fatty acid elongation

gomodel:YeastPathways_FASYN-ELONG2-PWY

Fatty acid elongation in Saccharomyces cerevisiae S288C uses CEM1, OAR1, FAS1, and FAS2 to condense and reduce acyl-carrier protein intermediates through 3-oxoacyl-[acp], (3R)-3-hydroxyacyl-[acyl-carrier-protein], enoyl-[acp], palmitoyl-[acp], and palmitoyl-CoA, then uses TES1 to hydrolyze palmitoyl-CoA to palmitate.

Pathway type

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

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Pathway network

30 nodes · 70 asserted directed edges

Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.

Reaction / activity
Chemical / cofactor
Protein / complex
Cell / process context
Solid arrow: mechanistic relation
Dashed arrow: membership, location or cofactor relation

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
fatty acid elongation `GO:0030497`	biological process
acetoacetyl-[acp] `CHEBI:2393`	protein
acyl-carrier protein `CHEBI:13534`	protein
hydron `CHEBI:15378`	small molecule
NADP(3-) `CHEBI:58349`	small molecule
cytosol `GO:0005829`	cellular component
FAS2 Scer `SGD:S000006152`	protein
OAR1 Scer `SGD:S000001538`	protein
hexadecanoate `CHEBI:7896`	lipid
water `CHEBI:15377`	small molecule
(3R)-3-hydroxyacyl-[acyl-carrier-protein] `CHEBI:84648`	protein
CEM1 Scer `SGD:S000000863`	protein
FAS1 Scer `SGD:S000001665`	protein
acyl-[acyl-carrier protein] `CHEBI:16018`	protein
coenzyme A(4-) `CHEBI:57287`	small molecule
NADPH(4-) `CHEBI:57783`	small molecule
carbon dioxide `CHEBI:16526`	small molecule
palmitoyl-CoA(4-) `CHEBI:57379`	small molecule
palmitoyl-[acyl-carrier protein] `CHEBI:5697`	protein
TES1 Scer `SGD:S000003780`	protein
mitochondrion `GO:0005739`	cellular component
peroxisome `GO:0005777`	cellular component
a (3R)-3-hydroxyacyl-[acyl-carrier protein] -> a trans-2-enoyl-[acyl-carrier protein] + H₂O `gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN`	molecular activity
a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP⁺ ← a 3-oxoacyl-[acp] + NADPH + H⁺ `gomodel:3-OXOACYL-ACP-REDUCT-RXN`	molecular activity
a 2,3,4-saturated fatty acyl-[acp] + a malonyl-[acp] + H⁺ -> acyl-carrier protein + a 3-oxoacyl-[acp] + CO₂ `gomodel:3-OXOACYL-ACP-SYNTH-RXN`	molecular activity
a 2,3,4-saturated fatty acyl-[acp] + NADP⁺ ← a trans-2-enoyl-[acyl-carrier protein] + NADPH + H⁺ `gomodel:ENOYL-ACP-REDUCT-NADPH-RXN`	molecular activity
palmitoyl-CoA + H₂O -> palmitate + coenzyme A + H⁺ `gomodel:PALMITOYL-COA-HYDROLASE-RXN`	molecular activity
a palmitoyl-[acp] + coenzyme A -> palmitoyl-CoA + acyl-carrier protein `gomodel:RXN3O-9780`	molecular activity
3-oxoacyl-[acyl-carrier-protein] synthase activity `gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411`	molecular activity
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity `gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP⁺ ← a 3-oxoacyl-[acp] + NADPH + H⁺ `gomodel:3-OXOACYL-ACP-REDUCT-RXN`	part_of	fatty acid elongation `GO:0030497`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:3-OXOACYL-ACP-REDUCT-RXN BFO:0000050 gomodel:YeastPathways_FASYN-ELONG2-PWY/YeastPathways_FASYN-ELONG2-PWY. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/0; endpoint types: /individuals/66/type; /individuals/68/type`
a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP⁺ ← a 3-oxoacyl-[acp] + NADPH + H⁺ `gomodel:3-OXOACYL-ACP-REDUCT-RXN`	has_input	acetoacetyl-[acp] `CHEBI:2393`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:3-OXOACYL-ACP-REDUCT-RXN RO:0002233 gomodel:B-KETOACYL-ACP_3-OXOACYL-ACP-SYNTH-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/1; endpoint types: /individuals/66/type; /individuals/0/type`
3-oxoacyl-[acyl-carrier-protein] synthase activity `gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411`	has_output	acyl-carrier protein `CHEBI:13534`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411 RO:0002234 gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003414. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/2; endpoint types: /individuals/74/type; /individuals/77/type`
