superoxide radicals degradation

gomodel:YeastPathways_DETOX1-PWY

Superoxide radicals degradation in Saccharomyces cerevisiae S288C uses SOD1 and SOD2 superoxide dismutase activities to convert superoxide and hydrons into dioxygen and hydrogen peroxide, then CTA1 and CTT1 catalase activities decompose hydrogen peroxide into water and dioxygen.

Pathway type

detoxification

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

Read the source YAML

Pathway network

23 nodes · 34 asserted directed edges

Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.

Reaction / activity
Chemical / cofactor
Protein / complex
Cell / process context
Solid arrow: mechanistic relation
Dashed arrow: membership, location or cofactor relation

Show at full size (scroll to explore)

Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
removal of superoxide radicals `GO:0019430`	biological process
water `CHEBI:15377`	small molecule
hydron `CHEBI:15378`	small molecule
SOD1 Scer `SGD:S000003865`	protein
dioxygen `CHEBI:15379`	small molecule
CTA1 Scer `SGD:S000002664`	protein
CTT1 Scer `SGD:S000003320`	protein
superoxide `CHEBI:18421`	small molecule
cytosol `GO:0005829`	cellular component
hydrogen peroxide `CHEBI:16240`	small molecule
SOD2 Scer `SGD:S000001050`	protein
cytoplasm `GO:0005737`	cellular component
mitochondrial intermembrane space `GO:0005758`	cellular component
peroxisomal matrix `GO:0005782`	cellular component
mitochondrial matrix `GO:0005759`	cellular component
copper cation `CHEBI:23378`	cofactor
zinc(2+) `CHEBI:29105`	cofactor
heme `CHEBI:30413`	cofactor
manganese(2+) `CHEBI:29035`	cofactor
catalase activity `gomodel:CATAL-RXN`	molecular activity
superoxide dismutase activity `gomodel:SUPEROX-DISMUT-RXN`	molecular activity
superoxide dismutase activity `gomodel:YeastPathways_DETOX1-PWY/6a4c244800000257`	molecular activity
catalase activity `gomodel:YeastPathways_DETOX1-PWY/6a4c244800000271`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
superoxide dismutase activity `gomodel:YeastPathways_DETOX1-PWY/6a4c244800000257`	part_of	removal of superoxide radicals `GO:0019430`	gomodel:YeastPathways_DETOX1-PWY Source assertion: The model asserts gomodel:YeastPathways_DETOX1-PWY/6a4c244800000257 BFO:0000050 gomodel:YeastPathways_DETOX1-PWY/YeastPathways_DETOX1-PWY. Source location `./YeastPathways_DETOX1-PWY.json#/facts/0; endpoint types: /individuals/24/type; /individuals/23/type`
catalase activity `gomodel:CATAL-RXN`	has_output	water `CHEBI:15377`	gomodel:YeastPathways_DETOX1-PWY Source assertion: The model asserts gomodel:CATAL-RXN RO:0002234 gomodel:CHEBI_15377_CATAL-RXN. Source location `./YeastPathways_DETOX1-PWY.json#/facts/1; endpoint types: /individuals/0/type; /individuals/1/type`
superoxide dismutase activity `gomodel:YeastPathways_DETOX1-PWY/6a4c244800000257`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_DETOX1-PWY Source assertion: The model asserts gomodel:YeastPathways_DETOX1-PWY/6a4c244800000257 RO:0002233 gomodel:YeastPathways_DETOX1-PWY/6a4c244800000258. Source location `./YeastPathways_DETOX1-PWY.json#/facts/2; endpoint types: /individuals/24/type; /individuals/25/type`
SOD1 Scer `SGD:S000003865`	enables	superoxide dismutase activity `gomodel:SUPEROX-DISMUT-RXN`	gomodel:YeastPathways_DETOX1-PWY Source assertion: The model asserts gomodel:SUPEROX-DISMUT-RXN RO:0002333 gomodel:MONOMER3O-1629_SUPEROX-DISMUT-RXN_controller. Source location `./YeastPathways_DETOX1-PWY.json#/facts/3; endpoint types: /individuals/8/type; /individuals/7/type`
