	asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002870`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002870 RO:0002333 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002875. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/19; endpoint types: /individuals/78/type; /individuals/82/type`
asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002822`	has_input	L-asparagine zwitterion `CHEBI:58048`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002822 RO:0002233 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002824. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/20; endpoint types: /individuals/39/type; /individuals/41/type`
asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002855`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002855 RO:0002233 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002856. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/22; endpoint types: /individuals/65/type; /individuals/66/type`
AAT1 Scer `SGD:S000001589`	enables	L-aspartate:2-oxoglutarate transaminase activity `gomodel:ASPAMINOTRANS-RXN`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:ASPAMINOTRANS-RXN RO:0002333 gomodel:YKL106W-MONOMER_ASPAMINOTRANS-RXN_controller. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/24; endpoint types: /individuals/0/type; /individuals/10/type`
L-aspartate:2-oxoglutarate transaminase activity `gomodel:ASPAMINOTRANS-RXN`	has_output	L-glutamate(1-) `CHEBI:29985`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:ASPAMINOTRANS-RXN RO:0002234 gomodel:CHEBI_29985_ASPAMINOTRANS-RXN. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/25; endpoint types: /individuals/0/type; /individuals/6/type`
L-aspartate:2-oxoglutarate transaminase activity `gomodel:ASPAMINOTRANS-RXN`	has_input	2-oxoglutarate(2-) `CHEBI:16810`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:ASPAMINOTRANS-RXN RO:0002233 gomodel:CHEBI_16810_ASPAMINOTRANS-RXN. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/27; endpoint types: /individuals/0/type; /individuals/4/type`
L-aspartate:2-oxoglutarate transaminase activity `gomodel:ASPAMINOTRANS-RXN`	has_output	oxaloacetate(2-) `CHEBI:16452`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:ASPAMINOTRANS-RXN RO:0002234 gomodel:CHEBI_16452_ASPAMINOTRANS-RXN. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/29; endpoint types: /individuals/0/type; /individuals/3/type`
asparaginase activity `gomodel:ASPARAGHYD-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:ASPARAGHYD-RXN BFO:0000066 gomodel:reaction_ASPARAGHYD-RXN_location_lociGO_0005829. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/30; endpoint types: /individuals/1/type; /individuals/24/type`
asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002855`	has_input	L-asparagine zwitterion `CHEBI:58048`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002855 RO:0002233 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002857. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/31; endpoint types: /individuals/65/type; /individuals/67/type`
L-aspartate:2-oxoglutarate transaminase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808`	has_input	2-oxoglutarate(2-) `CHEBI:16810`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808 RO:0002233 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002809. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/32; endpoint types: /individuals/26/type; /individuals/27/type`
asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002839`	has_output	L-aspartate(1-) `CHEBI:29991`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002839 RO:0002234 gomodel:CHEBI_29991_ASPARAGHYD-RXN. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/33; endpoint types: /individuals/52/type; /individuals/7/type`
L-aspartate:2-oxoglutarate transaminase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808`	has_input	L-aspartate(1-) `CHEBI:29991`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808 RO:0002233 gomodel:CHEBI_29991_ASPARAGHYD-RXN. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/34; endpoint types: /individuals/26/type; /individuals/7/type`
asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002870`	has_input	L-asparagine zwitterion `CHEBI:58048`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002870 RO:0002233 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002872. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/35; endpoint types: /individuals/78/type; /individuals/80/type`
asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002870`	has_output	L-aspartate(1-) `CHEBI:29991`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002870 RO:0002234 gomodel:CHEBI_29991_ASPARAGHYD-RXN. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/36; endpoint types: /individuals/78/type; /individuals/7/type`
asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002870`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002870 RO:0002233 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002871. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/37; endpoint types: /individuals/78/type; /individuals/79/type`
ASP3-1 Scer `SGD:S000004145`	enables	asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002822`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002822 RO:0002333 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002828. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/38; endpoint types: /individuals/39/type; /individuals/43/type`
L-aspartate:2-oxoglutarate transaminase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808`	has_output	L-glutamate(1-) `CHEBI:29985`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808 RO:0002234 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002810. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/39; endpoint types: /individuals/26/type; /individuals/28/type`
asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002855`	has_output	ammonium `CHEBI:28938`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002855 RO:0002234 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002858. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/40; endpoint types: /individuals/65/type; /individuals/68/type`
asparaginase activity `gomodel:ASPARAGHYD-RXN`	part_of	L-asparagine catabolic process `GO:0006530`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:ASPARAGHYD-RXN BFO:0000050 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/YeastPathways_ASPARAGINE-DEG2-PWY. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/41; endpoint types: /individuals/1/type; /individuals/25/type`
asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002839`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002839 RO:0002233 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002840. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/42; endpoint types: /individuals/52/type; /individuals/53/type`
asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002822`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002822 RO:0002233 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002823. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/43; endpoint types: /individuals/39/type; /individuals/40/type`
asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002839`	has_input	L-asparagine zwitterion `CHEBI:58048`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002839 RO:0002233 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002841. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/44; endpoint types: /individuals/52/type; /individuals/54/type`
asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002822`	has_output	ammonium `CHEBI:28938`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002822 RO:0002234 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002825. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/45; endpoint types: /individuals/39/type; /individuals/42/type`
asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002855`	part_of	L-asparagine catabolic process `GO:0006530`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002855 BFO:0000050 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/YeastPathways_ASPARAGINE-DEG2-PWY. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/47; endpoint types: /individuals/65/type; /individuals/25/type`
asparaginase activity `gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002855`	has_output	L-aspartate(1-) `CHEBI:29991`	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY Source assertion: The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002855 RO:0002234 gomodel:CHEBI_29991_ASPARAGHYD-RXN. Source location `./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/48; endpoint types: /individuals/65/type; /individuals/7/type`
ASP1 Scer `SGD:S000002729`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source	cytoplasm `GO:0005737`	UniProtKB:P38986 Source assertion: UniProtKB:P38986 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3660/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P38986 Source assertion: UniProtKB:P38986 has the exact SGD cross-reference SGD:S000002729. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3660/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
AAT2 Scer `SGD:S000004017`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:9288922) Source qualification: Targeted to peroxisomes in cells grown in oleate	cytoplasm `GO:0005737`	UniProtKB:P23542 Source assertion: UniProtKB:P23542 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/619/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P23542 Source assertion: UniProtKB:P23542 has the exact SGD cross-reference SGD:S000004017. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/619/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
AAT2 Scer `SGD:S000004017`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:9288922) Source qualification: Targeted to peroxisomes in cells grown in oleate	peroxisome `GO:0005777`	UniProtKB:P23542 Source assertion: UniProtKB:P23542 annotates location Peroxisome (SL-0204). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/619/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P23542 Source assertion: UniProtKB:P23542 has the exact SGD cross-reference SGD:S000004017. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/619/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ASP3-2 Scer `SGD:S000004147`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source	extracellular region `GO:0005576`	UniProtKB:P0CX77 Source assertion: UniProtKB:P0CX77 annotates location Secreted (SL-0243). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/288/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P0CX77 Source assertion: UniProtKB:P0CX77 has the exact SGD cross-reference SGD:S000004147. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/288/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ASP3-2 Scer `SGD:S000004147`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source	periplasmic space `GO:0042597`	UniProtKB:P0CX77 Source assertion: UniProtKB:P0CX77 annotates location Periplasm (SL-0200). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/288/comments/0/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P0CX77 Source assertion: UniProtKB:P0CX77 has the exact SGD cross-reference SGD:S000004147. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/288/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ASP3-4 Scer `SGD:S000004150`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source	extracellular region `GO:0005576`	UniProtKB:P0CX79 Source assertion: UniProtKB:P0CX79 annotates location Secreted (SL-0243). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/290/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P0CX79 Source assertion: UniProtKB:P0CX79 has the exact SGD cross-reference SGD:S000004150. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/290/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ASP3-4 Scer `SGD:S000004150`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source	periplasmic space `GO:0042597`	UniProtKB:P0CX79 Source assertion: UniProtKB:P0CX79 annotates location Periplasm (SL-0200). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/290/comments/0/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P0CX79 Source assertion: UniProtKB:P0CX79 has the exact SGD cross-reference SGD:S000004150. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/290/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ASP3-3 Scer `SGD:S000004148`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source	extracellular region `GO:0005576`	UniProtKB:P0CX78 Source assertion: UniProtKB:P0CX78 annotates location Secreted (SL-0243). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/289/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P0CX78 Source assertion: UniProtKB:P0CX78 has the exact SGD cross-reference SGD:S000004148. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/289/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ASP3-3 Scer `SGD:S000004148`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source	periplasmic space `GO:0042597`	UniProtKB:P0CX78 Source assertion: UniProtKB:P0CX78 annotates location Periplasm (SL-0200). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/289/comments/0/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P0CX78 Source assertion: UniProtKB:P0CX78 has the exact SGD cross-reference SGD:S000004148. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/289/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
AAT1 Scer `SGD:S000001589`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:14576278)	mitochondrial matrix `GO:0005759`	UniProtKB:Q01802 Source assertion: UniProtKB:Q01802 annotates location Mitochondrion matrix (SL-0170). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4042/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q01802 Source assertion: UniProtKB:Q01802 has the exact SGD cross-reference SGD:S000001589. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4042/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ASP3-1 Scer `SGD:S000004145`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source	extracellular region `GO:0005576`	UniProtKB:P0CZ17 Source assertion: UniProtKB:P0CZ17 annotates location Secreted (SL-0243). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/299/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P0CZ17 Source assertion: UniProtKB:P0CZ17 has the exact SGD cross-reference SGD:S000004145. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/299/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ASP3-1 Scer `SGD:S000004145`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source	periplasmic space `GO:0042597`	UniProtKB:P0CZ17 Source assertion: UniProtKB:P0CZ17 annotates location Periplasm (SL-0200). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/299/comments/0/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P0CZ17 Source assertion: UniProtKB:P0CZ17 has the exact SGD cross-reference SGD:S000004145. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/299/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
AAT2 Scer `SGD:S000004017`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:6811576); ECO:0000269 (PubMed:9655342)	pyridoxal 5'-phosphate(2-) `CHEBI:597326`	UniProtKB:P23542 Source assertion: UniProtKB:P23542 annotates CHEBI:597326 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/619/comments/0/cofactors/0` UniProtKB:P23542 Source assertion: UniProtKB:P23542 has the exact SGD cross-reference SGD:S000004017. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/619/uniProtKBCrossReferences/0`
AAT1 Scer `SGD:S000001589`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	pyridoxal 5'-phosphate(2-) `CHEBI:597326`	UniProtKB:Q01802 Source assertion: UniProtKB:Q01802 annotates CHEBI:597326 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4042/comments/0/cofactors/0` UniProtKB:Q01802 Source assertion: UniProtKB:Q01802 has the exact SGD cross-reference SGD:S000001589. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4042/uniProtKBCrossReferences/0`

References

gomodel:YeastPathways_ASPARAGINE-DEG2-PWY GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY (source version: Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json)
UniProtKB:P38986 Reviewed UniProtKB P38986 location annotations (source version: UniProt release 2026_03)
UniProtKB:P23542 Reviewed UniProtKB P23542 location annotations (source version: UniProt release 2026_03)
UniProtKB:P0CX77 Reviewed UniProtKB P0CX77 location annotations (source version: UniProt release 2026_03)
UniProtKB:P0CX79 Reviewed UniProtKB P0CX79 location annotations (source version: UniProt release 2026_03)
UniProtKB:P0CX78 Reviewed UniProtKB P0CX78 location annotations (source version: UniProt release 2026_03)
UniProtKB:Q01802 Reviewed UniProtKB Q01802 location annotations (source version: UniProt release 2026_03)
UniProtKB:P0CZ17 Reviewed UniProtKB P0CZ17 location annotations (source version: UniProt release 2026_03)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 7 activity location assignments and 7 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 12 independently supported location edges and quarantined 5 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
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