a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP⁺ ← a 3-oxoacyl-[acp] + NADPH + H⁺ `gomodel:3-OXOACYL-ACP-REDUCT-RXN`	provides_input_for	a (3R)-3-hydroxyacyl-[acyl-carrier protein] -> a trans-2-enoyl-[acyl-carrier protein] + H₂O `gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:3-OXOACYL-ACP-REDUCT-RXN RO:0002413 gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/3; endpoint types: /individuals/66/type; /individuals/65/type`
palmitoyl-CoA + H₂O -> palmitate + coenzyme A + H⁺ `gomodel:PALMITOYL-COA-HYDROLASE-RXN`	part_of	fatty acid elongation `GO:0030497`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:PALMITOYL-COA-HYDROLASE-RXN BFO:0000050 gomodel:YeastPathways_FASYN-ELONG2-PWY/YeastPathways_FASYN-ELONG2-PWY. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/4; endpoint types: /individuals/18/type; /individuals/68/type`
3-oxoacyl-[acyl-carrier-protein] synthase activity `gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411 RO:0002233 gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003412. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/5; endpoint types: /individuals/74/type; /individuals/75/type`
a 2,3,4-saturated fatty acyl-[acp] + NADP⁺ ← a trans-2-enoyl-[acyl-carrier protein] + NADPH + H⁺ `gomodel:ENOYL-ACP-REDUCT-NADPH-RXN`	provides_input_for	a palmitoyl-[acp] + coenzyme A -> palmitoyl-CoA + acyl-carrier protein `gomodel:RXN3O-9780`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:ENOYL-ACP-REDUCT-NADPH-RXN RO:0002413 gomodel:RXN3O-9780. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/6; endpoint types: /individuals/16/type; /individuals/19/type`
a 2,3,4-saturated fatty acyl-[acp] + NADP⁺ ← a trans-2-enoyl-[acyl-carrier protein] + NADPH + H⁺ `gomodel:ENOYL-ACP-REDUCT-NADPH-RXN`	has_output	NADP(3-) `CHEBI:58349`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:ENOYL-ACP-REDUCT-NADPH-RXN RO:0002234 gomodel:CHEBI_58349_ENOYL-ACP-REDUCT-NADPH-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/7; endpoint types: /individuals/16/type; /individuals/14/type`
a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP⁺ ← a 3-oxoacyl-[acp] + NADPH + H⁺ `gomodel:3-OXOACYL-ACP-REDUCT-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:3-OXOACYL-ACP-REDUCT-RXN BFO:0000066 gomodel:reaction_3-OXOACYL-ACP-REDUCT-RXN_location_lociGO_0005829. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/8; endpoint types: /individuals/66/type; /individuals/60/type`
FAS2 Scer `SGD:S000006152`	enables	a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP⁺ ← a 3-oxoacyl-[acp] + NADPH + H⁺ `gomodel:3-OXOACYL-ACP-REDUCT-RXN`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:3-OXOACYL-ACP-REDUCT-RXN RO:0002333 gomodel:YPL231W-MONOMER_3-OXOACYL-ACP-REDUCT-RXN_controller. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/9; endpoint types: /individuals/66/type; /individuals/25/type`
OAR1 Scer `SGD:S000001538`	enables	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity `gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428 RO:0002333 gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003433. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/10; endpoint types: /individuals/90/type; /individuals/94/type`
a 2,3,4-saturated fatty acyl-[acp] + NADP⁺ ← a trans-2-enoyl-[acyl-carrier protein] + NADPH + H⁺ `gomodel:ENOYL-ACP-REDUCT-NADPH-RXN`	part_of	fatty acid elongation `GO:0030497`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:ENOYL-ACP-REDUCT-NADPH-RXN BFO:0000050 gomodel:YeastPathways_FASYN-ELONG2-PWY/YeastPathways_FASYN-ELONG2-PWY. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/11; endpoint types: /individuals/16/type; /individuals/68/type`
palmitoyl-CoA + H₂O -> palmitate + coenzyme A + H⁺ `gomodel:PALMITOYL-COA-HYDROLASE-RXN`	has_output	hexadecanoate `CHEBI:7896`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:PALMITOYL-COA-HYDROLASE-RXN RO:0002234 gomodel:CHEBI_7896_PALMITOYL-COA-HYDROLASE-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/12; endpoint types: /individuals/18/type; /individuals/15/type`