catalase activity `gomodel:CATAL-RXN`	has_output	dioxygen `CHEBI:15379`	gomodel:YeastPathways_DETOX1-PWY Source assertion: The model asserts gomodel:CATAL-RXN RO:0002234 gomodel:CHEBI_15379_CATAL-RXN. Source location `./YeastPathways_DETOX1-PWY.json#/facts/4; endpoint types: /individuals/0/type; /individuals/3/type`
catalase activity `gomodel:YeastPathways_DETOX1-PWY/6a4c244800000271`	part_of	removal of superoxide radicals `GO:0019430`	gomodel:YeastPathways_DETOX1-PWY Source assertion: The model asserts gomodel:YeastPathways_DETOX1-PWY/6a4c244800000271 BFO:0000050 gomodel:YeastPathways_DETOX1-PWY/YeastPathways_DETOX1-PWY. Source location `./YeastPathways_DETOX1-PWY.json#/facts/5; endpoint types: /individuals/37/type; /individuals/23/type`
catalase activity `gomodel:CATAL-RXN`	part_of	removal of superoxide radicals `GO:0019430`	gomodel:YeastPathways_DETOX1-PWY Source assertion: The model asserts gomodel:CATAL-RXN BFO:0000050 gomodel:YeastPathways_DETOX1-PWY/YeastPathways_DETOX1-PWY. Source location `./YeastPathways_DETOX1-PWY.json#/facts/6; endpoint types: /individuals/0/type; /individuals/23/type`
CTA1 Scer `SGD:S000002664`	enables	catalase activity `gomodel:CATAL-RXN`	gomodel:YeastPathways_DETOX1-PWY Source assertion: The model asserts gomodel:CATAL-RXN RO:0002333 gomodel:YDR256C-MONOMER_CATAL-RXN_controller. Source location `./YeastPathways_DETOX1-PWY.json#/facts/7; endpoint types: /individuals/0/type; /individuals/9/type`
CTT1 Scer `SGD:S000003320`	enables	catalase activity `gomodel:YeastPathways_DETOX1-PWY/6a4c244800000271`	gomodel:YeastPathways_DETOX1-PWY Source assertion: The model asserts gomodel:YeastPathways_DETOX1-PWY/6a4c244800000271 RO:0002333 gomodel:YeastPathways_DETOX1-PWY/6a4c244800000275. Source location `./YeastPathways_DETOX1-PWY.json#/facts/8; endpoint types: /individuals/37/type; /individuals/40/type`
superoxide dismutase activity `gomodel:SUPEROX-DISMUT-RXN`	part_of	removal of superoxide radicals `GO:0019430`	gomodel:YeastPathways_DETOX1-PWY Source assertion: The model asserts gomodel:SUPEROX-DISMUT-RXN BFO:0000050 gomodel:YeastPathways_DETOX1-PWY/YeastPathways_DETOX1-PWY. Source location `./YeastPathways_DETOX1-PWY.json#/facts/9; endpoint types: /individuals/8/type; /individuals/23/type`
catalase activity `gomodel:YeastPathways_DETOX1-PWY/6a4c244800000271`	has_output	dioxygen `CHEBI:15379`	gomodel:YeastPathways_DETOX1-PWY Source assertion: The model asserts gomodel:YeastPathways_DETOX1-PWY/6a4c244800000271 RO:0002234 gomodel:YeastPathways_DETOX1-PWY/6a4c244800000273. Source location `./YeastPathways_DETOX1-PWY.json#/facts/10; endpoint types: /individuals/37/type; /individuals/39/type`
superoxide dismutase activity `gomodel:SUPEROX-DISMUT-RXN`	has_input	superoxide `CHEBI:18421`	gomodel:YeastPathways_DETOX1-PWY Source assertion: The model asserts gomodel:SUPEROX-DISMUT-RXN RO:0002233 gomodel:CHEBI_18421_SUPEROX-DISMUT-RXN. Source location `./YeastPathways_DETOX1-PWY.json#/facts/11; endpoint types: /individuals/8/type; /individuals/6/type`
superoxide dismutase activity `gomodel:YeastPathways_DETOX1-PWY/6a4c244800000257`	has_input	superoxide `CHEBI:18421`	gomodel:YeastPathways_DETOX1-PWY Source assertion: The model asserts gomodel:YeastPathways_DETOX1-PWY/6a4c244800000257 RO:0002233 gomodel:YeastPathways_DETOX1-PWY/6a4c244800000259. Source location `./YeastPathways_DETOX1-PWY.json#/facts/12; endpoint types: /individuals/24/type; /individuals/26/type`