a 2,3,4-saturated fatty acyl-[acp] + NADP⁺ ← a trans-2-enoyl-[acyl-carrier protein] + NADPH + H⁺ `gomodel:ENOYL-ACP-REDUCT-NADPH-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:ENOYL-ACP-REDUCT-NADPH-RXN BFO:0000066 gomodel:reaction_ENOYL-ACP-REDUCT-NADPH-RXN_location_lociGO_0005829. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/13; endpoint types: /individuals/16/type; /individuals/62/type`
a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP⁺ ← a 3-oxoacyl-[acp] + NADPH + H⁺ `gomodel:3-OXOACYL-ACP-REDUCT-RXN`	has_output	NADP(3-) `CHEBI:58349`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:3-OXOACYL-ACP-REDUCT-RXN RO:0002234 gomodel:CHEBI_58349_3-OXOACYL-ACP-REDUCT-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/14; endpoint types: /individuals/66/type; /individuals/13/type`
a palmitoyl-[acp] + coenzyme A -> palmitoyl-CoA + acyl-carrier protein `gomodel:RXN3O-9780`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:RXN3O-9780 BFO:0000066 gomodel:reaction_RXN3O-9780_location_lociGO_0005829. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/15; endpoint types: /individuals/19/type; /individuals/64/type`
palmitoyl-CoA + H₂O -> palmitate + coenzyme A + H⁺ `gomodel:PALMITOYL-COA-HYDROLASE-RXN`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:PALMITOYL-COA-HYDROLASE-RXN RO:0002233 gomodel:CHEBI_15377_PALMITOYL-COA-HYDROLASE-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/16; endpoint types: /individuals/18/type; /individuals/2/type`
a 2,3,4-saturated fatty acyl-[acp] + a malonyl-[acp] + H⁺ -> acyl-carrier protein + a 3-oxoacyl-[acp] + CO₂ `gomodel:3-OXOACYL-ACP-SYNTH-RXN`	has_output	acyl-carrier protein `CHEBI:13534`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:3-OXOACYL-ACP-SYNTH-RXN RO:0002234 gomodel:YeastPathways_FASYN-ELONG2-PWY/6690711d00001620. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/17; endpoint types: /individuals/67/type; /individuals/111/type`
a (3R)-3-hydroxyacyl-[acyl-carrier protein] -> a trans-2-enoyl-[acyl-carrier protein] + H₂O `gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN`	has_input	(3R)-3-hydroxyacyl-[acyl-carrier-protein] `CHEBI:84648`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN RO:0002233 gomodel:OH-ACYL-ACP_3-OXOACYL-ACP-REDUCT-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/18; endpoint types: /individuals/65/type; /individuals/17/type`
CEM1 Scer `SGD:S000000863`	enables	a 2,3,4-saturated fatty acyl-[acp] + a malonyl-[acp] + H⁺ -> acyl-carrier protein + a 3-oxoacyl-[acp] + CO₂ `gomodel:3-OXOACYL-ACP-SYNTH-RXN`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:3-OXOACYL-ACP-SYNTH-RXN RO:0002333 gomodel:YER061C-MONOMER_3-OXOACYL-ACP-SYNTH-RXN_controller. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/19; endpoint types: /individuals/67/type; /individuals/21/type`
a (3R)-3-hydroxyacyl-[acyl-carrier protein] -> a trans-2-enoyl-[acyl-carrier protein] + H₂O `gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN BFO:0000066 gomodel:reaction_3-HYDROXYDECANOYL-ACP-DEHYDR-RXN_location_lociGO_0005829. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/20; endpoint types: /individuals/65/type; /individuals/59/type`
FAS1 Scer `SGD:S000001665`	enables	a palmitoyl-[acp] + coenzyme A -> palmitoyl-CoA + acyl-carrier protein `gomodel:RXN3O-9780`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:RXN3O-9780 RO:0002333 gomodel:YKL182W-MONOMER_RXN3O-9780_controller. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/22; endpoint types: /individuals/19/type; /individuals/24/type`
a 2,3,4-saturated fatty acyl-[acp] + a malonyl-[acp] + H⁺ -> acyl-carrier protein + a 3-oxoacyl-[acp] + CO₂ `gomodel:3-OXOACYL-ACP-SYNTH-RXN`	provides_input_for	a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP⁺ ← a 3-oxoacyl-[acp] + NADPH + H⁺ `gomodel:3-OXOACYL-ACP-REDUCT-RXN`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:3-OXOACYL-ACP-SYNTH-RXN RO:0002413 gomodel:3-OXOACYL-ACP-REDUCT-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/23; endpoint types: /individuals/67/type; /individuals/66/type`
a palmitoyl-[acp] + coenzyme A -> palmitoyl-CoA + acyl-carrier protein `gomodel:RXN3O-9780`	part_of	fatty acid elongation `GO:0030497`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:RXN3O-9780 BFO:0000050 gomodel:YeastPathways_FASYN-ELONG2-PWY/YeastPathways_FASYN-ELONG2-PWY. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/24; endpoint types: /individuals/19/type; /individuals/68/type`
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity `gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428`	part_of	fatty acid elongation `GO:0030497`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428 BFO:0000050 gomodel:YeastPathways_FASYN-ELONG2-PWY/YeastPathways_FASYN-ELONG2-PWY. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/25; endpoint types: /individuals/90/type; /individuals/68/type`
3-oxoacyl-[acyl-carrier-protein] synthase activity `gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411`	provides_input_for	a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP⁺ ← a 3-oxoacyl-[acp] + NADPH + H⁺ `gomodel:3-OXOACYL-ACP-REDUCT-RXN`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411 RO:0002413 gomodel:3-OXOACYL-ACP-REDUCT-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/26; endpoint types: /individuals/74/type; /individuals/66/type`
3-oxoacyl-[acyl-carrier-protein] synthase activity `gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411 BFO:0000066 gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003418. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/27; endpoint types: /individuals/74/type; /individuals/80/type`
a 2,3,4-saturated fatty acyl-[acp] + a malonyl-[acp] + H⁺ -> acyl-carrier protein + a 3-oxoacyl-[acp] + CO₂ `gomodel:3-OXOACYL-ACP-SYNTH-RXN`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:3-OXOACYL-ACP-SYNTH-RXN RO:0002233 gomodel:CHEBI_15378_3-OXOACYL-ACP-SYNTH-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/28; endpoint types: /individuals/67/type; /individuals/4/type`
a 2,3,4-saturated fatty acyl-[acp] + a malonyl-[acp] + H⁺ -> acyl-carrier protein + a 3-oxoacyl-[acp] + CO₂ `gomodel:3-OXOACYL-ACP-SYNTH-RXN`	has_output	acetoacetyl-[acp] `CHEBI:2393`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:3-OXOACYL-ACP-SYNTH-RXN RO:0002234 gomodel:B-KETOACYL-ACP_3-OXOACYL-ACP-SYNTH-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/29; endpoint types: /individuals/67/type; /individuals/0/type`
palmitoyl-CoA + H₂O -> palmitate + coenzyme A + H⁺ `gomodel:PALMITOYL-COA-HYDROLASE-RXN`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:PALMITOYL-COA-HYDROLASE-RXN RO:0002234 gomodel:CHEBI_15378_PALMITOYL-COA-HYDROLASE-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/30; endpoint types: /individuals/18/type; /individuals/6/type`
a (3R)-3-hydroxyacyl-[acyl-carrier protein] -> a trans-2-enoyl-[acyl-carrier protein] + H₂O `gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN`	has_output	acyl-[acyl-carrier protein] `CHEBI:16018`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN RO:0002234 gomodel:TRANS-D2-ENOYL-ACP_3-HYDROXYDECANOYL-ACP-DEHYDR-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/31; endpoint types: /individuals/65/type; /individuals/20/type`
palmitoyl-CoA + H₂O -> palmitate + coenzyme A + H⁺ `gomodel:PALMITOYL-COA-HYDROLASE-RXN`	has_output	coenzyme A(4-) `CHEBI:57287`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:PALMITOYL-COA-HYDROLASE-RXN RO:0002234 gomodel:CHEBI_57287_PALMITOYL-COA-HYDROLASE-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/33; endpoint types: /individuals/18/type; /individuals/8/type`
3-oxoacyl-[acyl-carrier-protein] synthase activity `gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411`	has_output	acetoacetyl-[acp] `CHEBI:2393`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411 RO:0002234 gomodel:B-KETOACYL-ACP_3-OXOACYL-ACP-SYNTH-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/34; endpoint types: /individuals/74/type; /individuals/0/type`
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity `gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428`	provides_input_for	a (3R)-3-hydroxyacyl-[acyl-carrier protein] -> a trans-2-enoyl-[acyl-carrier protein] + H₂O `gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428 RO:0002413 gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/35; endpoint types: /individuals/90/type; /individuals/65/type`