catalase activity `gomodel:YeastPathways_DETOX1-PWY/6a4c244800000271`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_DETOX1-PWY Source assertion: The model asserts gomodel:YeastPathways_DETOX1-PWY/6a4c244800000271 BFO:0000066 gomodel:YeastPathways_DETOX1-PWY/6a4c244800000276. Source location `./YeastPathways_DETOX1-PWY.json#/facts/13; endpoint types: /individuals/37/type; /individuals/41/type`
superoxide dismutase activity `gomodel:SUPEROX-DISMUT-RXN`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_DETOX1-PWY Source assertion: The model asserts gomodel:SUPEROX-DISMUT-RXN RO:0002233 gomodel:CHEBI_15378_SUPEROX-DISMUT-RXN. Source location `./YeastPathways_DETOX1-PWY.json#/facts/14; endpoint types: /individuals/8/type; /individuals/2/type`
superoxide dismutase activity `gomodel:SUPEROX-DISMUT-RXN`	has_output	dioxygen `CHEBI:15379`	gomodel:YeastPathways_DETOX1-PWY Source assertion: The model asserts gomodel:SUPEROX-DISMUT-RXN RO:0002234 gomodel:CHEBI_15379_SUPEROX-DISMUT-RXN. Source location `./YeastPathways_DETOX1-PWY.json#/facts/15; endpoint types: /individuals/8/type; /individuals/4/type`
superoxide dismutase activity `gomodel:SUPEROX-DISMUT-RXN`	has_output	hydrogen peroxide `CHEBI:16240`	gomodel:YeastPathways_DETOX1-PWY Source assertion: The model asserts gomodel:SUPEROX-DISMUT-RXN RO:0002234 gomodel:CHEBI_16240_SUPEROX-DISMUT-RXN. Source location `./YeastPathways_DETOX1-PWY.json#/facts/16; endpoint types: /individuals/8/type; /individuals/5/type`
catalase activity `gomodel:YeastPathways_DETOX1-PWY/6a4c244800000271`	has_input	hydrogen peroxide `CHEBI:16240`	gomodel:YeastPathways_DETOX1-PWY Source assertion: The model asserts gomodel:YeastPathways_DETOX1-PWY/6a4c244800000271 RO:0002233 gomodel:CHEBI_16240_SUPEROX-DISMUT-RXN. Source location `./YeastPathways_DETOX1-PWY.json#/facts/18; endpoint types: /individuals/37/type; /individuals/5/type`
catalase activity `gomodel:CATAL-RXN`	has_input	hydrogen peroxide `CHEBI:16240`	gomodel:YeastPathways_DETOX1-PWY Source assertion: The model asserts gomodel:CATAL-RXN RO:0002233 gomodel:CHEBI_16240_SUPEROX-DISMUT-RXN. Source location `./YeastPathways_DETOX1-PWY.json#/facts/19; endpoint types: /individuals/0/type; /individuals/5/type`
superoxide dismutase activity `gomodel:YeastPathways_DETOX1-PWY/6a4c244800000257`	has_output	dioxygen `CHEBI:15379`	gomodel:YeastPathways_DETOX1-PWY Source assertion: The model asserts gomodel:YeastPathways_DETOX1-PWY/6a4c244800000257 RO:0002234 gomodel:YeastPathways_DETOX1-PWY/6a4c244800000260. Source location `./YeastPathways_DETOX1-PWY.json#/facts/20; endpoint types: /individuals/24/type; /individuals/27/type`
catalase activity `gomodel:YeastPathways_DETOX1-PWY/6a4c244800000271`	has_output	water `CHEBI:15377`	gomodel:YeastPathways_DETOX1-PWY Source assertion: The model asserts gomodel:YeastPathways_DETOX1-PWY/6a4c244800000271 RO:0002234 gomodel:YeastPathways_DETOX1-PWY/6a4c244800000272. Source location `./YeastPathways_DETOX1-PWY.json#/facts/22; endpoint types: /individuals/37/type; /individuals/38/type`
superoxide dismutase activity `gomodel:YeastPathways_DETOX1-PWY/6a4c244800000257`	has_output	hydrogen peroxide `CHEBI:16240`	gomodel:YeastPathways_DETOX1-PWY Source assertion: The model asserts gomodel:YeastPathways_DETOX1-PWY/6a4c244800000257 RO:0002234 gomodel:CHEBI_16240_SUPEROX-DISMUT-RXN. Source location `./YeastPathways_DETOX1-PWY.json#/facts/23; endpoint types: /individuals/24/type; /individuals/5/type`