a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP⁺ ← a 3-oxoacyl-[acp] + NADPH + H⁺ `gomodel:3-OXOACYL-ACP-REDUCT-RXN`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:3-OXOACYL-ACP-REDUCT-RXN RO:0002233 gomodel:CHEBI_15378_3-OXOACYL-ACP-REDUCT-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/36; endpoint types: /individuals/66/type; /individuals/3/type`
a (3R)-3-hydroxyacyl-[acyl-carrier protein] -> a trans-2-enoyl-[acyl-carrier protein] + H₂O `gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN`	has_output	water `CHEBI:15377`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN RO:0002234 gomodel:CHEBI_15377_3-HYDROXYDECANOYL-ACP-DEHYDR-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/37; endpoint types: /individuals/65/type; /individuals/1/type`
a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP⁺ ← a 3-oxoacyl-[acp] + NADPH + H⁺ `gomodel:3-OXOACYL-ACP-REDUCT-RXN`	has_input	NADPH(4-) `CHEBI:57783`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:3-OXOACYL-ACP-REDUCT-RXN RO:0002233 gomodel:CHEBI_57783_3-OXOACYL-ACP-REDUCT-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/38; endpoint types: /individuals/66/type; /individuals/11/type`
3-oxoacyl-[acyl-carrier-protein] synthase activity `gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411`	has_output	carbon dioxide `CHEBI:16526`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411 RO:0002234 gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003415. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/39; endpoint types: /individuals/74/type; /individuals/78/type`
a palmitoyl-[acp] + coenzyme A -> palmitoyl-CoA + acyl-carrier protein `gomodel:RXN3O-9780`	has_output	palmitoyl-CoA(4-) `CHEBI:57379`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:RXN3O-9780 RO:0002234 gomodel:YeastPathways_FASYN-ELONG2-PWY/6690711d00001534. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/40; endpoint types: /individuals/19/type; /individuals/107/type` gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:RXN3O-9780 RO:0002234 gomodel:CHEBI_57379_RXN3O-9780. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/48; endpoint types: /individuals/19/type; /individuals/10/type`
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity `gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428`	has_input	acetoacetyl-[acp] `CHEBI:2393`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428 RO:0002233 gomodel:B-KETOACYL-ACP_3-OXOACYL-ACP-SYNTH-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/41; endpoint types: /individuals/90/type; /individuals/0/type`
a 2,3,4-saturated fatty acyl-[acp] + a malonyl-[acp] + H⁺ -> acyl-carrier protein + a 3-oxoacyl-[acp] + CO₂ `gomodel:3-OXOACYL-ACP-SYNTH-RXN`	provides_input_for	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity `gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:3-OXOACYL-ACP-SYNTH-RXN RO:0002413 gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/42; endpoint types: /individuals/67/type; /individuals/90/type`
a 2,3,4-saturated fatty acyl-[acp] + NADP⁺ ← a trans-2-enoyl-[acyl-carrier protein] + NADPH + H⁺ `gomodel:ENOYL-ACP-REDUCT-NADPH-RXN`	has_input	NADPH(4-) `CHEBI:57783`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:ENOYL-ACP-REDUCT-NADPH-RXN RO:0002233 gomodel:CHEBI_57783_ENOYL-ACP-REDUCT-NADPH-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/44; endpoint types: /individuals/16/type; /individuals/12/type`
FAS1 Scer `SGD:S000001665`	enables	a 2,3,4-saturated fatty acyl-[acp] + NADP⁺ ← a trans-2-enoyl-[acyl-carrier protein] + NADPH + H⁺ `gomodel:ENOYL-ACP-REDUCT-NADPH-RXN`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:ENOYL-ACP-REDUCT-NADPH-RXN RO:0002333 gomodel:YKL182W-MONOMER_ENOYL-ACP-REDUCT-NADPH-RXN_controller. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/45; endpoint types: /individuals/16/type; /individuals/23/type`