SOD2 Scer `SGD:S000001050`	enables	superoxide dismutase activity `gomodel:YeastPathways_DETOX1-PWY/6a4c244800000257`	gomodel:YeastPathways_DETOX1-PWY Source assertion: The model asserts gomodel:YeastPathways_DETOX1-PWY/6a4c244800000257 RO:0002333 gomodel:YeastPathways_DETOX1-PWY/6a4c244800000262. Source location `./YeastPathways_DETOX1-PWY.json#/facts/24; endpoint types: /individuals/24/type; /individuals/28/type`
superoxide dismutase activity `gomodel:SUPEROX-DISMUT-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_DETOX1-PWY Source assertion: The model asserts gomodel:SUPEROX-DISMUT-RXN BFO:0000066 gomodel:reaction_SUPEROX-DISMUT-RXN_location_lociGO_0005829. Source location `./YeastPathways_DETOX1-PWY.json#/facts/25; endpoint types: /individuals/8/type; /individuals/22/type`
SOD1 Scer `SGD:S000003865`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11500508) Source qualification: A small percentage (around 1-5 percent) localizes to the mitochondrial intermembrane space	cytoplasm `GO:0005737`	UniProtKB:P00445 Source assertion: UniProtKB:P00445 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/32/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P00445 Source assertion: UniProtKB:P00445 has the exact SGD cross-reference SGD:S000003865. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/32/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
SOD1 Scer `SGD:S000003865`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11500508); ECO:0000269 (PubMed:22984289) Source qualification: A small percentage (around 1-5 percent) localizes to the mitochondrial intermembrane space	mitochondrial intermembrane space `GO:0005758`	UniProtKB:P00445 Source assertion: UniProtKB:P00445 annotates location Mitochondrion intermembrane space (SL-0169). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/32/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P00445 Source assertion: UniProtKB:P00445 has the exact SGD cross-reference SGD:S000003865. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/32/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
CTA1 Scer `SGD:S000002664`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:1986244)	peroxisomal matrix `GO:0005782`	UniProtKB:P15202 Source assertion: UniProtKB:P15202 annotates location Peroxisome matrix (SL-0202). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/408/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P15202 Source assertion: UniProtKB:P15202 has the exact SGD cross-reference SGD:S000002664. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/408/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
CTT1 Scer `SGD:S000003320`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P06115 Source assertion: UniProtKB:P06115 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3239/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P06115 Source assertion: UniProtKB:P06115 has the exact SGD cross-reference SGD:S000003320. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3239/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
SOD2 Scer `SGD:S000001050`	located_in Physical protein location from reviewed UniProt. ECO:0000250 (UniProtKB:Q9UQX0)	mitochondrial matrix `GO:0005759`	UniProtKB:P00447 Source assertion: UniProtKB:P00447 annotates location Mitochondrion matrix (SL-0170). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3217/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P00447 Source assertion: UniProtKB:P00447 has the exact SGD cross-reference SGD:S000001050. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3217/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
SOD1 Scer `SGD:S000003865`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10026301); ECO:0000269 (PubMed:36630448); ECO:0000269 (PubMed:8652572) Binds 1 copper ion per subunit. UniProt note evidence: ECO:0000269 (PubMed:10026301); ECO:0000269 (PubMed:8652572)	copper cation `CHEBI:23378`	UniProtKB:P00445 Source assertion: UniProtKB:P00445 annotates CHEBI:23378 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/32/comments/0/cofactors/0; /results/32/comments/0/note` UniProtKB:P00445 Source assertion: UniProtKB:P00445 has the exact SGD cross-reference SGD:S000003865. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/32/uniProtKBCrossReferences/0`
SOD1 Scer `SGD:S000003865`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10026301); ECO:0000269 (PubMed:11524675) Binds 1 zinc ion per subunit. UniProt note evidence: ECO:0000269 (PubMed:10026301); ECO:0000269 (PubMed:11524675)	zinc(2+) `CHEBI:29105`	UniProtKB:P00445 Source assertion: UniProtKB:P00445 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/32/comments/1/cofactors/0; /results/32/comments/1/note` UniProtKB:P00445 Source assertion: UniProtKB:P00445 has the exact SGD cross-reference SGD:S000003865. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/32/uniProtKBCrossReferences/0`
CTA1 Scer `SGD:S000002664`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:9931255)	heme `CHEBI:30413`	UniProtKB:P15202 Source assertion: UniProtKB:P15202 annotates CHEBI:30413 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/408/comments/0/cofactors/0` UniProtKB:P15202 Source assertion: UniProtKB:P15202 has the exact SGD cross-reference SGD:S000002664. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/408/uniProtKBCrossReferences/0`
CTT1 Scer `SGD:S000003320`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	heme `CHEBI:30413`	UniProtKB:P06115 Source assertion: UniProtKB:P06115 annotates CHEBI:30413 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3239/comments/0/cofactors/0` UniProtKB:P06115 Source assertion: UniProtKB:P06115 has the exact SGD cross-reference SGD:S000003320. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3239/uniProtKBCrossReferences/0`
SOD2 Scer `SGD:S000001050`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:Q9UQX0) Binds 1 Mn(2+) ion per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:Q9UQX0)	manganese(2+) `CHEBI:29035`	UniProtKB:P00447 Source assertion: UniProtKB:P00447 annotates CHEBI:29035 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3217/comments/0/cofactors/0; /results/3217/comments/0/note` UniProtKB:P00447 Source assertion: UniProtKB:P00447 has the exact SGD cross-reference SGD:S000001050. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3217/uniProtKBCrossReferences/0`

References

gomodel:YeastPathways_DETOX1-PWY GO-CAM superoxide radicals degradation model YeastPathways_DETOX1-PWY (source version: Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_DETOX1-PWY.json)
UniProtKB:P00445 Reviewed UniProtKB P00445 location annotations (source version: UniProt release 2026_03)
UniProtKB:P15202 Reviewed UniProtKB P15202 location annotations (source version: UniProt release 2026_03)
UniProtKB:P06115 Reviewed UniProtKB P06115 location annotations (source version: UniProt release 2026_03)
UniProtKB:P00447 Reviewed UniProtKB P00447 location annotations (source version: UniProt release 2026_03)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 4 activity location assignments and 4 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 5 independently supported location edges and quarantined 2 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
Read this curation session