palmitoyl-CoA + H₂O -> palmitate + coenzyme A + H⁺ `gomodel:PALMITOYL-COA-HYDROLASE-RXN`	has_input	palmitoyl-CoA(4-) `CHEBI:57379`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:PALMITOYL-COA-HYDROLASE-RXN RO:0002233 gomodel:CHEBI_57379_RXN3O-9780. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/46; endpoint types: /individuals/18/type; /individuals/10/type`
3-oxoacyl-[acyl-carrier-protein] synthase activity `gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411`	has_input	acyl-[acyl-carrier protein] `CHEBI:16018`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411 RO:0002233 gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003413. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/47; endpoint types: /individuals/74/type; /individuals/76/type`
a palmitoyl-[acp] + coenzyme A -> palmitoyl-CoA + acyl-carrier protein `gomodel:RXN3O-9780`	has_input	coenzyme A(4-) `CHEBI:57287`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:RXN3O-9780 RO:0002233 gomodel:CHEBI_57287_RXN3O-9780. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/49; endpoint types: /individuals/19/type; /individuals/9/type`
a palmitoyl-[acp] + coenzyme A -> palmitoyl-CoA + acyl-carrier protein `gomodel:RXN3O-9780`	has_input	palmitoyl-[acyl-carrier protein] `CHEBI:5697`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:RXN3O-9780 RO:0002233 gomodel:YeastPathways_FASYN-ELONG2-PWY/6690711d00001629. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/50; endpoint types: /individuals/19/type; /individuals/113/type`
a palmitoyl-[acp] + coenzyme A -> palmitoyl-CoA + acyl-carrier protein `gomodel:RXN3O-9780`	provides_input_for	palmitoyl-CoA + H₂O -> palmitate + coenzyme A + H⁺ `gomodel:PALMITOYL-COA-HYDROLASE-RXN`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:RXN3O-9780 RO:0002413 gomodel:PALMITOYL-COA-HYDROLASE-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/51; endpoint types: /individuals/19/type; /individuals/18/type`
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity `gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428`	has_output	NADP(3-) `CHEBI:58349`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428 RO:0002234 gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003431. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/52; endpoint types: /individuals/90/type; /individuals/93/type`
a 2,3,4-saturated fatty acyl-[acp] + NADP⁺ ← a trans-2-enoyl-[acyl-carrier protein] + NADPH + H⁺ `gomodel:ENOYL-ACP-REDUCT-NADPH-RXN`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:ENOYL-ACP-REDUCT-NADPH-RXN RO:0002233 gomodel:CHEBI_15378_ENOYL-ACP-REDUCT-NADPH-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/53; endpoint types: /individuals/16/type; /individuals/5/type`
FAS2 Scer `SGD:S000006152`	enables	3-oxoacyl-[acyl-carrier-protein] synthase activity `gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411 RO:0002333 gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003417. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/54; endpoint types: /individuals/74/type; /individuals/79/type`
a 2,3,4-saturated fatty acyl-[acp] + NADP⁺ ← a trans-2-enoyl-[acyl-carrier protein] + NADPH + H⁺ `gomodel:ENOYL-ACP-REDUCT-NADPH-RXN`	has_output	acyl-[acyl-carrier protein] `CHEBI:16018`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:ENOYL-ACP-REDUCT-NADPH-RXN RO:0002234 gomodel:YeastPathways_FASYN-ELONG2-PWY/6690711d00001631. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/55; endpoint types: /individuals/16/type; /individuals/115/type`
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity `gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428`	has_output	(3R)-3-hydroxyacyl-[acyl-carrier-protein] `CHEBI:84648`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428 RO:0002234 gomodel:OH-ACYL-ACP_3-OXOACYL-ACP-REDUCT-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/56; endpoint types: /individuals/90/type; /individuals/17/type`
a 2,3,4-saturated fatty acyl-[acp] + a malonyl-[acp] + H⁺ -> acyl-carrier protein + a 3-oxoacyl-[acp] + CO₂ `gomodel:3-OXOACYL-ACP-SYNTH-RXN`	has_input	acyl-[acyl-carrier protein] `CHEBI:16018`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:3-OXOACYL-ACP-SYNTH-RXN RO:0002233 gomodel:YeastPathways_FASYN-ELONG2-PWY/6690711d00001614. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/57; endpoint types: /individuals/67/type; /individuals/109/type`
3-oxoacyl-[acyl-carrier-protein] synthase activity `gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411`	provides_input_for	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity `gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411 RO:0002413 gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/58; endpoint types: /individuals/74/type; /individuals/90/type`
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity `gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428`	has_input	NADPH(4-) `CHEBI:57783`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428 RO:0002233 gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003430. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/59; endpoint types: /individuals/90/type; /individuals/92/type`
3-oxoacyl-[acyl-carrier-protein] synthase activity `gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411`	part_of	fatty acid elongation `GO:0030497`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411 BFO:0000050 gomodel:YeastPathways_FASYN-ELONG2-PWY/YeastPathways_FASYN-ELONG2-PWY. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/60; endpoint types: /individuals/74/type; /individuals/68/type`
a 2,3,4-saturated fatty acyl-[acp] + a malonyl-[acp] + H⁺ -> acyl-carrier protein + a 3-oxoacyl-[acp] + CO₂ `gomodel:3-OXOACYL-ACP-SYNTH-RXN`	part_of	fatty acid elongation `GO:0030497`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:3-OXOACYL-ACP-SYNTH-RXN BFO:0000050 gomodel:YeastPathways_FASYN-ELONG2-PWY/YeastPathways_FASYN-ELONG2-PWY. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/61; endpoint types: /individuals/67/type; /individuals/68/type`
a 2,3,4-saturated fatty acyl-[acp] + NADP⁺ ← a trans-2-enoyl-[acyl-carrier protein] + NADPH + H⁺ `gomodel:ENOYL-ACP-REDUCT-NADPH-RXN`	has_input	acyl-[acyl-carrier protein] `CHEBI:16018`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:ENOYL-ACP-REDUCT-NADPH-RXN RO:0002233 gomodel:TRANS-D2-ENOYL-ACP_3-HYDROXYDECANOYL-ACP-DEHYDR-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/62; endpoint types: /individuals/16/type; /individuals/20/type`
a 2,3,4-saturated fatty acyl-[acp] + a malonyl-[acp] + H⁺ -> acyl-carrier protein + a 3-oxoacyl-[acp] + CO₂ `gomodel:3-OXOACYL-ACP-SYNTH-RXN`	has_output	carbon dioxide `CHEBI:16526`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:3-OXOACYL-ACP-SYNTH-RXN RO:0002234 gomodel:CHEBI_16526_3-OXOACYL-ACP-SYNTH-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/63; endpoint types: /individuals/67/type; /individuals/7/type`
a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP⁺ ← a 3-oxoacyl-[acp] + NADPH + H⁺ `gomodel:3-OXOACYL-ACP-REDUCT-RXN`	has_output	(3R)-3-hydroxyacyl-[acyl-carrier-protein] `CHEBI:84648`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:3-OXOACYL-ACP-REDUCT-RXN RO:0002234 gomodel:OH-ACYL-ACP_3-OXOACYL-ACP-REDUCT-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/64; endpoint types: /individuals/66/type; /individuals/17/type`
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity `gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428 RO:0002233 gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003429. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/65; endpoint types: /individuals/90/type; /individuals/91/type`
a (3R)-3-hydroxyacyl-[acyl-carrier protein] -> a trans-2-enoyl-[acyl-carrier protein] + H₂O `gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN`	part_of	fatty acid elongation `GO:0030497`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN BFO:0000050 gomodel:YeastPathways_FASYN-ELONG2-PWY/YeastPathways_FASYN-ELONG2-PWY. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/66; endpoint types: /individuals/65/type; /individuals/68/type`
FAS1 Scer `SGD:S000001665`	enables	a (3R)-3-hydroxyacyl-[acyl-carrier protein] -> a trans-2-enoyl-[acyl-carrier protein] + H₂O `gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN RO:0002333 gomodel:YKL182W-MONOMER_3-HYDROXYDECANOYL-ACP-DEHYDR-RXN_controller. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/67; endpoint types: /individuals/65/type; /individuals/22/type`
a (3R)-3-hydroxyacyl-[acyl-carrier protein] -> a trans-2-enoyl-[acyl-carrier protein] + H₂O `gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN`	provides_input_for	a 2,3,4-saturated fatty acyl-[acp] + NADP⁺ ← a trans-2-enoyl-[acyl-carrier protein] + NADPH + H⁺ `gomodel:ENOYL-ACP-REDUCT-NADPH-RXN`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN RO:0002413 gomodel:ENOYL-ACP-REDUCT-NADPH-RXN. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/68; endpoint types: /individuals/65/type; /individuals/16/type`
TES1 Scer `SGD:S000003780`	enables	palmitoyl-CoA + H₂O -> palmitate + coenzyme A + H⁺ `gomodel:PALMITOYL-COA-HYDROLASE-RXN`	gomodel:YeastPathways_FASYN-ELONG2-PWY Source assertion: The model asserts gomodel:PALMITOYL-COA-HYDROLASE-RXN RO:0002333 gomodel:YeastPathways_FASYN-ELONG2-PWY/67c10cc400000547. Source location `./YeastPathways_FASYN-ELONG2-PWY.json#/facts/69; endpoint types: /individuals/18/type; /individuals/117/type`
OAR1 Scer `SGD:S000001538`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	mitochondrion `GO:0005739`	UniProtKB:P35731 Source assertion: UniProtKB:P35731 annotates location Mitochondrion (SL-0173). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3494/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P35731 Source assertion: UniProtKB:P35731 has the exact SGD cross-reference SGD:S000001538. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3494/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
CEM1 Scer `SGD:S000000863`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:16823961)	mitochondrion `GO:0005739`	UniProtKB:P39525 Source assertion: UniProtKB:P39525 annotates location Mitochondrion (SL-0173). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4662/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P39525 Source assertion: UniProtKB:P39525 has the exact SGD cross-reference SGD:S000000863. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4662/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
TES1 Scer `SGD:S000003780`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10092594)	peroxisome `GO:0005777`	UniProtKB:P41903 Source assertion: UniProtKB:P41903 annotates location Peroxisome (SL-0204). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1826/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P41903 Source assertion: UniProtKB:P41903 has the exact SGD cross-reference SGD:S000003780. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1826/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity `gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428`	occurs_in Activity compartment supported by an inspected functional annotation. ECO:0000250; ECO:0000269 (PubMed:9388293). Alternative isoenzymes may function elsewhere.	mitochondrion `GO:0005739`	UniProtKB:P35731 Source assertion: UniProtKB:P35731 describes the corresponding catalytic function in the mitochondrion; this projection applies to the activity enabled by SGD:S000001538. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3494/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`

References

gomodel:YeastPathways_FASYN-ELONG2-PWY SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY (source version: Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json)
UniProtKB:P35731 Reviewed UniProtKB P35731 location annotations (source version: UniProt release 2026_03)
UniProtKB:P39525 Reviewed UniProtKB P39525 location annotations (source version: UniProt release 2026_03)
UniProtKB:P41903 Reviewed UniProtKB P41903 location annotations (source version: UniProt release 2026_03)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 8 activity location assignments and 5 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 4 independently supported location edges and quarantined 3 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
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